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Journal of Academic Biology and Biology Education
Published by Cahaya Ilmu Cendekia Publisher
ISSN : 30631645     EISSN : 30629705     DOI : https://doi.org/10.37251/jouabe
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Education Veterinary Other
Focus and scope: Journal of Academic Biology and Biology Education is a double-blind peer-reviewed journal published by Cahaya Ilmu Ilmu Scholar, dedicated to disseminating advances in science and research in the field of biology education both in Indonesia and in the global context in other countries. develop. Committed to excellence, the Journal of Academic Biology and Biology Education publishes comprehensive research articles and invites reviews from leading multidisciplinary educational experts to optimally contribute to policy and practice. The selection criteria prioritize papers that demonstrate high scientific value, convey new knowledge, and have a significant impact on biology education. The focus of this journal is evaluation, ethnobiology, biology teaching, PISA Tasks, and the learning of biology and related topics at the school and college level.
Arjuna Subject : Umum - Umum
Articles 25 Documents
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SM2CL Model Innovation: Biology Learning Strategy to Sharpen Students' Critical Thinking Taufik, Muhammad Sultani; Awingan , Joan S.; Carollo , Feona S.
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1582

Abstract

Purpose of the study: This study aims to analyze the influence of the Synectics, Mind Maps, and Cooperative Learning (SM2CL) learning models on students' critical thinking skills in biology subjects. Methodology: This study is a quasi-experimental study with a pretest-posttest control group design. The sampling technique used was total sampling with 47 students as samples. The research instruments consisted of essay tests and critical thinking scale questionnaires. Data were analyzed using descriptive and inferential statistics with normality tests, homogeneity tests, and t-tests using SPSS software version 24. Main Findings: The Synectics, Mind Maps, and Cooperative Learning (SM2CL) learning model significantly improves students' critical thinking skills. The t-test results showed a significant difference between the experimental class and the control class, with a higher increase in post-test scores in the experimental class. The analysis data showed that the SM2CL model was effective in improving students' conceptual understanding and critical thinking skills in Biology subjects. Novelty/Originality of this study: This study combines three learning models Synectics, Mind Maps, and Cooperative Learning (SM2CL), as an innovative approach to improve students' critical thinking in Biology. This study expands the understanding of the effectiveness of collaborative and visual methods in learning, and provides new insights into the application of integrated learning strategies in improving the quality of education.
Exploring the Guided Inquiry Learning Model in Biology Practicum: Its Impact on Students' Scientific Attitudes and Cognitive Knowledge Fetmirwati, Fetmirwati; Franco, Luiz Gustavo; Tadena, Maria Theresa G.
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1642

Abstract

Purpose of the study: The purpose of this study was to determine the differences in scientific attitudes and cognitive knowledge of students between guided inquiry and direct learning models in practical activities by controlling students' prior knowledge. Methodology: This quasi-experimental study employed a Non-Equivalent Pretest-Posttest Control Group Design. From a population of 88 students, 57 were selected using purposive sampling. Instruments included multiple-choice tests and Likert scale observation sheets. Data were analyzed using Microsoft Excel and IBM SPSS 23 with One-Way MANCOVA and Partial Eta Squared for effect size. Main Findings: The guided inquiry learning model is effective in improving students' scientific attitudes and cognitive knowledge. The average scientific attitude of students in the experimental class was 85, compared to 70 in the control class. The average post-test cognitive knowledge score was 75.17 in the experimental class and 50.93 in the control class. The One Way MANCOVA test showed significant differences between groups (p = 0.0001; partial eta squared = 0.840). Partial eta squared is a measure of effect size that indicates the proportion of variance in the dependent variables explained by the independent variable. A value of 0.840 suggests a large effect, meaning the learning model had a strong influence on students’ outcomes. Novelty/Originality of this study: This study integrates guided inquiry learning into food testing on the digestive system topic, uniquely controlling prior knowledge to examine its impact on scientific attitudes and cognitive outcomes, thus enhancing inquiry-based learning insights.
Teratogenic Effects of Ethanolic Cinnamomum burmanni Leaf Extract on Fetal Development in White Mice (Mus musculus L.) Noroozi, Zeynab; Iii, Jose Dale Viacrucis
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1657

Abstract

Purpose of the study: This study aims to evaluate the teratogenic effects of ethanolic extract of Cinnamomum burmanni leaves on fetal development in white mice (Mus musculus L.). Methodology: This research is a laboratory experimental study using a Completely Randomized Design (CRD) and a pretest-posttest control group design. A total of 24 pregnant female mice were divided into four treatment groups: negative control (Na CMC), P1 (250 mg/kgBW), P2 (500 mg/kgBW), and P3 (1000 mg/kgBW). The extract was administered orally during the organogenesis period. Observed parameters included fetal weight and length, morphological abnormalities, hemorrhage, ossification, and resorption sites. Data were analyzed using One-Way ANOVA followed by Duncan’s test. Main Findings: The results of the study showed that administration of ethanolic extract of Cinnamomum burmanni leaves significantly (p < 0.05) reduced fetal weight and length, and induced morphological abnormalities and hemorrhage at doses of 250 mg/kgBW and above. However, no abnormalities were observed in the ossification process or resorption sites. Novelty/Originality of this study: The ethanolic extract of Cinnamomum burmanni leaves demonstrated potential teratogenic effects on fetal development in white mice, characterized by growth retardation and morphological abnormalities. This study provides an important basis for evaluating the safety of using this plant during pregnancy.
Molecular Docking-Based in Silico Evaluation of Leaf Compounds from Coleus blumei Against MRSA Sethanant, Pongpawan; Kim, Junhong; Brain, Maurizio Martin Cavani
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1660

Abstract

Purpose of the study: This study aims to investigate the potential of compounds derived from medicinal plants as target protein inhibitors against methicillin-resistant Staphylococcus aureus (MRSA) using an in silico approach. Methodology: This study employed an in silico molecular docking approach to evaluate active compounds from Coleus blumei leaves against MRSA. Target proteins included MecR1, PBP2a, and oxacilloyl-acylated MecR1. Docking was performed using PyRx, PyMOL, and Discovery Studio with molecular data sourced from GC-MS, PubChem, and PDB. Main Findings: The compound Hexahydro-3H-cyclopenta[a]pentalen-3-one, 2,4a,5,6,7,8-hexahydro-4,4,7a-trimethyl-, (4aR,7R,7aS) demonstrated the highest binding affinity across all three MRSA resistance-associated target proteins (PBP2a, MecR1, and oxacillin-acylated MecR1), surpassing penicillin as the control. Molecular interaction visualizations revealed stable hydrogen bonding and hydrophobic interactions with key active site residues, particularly SER, LEU, and PHE in PBP2a. Pharmacokinetic evaluation based on Lipinski's Rule of Five indicated that top-performing compounds, including this compound and Aristolone, exhibit favorable oral drug-like properties. These findings highlight the strong potential of these natural compounds as lead candidates for the development of antibacterial agents targeting MRSA resistance mechanisms. Novelty/Originality of this study: The novelty of this study lies in the utilization of specific natural compounds as potential antimicrobial agents against antibiotic resistance proteins, which have not been widely reported before. This study provides an initial basis for the development of herbal antimicrobial drug candidates for MRSA infections.
Cardiometabolic Effects of Sus barbatus Meat Consumption: Analysis of Blood Cholesterol Levels and Cardiac Histopathological Alterations in Mus musculus Sehularo, Kerapetse; Mbogua, Joseph; Kanifa, Kamatara
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1661

Abstract

Purpose of the study: This study aims to determine the effects of pork (Sus scrofa domesticus) and beef (Bos taurus) consumption on total cholesterol levels and the histopathological structure of the heart in male ICR mice (Mus musculus). Methodology: This study employed an experimental laboratory design using a Completely Randomized Design (CRD). Fifteen male ICR mice (Mus musculus), aged 2–3 months and weighing 25–30 g, were divided into control, pork-fed (Sus barbatus), and beef-fed (Bos taurus) groups. After 30 days of treatment, blood samples were analyzed for total cholesterol levels, and heart tissues were examined histologically using the Hematoxylin-Eosin (HE) staining method. Data were analyzed statistically using SPSS. Main Findings: Pork consumption increased total cholesterol in male ICR mice to 704 mg/dL. Beef-fed mice showed moderate cholesterol levels (319–321 mg/dL), while the control remained normal (114 mg/dL). Heart weight was highest in the pork group (0.25 g). Histopathology revealed fat cell accumulation only in pork-fed mice, with normal heart structures in both control and beef-fed groups. Novelty/Originality of this study: This study uniquely investigates the direct impact of pork consumption on total cholesterol levels and cardiac histopathology in male ICR mice. It provides new evidence of fat accumulation in heart tissue due to pork intake, contributing to early detection of dietary-induced cardiac risks and expanding current understanding of food-based cardiovascular effects in animal models.
Evaluation of Curcumin as NF-κB Inhibitor for Breast Cancer Therapy Using in Silico Approach Adillah, Endang; Albahri, Nour; Ekramy, Shrouk
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1947

Abstract

Purpose of the study: This study aims to evaluate the potential of curcumin as a breast cancer therapeutic agent by analyzing its ability to inhibit NF-κB activation using an in silico approach, specifically through molecular docking to assess absorption and interaction with the target protein. Methodology: This study used a quantitative experimental method with molecular docking as an in silico approach. Tools included a Lenovo laptop (Intel® Inside™, Windows 10 Pro). Software used: PyRx 0.8 (with AutoDock Vina), YASARA, PyMOL, and Discovery Studio 2019. Ligand data were obtained from PubChem; protein from Protein Data Bank. Lipinski’s Rule was applied for drug-likeness screening. Main Findings: Curcumin showed a binding affinity of -6.2 kcal/mol to NF-κB with RMSD < 2.00 Å. Visualization confirmed hydrogen bonds at ASN 32 and ASN 47, and hydrophobic pi-alkyl interactions at ALA 34 and ARG 50. Lipinski’s Rule of Five was fulfilled, indicating good oral drug-likeness and potential as an NF-κB inhibitor in breast cancer therapy. Novelty/Originality of this study: This study offers new insights into the potential of curcumin as a natural NF-κB inhibitor for breast cancer therapy through a comprehensive in silico approach. By combining molecular docking, visualization, and drug-likeness analysis, it advances current knowledge by highlighting curcumin’s binding efficiency and pharmacological feasibility, supporting its development as an alternative anticancer candidate.
Discovery Learning and Scientific Literacy: Integrating PISA Indicators in High School Science Welyta, Welyta; Vega, Mark Gil
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1941

Abstract

Purpose of the study: The aim of this study is to analyze the level of scientific literacy among Grade X students, identify problems during the learning process, and explore factors influencing the effectiveness of Discovery Learning in teaching environmental change topics within the Merdeka Belajar curriculum framework. Methodology: This study used a mixed methods approach with a sequential explanatory design. Data were collected using multiple-choice science literacy tests, interviews with a biology teacher, and documentation. Analysis was conducted with qualitative descriptive methods. Tools included printed tests, interview guides, and documentation logs. Data validation employed triangulation of methods and sources. Main Findings: This study found that the scientific literacy of tenth-grade students at State Senior High School 1 Kotaagung was relatively low, with an average achievement of only 48%. The weakest indicator was the use of scientific evidence (15%), followed by the identification of scientific problems (17%), and the explanation of scientific phenomena (31%). Low literacy was caused by limited learning time, lack of student focus, and a suboptimal learning approach. The Discovery Learning model has the potential to increase students' active participation, conceptual understanding, and critical thinking skills. Novelty/Originality of this study: This study offers a new perspective by integrating the Discovery Learning model with PISA-based scientific literacy indicators in the context of the Merdeka Belajar curriculum. It provides empirical evidence on students’ low scientific literacy in senior high school and identifies key instructional and contextual factors, contributing to more targeted strategies for improving science education in Indonesia.
Enhancing Plant Diversity Learning with an Ethnobotany-Based E-Booklet: A Focus on the Pandeglang Community Nurjanah, Ene; Laguatan, Rommel P.
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1989

Abstract

Purpose of the study: This study aims to develop an ethnobotany-based e-booklet of the Pandeglang community as a supplementary teaching material on plant diversity material for grade X high school students. Methodology: The method used is development research with the ADDIE model, which in this stage is focused on the analysis stage. The analysis was carried out on the concept of the material through concept maps from high school and Campbell Biology books, basic competencies and indicators, and medicinal plant data obtained through interviews and literature studies. Main Findings: The results of the analysis show that there is a match between the material between high school books and international reference books, especially on Bryophyta, Pterydophyta, and Spermatophyta. In addition, 48 types of medicinal plants were obtained that are commonly used by the Pandeglang community and are relevant to be included in the e-booklet. Novelty/Originality of this study: The novelty of this study lies in the integration of local ethnobotanical knowledge into digital learning media based on e-booklets that are contextual and easily accessible
Dual Gene Regulation by Hypoxia-Conditioned MSC Exosomes in a UV-B–Induced Collagen Loss Model: Targeting p21 and Cyclin D for Skin Regeneration Alcabedos, Riaflor; Fong, Ooi Siew
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.2016

Abstract

Purpose of the study: This study aims to investigate the effect of hypoxia-conditioned MSC-derived exosomes (E-MSCs) on the expression of p21 and Cyclin D genes in a UV-B-induced collagen loss mouse model, using in vivo experiments and gene expression analysis. Methodology: This in vivo experimental study used a Post-Test Only Control Group Design with male Wistar rats (Rattus norvegicus), UV-B lamp TLF72-100W/12 (Philips, 302 nm), RT-PCR machine (Bio-Rad CFX96), flow cytometer (BD FACSCalibur), centrifuge (Eppendorf 5804R), TFF filter (Repligen KrosFlo), Masson’s Trichrome staining, and SPSS 26.0 for data analysis. Main Findings: E-MSCs at 200 µL and 300 µL significantly increased p21 and Cyclin D gene expression in UV-B–induced collagen loss model in male Wistar rats. Highest expression was found in the 300 µL E-MSCs group. ANOVA and Kruskal–Wallis tests showed significant differences (p < 0.05) between treatment and control groups, confirming the therapeutic potential of E-MSCs in regulating gene expression related to skin regeneration. Novelty/Originality of this study: This study is the first to investigate the in vivo effects of hypoxia-conditioned MSC-derived exosomes (E-MSCs) on both p21 and Cyclin D gene expression in a UV-B–induced collagen loss model. It advances existing knowledge by revealing the dual regulatory role of E-MSCs in cell cycle arrest and proliferation, contributing to innovative skin regeneration therapies.
The Influence of Curiosity on Students' Critical Thinking Skills as Viewed from the Perspective of Learning Motivation in Biology Learning on Cell Material Lawal, FK; Isfa, Hanis; Hamid, Norsuhana Abdul
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1913

Abstract

Purpose of the study: This study aims to analyze the influence of curiosity on students' critical thinking skills as viewed from the learning motivation in biology learning on cell material, in government junior secondary school romin doko, Zaria. Methodology: The research method used is quantitative with an associative survey approach. The sample consisted of 100 students in Government Junior Secondary School Romin Doko, Zaria who were selected through purposive sampling technique. The research instruments were in the form of a curiosity questionnaire, learning motivation, and a critical thinking essay test. Data analysis used inferential statistics using the Structural Equation Modeling–Partial Least Square (SEM-PLS) method. Main Findings: The results show that curiosity has a significant effect on critical thinking skills (coefficient = 0.53) and learning motivation (coefficient = 0.48). Learning motivation also has an effect on critical thinking (coefficient = 0.23), and acts as a mediator in an indirect relationship. This model is able to explain 61% of the variation in students' critical thinking skills. Novelty/Originality of this study: This study confirms the importance of strengthening the character of curiosity and learning motivation in improving the quality of students' critical thinking in biology learning.

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