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Waras Nurcholis
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Tropical Biopharmaca Research Center (TropBRC) IPB University CRC Building, 2nd Floor, STP Area IPB Taman Kencana Campus Taman Kencana St. No. 3, Bogor West Java, Indonesia 16128
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 180 Documents
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Cardioprotective Effects of Red Ginger Extracted Using Natural Deep Eutectic Solvent on Lipid Profile in Atherosclerotic Rats Yulianita; Herlina, Nina; Tri Retno Handayani, Marybet; Al Aziz, Novan Masis; Safitri, Aditiya; Pamungkas, Ragil Raihan
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.410

Abstract

Atherosclerosis, a leading cause of cardiovascular disease, is closely related to dyslipidemia. This study evaluated the cardioprotective effects of red ginger (Zingiber officinale var. rubrum) extracted using a Natural Deep Eutectic Solvent (NADES) on lipid profiles and the risk of atherosclerosis in rats induced with an atherogenic diet and lipopolysaccharide (LPS). Thirty male Sprague-Dawley rats were divided into five groups: normal control, negative control, positive control (Simvastatin), and two treatment groups receiving red ginger extract at 25 mg/kg and 50 mg/kg body weight (BW). After 24 days of treatment, the 25 mg/kg BW dose significantly reduced total and LDL cholesterol while increasing HDL levels compared with the negative control (p < 0.05), showing comparable effects to Simvastatin. The 50 mg/kg BW dose did not significantly reduce total and LDL cholesterol but produced the highest HDL level. All treatment groups showed a significantly lower Atherogenic Index of Plasma (AIP) than the negative control, with the lowest AIP in the 50 mg/kg BW group. These findings demonstrate the cardioprotective potential of red ginger extracted with NADES as a natural, environmentally friendly approach to preventing dyslipidemia and atherosclerosis.
Optimization of Solvent Type on Antioxidant Activity of Spirulina platensis Extract and Its Pharmaceutical Tablet Formulation Bagiana, I Kadek; Franyoto, Yuvianti; Mutmainah; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.414

Abstract

Spirulina platensis contains nutrients such as proteins, essential amino acids, fatty acids, minerals, pigments, carotenoids, and vitamins, which have strong antioxidant properties. This study evaluated the impact of extraction solvents (70% methanol, 70% ethanol, and 70% acetone) on antioxidant activity, with the most effective extract formulated into tablets. Extraction was performed by maceration. Tablet preparations were characterized by moisture content, flow rate, angle of repose, organoleptic properties, weight uniformity, hardness, disintegration time, and friability. The results showed that the 70% methanol extract exhibited the highest antioxidant activity (IC₅₀ = 45.57 ± 0.01 ppm), superior to 70% acetone (IC₅₀ = 67.15 ± 0.07 ppm) and 70% ethanol (IC₅₀ = 85.32 ± 1.21 ppm), although lower than vitamin C (IC₅₀ = 3.52 ± 0.01 ppm). Tablets prepared from 70% methanol extract fulfilled all pharmaceutical quality requirements.
Optimizing Ultrasonic Extraction of Enhalus acoroides to Enhance Physicochemical Traits and Antioxidant Activity Mardiyanti, Siti; Anwar, Effionora; Desmiaty, Yesi; Sadiah, Siti
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.419

Abstract

Enhalus acoroides is a seagrass species known for its antioxidant potential due to its flavonoid content, including quercetin. This study aimed to optimize the extraction time using the ultrasound-assisted extraction (UAE) method based on physicochemical parameters and antioxidant activity. The simplicia was extracted for 20, 30, and 40 minutes, each in triplicate, using 96% ethanol acidified with 1% HCl. The results demonstrated that extraction time significantly influenced the physicochemical properties, including yield (highest at 30 minutes: 40.2%), total phenolic content (1.153 mg GAE/g), total flavonoid content (0.318 mg QE/g), quercetin content (0.316 mg/g), and antioxidant activity (IC₅₀ = 58.44 ppm), whereas no significant effect was observed on total ash content. Qualitative phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. Based on these findings, a 30-minute extraction time is recommended as the optimal condition for obtaining E. acoroides extract with the highest antioxidant activity.
Molecular Docking of Active Compound of Okra (Abelmoschus esculentus L.) on α-Glucosidase as Antidibetic Mellitus Drug Candidate Nuur'Alimah, Shobiroh; Ambarsari, Laksmi; Farhan, Muhammad
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.360

Abstract

Diabetes mellitus (DM) is a leading cause of death among degenerative diseases, primarily due to impaired insulin function that disrupts carbohydrate metabolism. One therapeutic strategy involves α-glucosidase inhibitors that delay glucose absorption. Abelmoschus esculentus (okra) is rich in phenolic and flavonoid compounds with antihyperglycemic and antioxidant activity, suggesting potential as α-glucosidase inhibitors. This study evaluated the inhibitory potential of okra-derived compounds against α-glucosidase using in silico molecular docking with PLANTS and YASARA Structure. The analysis included physicochemical screening, ligand–receptor preparation, and docking simulations, assessing docking score, Gibbs free energy (ΔG), and dissociation constant (Kd). Cannabiscitrin, a flavonoid from okra, demonstrated the strongest binding affinity, outperforming the reference drug acarbose in all parameters. These findings suggest its potential as an alternative antidiabetic agent. 
Metabolite Profiling and Bioactivity Assessment of Antioxidant and Antibacterial Properties in Bulb Fractions of Eleutherine bulbosa (Mill.) Urb Komalasari, Nurma Angeliani; Natalia Marbun, Natalia; Syahbirin, Gustini; Ambarsari, Laksmi; Sugita, Purwatiningsih
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.388

Abstract

Eleutherine bulbosa is known to contain diverse secondary metabolites with pharmacological potential. This study aimed to identify the bioactive compounds in the ethanol, n-hexane, and unsaponified n-hexane fractions of E. bulbosa bulbs and evaluate their antioxidant and antibacterial activities. The bulbs were extracted using ethanol, followed by n-hexane fractionation and saponification. Antioxidant activity was determined using the DPPH assay, and antibacterial activity was assessed against Staphylococcus aureus and Escherichia coli using the disc diffusion method. LC-MS/MS and GC-MS analyses identified compounds such as eleutherol, resveratrol, coniferaldehyde, and stigmasterol. The ethanol fraction exhibited the highest antioxidant activity (IC₅₀ = 47.54 ± 0.03 mg/L), while the unsaponified n-hexane fraction showed the strongest antibacterial effect (inhibition zone = 16.12 ± 0.16 mm). These findings confirm the potential of E. bulbosaas a natural source of antioxidant and antibacterial agents.
Comparative Analysis of Total Flavonoid Content and Antioxidant Activity in Medicinal Plant Leaf Extracts Using Ethanol and Citric Acid Aziz, Syaikhul; Mulyani, Isna; Nadiah, Syaadatun
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.394

Abstract

Flavonoids are bioactive compounds with antioxidant activity, and their extraction efficiency is strongly influenced by solvent selection. This study compared total flavonoid content and antioxidant activity of leaf extracts from Persea americana, Annona muricata, Piper betle, and Pandanus amaryllifolius obtained using ethanol and citric acid. Total flavonoid content was determined using the AlCl₃ spectrophotometric method with quercetin as the reference standard, while antioxidant activity was evaluated by the DPPH assay. Ethanol generally yielded higher flavonoid levels, with the highest content observed in P. americana leaves (3.87 mg QE/g), whereas citric acid extracts exhibited stronger antioxidant activity, reaching 94.21% DPPH inhibition in P. betle leaves. No significant correlation was observed between total flavonoid content and antioxidant activity. Overall, these results indicated that solvent selection critically determines extraction outcomes, and citric acid represents a viable green alternative for antioxidant-oriented applications.
In Silico Evaluation of Flavonoids from Imperata cylindrica as Potential Antidiabetic Agents Afnani, Moh. Royhan; Sutriyansyah, Riska Ayu; Ansori, Arif Nur Muhammad
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.404

Abstract

Diabetes mellitus is a metabolic disorder characterized by impaired insulin secretion and disrupted blood-glucose homeostasis. Novel therapies targeting the incretin system, such as dipeptidyl peptidase 4 (DPP-4) inhibitors, enhance insulin secretion, protect β-pancreatic cells, and restore glucose balance. Imperata cylindrica (reeds) has shown antidiabetic effects, including improved insulin release and reduced blood glucose, but its molecular mechanism remains unclear. This study investigated flavonoid compounds from I. cylindrica as potential DPP-4 inhibitors using molecular docking. The target protein (PDB: 6B1E) and drug-like flavonoids were evaluated via PyRx and visualized with Discovery Studio 2021. The results indicate that tricin binds strongly to DPP-4 (−8.4 kcal/mol) and forms stable interactions with residues ILEB102, ILEB76, and ILEB529. These findings suggest that tricin from I. cylindrica may inhibit DPP-4 and serve as a potential antidiabetic agent in silico.
Evaluation of the Antibacterial Activity of Muntingia calabura L. Leaf Extract in Anti-Acne Serum and Gel Moisturizer Formulations Rasyid, Andi Ulfah Magefirah; Nurfadilah, Nurfadilah; Usman, Fityatun; Zulkifli, Zulkifli; Zulham, Zulham; Burhan, Asril
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.413

Abstract

The cherry tree (Muntingia calabura L.) is known to contain bioactive compounds such as flavonoids, tannins, and saponins, which exhibit potential as natural antibacterial agents against acne-causing bacteria. This study aimed to evaluate and compare the antibacterial efficacy of serum and moisturizer gel formulations containing ethanol extract of M. calabura leaves against Propionibacterium acnes. Serum was selected due to its high concentration of active ingredients and superior skin penetration, while the gel moisturizer provides a light, non-greasy texture that is comfortable and easily absorbed. The results demonstrated that the serum formulation containing 18% extract (F3) exhibited the highest antibacterial activity against P. acnes, with a strong inhibition zone. Similarly, the gel formulation with 6% extract (F3) also showed a strong inhibitory effect. These findings highlight the potential of M. calabura leaf extract as an effective natural agent for the development of topical anti-acne skincare products.
Specific and Non-Specific Safety Testing of Red Gedi Leaf Ethanol Extract (Abelmoschus manihot L. Medik) Tandi, Joni; Susanto, Yuliet; Handayani, Tien Wahyu; Magfirah, Magfirah; Tuldjanah, Muthmainah
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.417

Abstract

Red gedi leaves (Abelmoschus manihot (L.) Medik) are traditionally used for their antidiabetic, antioxidant, and hepatoprotective properties. This study aimed to characterize the specific and non-specific quality parameters of red gedi leaf ethanol extract based on Herbal Pharmacopoeia standards. Extraction was performed by maceration using 96% ethanol, yielding 6.72%. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, quinones, and steroids, with a high total flavonoid content of 56.97 ± 3.75 mg/g. Non-specific parameters, including water content, drying loss, ash values, microbial contamination, and heavy metal levels (Pb and Cd), complied with the required standards. Organoleptic evaluation showed a viscous extract with brownish color, slightly astringent taste, and characteristic odor. These results indicate that red gedi leaf ethanol extract meets Herbal Pharmacopoeia quality requirements and has potential for development as a standardized antioxidant herbal product.
LC-MS/MS Profiling and Anti-inflammatory Activity of Red Onion (Allium cepa L. var. Bima Brebes) Extract-Based Liniment in Mus musculus Saragih, Melisa; Harefa, Siwardin; Rahel, Kezia; Ruhi, Ratu Sukma; Rahmaningtyas, Ekarin Lativa; Eliasari, Laurencia Chrisiana; Riskianto, Riskianto
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.422

Abstract

Allium cepa L. (Bima Brebes variety) is a prolific source of quercetin-type flavonols and organosulfur compounds, recognized for their potent anti-inflammatory and antioxidant activities.  Topical herbal liniments offer a practical approach to manage localized inflammation while minimizing systemic exposure. This study aimed to evaluate the anti-inflammatory activity of a topical liniment formulated with a 70% ethanolic extract of A. cepa. LC–MS/MS (UHPLC Vanquish Tandem Q) had identified ten secondary metabolites putatively linked to anti-inflammatory effects. Anti-inflammatory efficacy was evaluated in vivo using a carrageenan-induced paw oedema model in male mice. Oedema inhibition was recorded at 18% in the negative control, 47% in the positive control, and 38%, 42%, and 44% for the 2 g, 3 g, and 5 g formulations, respectively. One-way ANOVA revealed significant differences among groups (p = 0.001). These findings suggested that A. cepa-based liniment formulations may serve as promising candidates as natural topical anti-inflammatory agents.

Page 17 of 18 | Total Record : 180

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