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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Twelve Asteraceae Species as Tyrosinase Inhibitors: Selection and Assumption of Active Compounds Veby Tri Yani; Irma Herawati Suparto; Batubara, Irmanida
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.250

Abstract

Some Asteraceae plants have phytochemicals that are commonly used to treat some illness. However, research on the use of Asteraceae plants as tyrosinase inhibitor agents is still rare. Therefore, this study aims to select the most active fraction of Asteraceae species as tyrosinase inhibitors and suspect active compounds that play a role in it. About 12 species from Asteraceae are extracted using water. The resulting filtrate is partially fractionated using chloroform to obtain water extracts, water fractions, and chloroform fractions. Each extract and fraction of each plant determined the activity of its tyrosinase inhibitor using a microplate reader (ELISA) with L-DOPA as the substrate. Thitonia diversipholia water fraction provided the best activity of all the samples tested with the smallest IC50. The active compounds contained are analyzed using LC-MS / MS.  Compounds that act as tyrosinase inhibitors are alkaloid group that dominate the plant, namely trigonelline.
Review: Indonesian Herbal Ingredients as Immune Booster Yasmiwar Susilawati; Norisca Aliza Putriana; Silmi Auliya Zakariya
Jurnal Jamu Indonesia Vol. 7 No. 1 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i1.253

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 virus lead to massive death counts in parts of the world, including in Indonesia. Indonesian people often use herbal medicine as a way to increase their immune system, to prevent infection, and to accelerate the healing process of COVID-19. They are used to compose herbs with several medicinal plants as ingredients.  This review was aimed to provide information about immune booster herbs in Indonesia along with how to make it, its composition, its chemical contents, and how to use it in order to obtain scientific basis in understanding the efficacy and the herbal formulation. The method was carried out by browsing the literature from 2011-2021 through Google Scholar database from September 2021 to October 2021. The keywords used were "immune booster",  “immune boosting herbs”, “jamu”, “herbal ingredient”, “formulation” using the Boolean Operators 'AND' 'OR' and ‘NOT’. The literature that met the inclusion criteria were 30 journals. From the literature review, it was known that there are 22 species of medicinal plants that are used for 37 immune booster jamus with Zingiberaceae as the majority of the family (31%). The top ten plants commonly found in the ingredients are turmeric, ginger, lemongrass, temulawak, cinnamon, red ginger, lime, lesser galangal, meniran, and centella asiatica. Based on the plant’s chemical constituents, it was found that the secondary metabolites components which could potentially boost immunity are essential oils, flavonoids, saponins, tannins, and phenols. Meanwhile, the active compounds for immune booster were curcumin, gingerol, xanthorrhizol, citral, p-methoxycinnamate, and philanthine.
Characterization and The Effects Analysis of Purple-fleshed Sweet Potato Extract (Ipomoea batatas [L.]) Administration on Triglyceride Concentration and Pancreatic Histopathology Profiles of Triton X-100-induced Hyperlipidemia in Rats Kintoko; Hardi Astuti Witasari; Rizky Nurdhillah; Tsania Taskia Nabila
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i2.258

Abstract

Hypertriglyceridemia occurs when the triglyceride levels are increasing from the normal (>150 mg/dL) and it causes pancreatitis at a dose of more than 885 mg/dL. The triglyceride-lowering medicines consumption has several side effects on various organ systems. The plant-based medicine (phytomedicine) alternatives have been observed as the synthetic medicine substitution. Purple-fleshed sweet potato (Ipomoea batatas [L.]) contains anthocyanin that has proven to carry out the antioxidant mechanism and the capability to be used as anti-hypertriglyceridemia. This study aims to identify the activity of purple-fleshed sweet potato extracts on triglyceride levels and the histopathological profile of rats' pancreas-induced Triton X-100. Twenty-five male Wistar rats of week 8th were divided into five groups. The normal (N) group was treated with saline solution, and the treatment (T) groups were a single dose of 100 mg/kg of body weight (BW) Triton X-100 and purple-fleshed sweet potato extracts of 175 (T1); 350 (T2); and 700 (T3) mg/kg BW, while the negative (C-) control group was mere induced by a single-dose Triton X-100 of 100 mg/kg BW. The blood serum was isolated and the pre-and post-test was subsequent conducted. The triglyceride serum levels and histopathological data were analyzed by the Kolmogorov-Smirnov normality test and Kruskal-Wallis post-test statistical analysis. The results showed that Triton X-100-induced treatment could significantly increase the triglyceride levels compared to the normal group (P<0.05). The purple-fleshed sweet potato extracts started to lower the triglyceride level at a dose of 700 mg/kg BW (51.83 ±19.15(%)). The extract doses of 175 and 350 mg/kg BW could not reduce the triglyceride level significantly (3.03±2.77 and 5.63±4.24 (%), respectively). A dose of 700 mg/kg BW did not damage the exocrine gland and Langerhans islet of hyperlipidemia rat pancreas treated by Triton X-100. 
Review: Extraction of Temulawak Rhizome (Curcuma xanthorrhiza Roxb.) and Activity As Antibacterial Yasacaxena, Lidvina Niken; Defi, Matea Nirmala; Kandari, Vicha Putri; Weru, Putri Teresa Rery; Papilaya, Feranita Elsa; Oktafera, Melania; Setyaningsih, Dewi
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.265

Abstract

Temulawak (Curcuma xanthorrhiza) is one of Indonesia’s native plants belonging to Zingiberaceae family. The plant has been extensively used for treatment of various diseases such as inflammation and digestive tract swelling, gallstones, liver, dyspepsia, and antispasmodic. The rhizome becomes the plant’s part that is used the most. The rhizome contains a compound that could work as an antibacterial. An extract of the rhizome may be obtained through extraction process, some extractions that would be used in this research review is soxhletation, maceration, and ultrasound assisted extraction (UAE). As various extraction methods both involving simple and complex ones were found, it was shown that the result of extract content are therefore varied, which was also affecting the level of resulted antibacterial effectiveness. This article was carried out to analyze the most suitable extraction method of Curcuma’s rhizome that results the highest effectiveness of antibacterial activity. The method used in this article review was a literature review on the literatures published during the period of 2012 to 2022. The highest average yield was shown on maceration method which respectively was followed by soxhletation whereas the lowest yield was resulted by UAE method
Antioxidant Capacity, Total Phenolic, and Flavonoid Content from Java Tea (Orthosiphon aristatus) Extracts Arif, Zulhan; Zalukhu, Aurentinus; Karomah, Alfi Hudatul; Rafi, Mohamad
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.268

Abstract

Orthosiphon aristatus, known as kumis kucing in Indonesia, has some biological activity, i.e., as an anti-inflammatory, fever, rheumatism, diabetes, and kidney stone. This plant is also known for being rich in phenolic compounds such as flavonoids. In this study, we would like to compare the antioxidant activity, total phenolics, and flavonoid content from the stems and leaves of Orthosiphon aristatus extracted with water and ethanol by maceration. The yield stem and leaves of the water extract are 12.98-31.28%, and ethanol extract 3.58 - 9.82% (dry basis). The stem and leaves water extract contains a phenolic of 7.82-26.43 (mg GAE/g) and ethanol extract of 2.27-7.84 (mg GAE/g). Water extract Orthosiphon aristatus flavonoid content is 1.23-2.86 (mg EK/g), and ethanol extract is 1.09-3.95 (mg EK/g). The antioxidant activity of ethanol (IC50), extract from leaves was 123.91 (µg/mL) and from stems was 125.50 (µg/mL), while IC50 of water extract from leaves was 114.70 (µg/mL) and from stems was 125.03 (µg/mL). The correlation test result of active compounds using linear regression is phenolic compounds with antioxidants stronger than flavonoids. The qualitative thin-layer chromatography fingerprint analysis showed that ethanol and water extract contained natural sinensetin compounds.
Identification of Java Tea Adulteration by Babadotan and Tekelan using Machine Learning Ary Prabowo; Wisnu Ananta Kusuma; Annisa; Mohamad Rafi
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.273

Abstract

Java Tea (Orthosiphon aristatus) is a common herbal medicinal plant that functions as a health treatment and treats various diseases. The high demand for Java Tea causes high prices and a decrease in the amount of medicinal plant raw materials, causing various quality control problems such as the content of various bioactive components and adulteration from babadotan and tekelan. So far, the detection of adulteration has been carried out by various analyzes, including chemical analysis and statistical methods to process data. The data used is of high dimension with a very high-density level, thus causing difficulties in classification. The mixed data of Orthosiphon aristatus consists of 1201 features with a total sample of 216. This study uses a Random Forest (RF) method with a total of 100 trees, and the RF method is combined with the Recursive Feature Elimination (RFE) method. In the RF and RFE that can be produced, the optimum value for the number of features is 244. The experimental evaluation results revealed that the proposed method could achieve a high accuracy of 81.82% in identifying Orthosiphon aristatus.
Utilizing Program of Vacant Land on Public Facilities for Diabetes Mellitus Self-Medication Parks in Benteng Village, Bogor Regency Purnaningsih, Ninuk; Siti Sa’diah; Qodarian Pramukanto
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.278

Abstract

The prevalence of diabetes in Indonesia has increased substantially in the last 30 years, where individual chances of developing diabetes are higher for women than for men; and level of education is negatively related to diabetes mellitus. Independent therapy garden, is one of the functions of public park which is designed thematically for therapy (medication).The objectives of Program are: (1) Development of a participatory Diabetes Mellitus Self-therapy Garden at partner locations; (2) Cultivation training and education in using/processing of medicinal plants for self-therapy for Diabetes. Program partners are the Kecapi Posyandu RW 6 Benteng Village Bogor Regency, West Java Province. Partner problems are: (1) There are a large number of elderly people who have the potential to suffer from Type 2 Diabetes; (2) Lack of knowledge of partners and residents around partner locations about Diabetes: its characteristics, treatment and prevention; (3) Lack of skills in cultivating and processing of medicinal plants to maintain health, especially diabetes. The participatory approach was carried out by involving partners from the beginning of the program, started from discussing the activity plan, determining the location of the public facility land to be built into a therapy park, and determining program participants. The determination of the location of the park was chosen based on area that was easily visited by residents, so that they can interact with fellow residents in the park. Education about diabetes therapy was carried out by conveying information about diabetes mellitus and how to handle it. Education on the use of medicinal plants, processing them, concocting them, was carried out in practice. There has been an increase in knowledge, skills, and positive attitudes in the prevention and treatment of diabetes independently by partners. The sustainability of the program is carried out by providing diabetes self-therapy manuals, and mentoring through groups through periodic discussions.
Determination of Total Citronelal Levels and Development of FTIR-Chemometric Classification Model of Cymbopogon winterianus Jowitt Oil from Different Altitudes of Planting Areas Jazila, Yusrin Nur; Kristiningrum, Nia; Wulandari, Lestyo
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.279

Abstract

Cymbopogon winterianus Jowitt oil (CWJ oil) is a vegetable oil with very wide uses in food sector, cosmetics, medicines and chemical industry. Citronelal compound is one of the quality requirements that determine the quality of CWJ oil. This study aims to develop a chemometric-FTIR classification model and to determine the total citronellal content of Cymbopogon winterianus Jowitt oil grown in low and medium lands. The sample used was citronella oil from Jember and Banyuwangi regions. The cleaned CWJ herbal samples were withered, chopped and distilled to produce CWJ oil. CWJ oil was scanned using FTIR spectroscopy and then the FTIR spectras were analyzed using LDA, SVM and SIMCA to form a CWJ oil classification model. The selected classification model was then validated using leave one out cross validation and external validation. The LDA classification model showed the best results with 100% accuracy of model recognition and validation. The results of the determination of total citronellal levels of CWJ oil using the hydroxylamine method showed that samples of CWJ oil from Banyuwangi had higher levels of total citronellal than samples from Jember. The average levels of total citronellal CWJ oil from Banyuwangi and Jember regions were 32.84%, and 26.06%, respectively.
Phytochemical, Antioxidant and Antibacterial Screening of Orthosiphon stamineus Leaf Extract Two Phenotypes Waras Nurcholis; Fachrur Rizal Mahendra; Milanda Fiorella Gultom; Safira Khoirunnisa; Mayang Anggita Cahya Kurnia; Hamdan Hafizh Harahap
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.280

Abstract

Kumis kucing (Orthosiphon stamineus) is a medicinal plant that can treat various diseases. Kumis kucing has been known to contain bioactive compounds, namely polyphenol, alkaloid, and terpenoid which have antioxidant, antibacterial, antiviral, anti-inflammatory, anti-allergic and anti-cancer activities. This study aims to determine the phytochemical content, antioxidant activity, and antibacterial activity of the cat's whiskers leaf extract. Kumis Kucing leaf extract was obtained by sonication-maceration method. Antioxidant activity test of cat's kumis leaf extract was tested using the CUPRAC and ABTS methods. The results showed that the kumis kucing’s leaf extract contains bioactive compounds of polyphenol, alkaloid, and terpenoid. The highest average antioxidant activity was produced by the purple phenotype cat whiskers leaf extract using the ABTS method, which was 168.68 µg TE/g dry weight. The highest average antibacterial activity in Escherichia coli  strain was obtained from leaf extract of purple phenotype cat whiskers (U2) with an inhibition zone diameter of 3.2 mm.
Antibacterial Activity of Ethanol, Ethyl Acetate, and n-Hexane Extracts of Bidara Laut Lignum (Strychnos lucida R.Br) against Staphylococcus aureus and Escherichia coli Setyaningsih, Erwi Putri; Bahri, Saiful; Nurjanah, Rindang
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.283

Abstract

Strychnos lucida is empirically believed to have efficacy in treating various diseases such as fever, malaria, toothache, and stomachache and to treat wounds. The secondary metabolite of Strychnos lucida has various polarity. The purpose of this study was to compare the inhibitory activity of Strychnos lucida extracts against E. coli and S. aureus bacteria. The test was carried out by measuring the Diameter of the Inhibitory Region (DIR) using the disc diffusion method on a concentration of 90%, 75%, 60%, 45%, 30%, and 15%. The Minimum Inhibitory Concentration (MIC) was carried out by agar dilution method on a concentration of 15%, 12.5%, 10%, 7.5%, 5%, and 2.5%. The positive control was 1% ampicillin, and the negative control was 10% DMSO. The ethyl acetate extract showed the highest DIR of 14.30 mm against S. aureus and E. coli on a concentration of 45%, ethanol extract was 8,38 mm against S. aureus and 8.71 mm against E. coli, and n-hexane had no inhibitory activity on a concentration 45%. The result of the MIC test for ethanol and ethyl acetate extract for both bacteria was found at a concentration of 15%, while n-hexane extract against Staphylococcus aureus was found at a concentration of 90% and a concentration of 75% against Escherichia coli.

Page 11 of 17 | Total Record : 163

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