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Mochammad Amrun Hidayat
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Journal of Agropharmacy
Published by Universitas Jember
ISSN : -     EISSN : 30631580     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Agropharmacy is a scientific journal managed and published by the Faculty of Pharmacy, University of Jember. This journal is published three times a year. Scientific articles that can be published in this journal include research in the fields of pharmaceutical science and technology, clinical and community pharmacy, and pharmacy management. Published scientific articles include: - Pharmaceutical Technology - Pharmacology and Toxicology - Pharmaceutical Chemistry - Drug Discovery - Pharmacokinetics - Pharmaceutical Biology - Herbal Medicine - Pharmaceuticals - Pharmaceutical Microbiology and Biotechnology - Clinical and Community - Pharmaceutical Management - Pharmaceutical Bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Kadar Flavonoid Total dan Aktivitas Tabir Surya Ekstrak Kulit Edamame (Glycine max (L.) Merr.) Kristiningrum, Nia; Fadhil, Anfaq Syahriyal; Retnaningtyas, Yuni; Pangaribowo, Dian Agung; Pratoko, Dwi Koko; Sary, Indah Purnama; Wulandari, Lestyo
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Edamame pod waste (Glycine max (L.) Merr.) is often underutilized despite its potential to contain bioactive compounds such as flavonoids, which possess antioxidant and ultraviolet (UV) protective properties. Excessive exposure to UV radiation can cause various skin problems, including premature aging and increased risk of skin cancer, highlighting the need for safe natural sunscreen agents. This study aimed to determine the total flavonoid content and Sun Protection Factor (SPF) value of ethanol extract of edamame pods in vitro. Extraction was performed using the maceration method with 96% ethanol. Total flavonoid content was determined using UV–Vis spectrophotometry with AlCl₃ and CH₃COOK reagents, using quercetin as a standard at a maximum wavelength of 446 nm. The SPF value was evaluated in vitro using a UV–Vis spectrophotometer at wavelengths of 290–320 nm with 5 nm intervals and calculated using the Mansur equation. All measurements were performed in triplicate. The results showed that the ethanol extract of edamame pods contained a total flavonoid content of 5.177 ± 0.432 mg QE/g extract. At a concentration of 1500 µg/mL, the extract exhibited the highest SPF value of 17.22, which is categorized as ultra protection against UVB radiation. These findings indicate that the ethanol extract of edamame pods (Glycine max (L.) Merr.) has potential as a natural source of flavonoids and a photoprotective agent for sunscreen or cosmetic formulations.
Pengaruh Sifat Alir dan Kompresibilitas terhadap Kualitas Tablet Loratadin ODT Ramadhani, Dalifa; Zakiyah Darajat, Nur
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Tablet formulation quality is strongly influenced by manufacturing methods and powder characteristics, particularly flowability and compressibility. This study aimed to evaluate the physical properties of powder and tablet quality of loratadine orally disintegrating tablets (ODT) prepared by the direct compression method. The study was conducted using an experimental laboratory approach, where the powder mixture was evaluated for angle of repose, flow properties, and compressibility, followed by evaluation of tablet characteristics including weight uniformity, size uniformity, hardness, friability, and disintegration time in accordance with pharmacopeial standards. The results showed that the powder exhibited excellent flow properties with an angle of repose of 16.3°, indicating optimal flowability. The tablets met the requirements for size uniformity, friability (0.08%), and disintegration time (1.18–1.23 minutes), demonstrating good mechanical resistance and rapid disintegration suitable for ODT formulations. However, weight uniformity and hardness (2–2.8 kp) did not meet the required standards, indicating suboptimal compaction and powder distribution. These findings suggest that although direct compression is a simple and efficient method for ODT formulation, optimization of formulation components and process parameters, particularly mixing homogeneity, excipient composition, and compression force, is necessary to achieve consistent tablet quality.
Formulasi Tabir Surya Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) dan Seng Oksida Barikah, Kuni Zu''Aimah; Wisudyaningsih, Budipratiwi; Nur Fitriana, Mahmudah
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

UV rays can cause several risks such as premature aging, erythema and skin cancer when exposed too long to the skin. Based on this condition, sunscreen product urgently needed to provide maximal protection to the skin. Red dragon (Hylocereus polyrhizus) fruit peel extract has a flavonoid component that potential used as UV chemical blocker for sunscreen product. This study conducted to determine effectiveness of red dragon fruit peel extract when formulated as cream-based sunscreen using zinc oxide as UV physical blocker to optimize the effect. Cream-based sunscreen product formulated with oil-in-water system, with different concentrations of the red dragon fruit peel extract. The final characteristic of the cream was determined using the pH value, viscosity and spreadability, Sun Protection Factor (SPF) value, % Transmission of Erythema (%TE) value and % Transmission of Pigmentation (%TP) value. All the cream preparation successfully met the physical characteristics (pH, viscosity, and spreadibility) that previously determined. Cream with the 14 % extract concentration (F3) has the highest sunscreen effectivity determined by highest SPF value (15.57 ± 1.32), and lowest % TE value (0.88 ± 0.36) and % TP value (2.68 ± 0.10) (p<0,05). According to result, red dragon fruit peel extract has a great potential activity to develop into sunscreen product. Cream-based sunscreen using the extract able to produce ultra and total block protection based on SPF, % TE and % TP value.
Keamanan dan Efektivitas Analgesik pada Geriatrik: Peran Obat Konvensional dan Herbal Kuswandi, Nabila; Andi Ulfiana Utari
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

The increasing global geriatric population has led to a higher prevalence of chronic pain, particularly associated with musculoskeletal and degenerative conditions. Pain management in older adults is complex due to age-related physiological changes, comorbidities, and polypharmacy, which may increase the risk of adverse drug reactions. This review aims to evaluate the safety and effectiveness of conventional and herbal analgesics in geriatric patients. Conventional analgesics, including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and adjuvant therapies, remain the mainstay of pain management due to their proven efficacy. However, their use is often limited by potential adverse effects, especially gastrointestinal, renal, and cardiovascular complications, which are more pronounced in elderly populations. In recent years, herbal medicines such as curcumin (Curcuma longa), ginger (Zingiber officinale), and capsaicin (Capsicum annuum) have gained attention as alternative or complementary therapies. These agents exhibit anti-inflammatory and analgesic properties with relatively better safety profiles, particularly in mild to moderate pain conditions. Nevertheless, concerns regarding variability in active compounds, lack of standardization, and potential herb–drug interactions, including modulation of cytochrome P450 enzymes, remain significant challenges in clinical practice. In conclusion, an integrated and individualized approach combining conventional and herbal analgesics, guided by evidence-based practice, may optimize pain management outcomes in geriatric patients while minimizing risks.
Evaluasi Penggunaan Obat Pada Pasien Diabetes Melitus Tipe 2 di RSUD dr. H. Slamet Martodirdjo Pamekasan Norcahyanti, Ika; Rahman, S. Nadya Riskia; Aryani, Dhita Evi
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes, accounting for approximately 90% of all cases. Indonesia ranks sixth globally in diabetes prevalence, with national rates rising from 6,9% to 10,9%. Understanding drug utilization patterns can empower healthcare providers to optimize treatment. At RSUD dr. H. Slamet Martodirdjo Pamekasan, T2DM is among the top five diagnoses with highest prevalence in 2018. This observational descriptive study with a retrospective cross-sectional design evaluated drug use in 61 T2DM inpatients (January-June 2018) using a Drug Related Problems (DRPs) approach. Patient characteristics, drug utilization profiles, and DRP categories were analyzed descriptively from medical records. The majority of patients were male (50,82%), adults aged 25-64 years (80,33%), covered by BPJS insurance (88,52%), with hypertension as the most common comorbidity (30,51%). Drugs for the alimentary tract and metabolism were most frequently prescribed (32,15%), with metamizole injection having the highest individual use frequency (11,68%). A total of 238 DRP events were identified in 56 patients: drug interactions (54,20%), overdosage (16,39%), subtherapeutic dosage (15,13%), untreated indication (8,82%), and drug use without indication (5,46%). Drug interactions predominated, with the most frequent being ceftriaxone–Ringer Lactate (14 events, major), ciprofloxacin–insulin aspart (8 events, moderate), and sucralfate–furosemide (5 events, moderate). Standardization of medical records, prescribing practices, and active clinical pharmacist involvement are recommended to minimize DRPs in T2DM inpatient care.
Efek Analgesik Ekstrak Batang Mentigi (Vaccinium varingiaefolium) dan Kandungannya Ningsih, Indah Yulia; Zulfiah Nur Fajriani; Fransiska Maria Christianty; Ika Puspita Dewi; Ema Rachmawati
Journal of Agropharmacy Vol. 3 No. 1 (2026)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Mentigi (Vaccinium varingiaefolium) is one of the herbal medicines used by the Tengger tribe in East Java, Indonesia, to treat pain. Several investigations have showed that the plant possesses analgesic substances, including anthocyanins. The objective of the study is to assess the analgesic effect of a 70% ethanolic extract from the stem of mentigi using the hot-plate test and acetic acid-induced writhing test. Additionally, the study aims to evaluate the chemical constituents of the extract using phytochemical screening. The findings indicated that the dose of 1200 mg/kg had the most significant analgesic effect, increasing the latency time (12.80±1.33 seconds), reducing the number of writhing (20.00±2.92), and increasing the percentage of analgesic power (65.75±5.07%). The effect is related to the chemical content of the extract, namely saponins, flavonoids, polyphenols and tannins. The study suggested that the stem extract of mentigi has the potential to be developed as an analgesic agent.

Page 3 of 3 | Total Record : 26

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