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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 180 Documents
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Cytotoxic Effect of Brazilin on DU145 Prostate Cancer Cells Using the WST-8 Assay Alaydrus, Syafika; Niluh Puspita Dewi; Pratiwi, Dinda
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.423

Abstract

Prostate cancer is characterized by abnormal growth of prostate gland cells due to uncontrolled cellular proliferation. Brazilin, a homoisoflavonoid compound derived from Caesalpinia sappan L., is known for its anticancer activity. This study aimed to evaluate the cytotoxic effect of brazilin on DU145 prostate cancer cells through an in vitro assay employing the WST-8 method. The results showed that both brazilin and cisplatin significantly reduced the cancer cell survival rate compared to the negative control group (p < 0.05). Although no significant difference was observed between the two compounds at the highest concentration (ns), their IC₅₀ values differed significantly (p < 0.05), recorded at 18.92 ppm for brazilin and 0.03569 ppm for cisplatin; both were classified as highly active. These findings suggest that brazilin possesses cytotoxic potential comparable to cisplatin at elevated concentrations and may be developed further as a naturally derived anticancer agent.
Optimization of Black Orchid (Coelogyne pandurata Lindl.) Extraction Using Simplex-Centroid Design for Total Phenolics, Flavonoids, and Antioxidants Heriansyah, Pebra; Liwanda, Novian; Nurcholis, Waras
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.457

Abstract

Coelogyne pandurata Lindl., a black orchid endemic to Kalimantan, contains valuable antioxidant compounds. This study optimized its extraction using a Simplex-Centroid Mixture Design with ethanol, methanol, and acetic acid as solvents. Responses evaluated were total phenolic content (TPC), total flavonoid content (TFC), and antioxidant capacity (DPPH). The highest TPC was obtained with 100% ethanol (2.52 mg GAE/g), TFC with equal parts of all solvents (6.41 mg QE/g), and antioxidant activity with 100% methanol (10.33 µmol TE/g). Ethanol yielded the optimal extraction condition, with verification values of 2.27 mg GAE/g (TPC), 3.42 mg QE/g (TFC), and 10.22 µmol TE/g (DPPH), and a desirability of 0.739. Although regression models were not statistically significant (p > 0.05), the results provide preliminary insights into solvent efficiency for extracting bioactive compounds. Further studies with expanded experimental designs and validation are required to enhance model accuracy and extraction reliability.
Formulation of Antioxidant Cream from Mung Bean (Vigna radiata L.) Seed Coat Extract Hurit, Hermanus Ehe; Handayani, Linda; Pradana, Reinaldo; Putri, Dara Andini
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.475

Abstract

The skin is the body’s primary barrier against free radicals, which can induce oxidative stress and premature ageing. Antioxidants neutralize these radicals. This study aims to formulate and evaluate a cream containing ethanol extract of mung bean (Vigna radiata L.) seed coat. Four formulations were prepared with extract concentrations of 10%, 15%, 20%, and 25%. Physical evaluations included organoleptic tests, homogeneity, pH, viscosity, cream type, spreadability, and adhesiveness. Antioxidant activity was measured using the DPPH method. All formulations met physical standards, and formula F4 (25%) showed the highest antioxidant activity with an IC₅₀ value of 79.49 ppm. These findings indicate the potential of mung bean seed coat extract as an active antioxidant agent in topical preparations.
Formulation and Evaluation Stick Moisturizing Combination of Aloe Vera Extract (Aloe barbadensis mill) and Chamomile (Matricaria recutita) Tiandreas, Meilani Kezia; Darsono, Farida Lanawati; Simbolon, Shinta Marito
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.434

Abstract

Aloe vera (Aloe barbadensis mill) and chamomile (Matricaria recutita) contain active compounds in the form of aloin and apigenin, which function as moisturizers with soothing and antioxidant effects that can neutralize free radicals that cause oxidative stress on the skin. This study aims to determine the optimal formula for a moisturizing stick that combines Aloe vera and chamomile extracts, based on physical properties, effectiveness as a moisturizer, and antioxidant activity. The dry extract was obtained by percolation with 96% ethanol and dried using a spray dryer. The dry extract will be standardized for specific and non-specific tests. The optimum moisturizing stick formula was obtained using the factorial design method. The factors used were aloe vera extract with a concentration of (-1) 10% and a concentration of (+1) 20%, as well as chamomile extract with a concentration of (-1) 5% and a concentration of (+1) 15%. Determination of the optimum formula was carried out using a factorial design method using the following responses: hardness, spreadability, moisture [AUC], and antioxidant activity (IC50). The moisturizing stick formulation uses a hot melt extrusion method. The data from the parametric experiments between batches and formulas will be analyzed using the One-Way Anova (Yate's Treatment). The results showed that increasing aloe vera extract increased the spreadability and moisture, while increasing chamomile extract increased the antioxidant activity. The interaction between the extracts had a significant effect on all parameters. The optimum formula was obtained at a concentration of 18.711% aloe vera and 8.167% chamomile, which met the quality and effectiveness criteria.
Formulation and Antibacterial Evaluation of Ethanolic Garlic Peel Emulgel Against Staphylococcus aureus and Propionibacterium acnes Nisa, Michrun; Kursia, Sukriani; Mustarin, Rahmah; Zulfiah, Zulfiah; Karmianti, Wiranda
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.451

Abstract

Garlic peel (Allium sativum L.) is a household waste that contains bioactive compounds with potential antibacterial activity. This study aimed to formulate an emulgel containing ethanolic garlic peel extract and evaluate its physical characteristics and antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. The emulgel was evaluated for organoleptic properties, homogeneity, pH, and viscosity. Antibacterial activity was tested using the agar diffusion method. The formulation showed acceptable physical characteristics for topical use. The emulgel inhibited the growth of both bacteria, with inhibition zones of 12.16 mm against S. aureus and 11.02 mm against P. acnes. The antibacterial activity may be related to the presence of flavonoids, saponins, phenolic compounds, and allicin in garlic peel extract. These results suggest that garlic peel extract can be formulated into an emulgel with potential antibacterial activity.
Therapeutic Effects of Morus alba Leaf Extract on Fasting Blood Glucose and Pancreatic β-Cell Restoration in HFD–STZ-Induced Diabetic Rats Salampe, Mirnawati; Widiasri, Dewa Ayu Diah; Wahyuddin, Nurzadrina; Agus, Rezki Rahayu; Imrawati, Imrawati; Wahyuni, Wahyuni; Awaluddin, Akbar
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.452

Abstract

Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic β-cell dysfunction. Morus alba leaves contain bioactive compounds with potential antidiabetic activity. This study evaluated the hypoglycemic and β-cell protective effects of ethanolic M. alba leaf extract (EMA) in diabetic rats. The extract was obtained through maceration, yielding 12.14%. Wistar rats were divided into normal control, negative control, positive control, EMA100 (100 mg/kg BW), and EMA200 (200 mg/kg BW). Diabetes was induced using a high-fat diet, 2% sucrose solution, and low-dose streptozotocin. Fasting blood glucose (FBG) and pancreatic histopathology were analyzed. EMA significantly reduced FBG and improved pancreatic β-cell morphology, particularly at 200 mg/kg BW. These findings suggest that EMA has potential as a therapeutic candidate for T2DM by improving glycemic control and preserving pancreatic β-cell integrity. 
Molecular Docking and ADMET Analysis of Bioactive Compounds from Vitex trifolia as Potential COX-2 Anti-Inflammatory Agents Hibatulloh, Hanif; Oktoba, Zulpakor; Ulandari, Atri Sri; Iqbal , Muhammad; Patala, Recky
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.460

Abstract

Legundi (Vitex trifolia) has been reported to exhibit anti-inflammatory activity; however, the specific bioactive compounds responsible for this effect remain unclear. This study aimed to evaluate the anti-inflammatory potential of bioactive compounds from V. trifolia against cyclooxygenase-2 (COX-2; PDB ID: 5KIR) using an in silico molecular docking approach, along with the analysis of their pharmacokinetic and toxicity profiles. The results showed that persicogenin exhibited the lowest binding affinity of −9.2 kcal/mol and formed hydrogen bonds with key amino acid residues, namely THR 212, HIS 207, and TYR 385. ADMET prediction results indicated that persicogenin met the drug-likeness criteria for an oral drug candidate, demonstrated good intestinal absorption (HIA: 92.29%), high membrane permeability (Caco-2 permeability > 0.9), low volume of distribution (VDss < 0.45), inhibitory activity against CYP2C19 and CYP3A4, and no hepatotoxic potential. These findings suggest that persicogenin may serve as an anti-inflammatory agent.
Development and Evaluation of Topical Gel Containing Rosa spp. Extract for Anti-Acne and Anti-Aging Properties Zaelani, Diki; Irfani, Abdul Mulki; Sanggo, Merylance Stefany; Sodik, Jajang Japar; Pratama, Reza
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.470

Abstract

The present study aimed to develop and evaluate a topical gel containing ethanolic red rose flower extract as a potential natural anti-acne and anti-aging preparation. The extract was screened for phytochemicals, and the gel was formulated with varying concentrations of Carbopol 940 (0.25-1.25%). The gels were characterized for their organoleptic properties, pH, viscosity, spreadability, and in vitro antibacterial activity against Cutibacterium acnes. Phytochemical screening revealed the presence of alkaloids, flavonoids, quinones, tannins, saponins, triterpenoids, and anthocyanins in the extract. Organoleptic evaluation showed that Formulas 2 (0.5% Carbopol) and 3 (0.75% Carbopol) had the most suitable characteristics for a cosmetic gel, with moderate viscosity, non-greasiness, rapid absorption, and user comfort. Viscosity testing confirmed pseudoplastic flow behavior, with Formulas 2 and 3 exhibiting an optimal balance between physical stability and ease of application. Spreadability and adhesiveness tests further supported the suitability of these formulas. The pH of all formulas ranged from 7.02 to 7.08, requiring further optimization to match the skin's physiological pH. Antibacterial testing revealed that all gel formulas containing 1% extract showed strong inhibition against C. acnes (inhibition zones of 15.0 ± 1.2–1.3 mm), attributed to the presence of flavonoids, tannins, and other bioactive compounds. The results suggest that the red rose flower extract gel, particularly Formulas 2 and 3, has promising potential as a natural anti-acne and anti-aging preparation, offering a balance of physical stability, user comfort, and antibacterial activity.
Phytochemical Profile, Antioxidant Activity, and Hematological and Liver–Kidney Serum Markers of Lampung Green Robusta Coffee Extract in Lead-Induced Mice Khairani, Iffa Afiqa; Ananta, Jeni Putri; Firmansyah, Kiki; Anisa, Hida Arliani Nur; Riana, Elisa Nurma; Mulyana, Jeane Siswitasari; Fatriani, Rizka
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.472

Abstract

Lampung Province is one of Indonesia’s major robusta coffee–producing regions, and green coffee beans contain bioactive compounds with potential biological benefits. This study analyzed the phytochemical composition and antioxidant activity of ethanolic extract of Lampung green robusta coffee beans and evaluated its effects on hematological parameters and liver–kidney serum markers in lead acetate–induced mice. Phytochemical screening revealed alkaloids, flavonoids, phenolics, saponins, tannins, and terpenoids. Quantitative analysis showed total phenolics of 122.76 mg GAE/g extract, flavonoids of 12.23 mg QE/g extract, tannins of 208.86 mg TAE/g extract, and saponins of 1.32%. The extract exhibited very strong antioxidant activity (IC₅₀ = 21.99 ppm). Lead acetate exposure (20 mg/kg BW for 14 days) decreased erythrocyte counts and increased leukocyte and urea levels. Administration of the extract (400 mg/kg BW) improved erythrocyte counts, modulated leukocyte levels, and reduced urea concentrations.
In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts Chairunnisa, Afra; Rahardian, Muhammad Ryan Radix; Pangestuti, Ratih; Franyoto, Yuvianti Dwi; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.483

Abstract

Indonesia is rich in mangrove species, including Avicennia marina (brayo) and Bruguiera gymnorrhiza (lindur), whose fruits contain bioactive metabolites with potential anti-obesity activity. This study evaluated pancreatic lipase inhibition by brayo and lindur fruit flour extracts (raw and boiled) using in vitro and in silico approaches. Extracts were prepared by remaceration with 70% ethanol. Lipase inhibition was measured using a multimode microplate reader, while metabolites were identified by LC-HRMS and evaluated by molecular docking. Raw brayo showed the highest inhibition (84.29 ± 4.24%), followed by boiled brayo (83.01 ± 4.59%), raw lindur (75.24 ± 3.02%), and boiled lindur (73.88 ± 4.00%). Docking indicated strong binding of luteolin (−8.23 kcal/mol), 9-oxo-10(E),12(E)-octadecadienoic acid (−6.75 kcal/mol), and methyl eleostearate (−6.59 kcal/mol) to pancreatic lipase. These findings support mangrove fruit flour as a natural source of lipase inhibitors for obesity management.

Page 18 of 18 | Total Record : 180

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