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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 190 Documents
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Aktivitas Ekstrak Daun Teh Hijau (Camellia sinensis (L.) Kuntze) Terhadap Bakteri Streptococcus Mutans Dengan Perbedaan Tingkat Kepolaran Pelarut Rosalina L.S, Fazrisa; Septiani Agustien, Gina; Rizkuloh, Lina Rahmawati
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.352

Abstract

Oral health is an important aspect that should be considered as part of broader efforts to improve overall health (Ministry of Health of the Republic of Indonesia, 2019). The prevalence of dental issues has increased from 23.3% to 25.9%. One of the major dental problems in Indonesia is dental caries, which is classified as a disease. Research on the activity of green tea leaf extract (Camellia sinensis (L.) Kuntze) from various solvent polarity levels has been conducted. This study aims to identify the activity of green tea leaf extract and its inhibitory effect on the growth of Streptococcus mutans bacteria. The extraction method used in this study was maceration with three solvent polarities: n-hexane (non-polar), ethyl acetate (semi-polar), and ethanol (polar). The extract's ability to inhibit bacteria was tested using the disc diffusion method. The results showed that 96% ethanol at a concentration of 10% had an inhibition zone of 11.02 mm (strong category).
Pengaruh Variasi Konsentrasi Natrium Hidroksida (NaOH) Terhadap Sifat Fisik Sabun Padat Berbahan Minyak Goreng Bekas Pakai Mikhania Christiningtyas; Nur; Risky Ayu Paramita, Denok; Patihul; Riskha Nurmalasari, Dewi
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.378

Abstract

Soap is a cleanser made by a chemical reaction between sodium or potassium and fatty acids from vegetable oils or animal fats. Used cooking oil can be used as the main ingredient for the oil component in making solid soap used for washing dishes. This research aims to determine the effect of variations in NaOH concentration on the physical properties of solid soap preparations made from used cooking oil. Preparations were made with NaOH concentrations between 5% (F1), 8.5% (F2) and 12% (F3). The physical property tests carried out are organoleptic tests including texture, color and odor, pH test, water content test and foam height test. Organoleptic data shows that F1 has a smooth texture, yellow color and a weak lemon smell. F2 has a slightly rough texture, yellow color and a weak lemon smell. F3 has a rough texture, yellow color and does not smell like lemon. F1 pH value is 10.36 ± 0.16; F2 was 10.52 ± 0.33; and F3 of 10.47 ± 0.18. The results of the water content test showed that F1 data was 0.91% ± 0.25; F2 was 0.88% ± 0.04; and F3 of 1.04% ± 0.20. The foam height test results showed that F1 data was 6.97 ± 1.00 cm, F2 was 6.57 ± 0.38 cm, and F3 was 5.83 ± 0.32 cm. The conclusion is that NaOH variations concentration have an effect on the texture and smell of soap but have no effect on color, pH, water content and height of soap foam.
Pengembangan Sediaan Gel Ekstrak Bonggol Pisang Ambon Husni, Patihul; Prayitno, Adi; Baitariza, Ardian; Christiningtyas Eryani, Mikhania; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.382

Abstract

Ambonese banana (Musa paradisiaca var. Sapientum (L.)) has a tuber with several benefits including for wound-healing. The Ambonese banana tuber contains protein, fat, vitamins A and C. In addition, the tannins, flavonoids, and saponins contained in the sap of the Ambonese banana tuber are beneficial in wound healing. The purpose of this study was to obtain the best gel formula containing extract of Ambonese banana tuber based on physical evaluation. The study was conducted by making three different gel formulations (F1, F2, F3) containing 5% Ambonese banana tuber extract. Physical assessment of the gel preparation included organoleptic tests, pH determination, homogeneity, viscosity, and spreadability evaluation. The results showed that the preparation was in the form of a homogeneous gel with a reddish-brown color and a distinctive odor. The pH of the preparation was around 5-8 with a viscosity between 500-3500 cps and a spreadability of 5-8 cm. F2 is the best gel formula based on physical evaluation during four weeks of storage with a composition of 5% HPMC, 15% propylene glycol, 0.2% methylparaben, 5% Ambonese banana tuber extract, and 100% aquadest.
Identifikasi Makroskopis, Mikroskopis, Dan Skrining Fitokimia Bunga Telang (Clitoria ternatea, L.) Varian Biru Dan Ungu Muda Lingir Huar, Salestina; Rumaseuw, Ellen Stephanie
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.386

Abstract

Butterfly pea flower (Clitoria ternatea, L.) is a medicinal plant known for its pharmacological properties due to the presence of various bioactive compounds. This study aims to identify the macroscopic, microscopic, and phytochemical characteristics of the blue and light purple variants of butterfly pea flowers cultivated in Cipangeran Village, Saguling District, West Bandung Regency. The research employed a descriptive qualitative method with an experimental approach. Macroscopic identification was conducted by observing the color, shape, odor, and texture of the flowers, while microscopic observation was performed using powdered simplicia preparations under a microscope finding indentifier fragmen. Phytochemical screening was conducted using specific reagents to detect the presence of secondary metabolites such as alkaloids, flavonoids, saponins, steroids/triterpenoids, and tannins. The results showed that both flower variants have morphological features typical of the Fabaceae family, with distinct color gradients and varied textures. Microscopic analysis revealed identifying fragments such as sclerenchyma, pollen grains, vascular bundles, covering trichomes, collenchyma, and idioblasts containing oil cells. Phytochemical screening indicated the presence of flavonoids, steroids/triterpenoids, tannins, and alkaloids in both variants. Saponins were detected only in the blue variant. These findings suggest that both blue and light purple butterfly pea flower variants have potential as raw materials for herbal health products.
Evaluation Of Standard Operating Procedures For Carrying Vaccines At Tabanan District Health Office Komang Dian Aditya Putra; G.A. Desya Pradnyaswari; Ni Luh Putu Taksayani Putri; Rini Noviyani
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.387

Abstract

Vaccination is crucial for public health, saving countless lives annually. Standard operating procedures (SOPs) are essential for effective health service delivery. The Tabanan District Pharmacy Installation followed the SOPs to transport vaccines from the Provincial Health Office. This study examines the current practice of implementing the relevant SOPs. Interviews were conducted to gather data. The SOP comprises 14 detailed procedures. It starts with determining the vaccine pickup time and submitting a comprehensive Proof of Goods Out and Vaccine Arrival Report to the Head of Pharmacy Installation. The review of the SOP implementation shows that it effectively addresses various challenges in distributing vaccines to the Bali Provincial Health Office. This indicates that the Tabanan District Pharmacy Installation has successfully prepared and implemented the SOP for carrying vaccines from the Bali Provincial Health Office. However, there are opportunities for improvement, particularly in replacing outdated regulations with the latest ones.
Analisis Kualitatif Bahan Kimia Obat Dalam Jamu Pegel Linu Di Wilayah Temanggung Dwibara Bayuaji; Haresmita, Perdana Priya
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.301

Abstract

Jamu pegal linu merupakan obat tradisional yang banyak diminati oleh masyarakat karena memiliki banyak manfaat. Bahan Kimia Obat (BKO) sering ditambahkan pada jamu pegal linu untuk menambah khasiatnya. Tujuan dari penelitian kali ini akan melakukan analisis kualitatif sampel jamu pegal linu dengan tujuan untuk mengetahui apakah produk yang mengandung bahan kimia obat (BKO) dengan standar pembanding prednison, asam mefenamat, natrium diklofenak dan ibuprofen. Sampel A, B, C dan D merupakan sampel jamu pegal linu yang diperoleh dari toko jamu di wilayah Temanggung. Analisis kualitatif BKO dilakukan dengan Kromatografi Lapis Tipis (KLT) menggunakan fase diam silika gel 60 F254, fase gerak Etil asetat : klorofom (4:1), etil asetat : heksana (1:4), kloroform : etanol (4,5:0,5), klorofom : Etil asetat (4,5:0,5)  dan dideteksi sinar UV 254 nm. Berdasarkan uji organoleptis diperoleh data yang bervariasi. Setiap sampel jamu memiliki bau, rasa, warna, bentuk, dan sediaan yang beragam. Berdasarkan uji KLT tidak ditemukan kandungan prednison, ibuprofen dan asam mefenamat pada seluruh sampel. Sampel B, C dan D positif mengandung natrium diklofenak.
Analisis Parameter Spesifik Dan Non Spesifik Simplisia Daun Cengkeh (Syzygium aromaticum L.) Balqis Tamatantri, Amani; Mulatasih, Endah
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.383

Abstract

The leaves of the clove plant (Syzygium aromaticum L.) have not been optimally utilized despite containing active compounds such as flavonoids, triterpenoids, phenolics, and tannins with potential antibacterial properties. This study aims to evaluate the quality of clove leaf simplicia through specific and non-specific parameter analysis as a basis for establishing pharmaceutical raw material standards. The research employed a non-experimental design with a descriptive- analytical approach. Specific parameters assessed included simplicia identification, organoleptic characteristics, microscopic analysis, and water- and ethanol-soluble extract content. Non-specific parameters covered drying loss, moisture content, total ash, and acid-insoluble ash. The results showed that the simplicia powder had a green color, a distinct aroma, a bitter taste, and contained active compounds such as saponins, tannins, alkaloids, flavonoids, and steroids. The water-soluble extract content was 25.569%, and the ethanol-soluble extract content was 14.106%. Meanwhile, the non-specific test results indicated a drying loss of 8.8%, moisture content of 10.23%, total ash content of 3.87%, and acid-insoluble ash content of 0.85%. Based on these findings, clove leaf simplicia meets quality standards and has potential for use as a raw material in traditional medicine formulations
Tingkat Pengetahuan Dan Penggunaan Jamu Di Desa Jawa Laut Kota Martapura: Studi Cross-Sectional Fitriah, Rahmayanti; Sihombing, Yuliana; Wahyudi, Wahyudi
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.388

Abstract

Herbal medicine is one form of traditional medicine that is still widely used by the Indonesian people. The perception that herbal medicine is safer than modern medicine is one of the reasons for the high demand for its use. However, the trend of increasing consumption of herbal medicine among the public has brought new challenges, particularly regarding safety, quality, and efficacy claims. Without adequate knowledge, the use of jamu carries the risk of side effects, interactions with modern medications, or improper dosing. Therefore, a good understanding of the proper and safe use of jamu is crucial to prevent potential hazards and ensure optimal benefits. The objective of this study is to investigate the relationship between knowledge levels and jamu use in Jawa Laut Village, Martapura City. This study employed an analytical observational method with a cross-sectional approach using non-random sampling, specifically accidental sampling, conducted from January to March 2022. In this study, univariate and bivariate data were analyzed using the Chi-Square test. The results showed that the community's knowledge was in the good category, with 79 respondents (79%), and herbal medicine use was in the high category, with 76 respondents (76%). Thus, there is a relationship between knowledge and herbal medicine use in Jawa Laut Village, Martapura City, South Kalimantan, Indonesia.
Analisis Bioinformatika Ekspresi MIER3 sebagai Biomarker Potensial dan Target Terapeutik pada Kanker Esofagus Amukti, Danang; Ria Indah Pratami
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.389

Abstract

Esophageal cancer (ESCA) is one of the cancers with high mortality rates worldwide. Determination of prognostic biomarkers that can predict patient survival is very important to support more effective therapy management. The MIER3 gene has been reported to play a role in the regulation of gene expression and cell proliferation pathways, but its role in ESCA is still not fully understood. MIER3 gene expression data and patient clinical information were obtained from the UALCAN database based on TCGA. Survival analysis was performed using the Kaplan-Meier method to evaluate the effect of MIER3 expression levels on ESCA patient survival. Further analysis was performed by combining MIER3 expression with clinical variables such as tumor grade, race, gender, and weight status. MIER3 expression was significantly higher in tumor tissue than in normal tissue. Kaplan-Meier showed that patients with high MIER3 expression had significantly lower survival than the low expression group (p = 0.00013). The combination of MIER3 expression and clinical factors such as gender (p = 0.00046), race (p = 0.0095), and body weight (p = 0.008) also showed a prognostic relationship to survival. MIER3 has the potential as a prognostic biomarker in esophageal cancer. High MIER3 expression correlates with poor prognosis, especially when combined with certain clinical factors. These findings suggest that MIER3 may play a role in tumor progression through molecular mechanisms involving activation of proliferative pathways and inhibition of apoptotic pathways, and support the development of gene expression-based targeted therapy.
Uji Efek Ekstrak Etanol Herba Ketumbar (Coriandrum sativum L.) Sebagai Afrodisiak Terhadap Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Wirasti, Wirasti; Anjani, Lestari Dwi; Waznah, Urmatul; Wahyu Permadi, Yulian
JURNAL FARMASI GALENIKA Vol 12 No 2 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i2.303

Abstract

One of the common male sexual disorders is low libido (sexual desire). An alternative approach to overcome this problem is the use of aphrodisiacs, substances that stimulate and enhance sexual desire. Coriander (Coriandrum sativum L.) contains flavonoids, alkaloids, saponins, and terpenoids, which may improve blood circulation and potentially enhance sexual activity. This study aimed to evaluate the aphrodisiac activity of ethanolic extract of coriander herb (EHC) on the libido of male Wistar rats (Rattus norvegicus). The extract was obtained using the maceration method, while the aphrodisiac test was conducted on 25 male and 25 female rats aged 2–2.5 months with body weight ranging from 150–200 g. The animals were divided into five groups, each consisting of 5 males and 5 females: negative control (1% Na CMC), positive control (sildenafil 50 mg), and three treatment groups receiving EHC at doses of 400 mg/kgBW, 600 mg/kgBW, and 800 mg/kgBW. For five consecutive days (6:00 p.m.–7:00 a.m.), one male and one female were placed in the same cage, and sexual activities of male rats (introducing and mounting) were observed using CCTV recordings. The results showed that EHC exhibited aphrodisiac activity at a dose of 800 mg/kgBW, which was not significantly different from the positive control (sildenafil 50 mg) (p=0.571). Statistical analysis using One-Way ANOVA indicated a significant difference among groups (p<0.05), and Tukey’s post-hoc test confirmed significant differences among all EHC dose groups (p<0.05). In conclusion, the ethanolic extract of coriander herb demonstrates potential as an aphrodisiac to enhance libido in male Wistar rats.

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