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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Ethnopharmacy Study of Medicinal Plants Lampung Tribe in Pekon Tabuan Island, District Cukuh Balak, Tanggamus Regency, Lampung Province Oktoba, Zulpakor; Adjeng, Andi Nafisah Tendri; Romulya, Ari Irawan
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.286

Abstract

People in the Indonesian archipelago have long used medicinal plants as an alternative disease treatment. Tabuan Island is an area in Cukuh Balak District, Tanggamus Regency, Lampung Province, where most people are Lampung Peminggir /Pesisir tribe who still practice empirical medicine with local wisdom. Ethnopharmacy studies on Tabuan Island in the Lampung tribe have never been conducted and published. The study aimed to explore the knowledge of local communities regarding the types of medicinal plants for the search and development of new medicines. This research method includes area studies and descriptive studies in the form of ethnopharmacognosy-ethnopharmacology approaches in the Tabuan island community in 4 (four) villages or Pekon namely Pekon Sawang Balang, Pekon Suka Banjar, Pekon Kuta Kakhang, and Pekon Karang Buah used participatory observation methods and open interviews. The results showed that the Lampung Peminggir ethnic group on Tabuan Island still maintains ethnopharmaceutical traditions by utilizing plants used as medicine in 36 families of 76 species to treat diseases used singly or as a concoction accompanied by jampi. The most widely used plant families are Fabaceae, Zingiberaceae, Malvaceae, Meliaceae, and Poaceae. These medicinal plants in the Fabaceae family are most widely used to remedy mouth ulcers and skin problems such as tinea versicolor, ringworm, itching, acne, dandruff, diarrhea, and diabetes. Leaves are the most widely used plant parts, as much as 49.52%, and the least used plant parts are herbs, thallus, and fungi, while most of these plants are obtained in the garden. The most common way of processing medicinal plants is by stewing.
Antioxidant Activities of Various Fraction Levels of Kaik Kaik (Uruparia Multiflora K.Schum. & Lauterb): indonesia Hadi, Samsul; Setiawan, Deni; Nastiti, Kunti
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.291

Abstract

Borneo has abundant biodiversity, especially regarding medicinal plants. One of the plants used in traditional medicine by the Dayak tribe in Kalimantan is kaik-kaik (Uncaria cordata (Lour.) Merr.), so research is needed to evaluate the activity of this plant. One of the methods used to assess its medicinal properties is through its antioxidant activity. This research aimed to test the antioxidant activity of various fractions derived from U. cordata stems. The study began with ethanol extraction followed by fractionation using n-hexane, ethyl acetate, and distilled water. The extracts and fractions obtained were then tested for antioxidant activity using the DPPH radical capture method. The results indicated that the n-hexane fraction, with a yield of 0.69%, contains terpenoids/steroids, alkaloids, and flavonoids; the ethyl acetate fraction, with a yield of 1.453%, contains alkaloids and flavonoids; and the distilled water fraction, with a yield of 4.832%, contains saponins, tannins, alkaloids, phenols, and flavonoids. The n-hexane, ethyl acetate, and distilled water fractions exhibited antioxidant capacity with IC₅₀ values of 138.39 ± 0.3777 ppm, 48.51 ± 0.056 ppm, and 36.31 ± 0.111 ppm, respectively. This research concluded that the distilled water fraction was the most active and is classified as a very strong antioxidant.
Total Phenolic Content in Black Rice (Oryza sativa L. indica) Bran Ethanolic Extract from Two Different Regions in Java, Indonesia Vardhani, Afifah; Anggraini, Nadia Bunga; Jufri, Mahdi; Purwaningsih, Erni; Perdanastuti, Hidayah Sunar
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.293

Abstract

Rice bran, a rice by-product yielded by the milling process, has recently been recognized as a potential source of natural active constituents. Black rice bran has the highest antioxidant capacity compared to white and brown rice bran. It is correlated with the contribution of phenolic compounds in rice bran. The purpose of this study was to determine the total phenolic content in black rice (Oryza sativa L. indica) bran ethanolic extract from two different regions in Java, Indonesia, using Folin-Ciocalteu Reagent (FCR). Black rice bran samples used in this study were planted in Ciletuh Geopark Sukabumi, West Java (BRBE1), and Karanganyar Regency, Central Java (BRBE2). The parameters observed were total phenolic content, and the result was statistically tested with an unpaired t-test by GraphPad Prism 8.3.0 application. The samples contained 175.48 mg GAE/g extract in BRBE1 and 174.39 mg GAE/g extract in BRBE2. There was no significant difference based on these results. It can be concluded that both samples contained phenolic compounds and statistically, there was no significant difference.
Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study Cahya, Hanifah Dwi; Nurlela, Nurlela; Tohir, Dudi; Batubara, Irmanida; Asoka, Shadila Fira; Yamauchi, Kosei
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.296

Abstract

Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.
Combination Effects of African Leaf Ethanol Extract (Vernonia amygdalina Del.) with Red Onion Peel (Allium cepa L.) as Antidiabetes in Streptozotocin-induced Mice Setiani, Lusi Agus; Wiendarlina, Ike Yulia; Marcella, Nurma
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.299

Abstract

Type 2 diabetes arises when the body becomes resistant to insulin or when the pancreas fails to produce sufficient insulin. This study aimed to evaluate the antidiabetic effects of reducing blood glucose levels in white male mice through the administration of an ethanol extract of African leaves and onion peel, as well as to determine the duration of these effects. Streptozotocin was used to induce diabetes in the mice, and the experiment was conducted over a period of 21 days. The mice were divided into seven groups: Group 1 received a placebo (CMC Na 0.5%), Group 2 received glibenclamide (0.013 mg/20 g body weight), Group 3 received a single dose of African leaf extract (4.2 mg/20 g BW), Group 4 received a single dose of onion peel extract (4 mg/20 g BW), and Groups 5, 6, and 7 received combinations of African leaf and onion peel extracts at ratios of 1:1, 1:2, and 2:1, respectively. The results demonstrated that the combined administration of African leaf and onion peel extracts significantly reduced blood glucose levels, with decreases of 44.701%, 49.929%, and 51.996% in the 1:1, 1:2, and 2:1 group, respectively. The 1:1 combination was particularly effective, showing a reduction in blood glucose levels comparable to the positive control, which achieved a 45.957% decrease. The administration of the test preparations effectively reduced blood glucose levels over 21 days, with significant reductions observed on both the 14th and 21st days.
In Silico Study of Bioactive Compounds in Herba Sambiloto (Andrographis paniculata Burm. F. Nees) as HIV-1 Reverse Transcriptase Inhibitor Prasetiyo, Andri; Martati, Titiek; Saputra, Putri Windari
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.300

Abstract

A medicinal plant known as sambiloto (Andrographis paniculata Burm. F. Nees) contains certain active compounds that potentially are anti-HIV. However, it is not yet known which compounds are involved in inhibiting HIV activity. This study aimed to identify potentially active compounds from the sambiloto plant that could inhibit the HIV-1 reverse transcriptase enzyme using the in-silico method. In silico methods that will be carried out are internal validation, molecular docking, ADMET prediction, and molecular dynamics. The molecular docking results showed that the five best compounds have potential as anti-HIV drugs compared to efavirenz with the rerank score -152.119 until -125.177 kcal/mol. In contrast, the rerank score of the comparison ligand is -94.7639 kcal/mol. The ADMET prediction showed that the selected compounds have a good pharmacokinetics profile and are nontoxic. The molecular dynamic results showed that deoxy-11,12-didehydroandrographiside and andropraphiside are stable and have potential as anti-HIV drugs with average RMSD values of 1.88 and 2.02 Å while the comparison ligand is 1.67 Å.
Traditional Uses, Biological Activities, and Phytochemical Profile of Keji Beling (Strobilanthes crispus) Leaf Extract: A Review Sukendi, Yeli; Rafi, Mohamad; Silviani, Dea; Wahyuni, Wulan Tri
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.305

Abstract

Health treatment in Indonesia is diverse, encompassing both modern medicines using synthetic drugs and traditional practices relying on herbal plants. Traditional medicine is often preferred due to its lower cost and perceived lack of side effects. Keji beling (Strobilanthes crispus) is one such herb with potential medicinal properties. This article summarizes information regarding traditional uses, biological activities, phytochemical profiles, and active compounds of keji beling leaf extract. Traditionally, keji beling leaves are consumed as tea. The plant has demonstrated antioxidant, anti-diabetic, anticancer, antitumor, and antibacterial properties. These biological effects are attributed to its phytochemical constituents, including flavonoids, alkaloids, saponins, tannins, and terpenoids. Specific bioactive compounds in keji beling leaf extract comprise silicic acid, polyphenols, glycosides, catechins, rutin, epicatechin, myricetin, luteolin, apigenin, naringenin, and kaempferol.
The Business Development Strategy of Jamu at PT. Firdaus Kurnia Indah (FKI) in Bangkalan Regency Pratiwi, Yunita Eka Dyah; Setiani, Setiani; Kurniyanto, Ifan Rizky
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.306

Abstract

Jamu is a traditional medicine that Indonesians have consumed for generations. Several herbal medicine industries in the Bangkalan district have difficulty surviving and developing their businesses. This study aims to determine the strategy for developing the herbal medicine business at PT. FKI, Bangkalan. This research is part of the MBKM-KWU UTM Agricultural Agribusiness Study Program in 2022, which is carried out in the form of a one-month internship as preliminary research. Data was collected from March to June 2023 using questionnaires and deep interviews with respondents. The 4C diamond, SWOT, and QSPM analysis are used to determine strategies that can be implemented for PT. FKI. Internally, the main strength is using natural ingredients, and a shortage of product stock is the main weakness. Assessment of external factors reveals that technological progress, especially social media, is the main opportunity, while the main threat faced is the existence of similar competitors. PT. FKI is in an aggressive strategic position to increase competitiveness by exploiting the company's opportunities and strengths.
The Potential of Ethanol Extract of Temu Kunci (Boesenbergia rotunda (L.) Mansf.) Rhizomes as an Anticonvulsant Against Male White Rats Pabenjanan, Agustin Yumita; Dwitiyanti; Risda Hidayati Winza Putri
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.308

Abstract

The temu kunci extract was previously reported to have quite good antioxidant activity. One of the causes of seizures is oxidative stress. There has yet to be much exploration of temu kunci extract as an anticonvulsant. This study examines the anticonvulsant activity of 70% ethanol extract of Boesenbergia rotunda (L.) Mansf. against male white rats. The parameters observed were the onset and duration of HLE (Hind Limb Extension) with a digital electroconvulsiometer with a power of 150 mAmp and 50 hertz for 0.2 seconds. The test group was divided into five treatment groups, namely group 1 to group 3 (K1-K3), with extract doses: 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively, while K4 was a positive control using valproic acid (Depakote 1.54 mg/kgBW), and normal control group (K5) with Na-CMC 0.5%. The results were analyzed using one-way ANOVA and continued with the Tukey test. From the research carried out, information was obtained that 70% ethanol extract of temu kunci at a dose of 400 mg/kgBB had the best potential as an anticonvulsant in prolonging the onset of HLE (seconds) and shortening the duration of HLE (seconds) in mice comparable to the positive control. Temu kunci has the potential to be further developed as an anticonvulsant drug candidates in the future.
Anatomy and Histochemistry of Alliaceae and Iridaceae Species: Quality Control of Traditional Medicine Raw Materials Syahruni, Reny; Abdul Halim Umar; Halim, Nur Afiah Ramadhani
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.309

Abstract

Alliaceae (Allium cepa and Allium ascalonicum) and Iridaceae (Eleutherine bulbosa) are widely used as spices, condiments, and traditional medicine. These three species are vulnerable to adulteration because they are morphologically similar in shape and colour. This study aims to identify and authenticate the three samples through anatomical and histochemical approaches. Anatomical and histochemical analyses were performed on fresh sections of the bulbs samples according to standard anatomical procedures with a razor blade and identification of the main compound groups using specific reagents. Anatomically, the three samples had similar patterns and cell organelles (cell nucleus, cytoplasm, and cell wall). Histochemical techniques identified the presence of alkaloids, phenolics, lipophilics, and terpenoids groups. Histochemical techniques can be applied in identifying the compound groups of the three samples and can be used as an alternative in testing the quality control of traditional medicine raw materials.

Page 12 of 17 | Total Record : 163

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