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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Exploration of Wedelia trilobata, Acmella paniculata, Ageratum conyzoides, and Crassocephalum crepidiodes as Antibacterial Plants Ryadi, Yusuf; Alzamori, Winda; Batubara, Irmanida; Suparto, Irma Herawati
Jurnal Jamu Indonesia Vol. 8 No. 3 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i3.347

Abstract

Some Asteraceae plants are reported to contain phytochemicals and to show high antibacterial activity. This study aims to determine the highest antibacterial activity of Wedelia trilobata, Acmella paniculata, Ageratum conyzoides, and Crassocephalum crepidiodes and to predict the chemical compounds that have a role as antibacterial. The samples were extracted with water and further fractionated using chloroform in the laboratory. Extracts determined the phytochemical compounds, antibacterial activity diffusion method, and compounds that have a role as antibacterial through literature review. Acmella paniculata demonstrated high antibacterial activities with the highest diameter of the zones of inhibition with a concentration of just 0.5 mg/disc. The compound that seems to have a role in antibacterial activity is spilanthol.
Network Pharmacology Approach to Explore Active Compounds and Molecular Mechanisms of Jamu Setiani, Lusi Agus
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.352

Abstract

Chewable Tablet Formulation from Ethanol Extracts of Betel, Areca, and Gambir as a Substitute for Betel Lestari, Uce; Novra, Ardi; Kurniadi, Romi
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.311

Abstract

The tradition of betel nut needs to be preserved because it is useful for maintaining oral health and the digestive system, but this betel nut has an impact on oral cavity injuries. Therefore, to prevent injuries to the oral cavity, this research makes an interesting innovation from the betel nut tradition in the form of formulating safe chewable tablets using natural ingredients, such as betel nut, areca nut, and gambier. This study aimed to determine the best chewable tablet formula from three formulas with different concentrations of betel, areca nut, gambier, and whiting, by testing the physical properties of both granules and formulated tablets. The selection of raw materials begins with the extraction of betel, areca nut, gambier, and whiting by maceration using 70% ethanol solvent and the addition of chewable tablet auxiliaries, such as talcum, magnesium stearate, PVP, aspartame, sorbitol, and aerosol. These chewable tablets are designed to provide the same health benefits as betel nuts, without the risk of tooth damage. The results showed that F2 chewable tablets had the best physical properties of the whole formula, namely weight uniformity with an average of 185±1 mg, average tablet diameter of 9.830±1 mm, average tablet thickness of 2.032±1 mm, and average tablet friability of 1.08±1%. The best formulation F2 contains 10% betel extract, 7% areca nut, 7% gambier, and 4% whiting.
The Tradition of Drinking Jamu and Efforts to Increase the Economic Potential of the Nguter Community, Sukoharjo District Oktaviani, Diah Ayu; Witasari, Nina; Amalia, Niken Putri
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.307

Abstract

The study examined the tradition of Jamu in Nguter District, Sukoharjo Regency, Central Java, which has faced intense competition with modern health products. The community practiced Jamu as part of traditional medicine passed down through generations; however, the tradition has encountered significant challenges in maintaining its existence. The study aimed to identify the obstacles faced by traditional Jamu entrepreneurs and evaluate the efforts made to address these issues. Researchers collected data using historiographic methods, including literature review, field observations, and interviews with Jamu entrepreneurs and consumers. The results of the study showed that Jamu entrepreneurs faced limitations in raw material, inconsistency in quality, and strict licensing regulations. Additionally, Jamu entrepreneurs struggled to compete with modern health product, which were more practical and popular. The conclusion of the study stated that the collaboration between Jamu entrepreneurs and the local government had successfully raised public awareness about the importance of preserving Jamu traditions. The jamu tradition has great potential to support the green economy by relying on sustainable and environmentally friendly natural ingredients. Innovation in packaging and distribution is expected to improve the local economy while preserving the environment. The novelty of the research lies in the integration of cultural, green economic, and health aspects into strategies for preserving the Jamu tradition amid modernization.
Effectiveness of Sambiloto Leaf Infusion (Andrographis paniculata Nees.) as an Antidiarrheal in Mice (Mus musculus) Anggraini, Lutvi; Mustika, Aulia Andi; Priosoeryanto, Bambang Pontjo; Sutardi, Lina Noviyanti
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.350

Abstract

Sambiloto is one of the most diverse herbal plants. The active content found in sambiloto is believed to fight diseases, one of which is diarrhea. This study aimed to determine the content of secondary metabolite compounds with phytochemical tests, the antidiarrheal effectiveness of sambiloto leaf infusa using the intestinal protection method, and the effective concentration of antidiarrheal in mice. This study used 25 mice, which were divided into five groups: control (+), control (-), and three treatment groups of sambiloto leaf infusa with concentrations of 25%, 50%, and 100% given orally. The results of phytochemical tests of sambiloto that have the potential to be antidiarrheal compounds are alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins. The parameters observed were the frequency of defecation and consistency of mice's feces every 30 minutes for 9 hours. The results of this study showed that bitter melon leaf infuse preparations at concentrations of 25%, 50%, and 100% had antidiarrheal activity, with the best antidiarrheal activity shown at a concentration of 25%.
Crude Drug Standardization, Formula Optimization, and Interaction Effects of a Five-Component Antioxidant Polyherbal Formulation Wardani, Tri Kusuma; Arianingsih, Elfa; Syarifah, Arini; Hamad, Alwani; Hartanti, Dwi
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.353

Abstract

A polyherbal formulation was developed from java tea (Orthosiphon aristatus (Blume) Miq.), turmeric (Curcuma longa L.), seed-under-leaf (Phyllanthus niruri L.), cinnamon (Cinnamomum verum J. Presl), and ginger (Zingiber officinale Roscoe). This study aimed to standardize crude drugs, optimize polyherbal formulations, and evaluate the interaction effect of the crude drug mixture. Standardization followed these methods and compared them with the Indonesian Herbal Pharmacopeia (IHP) standards. The crude drugs were mixed in 26 different ratios, and each formulation was extracted using the decoction method. The antioxidant activities of the extracts were evaluated using 2-diphenyl-2-picryl hydroxyl scavenging (DPPH) radical scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The optimum formula was obtained by antioxidant activity-based prediction using the simplex lattice design (SLD) method. The interaction effects of crude drug mixtures were determined using a statistical comparison method for the predicted and obtained antioxidant activities. Crude java tea, turmeric, cinnamon, and ginger were of good quality. The five-component formulation with optimum antioxidant activity consisted of java tea, turmeric, seed-under-leaf, cinnamon, and ginger crude drugs in a ratio of 20-20-40-10-10 with interaction effects of additive toward DPPH radical scavenging activity (7.05±0.94 µmol TE/g) and antagonistic toward FRAP (19.37±0.94 µmol TE/g). Formula 21 (mixture of java tea and seed-under-leaf crude drugs) showed the highest DPPH scavenging activity (6.39±0.16 µmol TE/g) with synergistic effects, while the synergistic, highest FRAP (23.74±0.03 µmol TE/g) was shown by Formula 13 (mixture of seed-under-leaf and ginger crude drugs). 
Determination of Sun Protection Factor and Total Phenolic Content of Extract and Fraction of Matoa Leaves (Pometia pinnata) Lestari, Siti Marwah; Aini, Sindhi Hurul; Sabrina, Naya; Soleha, Rahmatus
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.356

Abstract

Matoa leaves (Pometia pinnata J.R. & G. Forst) are known to contain phenolic compounds with potential as natural sunscreen agents due to their ultraviolet (UV) absorption capabilities. The presence of conjugated double bonds or aromatic rings in these compounds allows absorption in the 200–400 nm wavelength range, making them suitable candidates for photoprotection. This study aimed to evaluate the sun protection factor (SPF)—a measure of a substance’s ability to protect the skin against UVB radiation—and total phenolic content of the extract and fraction derived from matoa leaves. Extraction was performed using Soxhlet apparatus with 70% ethanol, followed by liquid–liquid partitioning to obtain fractions. Total phenolic content was determined using the Folin–Ciocalteu method, while SPF was evaluated using a UV–Vis spectrophotometer in the 290–320 nm range at 5 nm intervals. The total phenolic contents of the ethanolic extract and ethyl acetate fraction were 50.51 ± 0.18 mg GAE/g and 39.27 ± 0.09 mg GAE/g, respectively. The SPF values were 19.60 ± 0.11 for the ethanolic extract and 16.37 ± 0.80 for the ethyl acetate fraction. These findings suggest that the extract and fraction of matoa leaves exhibit SPF values within the ultra-protection category, indicating their potential as natural sunscreen agents.
Formulation of Fermented Earthworm (Lumbricus rubellus) Lotion as a Therapy for Atopic Dermatitis Irianto, Iramie Duma Kencana; Kurniadi, Muslih; Ismiyati, Ismiyati; Trilestari, Trilestari
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.358

Abstract

The prevalence of atopic dermatitis in industrialised countries has increased two- to threefold over the past 30 years. Fermented earthworm (Lumbricus rubellus) extract has been shown to effectively reduce atopic dermatitis by increasing interleukin-10 (IL-10) and FOXP3, and decreasing interleukin-5 (IL-5), interleukin-31 (IL-31), immunoglobulin E (IgE), and eosinophils. The extract has also been reported to inhibit the growth of skin surface bacteria, particularly Streptococcus aureus, at a minimum inhibitory concentration (MIC) of 0.625%. L. rubellus contains lumbricin-I, proline-rich antimicrobial peptides (AMPs), lumbrokinase, lysenin, and coelomic cytolytic factor-1 (CCF-1), which play important roles in anti-inflammatory and antibacterial responses. Cetyl alcohol influences the viscosity of semi-solid preparations, thereby affecting the lotion's quality and stability. This study aimed to determine the optimum concentration of cetyl alcohol in the formulation of fermented L. rubellus lotion with good physical characteristics. The lotion was formulated by varying the concentration of cetyl alcohol and comparing it with commercial lotion based on organoleptic properties, pH, adhesion, spreadability, and physical stability using a cycling test. Lotion formulas F2 (0.5% cetyl alcohol) and F3 (1% cetyl alcohol) exhibited physical properties similar to the positive control, remained semi-solid, and were comfortable to use. A 1% concentration of cetyl alcohol was found to be optimal for maintaining pH stability and spreadability of the fermented L. rubellus lotion.
Virtual Screening of Flavonoid Compounds as Potential Antibiofilm Agents Targeting Glucosyltransferase Kurniatin, Popi Asri; Putri, Fadhilah Eka; Purwanto, Ukhradiya Magharaniq Safira
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.372

Abstract

Dental caries are caused by plaque formation resulting from biofilm accumulation on tooth surfaces. The bacterium Streptococcus mutans plays a crucial role in biofilm formation, partly through the production of glucosyltransferase, which catalyzes biofilm synthesis. Flavonoids are secondary metabolites commonly found in plants, known for diverse biological properties, including antibiofilm effects. This study aimed to screen the potential of flavonoid compounds as antibiofilm agents through inhibition of glucosyltransferase using an in-silico approach. A total of 87 flavonoid compounds obtained from the ZINC database were evaluated via molecular docking methods. Screening results based on binding free energy (ΔG) values, analyzed using the PyRX-Virtual Screening Tool, indicated that 36 compounds had potential to inhibit glucosyltransferase. Further molecular docking using AutoDock Vina identified nine compounds with ΔG values more favorable than the natural ligand of glucosyltransferase (maltose). Molecular interaction analysis using LigPlot+ and PyMOL revealed that taxifolin, gallocatechin, and sakuranetin interacted with three catalytic residues of the enzyme, whereas the remaining six compounds interacted with two catalytic residues. Liquiritigenin exhibited the lowest ΔG (-7.0 kcal/mol) and an inhibition constant (Ki) of 7.39 µM, indicating high affinity for glucosyltransferase. This compound formed two hydrogen bonds and four hydrophobic interactions, engaging two catalytic residues of the enzyme, Asn481 and Trp517. These findings highlight the potential of flavonoids as antibiofilm agents via glucosyltransferase inhibition. Further experimental validation through in vitro studies is necessary to confirm these in-silico findings.
Molecular Insights into the Therapeutic Potential of Curcuma amada Rhizome: A Network Pharmacology and Docking Approach Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.397

Abstract

The rhizome of Curcuma amada (ginger mango) has traditionally been used for various medicinal purposes. However, its molecular targets and mechanisms of action are still poorly understood. This study aimed to predict the potential bioactive compounds and target proteins of C. amada using network pharmacology and molecular docking approaches. A total of 110 compounds were identified, and their predicted targets were analyzed through a protein-protein interaction (PPI) network, enrichment, and disease analysis. Key targets include phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and tyrosine-protein kinase JAK2 (JAK2), both of which are closely related to cancer-related pathways. Four compounds, β-eudesmol, (E,Z)-farnesol, spathulenol, and τ-muurolol, were selected for molecular docking studies. Validation of the docking protocol through re-docking showed low RMSD values ​​(0.667 Å for PIK3CA and 0.474 Å for JAK2), confirming the reliability of the method. The docking results demonstrated that the native ligands and selected compounds formed multiple hydrogen bonds and extensive hydrophobic interactions with key residues in the active site. Notably, most of the interactions were hydrophobic, which is consistent with the volatile nature of the ligands. The binding affinity was below –5 kcal/mol for all tested compounds. These findings suggest that C. amada rhizomes contain bioactive compounds capable of modulating cancer-related targets, thus providing a molecular basis for their potential therapeutic effects. 

Page 15 of 17 | Total Record : 163

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