cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Mohamad Aprianto Paneo
Contact Email
apriyanto07@ung.ac.id
Phone
+6282292479459
Journal Mail Official
jftskjurnal@gmail.com
Editorial Address
Jl. IR. H. Joesoef Dalie, Kec. Kota Tengah, Kota Gorontalo
Location
Kota gorontalo,
Gorontalo
INDONESIA
Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK)
Published by CV Jurnal Literasi Mandiri
ISSN : -     EISSN : 30632226     DOI : https://doi.org/10.70075/jftsk.v2i1.145
Core Subject : Health, Engineering,
Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology
Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) merupakan jurnal yang di rilis oleh Jurnal Literasi Mandiri (JLM). Jurnal ini menerima publikasi dari Dosen, Peneliti, Guru, Mahasiswa, Siswa dan Semua Kalangan yang ruang lingkup penelitiannya berfokus pada Teknologi Sediaan farmasi dan Kosmetika. Adapun penjabaran fokus Jurnal Farmasi Teknologi Sediaan dan Kosmetika yaitu 1. Pengembangan Teknologi Sediaan Farmasi 2. Pengembangan Sediaan Kosmetika 3. Pengembangan Teknologi Penghantaran obat Dengan adanya Jurnal ini diharapkan dapat membantu dalam penelusuran penelitian dan memperkaya literasi terkait Teknologi Sediaan dan Kosmetika.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 34 Documents
 1   2   3   4 
Effect of Centrifugation on Nanoemulsion Stability with Tween, PEG, Poloxamer 188, and Transcutol-p Rahmola, Fauziah; Mustapa, Mohamad Adam; Paneo, Mohamad Aprianto; Djuwarno, Endah Nurrohwinta; Taupik, Muhammad
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.271

Abstract

This study evaluated the effect of centrifugation speed on the physical stability of a nanoemulsion base formulated with grapeseed oil (long-chain triglyceride, LCT) and stabilized using Tween 80–PEG 400, Poloxamer 188, and Transcutol-P, as a preliminary platform for topical and oral pharmaceutical applications. A descriptive–experimental design was employed. Nanoemulsion bases were prepared by the aqueous titration method followed by 60-minute sonication. Four formulations (F1–F4) contained 5% grapeseed oil and 2% Poloxamer 188, while Tween 80/PEG 400 levels and Transcutol-P (0.5–2%) were varied. Accelerated physical stability was assessed by centrifugation at 2000, 4000, 6000, and 8000 rpm for 30 minutes, followed by organoleptic observation, emulsion type determination, pH measurement, and viscosity testing. All formulations remained visually stable at 2000 rpm. At 4000 rpm, F1–F2 showed increased turbidity with a thin top layer (incipient creaming), whereas F3–F4 remained stable without phase separation. At 6000 rpm, F1–F2 became more turbid with the onset of a surface oil layer, while F3–F4 maintained stability. At 8000 rpm, F1–F2 exhibited complete phase separation; F3 showed a slight oil layer; and F4 was the most stable, showing only minimal turbidity without total phase breaking. All formulations were classified as oil-in-water (O/W). The pH ranged from 6.0 to 7.0 (mean 6.45 ± 0.42) and viscosity from 176 to 220 cP (mean 196.25 ± 18.89). In conclusion, increasing centrifugation speed effectively differentiated formulation robustness, with F4 demonstrating the highest resistance to mechanical stress up to 8000 rpm.
The Effect of Centrifugation Test on the Physical Stability of Nanoemulsion Containing a Combination of Poloxamer 407, Tween 80, PEG 400, and DMSO A. Unga, Rani Orelia; Tuloli, Teti Sutriyati; Paneo, Mohamad Aprianto; Aman, La Ode; Mustapa, Mohamad Adam
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.272

Abstract

The development of nanoemulsion-based drug delivery systems has gained significant attention due to their ability to enhance drug solubility, stability, and therapeutic effectiveness. Optimizing the combination of surfactants, co-surfactants, and penetration enhancers is essential to produce a kinetically stable nanoemulsion system. This study aimed to formulate and evaluate the physical stability of nanoemulsions prepared using Tween 80, PEG 400, Poloxamer 407, and dimethyl sulfoxide (DMSO), and to determine the optimal formulation based on physicochemical characteristics and accelerated stability testing. Four nanoemulsion formulations (F1–F4) were prepared with varying concentrations of surfactant and co-surfactant. The formulations were evaluated for organoleptic properties, emulsion type, pH, viscosity, and physical stability using a centrifugation test at speeds up to 8000 rpm to detect phase separation, flocculation, or coalescence. The results showed that all formulations were classified as oil-in-water (o/w) nanoemulsions. No phase separation was observed after centrifugation, indicating good physical stability. However, F1 and F2 appeared turbid, whereas F3 and F4 demonstrated better clarity and overall stability. The pH values ranged from 6.6 to 7.4, which are acceptable for topical application, and viscosity values ranged from 405 to 427 cPs, indicating suitable rheological properties for topical use. In conclusion, the combination of Tween 80, PEG 400, Poloxamer 407, and DMSO successfully produced a kinetically stable nanoemulsion system. Among the tested formulations, F3 and F4 exhibited the most optimal characteristics and show strong potential for further development in pharmaceutical nanoemulsion formulations.
Characterization of Tannic Acid Chemically Crosslinked PVA Chitosan Hydrogel Upara, Nana Nurindah; Taupik, Muhammad; Latif, Multiani S; Rasdianah, Nur; Suryadi, A. Mut’hi Andy
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.287

Abstract

Hydrogel is a hydrophilic material that can absorb and retain large amounts of water through the formation of hydrogen bonds between polymer functional groups to form a stable three-dimensional network. The physicochemical characteristics of hydrogels are greatly influenced by the cross-linking process that determines the network density and stability of the preparation. This study aims to determine the effect of variations in the concentration of tannic acid as a chemical crosslinker on the physicochemical characteristics of polyvinyl alcohol (PVA)-chitosan-based hydrogels. Hydrogels were formulated with varying concentrations of tannic acid of 1%, 3%, and 5%, then evaluated including organoleptic tests, pH, viscosity, spreadability, adhesion, swelling index, irritation test, and characterization using Fourier Transform Infrared (FTIR). The results showed that increasing the concentration of tannic acid caused the formation of a denser hydrogel network, which was characterized by a decrease in the swelling index value and an increase in adhesion and changes in viscosity. The pH values ​​of all formulas were within the physiological pH range of the skin. Irritation tests on 20 panelists showed that all formulas did not cause irritation reactions. FTIR analysis confirmed the presence of molecular interactions between PVA, chitosan, and tannic acid through hydrogen bond formation. Overall, variations in the concentration of tannic acid as a chemical crosslinker affected the physicochemical characteristics of the PVA–chitosan hydrogel and resulted in stable preparations with good quality
Formulation and Antioxidant Activity Test of Emulgel Extract of Guava (Psidium Guajava Linn.) Using DPPH (2,2-Diphenyl-1- Picrylhydrazyl) Methods Thomas, Nurain; Paneo, Mohamad Aprianto; Tuloli, Teti Sutriyati; Ayuhastuti, Angreni; Arifin, Lutfia Nurfadila
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.291

Abstract

Plants that have the potential to contain antioxidants are guava leaves (Psidium guajava Linn.) which contain one of the compounds, flavonoids, which have antioxidant activity that can reduce free radicals. Emulgel has advantages such as thixotropic, easy to spread, easy to clean, does not leave stains, durable and can be a delivery system for hydrophobic and hydrophilic substances. This study aims to formulate guava leaf extract emulgel and determine antioxidant activity using DPPH method. This research began with guava leaf extraction and base optimization with varying concentrations of stearic acid as an emulsifier consisting of F1 8%, F2 10% and F3 12%. The base that meets the requirements of good physical stability is F2. F2 base was made into emulgel preparations with 3 variations of guava leaf extract concentration, namely F2a 1%, F2b 2% and F2b 3%. The three formulas were tested for physical stability including organoleptic test, emulsion type, pH test, spreadability, adhesiveness, viscosity test, and freeze thaw test as well as antioxidant activity test with DPPH method. The results of the physical stability test showed that the preparations F2a, F2b and F2c met the requirements. The IC50 value in each formulation has a different antioxidant activity value. F2a formulation is 123.59 ppm and F2b is 107.08 ppm which is classified as moderate antioxidant activity, while F2c is 61.74 ppm which is classified as strong antioxidant activity. Guava leaf extract emulgel formula, especially the second formula (F2c), has great potential to be considered by the pharmaceutical industry to be developed into antioxidant products because the results of the evaluation that have been carried out meet the requirements in terms of physical evaluation and potential antioxidant strong.

Page 4 of 4 | Total Record : 34

 1   2   3   4 

Filter by Year

2024 2026


Reset
Filter By Issues
All Issue Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026 Vol. 2 No. 3 (2025): Volume 2 Nomor 3 Tahun 2025 Vol. 2 No. 2 (2025): Volume 2 Nomor 2 Tahun 2025 Vol. 2 No. 1 (2025): Volume 2 Nomor 1 Tahun 2025 Vol. 1 No. 3 (2024): Vol 1, No. 3, 2024 : Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 1 No. 1 (2024): Vol. 1 No. 1 (2024): Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 1 No. 2 (2024): Jurnal Farmasi Teknologi Sediaan dan Kosmetika