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Waras Nurcholis
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Tropical Biopharmaca Research Center (TropBRC) IPB University CRC Building, 2nd Floor, STP Area IPB Taman Kencana Campus Taman Kencana St. No. 3, Bogor West Java, Indonesia 16128
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Consumer Profiles and Drink Menus Made from Medicinal Plants at the Jamu Cafe in Depok Sleman District, Yogyakarta Hartini, Yustina Sri; Setiawati, Agustina; Dwiatmaka, Yohanes
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.310

Abstract

The use of medicinal plants as ingredients in making drinks in cafes is increasing along with the number of cafes. Herbal café makes a unique menu using medicinal plants in drink recipes to produce a distinctive taste, color, and aroma. This research aims to identify visitor profiles and drink menus made from medicinal plants and explore the understanding of visitors and cafe owners regarding the benefits of medicinal plants added to drinks. The research data collection technique uses a questionnaire equipped with an interview sheet. The questionnaires and interview sheets used have been tested for language comprehension and validity. The research was conducted at 272 cafes in Depok District, Sleman Regency, Special Region of Yogyakarta. The sample was determined using purposive sampling, data was collected after obtaining ethical clearance approval from the Health Research Ethics Committee Team. Data was obtained through filling out surveys by visitors and cafe owners, complemented by interviews with cafe owners. Data was collected three times: August, September, and October 2023. Data analysis was carried out descriptively and qualitatively. Most herbal cafe visitors (70%) are aged between 21–30 years with the majority of professions (44%) being students. The source of information about herbal cafe menus was mostly obtained (56%) from friends or family, and the frequency of visits to cafes was mostly (82%) between 1–5 times per month. More than 98% of visitors stated the benefits of medicinal plants in the drink menu, namely as a refresher or body warmer. There are 14 types of medicinal plants used as ingredients in the herbal cafe's drink menu, with a total monthly requirement for all medicinal plants of 545.1 kilograms; ginger ranks among the highest requirements. Recipe information for the menu was obtained from the family, the Ministry of Health Republic Indonesia website, and the herbal cafe owner made the recipe independently.
Standardization of 96% Ethanol Extract of Beluntas Leaves, Kenikir Leaves, and Purple Corn Kernels Riwanti, Pramudita; Ma'arif, Burhan; Primadini, Filicia Regya; Maulidiah, Erika Nur; Ramadhan, Ravy Irsyad
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.312

Abstract

Beluntas (Pluchea indica) leaves, kenikir (Cosmos caudatus) leaves, and purple corn (Zea mays) kernels have the potential to be developed into preparations of traditional medicine, which requires standardization of raw materials. The 96% ethanol extract P. indica leaves from Batu, C. caudatus leaves from Wonosari, and purple corn kernels from Sukabumi have been standardized. Both specific and non-specific requirements are covered. Fragment identifiers of P. indica leaves, such as stomata and trichoma. C. caudatus leaves, such as vascular tissue with stair thickening and multicellular hair covering. Purple corn kernels such as amylum and hilum in the form of stars. The thick extracts were obtained from the results of ultrasonic-assisted extraction with yields of 14.76% for P. indica leaves, 7.49% for C. caudatus leaves, and 5.79% for purple corn kernels. The organoleptic of ethanolic extract P. indica leaves is thick and greenish-black, C. caudatus leaves is thick and brown, and purple corn kernels is thick and purple. The water-soluble content from P. indica leaves, C. caudatus leaves, and purple corn kernels was 13.85%, 11.13%, and 10.62%, respectively. The ethanol soluble content was 16.58%, 14.87%, and 15.89%. The total ash content for P. indica leaves, C. caudatus leaves, and purple corn kernels was 15.04%, 9.37%, and 4.76%. The percentage of water content was 9.07%, 14.34%, and 11.12%. The standardized data collected was compared with the requirements in the official monographs of Materia Medika Indonesia and Farmakope Herbal Indonesia. The results showed that the three samples used had met most of the standardization parameters and could be developed into traditional medicine.
Authentication of Java Turmeric (Curcuma xanthorrhiza) from Turmeric (Curcuma longa) Using a Combination of UV-VIS-IR Spectrum and Chemometrics Izzati, Mumpuni Nur; Syafitri, Utami Dyah; Mohamad Rafi
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.313

Abstract

Java turmeric (Curcuma xanthorriza) and turmeric (Curcuma longa) show similar colors, so they have the potential to be adulterated with each other, especially if they are presented in powder. This research aims to develop an analytical method for authenticating both types of samples with adulterant concentrations of 0.01% w/w and 0.005% w/w for the infrared range and 0.5 μg/g and 1 μg/g for the UV-Vis range. The pure sample was extracted for 40 minutes with 1:10 ethanol using ultrasonication. The extract was then concentrated using a rotary evaporator and freeze dryer. Adulterant samples were prepared by mixing both types of extracts. The absorption of the solution was measured at a wavelength of 200–800 nm and a wave number of 4000–400 cm-1. Multivariate analysis using partial least squares-discriminant analysis (PLS-DA) and soft independent modeling of class analogies (SIMCA) was performed on the spectra. PLS-DA has not been able to authenticate adulterated samples. However, SIMCA analysis can detect differences between pure curcuma and adulterated samples in the infrared range until a concentration of 0.005% w/w, while it can only authenticate correctly in the UV-Vis range until a 1 μg/g concentration.
Phytochemical Analysis and Determination of MIC and MFC of Cacao Leaves Extract (Theobroma cacao L.) against Malassezia furfur Lestari, Siti Marwah; Camelia, Leonyta; Rizki, Widya Twini; Pratama, Septa; Khutami, Chindiana; Amelia, Amraini; Rahmadevi, Rahmadevi; Andriani, Yuni
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.316

Abstract

Pityriasis versicolor is a disease caused by Malassezia furfur. One of the plants that can potentially act as antifungal is cacao leaves (Theobroma cacao L.), which contain several secondary metabolite compounds, including alkaloids, flavonoids, tannins, quinones, terpenoids, and saponins. This study aims to determine the phytochemical analysis and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of cacao leaves ethanolic extract against M. furfur. Extracts were obtained by maceration using 70% ethanol and phytochemicals analysis using Herborne’s method. Furthermore, the extracts were made into concentrations’ variations of 3.125%; 6.25%; 12.5%; 25%; 50%; and 100% for testing antifungal activity, with 10% DMSO as negative control and 2% Ketoconazole and Itraconazole as positive controls. MIC was performed with liquid macrodilution method, and MFC was performed with spread method. The results of phytochemical analysis showed that the extract contained alkaloids, flavonoids, phenols, tannins, quinones, terpenoids and saponins. MIC value was obtained at concentration of 50% and MFC value was obtained at 100%. Cacao leaves ethanolic extract with concentration of 50% can inhibit M. furfur’s growth and with 100% can eliminate M. furfur.
Jamu as Indonesian Cultural Heritage and Modern Health Innovation Nurcholis, Waras; Arianti, Rini
Jurnal Jamu Indonesia Vol. 9 No. 1 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i1.317

Abstract

Growth, Phenolic, and Flavonoid Production of Adenostemma platyphyllum at Different Dosages of Cow Manure Ridwan, Taopik; Ananda, Fira; Maulana, Faizal; Takemori, Hiroshi; Azis, Sandra; Batubara, Irmanida
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.318

Abstract

Adenostemma platyphyllum is a weed plant containing various secondary metabolites, such as phenolics and flavonoids, making it essential to cultivate properly. This study aims to determine the optimal cow manure dosage for plant growth, focusing on phenolic and flavonoid production in the cultivation of A. platyphyllum. The experiment employed a randomized complete block design (RCBD) with a single factor: cow manure doses of 0.5, 5, 10, 15, and 20 ton/Ha. Phenolic content was measured using the Folin Ciocalteu reagent, while flavonoid content was assessed using the AlCl₃ reagent. Results indicate that the highest phenolic and flavonoid production occurred in plants treated with 20 ton/Ha manure. This dosage also resulted in the best plant growth, yielding the highest crop, number of leaves, and branches compared to other treatments.
The Diversity of Medicinal Plant Used by Local Community in Borneo, Indonesia: A Review Nina Sari, Tri Astuti; Nurfitriani, Desty; Mutamimah, Rofiatul; Yudianto; Wakhidah, Anisatu Z
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.324

Abstract

As one of the biggest islands in Indonesia, Borneo or Kalimantan, is considered one of the lungs of the world. The local communities utilize the large biodiversity in Borneo as traditional knowledge on medicinal use. The purpose of this article was to find out data on the diversity of medicinal plants utilized by local communities as well as the parts of plants used, the preparation in the use of medicinal plants, and the phytochemical content of several types of plant species that are most widely used in the Kalimantan region. This article was developed using the literature review method by searching for articles, journals and literature on Google Scholar. A total of 204 species from 74 families are utilized by the people of Kalimantan as medicine. The results showed that the types of plants that the people of Kalimantan widely use came from the Asteraceae family (16 species), Euphorbiaceae (15 species), Rubiaceae (11 species), Zingiberaceae (10 species), and others. The local people of Kalimantan mostly utilize plant leaves and roots by boiling since the boiling method is more effective in the healing process for fever and stomach pain. The people of Kalimantan most often apply medicinal plants by boiling them and then drinking them because this treatment is the most effective. It is believed that drinking it can accelerate healing. Therefore, there is a need for new knowledge and data collection related to the use of plants as medicine by the people of Kalimantan.
Patterns and Marketing Strategies of Herbal Medicine at Sukoharjo Regency Purnaningsih, Ninuk; Saraswati, Yudhistira; Anggrasari, Herdiana
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.325

Abstract

The development of the herbal industry, especially in the sector of herbal medicine, is increasingly gaining momentum. The COVID-19 pandemic has heightened the demand for a healthy life. Consequently, many institutions are involved in the marketing and distribution of herbal products. This study aimed to analyze the institutions involved, marketing patterns, and marketing strategies for industrially processed herbal medicine products. A qualitative approach with descriptive analysis was employed in this study. Data collection methods included observation, literature study, and interviews with informants. The key informants in this research included herbal medicine business actors and market managers. These business actors consist of herbal medicine processors and marketers. This research was conducted in Sukoharjo Regency. The results show that the institutions involved in the marketing chain of herbal medicine products comprise raw material suppliers, manufacturers functioning as distributors, retailers, and consumers. The marketing chain for processed herbal medicine products can be categorized into 6 marketing channels. The marketing strategies for industrially processed herbal medicine products that can be implemented include promotion via social media; employing a super value strategy; adding distribution agents; developing research on standardization and market opportunities; and innovation in industrially processed herbal medicine products.
Novel Compounds Design of Acertannin, Hamamelitannin, and Petunidin-3-Glucoside Typical Compounds of African Leaves (Vernonia amygdalina Del) as Antibacterial Based on QSAR and Molecular Docking Kurniawan, Ilham; Ambarsari, Laksmi; Kurniatin, Popi Asri; Wahyudi, Setyanto Tri
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.326

Abstract

Antibacterial secondary metabolites such as tannins and their derivatives are found in the Vernonia amygdalina Del. Antibiotic resistance can develop due to overuse, reducing the efficacy of drugs to prevent and treat infections. This research aims to use the Quantitative Structure-Activity Relationship (QSAR) and the semi-empirical method Austin Model 1 (AM1) to design a modified novel compound from African leaves that has improved antibacterial activity. This research includes a descriptor calculation of QSAR using AM1 MOE on typical compounds from African leaves, and calculation results are chosen based on a multilinear regression statistical analysis. The model equation represents the three primary parameters of QSAR, which are electronic, hydrophobic, and steric parameters, which will be used to measure modified compounds. Molecular docking using Autodock Tools (The Scripps Research Institute, USA), and analysis of results of docking Autodock Tools using Discovery Studio 3.5 Client. The best QSAR model obtained is LogEC50 = (0.829 x LogP) - (1,302 x AM1_HOMO) - (0.339 x AM1_dipole) - (5,128 x mr) + (0.145 x vol) - (11,355). The results showed that EC50 prediction of modified hamamelitannin has the best activity with the lowest ΔGbind -9.0 kcal/mol and inhibition constant of 0.249 μM. In summary, the novel compound's design calculation has better antibacterial activity, as indicated by a lower EC50, than fosfomycin or compounds without modification. The modified hamamelitannin compound was found to have better antibacterial activity (prediction EC50 = 0.1933 μM) than the original (experimental EC50 = 145.50 μM).
Molecular Docking Study of Bioactive Compounds from Curcuma aeruginosa Roxb. as Antioxidant and Anticancer Activities Ambarsari, Laksmi; Nurjanah, Siti; Artika, I Made; Fatriani, Rizka
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.327

Abstract

Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations (cancer). Cancer will develop uncontrollably due to the occurrence of the cell cycle and the presence of compounds that trigger cell proliferation and inhibit the process of apoptosis. This cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. Curcuma aeruginosa RoxB., the plant, is known to have the potential for antioxidant and anticancer properties. This study aims to determine the molecular interaction between the dominant compound in the ethanol extract of C. aeruginosa with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (∆G), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the gajutsulacton A had the best potential in inhibiting CDK2. The cucumenol may be a COX-2 inhibitor, and there are no compounds that can inhibit LOX as well as an antioxidant. Thus, our findings demonstrate the potential for C. aeruginosa bioactive to serve as anticancer candidate molecules against CDK2 and COX-2 receptors.

Page 13 of 17 | Total Record : 163

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