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Journal of Tropical Pharmacy and Chemistry
Published by Universitas Mulawarman
ISSN : 20877099     EISSN : 24076090     DOI : 10.25026/jtpc
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Tropical Pharmacy and Chemistry is a Six monthly (June and December), international, open access, journal dedicated to various disciplines of pharmaceutical and allied sciences. Journal of Tropical Pharmacy and Chemistry publishes manuscripts (Original research Article, review articles, Mini-reviews, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics & Biopharmaceutics, Novel &Targeted Drug Delivery, Nanotechnology & Nanomedicine, Pharmaceutical Chemistry, Pharmacognosy & Ethnobotany, Phytochemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Pharmacogenomics, Pharmacovigilance, Natural Product Research, Drug Regulatory Affairs, Case Study & Full clinical trials, Biomaterials & Bioactive polymers, Analytical Chemistry, Organic Chemistry, Physical Pharmacy, Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 298 Documents
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Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.625

Abstract

This study investigated the antidiabetic activity of the crude ethanol extract of Diospyros mespiliformis (DM) and its ethyl acetate (EEF) and aqueous (AQF) fractions on alloxan-induced diabetic rats. The result indicated a significant (p < 0.05) decrease and improvement in fasting blood glucose (FBG) level and body weight, respectively. The treatment groups exhibited a significantly (p < 0.05) decreased aspartate aminotransferase (AST) level (100-117 IU/L) and decreased gamma-glutamyl transferase (GGT) level in the EEF (4.80 ± 1.02 IU/L) and AQF (5.80 ± 0.80 IU/L) groups only. All the extract-treated groups exhibited a significant increase (p < 0.05) in urea and creatinine levels than the naïve control group (6.94 ± 0.20 mM/L). Moreover, the Na+ remained significantly (p > 0.05) unchanged while the K+ level was significantly (p < 0.05) increased for the treatment groups. The HCO3- of the treated groups increased significantly (p < 0.05) except for the AQF (21.60 ± 1.63 mM/L) group. The total cholesterol and triglyceride levels decreased significantly (p < 0.05) for the treatment groups while the high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels remained unchanged but significantly higher than the metformin group. DM possesses significant hypoglycemic and hypolipidemic activity lowering hyperglycemia and hyperlipidemia, and improving body weight and diabetic markers.
A Review on Current Knowledge of Medicinal Properties of Garcinia quaesita Srikokulan, Sivasinthujah; Nirubini, A. S.
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.627

Abstract

Garcinia quaesita is an endemic plant to Sri Lanka, has garnered attention from traditional medicine practitioners and researchers due to its diverse medicinal properties. G. quaesita have been traditionally used to treat conditions like fevers, fractures, hyperlipidemia, wounds, and hemorrhoids. This review amalgamates data from scientific papers, ayurvedic texts, and other sources. It provides information on its botanical descriptions, phyto-constituents, antioxidant, antibacterial, anti-hyperglycemic, anti-inflammatory, cytotoxic and anticancer activities. There have been few studies that reported the medicinal properties of the leaf, fruit rind and fruit. The presences of phytoconstituents such as alkaloids, glycosides, flavonoids, saponins, tannins, terpenoids, polyphenolics, coumarins, phytosterols, betacyanin, quinones were found as the responsible for the medicinal properties, Notably, the presence of garcinol was one of the responsible compounds for the bioactivity of G. quaesita. This all-encompassing review accentuates the diverse aspects of medicinal property of G. quaesita and its chemical composition, facilitates the identification of novel pharmaceutical products.
Investigation of Total Tannin, Phenolic & Flavonoid Content of Araucaria Heterophylla for Antioxidant Source Ghosh, Ankita; Paul, Shimanta; Ghosh, Susmita; Akter, Sadia; Mahedi, Rezwan Ahmed; Afrin, Sadia; Hasan, Akayed; Hasan, Ali Mohamod Wasaf; Sayeed, Md Abu; Syrmos, Nikolaos
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.634

Abstract

Secondary metabolites, a type of bioactive molecule with many functions, are abundant in Araucaria Heterophylla. The secondary metabolites flavonoids, phanolic acid, and tannin have been found to have anti-inflammatory, antiviral, antibacterial, antioxidant, and anticancer properties. The present study was conducted to analyze the phytochemical and determine the total flavonoid, tannin, phenolic content of Araucaria Heterophylla leaves extract using two different solvents (methanol and dichloromethane) using UV-Vis spectrophotometric. The plant was identified by NHB (ID No: DACB 48435) and prepared the methanolic extract to estimate the total content of tannin, phenolic & flavonoid in Araucaria Heterophylla. Folin-ciocaltu method was used for the investigation of total phenolic and tannin content. The A. heterophylla leaf methanolic and dichloromethane extract had remarkable antioxidant effects due to its high flavonoid and phenolic content. This standardised bioactive ingredient could be used in many phytopharmaceutical preparations
Factors Affecting Bangladeshi High School Students' Practices of Sanitation and Hygiene Hoque, Majedul
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.635

Abstract

Better sanitation and hygiene standards are beneficial for preventing infections, limiting the spread of pathogens, and fostering overall health in educational environments. On the other hand, not much is known about school-student's hygiene and sanitation habits. The purpose of this study is to identify and comprehend the variables that affect students' behaviour related to sanitation and hygiene in classrooms. This study was carried out at the Katiadi Government High School, a high school in a Bangladeshi upazilla town. An exploratory qualitative study design, based on the Integrated Behavioural Model for Water, Sanitation, and Hygiene (IBM-WASH) was used. Before utilizing them, the effectiveness and clarity of the semi-structured interview guides were tested, which included questions about behaviour, access, and practices related to sanitation and hygiene. The students had quite low sanitation and hygiene practices despite having a reasonable level of awareness and knowledge. Sanitation and hygiene practices were influenced by a wide range of interrelated factors, which also affected one another. Contextual factors (lack of upkeep and cleanliness, availability of sanitary products), socio-behavioural factors (norms, peer influence), and individual factors (gender awareness, perception, and sense of health benefits). To advance improved sanitation and hygiene practices among school students, multi-level interventions such as regular delivery of WASH-related materials and agents, promotion of low-cost WASH interventions, quality cleaning services improvement, close observation of cleaning activities, individual hygiene behaviour promotion, and introduction of gender-sensitive WASH infrastructure and construction may be helpful.
Insulin Treatment Perception and Factors affecting the Acceptance in Type 2 Diabetes Mellitus Patients attending a Specialist Clinic in Ilorin, Nigeria Agede, Olalekan A.; Olarinoye, John Kola; Ogunmodede, James Ayodele; Sanni, Nasiru; Bojuwoye, Matthew Olumuyiwa; Opeyemi, Christopher Muyiwa; Ologe, Mary Olufunmilayo; Oyedepo, Dapo S
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.650

Abstract

Type 2 Diabetes Mellitus (T2DM) is a significant global health challenge, with increasing prevalence and diverse management approaches. Insulin therapy, a cornerstone in the management of advanced T2DM, is often met with reluctance and negative perceptions. A better understanding of the multifaceted factors influencing insulin acceptance is crucial for tailored interventions. This study explored the perception regarding insulin treatment using the validated Insulin Treatment Appraisal Scale (ITAS). This study aimed to explore socio-demographic and clinical factors influencing insulin therapy perception and acceptance among T2DM patients in Ilorin, Nigeria. It was a cross-sectional study among T2DM patients. Data on socio-demographic characteristics, diabetes related features and ITAS were collected and analyzed. Statistical methods, including t-tests and chi square were employed to assess the impact of various variables on insulin treatment perception. There was a statistically significant difference (p=0.029) between the age of insulin naïve and experienced patients. Some insulin-experienced patients had positive perceptions of insulin, like their belief in insulin’s health benefits (p = 0.001) and ability to control blood glucose (p = 0.048). Insulin-naive individuals exhibited more negative attitudes toward insulin, emphasizing the need for targeted interventions and patients’ health education. This study provides valuable insights into the intricate interplay of socio-demographic characteristics, diabetes related features, and individual perceptions influencing insulin therapy acceptance among participants with T2DM. The findings underscore the importance of personalized interventions to address negative perceptions, ultimately enhancing diabetes management and treatment outcome.
Antioxidant Activity of Bajakah Kuning (Arcangelisia flava (L.) Merr) Herman, Herman; Almaida, Maria; Haeruddin, Haeruddin; Bone, Mahfuzun; Rusman, Arman
Journal of Tropical Pharmacy and Chemistry Vol. 8 No. 2 (2024): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v8i2.652

Abstract

Indonesia is a tropical country with potential plants that have been used as traditional medicine for generations. One of them is bajakah. This study aims to determine the phenolic content and antioxidant activity of yellow bajakah extract and the relationship between phenolic content and antioxidant activity. The study began with making yellow bajakah extract using maceration method. The bajakah extract obtained then analysed the phenolic content quantitatively using the Folin-Ciocalteu method. Antioxidant activity was tested using the DPPH and ABTS methods. The results showed that yellow bajakah extract contained phenolic compounds with levels of 27.15 ± 1.28 mg/g GAE. IC50 measurements to determine antioxidant activity obtained a value of 47.01 ± 1.16 µg / ml in the DPPH method and 61.21 ± 0.83 µg / ml in the ABTS method. Based on these results, yellow bajakah skin is known to have antioxidant activity with a strong category and phenolic content in yellow bajakah skin has an influence on antioxidant activity.
Assessment of Bisphenol A and Heavy Metals in Some Commercial Brands of Canned Fish Opatola, Segun F.; Akpambamg, V.O. E; Lere-Aliu, M. O.
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.552

Abstract

Bisphenol A are commonly referred to as endocrine disruptive chemicals that migrates into food through canning. Even at low levels, they can result in a variety of health issues, Heavy metal toxicity has become a severe threat and is linked to a number of health risks. When fish are exposed to chemical pollutants, especially when being canned for preservation, bioaccumulation usually occurs. Acid digestion methods were used to measure the specified heavy metals in canned fish, and an atomic adsorption spectrophotometer was used to conduct the analysis. The results of Heavy metals show that Iron, copper and Zinc have the highest concentration indicating that the canned fish are rich in Iron, copper and Zinc, while Lead has the lowest concentration. For Bisphenol A, the concentration ranges from 0.019 to 0.403 ?g/g and satisfied this stipulated standard. Based on the results, the four selected heavy metals, Cu, Fe, Zn, and Pb, as well as Bisphenol A, have concentrations that are within WHO-acceptable levels in canned fish.
Assessment of Bisphenol A in Some Aquatic Food Samples from Eti-Osa Area of Lagos Lere-Aliu, Moromade; Akpambang, V. O. E; Opatola, S. F
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.555

Abstract

Aquatic organisms, being one of the most abundant groups in the aquatic ecosystem are sometimes exposed to all sorts of environmental assaults. These assaults can have serious effects on the nutritive quality of aquatic organisms inhabiting the contaminated aquatic environment. Thus, this study investigated the level of Bisphenol A (BPA) and estimated risk assessment in crayfish, shrimp, periwinkle and crabs obtained from Eti Osa in Lagos Nigeria. The samples were analyzed using solvent extraction, separation and quantitation by gas Chromatography- mass spectrometric method. The recovery value for BPA in the method was 89% with relative standard deviation of 3%. The concentration of Bisphenol A ranged from 0.012 mg/kg to 0.245 mg/kg. Crayfish has the highest concentration of Bisphenol A while periwinkle has the lowest concentration of Bisphenol A. The concentration of Bisphenol A followed this order crayfish > shrimp > crabs > Periwinkle. The concentrations of crayfish is higher than the European Food Safety Authority Specific Migration Limit (SML) of 0.006 mg/kg in food sample while the concentration of crayfish is within the limit set by European Food Safety Authority Specific Migration Limit (SML) {10}. Also, The US environmental protection agency (USEPA) has established the tolerable daily intakes (TDI) for BPA at 0.8 mg/kg-bw/day. Contamination from aquatic environment is a major source of BPA exposure to aquatic organisms and the samples analyzed in this work maybe therefore, of a potential health concern to the consumers particularly for vulnerable population groups after a long term consumption hence there is need for regular monitoring of our aquatic environment.
Phytoconstituents, Nutritional Value, UV and IR Spectra of Extracts and Dyes from Bixa orellana Seeds, Sorghum bicolor Stalks, and Parkia biglobosa Peels Alio Sanda, Mahamadou Djibrilla; Badu, Mercy; Boadi, Nathaniel; Djika, Hachimou; Awudza, Johannes
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.582

Abstract

The increasing consciousness about the usefulness of renewable and biodegradable source of materials, plants-based precursors for products development are preferred against synthetic sources mostly because of fear of adverse effect and source extinction. In this study, the dietetic and biological characteristics of raw materials from Bixa orellana (Achiote), Sorghum bicolor (Sorghum) and Parkia biglobosa (Dorowa) were investigated. The results showed phytochemical compounds such as alkaloids, flavonoids, tannins, coumarins, sterols, triterpenoids, saponins, anthraquinones and anthocyanin with functional groups such as carbonyl, hydroxyl and nitrogenous groups confirmed by the FTIR results while UV spectroscopy showed absorption within visible light.  Sorghum stalks presented the highest amount of crude fiber content (31.138% ±1.15) whereas the peels of Dorowa were the richest sample in carbohydrate content (82.209%) and the seeds of Achiote contained the highest amount of protein (14.805% ±0.12) and lipids (2.339%). Isolating necessary chemical components could lead to drug, food and paint development.
Phytochemical, Toxicity, and Antimalarial Activity Methanol Extracts from Mangrove Coastal Beach Muara Badak, East Kalimantan Usman, Usman; Masruhim, Muh. Amir; Rahmadani, Agung; Aziz, Abdul
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 1 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i1.592

Abstract

The purpose of this study was to determine the content of secondary metabolites, toxicity to Artemia salina, and antimalarial activity of methanol extracts of Avicennia marina, Rhizophora mucronata, and Sonneratia caseolaris leaves. Extraction of the third mangrove leaf species was done by maceration using methanol solvent. Then phytochemical test to determine secondary metabolite compounds, then toxicity test against shrimp larvae A. salina with BSLT method, and Antimalarial activity test in vitro against Plasmodium falciparum strain3D7 (chloroquine sensitive) using Giemsa staining microscopic method. Secondary metabolite compounds contained in methanol extracts of the third species of mangrove leaves are alkaloids, flavonoids, saponins, phenolics compounds, steroids, triterpenoids and tannins. The toxicity of the methanol extract from mangrove leaves of A. Marina, R. mucronata and S. caseolaris against A. salina is strong category with a LC50 value of 256.132 ± 45.63;  48.165 ± 52.25; and 104.96 ± 9.99 ppm respectively. However, the methanol extract of R. mucronata leaves was most toxic to A. salina due to its lowest LC50 value. Mangrove species R. mucronata and S. caseolaris showed activity against P. falciparum 3D7 in a fairly good category with IC50 values < 50 ?g/ml, while the activity of mangrove species A. marina against P. falcifarum 3D7 included unfavorable category with IC50 value > 50 ?g/ml. The other tissue parts of the third mangrove plant species still need to be further explored regarding their bioactivity against A. salina and P. falciparum 3D7.

Page 29 of 30 | Total Record : 298

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