cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Mochammad Amrun Hidayat
Contact Email
amrun.farmasi@unej.ac.id
Phone
+62331-324736
Journal Mail Official
joa.farmasi@unej.ac.id
Editorial Address
Kalimantan 37 Jember
Location
Kab. jember,
Jawa timur
INDONESIA
Journal of Agropharmacy
Published by Universitas Jember
ISSN : -     EISSN : 30631580     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Journal of Agropharmacy is a scientific journal managed and published by the Faculty of Pharmacy, University of Jember. This journal is published three times a year. Scientific articles that can be published in this journal include research in the fields of pharmaceutical science and technology, clinical and community pharmacy, and pharmacy management. Published scientific articles include: - Pharmaceutical Technology - Pharmacology and Toxicology - Pharmaceutical Chemistry - Drug Discovery - Pharmacokinetics - Pharmaceutical Biology - Herbal Medicine - Pharmaceuticals - Pharmaceutical Microbiology and Biotechnology - Clinical and Community - Pharmaceutical Management - Pharmaceutical Bioinformatics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 20 Documents
 1   2 
Evaluasi Penggunaan Antibiotik pada Pasien ISPA Non-pneumonia di Puskesmas Senduro Kabupaten Lumajang Tahun 2019 Pratiwi, Permata Sari; Rachmawati, Ema; Rachmawati, Sinta; Aryani, Dhita Evi; Norcahyanti, Ika; Machlaurin, Afifah; Muhammad Hilmi Afthoni
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1330

Abstract

Acute Respiratory Infection (ARI) is an infectious disease of the upper and lower respiratory tract. Non-pneumonic ARI is mostly caused by viral infections so symptomatic therapy can be given, but it can also be caused by bacterial infections so antibiotic therapy is needed. Unwise use of antibiotics can increase bacterial resistance, thereby increasing morbidity and mortality rates. Regular evaluations need to be carried out to reduce the unwise use of antibiotics. The evaluation method that can be used is a quantitative method (ATC/DDD) to determine trends in antibiotic use. This research was conducted on 278 outpatient non-pneumonic ARI patients at the Senduro Lumajang Community Health Center in 2019, with the aim of knowing patient characteristics, antibiotic use profile, and description of antibiotic use using the ATC/DDD method. The results showed that female patients (n=154; 55.4%), were more dominant than male (n=124; 44.6%), patients with the highest age range being 36-45 years (n=70; 25, 2%), the highest diagnosis of ARI was other acute infections of the upper respiratory tract (J06) (n=147; 52.9%), the most commonly used antibiotic was amoxicillin (n=227; 81.6%) and the most rarely used was cefadroxil (n=13; 4.7%). Based on the evaluation results using the ATC/DDD method, it shows that amoxicillin is the antibiotic with the highest DDD value of 7.5 DDD/1000 patients/day and the antibiotic levofloxacin with the lowest DDD value of 0.3 DDD/1000 patients/day.
Formulasi Krim Ekstrak Daun Jambu Biji (Psidium guajava L.) dan Avobenzone sebagai Sediaan Tabir Surya Nurjannah, Siti; Wisudyaningsih, Budipratiwi; Puspitasari, Endah
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1394

Abstract

Skin exposed to ultraviolet (UV) rays for a long period of time can cause adverse effects on the skin such as erythema, premature aging and skin cancer so that the use of sunscreen is needed to protect the skin from UV exposure. Sunscreen is used to protect the skin from damage caused by UV exposure by absorbing and scattering UV rays that hit the skin. The study was conducted by making a formulation of guava leaf extract cream and avobenzone in a sunscreen cream preparation, evaluating physical quality, evaluating the in vitro effectiveness of sunscreen preparations including SPF,% TE, and% TP values ​​and data analysis. Sunscreen cream preparations with additional concentrations of guava leaf extract can reduce pH and spreadability, TE and TP but can increase viscosity and SPF values. Formula F3 (7%) has physical quality that meets the criteria of the expected cream preparation and can increase the effectiveness in vitro in sunscreen cream preparations and get the best results with an SPF value of 18.49 ± 1.02 which is included in the ultra protection category and a decrease in the %TE value of 0.486 ± 0.004 and a decrease in %TP of 0.158 ± 0.005 which is included in the total block category. It is recommended in further research to conduct compatibility tests and stability tests of guava leaf extract and avobenzone sunscreen cream preparations.
Baricitinib for the treatment of COVID-19 Firdha Aprillia Wardhani; Syafika, Devina Sarah; Kusumaningrum, Yunita Dyah; Adelia Firandi
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1422

Abstract

Baricitinib which is one of the therapies for rheumatoid arthritis is a JAK inhibitor. WHO recommended therapy with the combination of baricitinib and corticosteroids in COVID-19 patients with severe or critical condition. Effectivity and safety assessment of Baricitinib use were carried out by reviewing the literature published between December 2019 – February 2022, and showed that the use of Baricitinib in COVID-19 patients resulted in an improvement of lung function, improvement of oxygen saturation, higher recovery rate, and lower mortality, with similar adverse event incidence. A loading dose or a higher dose can be recommended for patient with caution and consideration of higher possibility in the incidence of adverse events
Pengaruh Waktu Pengadukan Terhadap Sintesis Senyawa Kalkon Melalui Reaksi Kondensasi Claisen-Schmidt Nur, Atiqah; Qodri, Udrika Lailatul; Atiqah , Sri Nur
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1533

Abstract

Chalcone compound is a secondary metabolite compound of the flavonoid class which has biological activity as an antibacterial. The purpose of this study was to determine the optimum stirring time in the synthesis of chalcone compounds using NaOH as an alkaline catalyst through the Claisen-Schmidt condensation reaction between acetophenone and benzaldehyde. The method for synthesizing chalcone compounds with stirring variations of 3 hours, 5 hours and 7 hours was carried out through three stages. The first stage is the manufacture of NaOH base catalyst. The second step is to mix acetophenone with NaOH solution to produce a nucleophilic enolate ion. The third step is to mix the enolate ion with benzaldehyde. The synthesized chalcone compound was characterized through organoleptic test, melting point test, solubility test, TLC test, UV-Vis Spectrophotometry, and FTIR. The characterization results show that each chalcone compound synthesized with variations in stirring time is generally produced in the form of crystals with color values of 13, 10 and 8 as seen in standard colors, melting point 50-51oC, highly soluble in chloroform and dichloromethane, slightly soluble in ethanol and practically insoluble in distilled water. The results of the TLC showed that the Rf value of the synthesized chalcone compound was different from the Rf value of the starting material. The results of UV-Vis spectrophotometry showed that there was a maximum absorption of benzoyl compounds in the 220 nm area and showed that there was a maximum absorption of cinnamyl compounds in the area of 370-390 nm. The FTIR spectrum shows the presence of functional groups =C-H (Alkene), C-H (Aromatic), C=C (Aromatic), C=C (Alkene), and C-H (Aromatic). The synthesis results show that the most optimal stirring time is 7 hours with a percent yield of 95.112%. The results of data analysis using the one way annova test showed that H0 was rejected and H1 was accepted, meaning that there was an effect of stirring time on the percent yield of the synthesized chalcone compound.
Evaluasi Perencanaan dan Pengadaan Obat dengan Dana JKN di Puskesmas Rambipuji Jember Norcahyanti, Ika; Firandi, Adelia; Ramadhani, Nuril Izzati Farihatur; Rachmawati, Sinta; Rachmawati, Ema; Aryani, Dhita Evi; Wardhani, Firdha Aprillia; Kusumaningrum , Yunita Dyah
Journal of Agropharmacy Vol. 1 No. 3 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i3.1811

Abstract

Public Health Center is a health facility that organizes drug management activities, including planning and procurement activities. Evaluation needs to assess the success of achieving the objectives and results of the action. Indicators that can use are efficiency indicators published by the Ministry of Health of the Republic of Indonesia and efficiency indicators developed by Pudjaningsih. Rambipuji Public Health Center with spending funds for the most significant drug procurement in Jember Regency in 2020. Therefore, it is necessary to evaluate the results that can improve the quality of service in the next period. This research aims to determine the results of the evaluation of drug planning and procurement with JKN funds at Rambipuji Public Health Center for 2020. This research is descriptive, primary data through interview results. Secondary data includes total funds available, drug procurement funds, Drug Usage Reports, and Drug Demand Sheets for drugs purchased through JKN funds and stock cards. The data is analyzed descriptively, presented in the form of tables supported by interview results. The results showed that the Government of Indonesia had governed drug planning and procurement activities with JKN funds. The percentage indicator of available funds compared to the general funds needed is 114.26%. The percentage indicator of drug procurement fund allocation is 3.46%. Results on percentage indicator procurement conformity with the reality of the use of each drug item amounted to 133.33% and on the procurement frequency indicator of each drug item once a year. Through this research, it can be concluded that the evaluation results on indicators of the efficiency of drug planning and procurement activities at Rambipuji Public Health Center have not been by established standards. This matter was influenced by several factors, including a decrease in the number of patient visits due to the COVID-19 pandemic, changes in the organizational structure in the Jember Health Office that resulted in the frequency of procurement activities only once throughout 2020, and the absence of government regulations that regulate in more detail about the percentage of JKN funds allowed for drug procurement activities.
Formulasi Krim Ekstrak Daun Kersen (Muntingia calabura L.) dan Seng Oksida Sebagai Sediaan Tabir Surya Rosyidi, Viddy Agustian; Ameliana, Lidya; maarif, safirul
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sunscreen has two types of working mechanisms, namely chemical absorber and physical blocker. Sunscreens are usually made from synthetic chemicals, but currently there are many natural ingredients that have potential as sunscreens and are believed to have little negative effect compared to synthetic chemicals. One example of a natural ingredient that has potential as a sunscreen is kersen leaves. Kersen leaves contain quite a lot of flavonoid and polyphenol compounds, therefore cherry leaves have the potential to be an antioxidant and natural sunscreen. The effectiveness of cherry leaf sunscreen can be optimized by adding a physical blocker sunscreen ingredient, namely zinc oxide. Based on research results, the in vitro effectiveness value of sunscreen cream preparations provides the best results with an SPF value of 2.193 ± 0.152 which is included in the minimal protection category with a reduction in the percentage transmission value of erythema (%TE) of 1.513 ± 0.523 which is included in the sunblock category. and the percent pigmentation transmission (%TP) value was 1,378 ± 0.325, which is included in the sunblock category.
Formulasi Dan Evaluasi Sifat Fisik Blush On Powder Ekstrak Buah Tomat (Solanum lycopersicum L.) Sebagai Pewarna Alami Eryani, Mikhania Christiningtyas; Syuhuriah, Ainin; Azizah, Siti Nur; Husni, Patihul
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Blush on is a cosmetic product that is used to provide color or add aesthetics to facial makeup. Tomato fruit (Solanum lycopersicum L.) contains red carotenoid pigments which can be used as natural dyes. This research aims to formulate and evaluate the physical properties of blush on tomato fruit extract with concentrations of 3% (F1),5% (F2) and 7% (F3). The results of organoleptic research showed that F1 was light orange, F2 was bright orange and F3 was bright orange. The entire formula smells of rosae, has a smooth and homogeneous texture. The pH value of the entire formula is 6.0. Evaluation of spreadability shows that the entire formula adheres after 5 applications. The conclusion of this research is that tomato fruit extract has an effect on the physical properties of blush on powder, namely organoleptic odor and color. However, it has no effect on organoleptic texture, pH, homogeneity and spreadability
Optimasi Moringa Gum dan Hidroksi Propil Metil Selulosa dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Sari, Lusia Oktora Ruma Kumala; Hanif, Mohammad Ainul Fakhruddin; Irawan, Eka Deddy; Winarti, Lina; Barikah, Kuni Zu’aimah; Rosyidi, Viddy Agustian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Moringa gum is a natural polymer obtained from Moringa oleifera plant and has been used as a stabilizer, binder, disintegrant, and controlled release matrix. Moringa gum has a polyuronide group, which can potentially be a mucoadhesive agent. This study used moringa gum as a mucoadhesive agent in diltiazem HCl mucoadhesive buccal film. This research aimed to determine the effect of the combination of moringa gum and HPMC on surface pH, swelling index, and in-vitro mucoadhesive residence time. Mucoadhesive buccal films were evaluated for weight and thickness uniformity, folding resistance, drug content, surface pH, swelling index, in-vitro mucoadhesive residence time, and characterization in the form of FTIR and release studies. All formulations met the tests of uniformity of weight and thickness, folding resistance, and drug content. The results showed FB as the optimum formula with a surface pH of 5.803±0.101, a swelling index of 7.031±0.134, and a residence time of 505.67±4.51 minutes. FTIR showed no interaction, and the release study showed 82.197±1.178% release at 480 minutes. In conclusion, a combination of moringa gum and HPMC mucoadhesive buccal film has been successfully prepared with moringa gum as a mucoadhesive agent that increases the residence time.
Validasi Metode Penentuan Kadar Asam Klorogenat dan Kafein secara Simultan pada Serbuk Daun Kopi Robusta (Coffea Canephora) dengan Metode KLT Densitometri Putri Aditama, Tiara Sagita; Kristiningrum, Nia; Wulandari, Lestyo; Holidah, Diana; Alishlah, Tanfidz; Puspitasari, Endah
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee contains bioactive compounds such as chlorogenic acid and caffeine. Chlorogenic acid is recognized as a natural antioxidant, while caffeine is widely used to reduce fatigue and drowsiness. This study aims to simultaneously determine the content of chlorogenic acid and caffeine in robusta coffee leaf powder (Coffea canephora) using Thin Layer Chromatography (TLC) densitometry. The study identified an optimal eluent composition of ethyl acetate:formic acid:distilled water (18:1:1), with maximum wavelengths of 330 nm for chlorogenic acid and 274 nm for caffeine. High linearity was demonstrated with correlation coefficients of 0.993 for chlorogenic acid and 0.994 for caffeine. Sensitivity was validated with LOD values of 100.664 ng for chlorogenic acid and 297.232 ng for caffeine, and LOQ values of 301.994 ng for chlorogenic acid and 891.697 ng for caffeine. Selectivity was confirmed as the method effectively separated chlorogenic acid, caffeine, and other compounds with a resolution (Rs) ≥ 1.5, while specificity was evidenced through purity and identity values exceeding 0.99. Precision was proven through repeatability (%RSD for chlorogenic acid: 2.94%; caffeine: 2.27%) and intermediate precision (%RSD for chlorogenic acid: 2.26%; caffeine: 2.18%). Accuracy was achieved with mean recovery rates of 102.22% for chlorogenic acid and 99.73% for caffeine. The determination of chlorogenic acid and caffeine concentrations in robusta coffee leaf powder revealed variations between samples: PTPN XII Renteng yielded 2.278% ± 0.209% for chlorogenic acid and 1.171% ± 0.821% for caffeine, while Puslitkoka Indonesia samples showed 1.238% ± 0.206% for chlorogenic acid and 0.917% ± 0.823% for caffeine. Based on validation parameter assessments, the method is deemed valid as it meets all acceptance criteria for each parameter. This research provides an efficient and accurate analytical approach for simultaneous determination of bioactive compounds in robusta coffee leaves.
Evaluasi Penggunaan Antibiotik pada Pasien ISPA non Pneumonia Rawat Jalan dengan pendekatan Drug Utilization 90% Rachmawati, Ema; Norcahyanti, Ika; Aryani, Dhita Evi; Machlaurin, Afifah; Kurniawan, Eka Cahya
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acute respiratory infections (ARI) are infections most commonly caused by viruses, and antibiotics are not always necessary. However, antibiotics are still frequently used needlessly in ARI patients. Unreasonably using antibiotics can affect the likelihood of adverse medication reactions, raise medical expenses, and lead to antibiotic resistance. Regular assessments are required to prevent the overuse of antibiotics. This surveillance study uses retrospective and cross-sectional data to monitor antibiotic use. We measured the amount of antibiotic use using the DDD method in combination with DU 90%. Outpatient non-pneumonia ARI patients at the Teja Health Center in the Pamekasan Regency in 2020 served as the study's sample. The study's samples consisted of 193 adult non-pneumonia ARI patients. The kind and quantity of antibiotics used were gathered from patient medical records. The daily consumption of each antibiotic was calculated in DDD/1000 inhabitants/day, then grouped into the DU 90% segment. Six types of antibiotics were used for the therapy of non-pneumonia ARI patients: amoxicillin, erythromycin, co-trimoxazole, chloramphenicol, cefadroxil, and ciprofloxacin. The most widely used antibiotic is co-trimoxazole, valued at 4.71 DDD/1000 inhabitants per day. Two antibiotics are included in the 90% DU segment: co-trimoxazole and amoxicillin. This shows that the selection of antibiotics in ARI cases is increasingly specific. However, the use of co-trimoxazole in the therapy of non-pneumonia ARI needs to be further evaluated to assess the accuracy of drug prescription. This is because co-trimoxazole is not included in one of the antibiotic choices in the therapy management guidelines.

Page 2 of 2 | Total Record : 20

 1   2 

Filter by Year

2024 2025


Reset
Filter By Issues
All Issue Vol. 2 No. 1 (2025) Vol. 1 No. 3 (2024) Vol. 1 No. 2 (2024) Vol. 1 No. 1 (2024)