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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 212 Documents
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Formulation and Physicochemical Characterization of Herbal Facial Wash Containing Moringa oleifera and Solanum lycopersicum Extracts Novaliana Devianti Sagita; Meylani Sutoro; Syifa Salsabilla; Reza Pratama
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.471

Abstract

Cleansing products based on plant extracts require acceptable physicochemical properties and retained antioxidant activity. This study formulated a herbal facial wash containing Moringa oleifera leaf extract and Solanum lycopersicum fruit extract and evaluated its physicochemical characteristics and antioxidant activity. Three formulas were prepared with different excipient compositions and assessed for organoleptic properties, pH, viscosity, foaming ability, free alkali content, phytochemical profile, TLC pattern, and DPPH radical-scavenging activity. Phytochemical screening detected flavonoids, tannins, saponins, alkaloids, quinones, and triterpenoids. The selected formulation showed chromatographic bands comparable to the extracts, indicating retention of major constituents after formulation. The IC₅₀ values were 30.891 ± 0.40 µg/mL for M. oleifera extract, 50.532 ± 0.92 µg/mL for S. lycopersicum extract, and 46.350 ± 0.08 µg/mL for the selected facial wash. These results indicate that the extracts can be incorporated into a facial wash with measurable antioxidant activity.
Metabolite Profiling and Cytotoxicity of Bajakah Tampala (Uncaria lanosa var. ferrea) Stem Fractions Against Breast Cancer Cells Mashuri Yusuf; Muhaimin Muhaimin; Riezki Amalia; Iskandar Yoppi
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.498

Abstract

Bajakah Tampala (Uncaria lanosa var. ferrea (Blume) Ridsdale) has been used in traditional medicine, but its cytotoxic activity against breast cancer cells remains insufficiently characterized. This study evaluated the cytotoxicity of U. lanosa stem fractions against MCF-7 breast cancer cells and profiled metabolites in the most active fraction. The stem extract was fractionated using hexane, ethyl acetate, and water, and cytotoxicity was assessed using the WST-8 assay. Metabolite profiling was performed using UHPLC-HRMS. Among the plant fractions, the hexane fraction showed the lowest IC₅₀ value, 105.37 ± 2.51 µg/mL, followed by the ethyl acetate fraction, 130.58 ± 13.41 µg/mL, and the water fraction, 209.91 ± 16.48 µg/mL. Cisplatin showed a markedly lower IC₅₀ value of 4.50 ± 1.92 µg/mL. UHPLC-HRMS tentatively identified ten metabolites in the hexane fraction. These findings indicate that U. lanosa var. ferrea stem fractions exhibit measurable cytotoxic activity against MCF-7 cells.
Ultrasound-Assisted Extraction Enhances Phenolic, Flavonoid, and Antioxidant Profiles of Spatholobus littoralis Roots Muchammad Reza Ghozaly; Berna Elya; Muhammad Hanafi; Heri Setiawan
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.501

Abstract

Spatholobus littoralis Hassk. roots contain antioxidant-related compounds whose recovery may be influenced by extraction method and solvent polarity. This study compared ultrasound-assisted extraction and microwave-assisted extraction using n-hexane, ethyl acetate, and 96% ethanol to evaluate their effects on total phenolic content, total flavonoid content, and DPPH radical-scavenging activity. Among the tested conditions, 96% ethanol combined with ultrasound-assisted extraction produced the highest phenolic content, flavonoid content, and antioxidant activity, with values of 89.33 mg GAE/g, 40.10 mg QE/g, and IC₅₀ 72.27 µg/mL, respectively. Strong negative correlations were observed between DPPH IC₅₀ and both total phenolic content (r = −0.961) and total flavonoid content (r = −0.941). These findings indicate that ultrasound-assisted extraction with 96% ethanol was the most effective condition for obtaining antioxidant-rich S. littoralis root extract in this study.
Antibacterial Activity of Imperata cylindrica Root Fractions against Pathogenic Bacteria Desi Sri Rejeki; Shofa Khoirun Nida; Eti Purwatih
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.453

Abstract

Antibiotic resistance has increased the need for new antibacterial agents from natural sources. This study evaluated the antibacterial activity of ethanolic root extract fractions of Imperata cylindrica against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Root powder was extracted with 70% ethanol and sequentially fractionated using n-hexane, ethyl acetate, n-butanol, and distilled water. Antibacterial activity was determined by the disk diffusion method at concentrations of 62.5–500 mg/mL. The most active fraction was further analyzed using thin-layer chromatography and silica gel column chromatography. The n-butanol fraction exhibited the strongest antibacterial activity, producing inhibition zones of 11.50, 9.00, and 8.17 mm against S. aureus, E. coli, and P. aeruginosa, respectively, at 500 mg/mL. Column chromatography generated 92 vials that were combined into nine subfractions. These findings indicate that the n-butanol fraction is a promising source of antibacterial compounds for further isolation and characterization.
Phytochemical Profile and Preliminary Antituberculosis Activity of Tabernaemontana divaricata Extract and Fractions Against Mycobacterium tuberculosis H37Rv Ayik Rosita Puspaningtyas; Indah Purnama Sary; Ulfa Ernasari; Agnes Dwi Sis Perwitasari
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.441

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. This study evaluated the phytochemical profile and preliminary antituberculosis activity of a methanol extract and solvent fractions of Tabernaemontana divaricata. The dried plant material was macerated with methanol and sequentially fractionated using n-hexane, dichloromethane, and ethyl acetate. Phytochemical screening was performed by thin-layer chromatography. Antimycobacterial activity against M. tuberculosis H37Rv was assessed using a resazurin-based assay at 25, 100, 500, and 1,000 µg/mL. Alkaloids, flavonoids, saponins, and tannins were detected in all samples, whereas terpenoids were not detected. The methanol extract and all solvent fractions inhibited mycobacterial growth, with the dichloromethane and ethyl acetate fractions showing consistently high inhibition across the tested concentrations. These findings indicate that T. divaricata is a promising source of antimycobacterial constituents and support further bioassay-guided fractionation, compound isolation, and confirmatory antituberculosis testing.
Antioxidant Activities and Phytochemical Profiles of Pepino (Solanum muricatum) Fruit Ethanol Extract and Solvent Fractions Girly Risma Firsty; Prihastini Setyo Wulandari; Oktariani Pramiastuti
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.455

Abstract

Pepino fruit (Solanum muricatum Aiton) contains bioactive compounds with potential antioxidant properties. This study evaluated the total phenolic and flavonoid contents, thin-layer chromatographic profiles, and antioxidant activities of a 70% ethanol extract and its n-hexane, ethyl acetate, and water fractions. The ethyl acetate fraction contained the highest total phenolic and flavonoid contents, at 13.07 ± 0.47 mg GAE/g and 4.33 ± 0.13 mg QE/g, respectively. It also exhibited the strongest antioxidant activity among the tested fractions, with IC₅₀ values of 99.56 ± 6.00 µg/mL in the DPPH assay and 67.69 ± 0.86 µg/mL in the ABTS assay, and an EC₅₀ of 59.95 ± 0.87 µg/mL in the FRAP assay. These findings identify the ethyl acetate fraction as the most promising fraction for further investigation as a natural source of antioxidant compounds.
Haematological Effects of Dried Gedi Leaf Infusion in Postpartum Female Wistar Rats Dingse Pandiangan; Linda Kakali; Henny Lieke Rampe; Nelson Nainggolan; Paulina Veronika Yolanda Lamleam
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.461

Abstract

The haematological effects of dried Gedi (Abelmoschus manihot L. Medik.) leaf infusion during the postpartum period remain unclear. This study evaluated its effect on the haematological profile of postpartum female Wistar rats. Six female Wistar rats were assigned to a control group or a dried Gedi infusion group (n = 3 each). The infusion was prepared from 2 g of dried leaf powder in 200 mL of boiled water and administered ad libitum for 34 days. Blood samples were collected 14 days postpartum and analysed for WBC, RBC, HGB, HCT, PLT, MCV, MCH, and MCHC. No significant differences were observed between groups for any haematological parameter (all p > 0.05). These findings indicate that dried Gedi leaf infusion did not produce detectable adverse changes in the haematological profile of postpartum female Wistar rats under the conditions of this study.
Optimization of a Three-Extract Polyherbal Antioxidant Formulation Using Simplex Lattice Design Ida Ayu Alit Widhiartini; Putu Yudha Ugrasena; I Gusti Ayu Widianti; I Made Oka Adi Parwata; I Made Agus Gelgel Wirasuta
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.454

Abstract

Polyherbal formulations have attracted increasing interest because combining plant extracts may improve phytochemical composition and antioxidant performance. This study aimed to optimize the proportions of ethanolic extracts of Cinnamomum burmannii bark, Gyrinops versteegii leaves, and Caesalpinia sappan wood using a simplex lattice design. Ten formulations were generated and evaluated for total phenolic content (TPC), total flavonoid content (TFC), total tannin content (TTC), and DPPH radical-scavenging activity (IC₅₀). The optimized formulation contained 10.00% C. burmannii, 21.51% G. versteegii, and 68.49% C. sappan, with experimental values of 79.27 mg GAE/g TPC, 197.64 mg QE/g TFC, 102.08 mg TAE/g TTC, and an IC₅₀ of 24.78 µg/mL. Experimental verification closely agreed with model predictions, with an average relative deviation of 2.95%. These findings demonstrate that simplex lattice design is an effective approach for optimizing polyherbal antioxidant formulations based on integrated phytochemical characteristics and antioxidant activity.
Formulation and Evaluation of Antidesma bunius Gel: Antibacterial Activity, Stability, and Skin Irritation Nur Khairi; Maulita Indrisari; Maria Ulfa; Fhahri Mubarak
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.482

Abstract

Acne is associated with the proliferation of acne-related bacteria, particularly Propionibacterium acnes and Staphylococcus epidermidis. This study evaluated the antibacterial activity, physical stability, microbiological quality, and skin irritation potential of an Antidesma bunius extract gel. The extract was tested against both bacterial species using an agar diffusion method, and a gel containing 2.5% extract was prepared with different Carbopol concentrations. The extract produced inhibition zones of 13.31–23.64 mm, whereas the gel formulations produced inhibition zones of 17.51–19.69 mm. The formulations remained homogeneous and showed acceptable organoleptic properties, pH, viscosity, spreadability, and adhesion after stability testing. Total plate and yeast and mold counts met the applicable microbiological limits. No erythema or edema was observed in albino rabbits. These findings indicated that A. bunius extract gel has potential as a topical anti-acne formulation.
Leukocyte Responses to Karika (Vasconcellea pubescens) Leaf Ethanol Extract in Carrageenan-Induced Mice Fania Putri Luhurningtyas; Dwi Cahya Kumalasari
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.448

Abstract

Inflammation involves systemic changes in leukocyte counts. This study characterized the phytochemical constituents of ethanol extract of karika (Vasconcellea pubescens) leaves and evaluated leukocyte responses in carrageenan-induced mice. The extract was prepared by maceration with 70% ethanol and analyzed by qualitative phytochemical screening and thin-layer chromatography. Twenty-four male Swiss Webster mice were randomized to six groups: negative control, vehicle control, diclofenac, and extract at 100, 200, or 400 mg/kg. Leukocyte counts were measured at baseline and 3 and 6 h after carrageenan induction. Friedman tests showed significant within-group changes over time in all groups (p < 0.05). Mean leukocyte counts at 3 and 6 h were descriptively lower in extract-treated groups than in negative and vehicle controls, with the 400 mg/kg group approaching diclofenac values. Alkaloids, flavonoids, and tannins were detected. These findings are consistent with potential anti-inflammatory activity, although between-group efficacy was not statistically tested.

Page 20 of 22 | Total Record : 212

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