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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Cardioprotective Effects of Red Ginger Extracted Using Natural Deep Eutectic Solvent on Lipid Profile in Atherosclerotic Rats Yulianita; Herlina, Nina; Tri Retno Handayani, Marybet; Al Aziz, Novan Masis; Safitri, Aditiya; Pamungkas, Ragil Raihan
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.410

Abstract

Atherosclerosis, a leading cause of cardiovascular disease, is closely related to dyslipidemia. This study evaluated the cardioprotective effects of red ginger (Zingiber officinale var. rubrum) extracted using a Natural Deep Eutectic Solvent (NADES) on lipid profiles and the risk of atherosclerosis in rats induced with an atherogenic diet and lipopolysaccharide (LPS). Thirty male Sprague-Dawley rats were divided into five groups: normal control, negative control, positive control (Simvastatin), and two treatment groups receiving red ginger extract at 25 mg/kg and 50 mg/kg body weight (BW). After 24 days of treatment, the 25 mg/kg BW dose significantly reduced total and LDL cholesterol while increasing HDL levels compared with the negative control (p < 0.05), showing comparable effects to Simvastatin. The 50 mg/kg BW dose did not significantly reduce total and LDL cholesterol but produced the highest HDL level. All treatment groups showed a significantly lower Atherogenic Index of Plasma (AIP) than the negative control, with the lowest AIP in the 50 mg/kg BW group. These findings demonstrate the cardioprotective potential of red ginger extracted with NADES as a natural, environmentally friendly approach to preventing dyslipidemia and atherosclerosis.
Optimization of Solvent Type on Antioxidant Activity of Spirulina platensis Extract and Its Pharmaceutical Tablet Formulation Bagiana, I Kadek; Franyoto, Yuvianti; Mutmainah; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.414

Abstract

Spirulina platensis contains nutrients such as proteins, essential amino acids, fatty acids, minerals, pigments, carotenoids, and vitamins, which have strong antioxidant properties. This study evaluated the impact of extraction solvents (70% methanol, 70% ethanol, and 70% acetone) on antioxidant activity, with the most effective extract formulated into tablets. Extraction was performed by maceration. Tablet preparations were characterized by moisture content, flow rate, angle of repose, organoleptic properties, weight uniformity, hardness, disintegration time, and friability. The results showed that the 70% methanol extract exhibited the highest antioxidant activity (IC₅₀ = 45.57 ± 0.01 ppm), superior to 70% acetone (IC₅₀ = 67.15 ± 0.07 ppm) and 70% ethanol (IC₅₀ = 85.32 ± 1.21 ppm), although lower than vitamin C (IC₅₀ = 3.52 ± 0.01 ppm). Tablets prepared from 70% methanol extract fulfilled all pharmaceutical quality requirements.
Optimizing Ultrasonic Extraction of Enhalus acoroides to Enhance Physicochemical Traits and Antioxidant Activity Mardiyanti, Siti; Anwar, Effionora; Desmiaty, Yesi; Sadiah, Siti
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.419

Abstract

Enhalus acoroides is a seagrass species known for its antioxidant potential due to its flavonoid content, including quercetin. This study aimed to optimize the extraction time using the ultrasound-assisted extraction (UAE) method based on physicochemical parameters and antioxidant activity. The simplicia was extracted for 20, 30, and 40 minutes, each in triplicate, using 96% ethanol acidified with 1% HCl. The results demonstrated that extraction time significantly influenced the physicochemical properties, including yield (highest at 30 minutes: 40.2%), total phenolic content (1.153 mg GAE/g), total flavonoid content (0.318 mg QE/g), quercetin content (0.316 mg/g), and antioxidant activity (IC₅₀ = 58.44 ppm), whereas no significant effect was observed on total ash content. Qualitative phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. Based on these findings, a 30-minute extraction time is recommended as the optimal condition for obtaining E. acoroides extract with the highest antioxidant activity.

Page 17 of 17 | Total Record : 163

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