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Waras Nurcholis
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Tropical Biopharmaca Research Center (TropBRC) IPB University CRC Building, 2nd Floor, STP Area IPB Taman Kencana Campus Taman Kencana St. No. 3, Bogor West Java, Indonesia 16128
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Anti-Aging Efficacy of Averrhoa bilimbi Fruit Extract Cream: A Human Clinical Trial Suharsanti, Ririn; Ryan Radix Rahadhian, Muhammad; Sugihartini, Nining; Lukitaningsih, Endang
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.401

Abstract

Averrhoa bilimbi, a plant native to Indonesian, exhibits antioxidant, sunscreen, and tyrosinase inhibitory activities due to its polyphenol and flavonoid content. This study aimed to evaluate the anti-aging efficacy of a topical cream containing A. bilimbi fruit extract through a human clinical trial. The extract was obtained by maceration using 70% ethanol and formulated into a water-in-oil (W/O) cream at concentrations of 1% (F1), 3% (F2), and 5% (F3). Each formulation was evaluated for its physical characteristics, including organoleptic properties, homogeneity, pH, and viscosity. Irritation tests were conducted on animals and human volunteers. A total of 24 human subjects applied the cream for 30 days. Skin condition parameters—sebum, moisture, pigmentation, pore size, elasticity, and collagen fibers—were assessed before and after treatment using a skin analyzer. The results showed that the F3 formulation produced the most notable improvements, including increased skin moisture and elasticity, and decreased pigmentation and pore size. Statistical analysis revealed significant improvements (p < 0.05) in pore size and elasticity for the F3 group. These findings indicate that the 5% A. bilimbi extract cream is a safe and effective anti-aging topical formulation.
Anti-inflammatory Activity of Ipomoea batatas Leaves Ethanolic Extract Tablet with Variation of Polyvinylpyrrolidone and Amylum Binders Pramiastuti, Oktariani; Rizqi, Muhammad Irsan; Nurhidayati, Lailiana Garna; Firsty, Girly Risma
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.402

Abstract

Purple sweet potato (Ipomoea batatas (L.) Lam.) leaves are traditionally used as an anti-inflammatory remedy. This study investigated the anti-inflammatory activity of purple sweet potato leaf ethanolic extract and its formulation into tablet dosage forms with varying concentrations of polyvinylpyrrolidone and amylum as binders. The extract was obtained through maceration using 96% ethanol and tested for anti-inflammatory activity using the bovine serum albumin denaturation method. The extract showed strong anti-inflammatory activity with an IC₅₀ value of 62.628 ppm compared to sodium diclofenac with an IC₅₀ of 57.326 ppm. The extract was then formulated into tablets with binder ratios of 1:0, 0:1, 1:1, 2:3, and 1:4 (polyvinylpyrrolidone: amylum) using wet granulation. Evaluation of physical properties indicated that the 1:1 binder ratio produced tablets that met quality requirements, including hardness, friability, and disintegration time. These results suggest that I. batatas leaf extract has potent anti-inflammatory properties and is suitable for development into a tablet formulation with appropriate binder ratios.
Formulation and Characterization of Peel-Off Gel Mask Containing Secang (Caesalpinia sappan L.) Wood Extract with Strong Antioxidant Activity Cahyani, Intan Martha; Tanzaq, Tan Tanando; Agustina, Ruth Ditya; Setiawati, Kemala Endar
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.403

Abstract

Secang (Caesalpinia sappan L.) wood contains flavonoid compounds such as brazilin, 3'-O-methylbrazilin, sappanin chalcone, and sappan chalcone, which act as primary and secondary antioxidants. Antioxidants are substances that can inhibit oxidation reactions by neutralizing free radicals. Enhancing the antioxidant potential of C. sappan wood can be achieved by developing a topical dosage form. Peel-off gel masks are an ideal form due to their ability to improve skin health and provide ease and comfort in application. This study aimed to formulate a peel-off gel mask containing C. sappan extract and evaluate its physical properties and antioxidant activity. The formulations were prepared using 2.5%, 5%, and 7.5% extract with sodium carboxymethyl cellulose, polyvinyl alcohol, and propylene glycol as the base. The resulting masks were assessed for physical characteristics (pH, viscosity, spreadability, adhesiveness, and drying time) and antioxidant activity using the DPPH method. The results indicated that increasing the extract concentration significantly (p < 0.05) increased viscosity, adhesiveness, and drying time, while decreasing pH, spreadability, and IC₅₀ value. All formulations demonstrated strong antioxidant activity (IC₅₀ between 50–100 µg/mL), with IC₅₀ values of 88.71 µg/mL, 81.58 µg/mL, and 79.04 µg/mL, respectively.
In Silico Exploration of Orthosiphon stamineus Compounds as Potential Angiotensin Receptor Blockers for Hypertension Therapy Prasetiyo, Andri; Indriani, Aqilah Idelia; Ramadhani, Karina Natasya; Natthawani, Amitta; Ramadhan, Islami Al-Kaffah; Yogaswara, Amira Thufailla; Audrey, Cresentia; Mulatsari, Esti; Mumpuni, Esti; Zahra, Nurulita Az
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.370

Abstract

Orthosiphon stamineus has demonstrated antihypertensive potential, but the specific bioactive compounds involved remain unclear. This study aimed to evaluate selected phytochemicals from O. stamineus as angiotensin receptor blockers (ARBs) targeting protein 4ZUD using in-silico methods. Molecular docking was conducted to assess binding affinity, while ADMET analysis evaluated pharmacokinetics and toxicity. Salvianolic acid E showed the strongest binding affinity with a rerank score of −134.02 kcal/mol, surpassing olmesartan (−124.52 kcal/mol). Key interactions were observed with amino acid residues Arg167, Tyr92, and Asp281. ADMET predictions revealed that Salvianolic acid E has good aqueous solubility, moderate intestinal absorption (HIA 45.99%), and low membrane permeability (Caco-2 < 0.4). It does not inhibit major cytochrome P450 isoenzymes and is predicted to be non-hepatotoxic, suggesting favorable safety and metabolic profiles. These findings highlight Salvianolic acid E as a promising phytochemical candidate for antihypertensive drug development.
Phytochemical Profile and Pharmacological Mechanisms of Pandanus tectorius Fruit: A Comprehensive Review Setiani, Lusi Agus; Herlina, Nina; Wahyuningrum, Cyntia; Putri, Nabilah Yuliana
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.374

Abstract

The fruit of Pandanus tectorius, commonly known as screw pine or sea pandan, contains various secondary metabolites with significant therapeutic potential but remains underutilized in clinical applications. This review summarizes findings from 2014 to 2025 regarding its phytochemical composition and pharmacological effects. Sixteen bioactive compounds have been identified, including pandanusin A, bergapten, scoparone, scopoletin, several lignans, isoamericanin A, kaempferol, chrysin, phenolic acids, betulinic acid, and β-sitosterol. These constituents demonstrate antioxidant, anti-inflammatory, analgesic, antidiabetic, antimicrobial, and anticancer activities. Mechanistic actions include inhibition of alpha-glucosidase, reduction of oxidative stress, and induction of cytotoxicity in cancer cells. The ethyl acetate fraction, in particular, exhibits strong activity against HeLa cells. Novel delivery systems, such as nanoemulsions, are being explored to enhance solubility and bioavailability. Additionally, preclinical studies suggest roles in immune modulation, wound healing, and pain relief. Although promising, further clinical validation and formulation standardization are needed. This review highlights the potential of P. tectorius fruit as a candidate for evidence-based phytotherapeutic development.
Ethnopharmacological Study of Medicinal Plants Used by the Dayak Tunjung Benuaq Tribe in East Kalimantan, Indonesia Fadhillah, Reza Nur; Kustiawan, Paula Mariana
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.376

Abstract

Ethnopharmacology is a scientific approach used to document traditional knowledge regarding the use of medicinal plants. The Dayak Tunjung Benuaq Tribe in Putak Village, East Kalimantan, Indonesia, continues to rely on herbal remedies for treating various ailments. This study aimed to identify plant species used, their therapeutic applications, and preparation methods. Data were collected through purposive and snowball sampling techniques, using semi-structured interviews with knowledgeable informants. Quantitative analysis was performed using Use Value (UV), Informant Consensus Factor (ICF), and Fidelity Level (FL). A total of 31 species from 19 families were recorded, including Carica papaya, Zingiber officinale, Psidium guajava, and Eleutherine bulbosa. Leaves were the most commonly used plant part (58%), most often prepared by boiling (93.6%) and administered orally (93.6%). C. papaya had the highest UV (0.23), while seven disease categories, such as malaria, fever, and joint pain, achieved perfect consensus (ICF = 1.0). Several species, including E. bulbosa and Syzygium polyathum, reached 100% FL, reflecting strong cultural preference for specific treatments. These findings emphasize the significance of traditional knowledge within the community, the need for documentation and preservation, and the potential of these plants for future pharmacological exploration and biodiversity conservation.
Optimizing Curcumin SNEDDS via D-Optimal Design and Evaluating Wound Healing Efficacy in Wistar Rats Setyawan, Ferdinta Daniasta; Herman; Imba, Farhan
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.393

Abstract

Curcumin, a bioactive compound extracted from turmeric, exhibits extensive pharmacological properties, including anti-inflammatory and wound-healing activities. Nevertheless, its clinical application is hindered by low aqueous solubility and poor bioavailability. This study aimed to optimize a curcumin-loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) using a D-Optimal experimental design to improve its solubility, stability, and therapeutic efficacy. The SNEDDS formulation was developed by varying the proportions of oil, surfactant, and co-surfactant. The optimized formulation demonstrated a particle size of 120 nm and an encapsulation efficiency of 94.5%, significantly accelerating wound closure by 98% within 14 days in Wistar rats. These results highlight the potential of curcumin SNEDDS as an effective topical formulation for wound therapy.
Antibacterial Activity of 70% Ethanol Extract of Red Hanjuang (Cordyline fruticosa L.) Leaves Against Staphylococcus aureus Nurviana, Vera; Faridah, Ida; Zustika, Diana Sri
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.395

Abstract

Productive cough is a common symptom of bacterial respiratory infections. Red hanjuang (Cordyline fruticosa L.) leaves have been traditionally used to relieve such conditions. This study aimed to standardize red hanjuang leaf plant material and evaluate the antibacterial activity of its 70% ethanol extract against Staphylococcus aureus. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, polyphenols, quinones, steroids, monoterpenoids, and sesquiterpenoids. Antibacterial activity was tested using the well diffusion method at concentrations of 10%, 25%, 35%, and 50%, with minimum inhibitory concentration (MIC) tests ranging from 10% to 0.8%. Specific and non-specific standardization showed water-soluble extract at 34.593%, ethanol-soluble extract at 31.663%, moisture content at 4.67%, drying loss at 9.57%, total ash content at 7.70%, and acid-insoluble ash at 0.89%. The extract demonstrated strong antibacterial activity at all tested concentrations. The lowest active concentration was 10%, with an MIC value at 8%, forming an inhibition zone of 2.43 mm. These findings support the potential of red hanjuang leaves as an herbal antibacterial agent.
Phytochemical Screening and Antibacterial Activity of Jackfruit Seed Extract (Artocarpus heterophyllus Lamk.) Against Salmonella typhi In Vitro Febriza, Ami; Amalia Kartika, Salwa; Asdar
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.400

Abstract

Salmonella typhi infection remains a public health concern, necessitating natural treatment alternatives. This study aimed to evaluate the antibacterial activity and identify the active compounds of jackfruit seed (Artocarpus heterophyllus Lamk) ethanol extract against S. typhi in vitro. Antibacterial activity was tested using the well diffusion method at extract concentrations of 25%, 50%, 75%, and 100%, with chloramphenicol and 10% DMSO as positive and negative controls. All extract concentrations produced significant inhibition zones (mean: 19.83 mm to 31.42 mm; p<0.05). Phytochemical screening revealed flavonoids, alkaloids, steroids, and saponins as the active compounds. Antibacterial efficacy increased with concentration and was comparable to chloramphenicol (mean: 33.49 mm). These results indicate that jackfruit seed extract holds promise as a natural antibacterial agent against S. typhi.
Hepatoprotective Potential of Schleichera oleosa Leaf Extract Against Paracetamol-Induced Liver Injury in Rats Zulham, Zulham; Rasyid, Andi Ulfah Magefirah; Burhan, Asril
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.407

Abstract

Schleichera oleosa L. is traditionally used in herbal medicine and has shown pharmacological activities such as antioxidant, anticancer, and antimicrobial effects. Its antioxidant capacity is attributed to polyphenols, which neutralize free radicals and contribute to liver protection. This study evaluated the hepatoprotective effect of S. oleosa leaf extract against paracetamol-induced liver injury in rats. Antioxidant activity was measured using the DPPH method, yielding an IC₅₀ of 11.43 µg/mL, indicating strong activity. Rats were administered 50, 100, or 150 mg/kg body weight of extract, followed by 1000 mg/kg paracetamol to induce liver damage. SGOT and SGPT levels were significantly reduced in all extract groups compared to the negative control, with the 100 mg/kg dose being the most effective. However, curcumin showed superior protection. These results suggest that S. oleosa has hepatoprotective potential, but further studies are needed to confirm its long-term safety and efficacy.

Page 16 of 17 | Total Record : 163

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