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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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Jamoetics: A Web-Based Information System for Indonesian Herbal Database Oeke Yunita; Jimmy Jimmy; Jasti Ohanna; Theophil Henry Soegianto; Erlin Theterissa
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.425

Abstract

This study aimed to develop a web-based information system for herbal plants in Indonesia. This research began with data collection, prototype making, and evaluation. This research was conducted by combining a literature review, simulation, and survey. Literature reviews were used to gather scientific information about various herbal medicines. The website was hosted on a platform-as-a-service cloud service. The web is accessible at https://www.jamoetics.com. All data from the questionnaire were analyzed using descriptive statistics. The data on this website were obtained from various sources grouped into monographs, public databases, and scientific journals. The “Jamoetics” system evaluation survey showed that 98.25% of respondents felt confident and interested in using the “Jamoetics” website because of its ease of access to information, completeness of information, and user-friendly interface. Jamoetics, a web-based information system, can help communities easily access information about herbal plants in Indonesia.
Production and Phytochemical Variation of Kaempferia rotunda Rhizomes in Relation to Soil Nutrient Conditions on Madura Island Diana Nurus Sholehah; Risqiyah Risqiyah; Suci Aulia Putri; Choirul Umam; Fadlilaturrahmah Fadlilaturrahmah; Sinar Suryawati
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.459

Abstract

Kaempferia rotunda L. is a traditional medicinal plant in Madura. This study aimed to evaluate the production and phytochemical variation of K. rotunda rhizomes from Madura Island and to determine the soil chemical factors associated with these traits. Plant materials and soil samples were collected from ex situ cultivation areas in Bangkalan, Sampang, Pamekasan, and Sumenep. Rhizome production, simplicia yield, extract yield, total phenolics, total tannins, total steroids, and soil nutrient contents were analyzed. The results showed substantial variation among accessions in both production and phytochemical contents. Primary rhizome weight was positively correlated with the number of secondary rhizomes, whereas secondary rhizome simplicia yield was positively correlated with total rhizome simplicia yield. Soil nutrients showed low-to-moderate correlations with production traits but strong correlations with phytochemical contents. Suitable accession selection combined with balanced macro- and micronutrient availability may improve rhizome yield and quality.
Gastroprotective Effect of the Aqueous Fraction of Tamarindus indica L. Leaves Against Aspirin-Induced Gastric Injury in Mice Sitti Rahimah; Maulita Indrisari; Devia Novelia Patabang
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.462

Abstract

Tamarindus indica L. leaves contain bioactive compounds, particularly tannins and saponins, which may contribute to gastric mucosal protection. This study aimed to evaluate the gastroprotective effect of the aqueous fraction of T. indica leaves in aspirin-induced gastric injury in mice. Twelve mice were randomly divided into four groups (n = 3): normal control, negative control, and two treatment groups receiving the aqueous fraction at doses of 6 mg/30 g and 12 mg/30 g body weight prior to aspirin induction. Gastroprotective activity was assessed through macroscopic observation and histopathological examination of gastric tissues. Aspirin administration caused gastric mucosal injury characterized by erosion, ulceration, and hemorrhage. Treatment with the aqueous fraction reduced gastric damage and improved epithelial integrity. The dose of 12 mg/30 g body weight showed the most pronounced protective effect. These findings suggest that the aqueous fraction of T. indica leaves has potential gastroprotective activity.
Anticholesterolemic Evaluation of Physalis angulata L. Ethanolic Extract Using In Vitro, GC-MS, and Docking Approaches Eka Susanti Hanhadyanaputri; Muhammad Rahardhian; Eka Septiana
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.428

Abstract

Physalis angulata L. is traditionally used as a medicinal plant and contains various pharmacologically active metabolites. This study evaluated the anticholesterolemic potential of P. angulata ethanolic extract using in vitro assays, gas chromatography–mass spectrometry (GC-MS), and molecular docking. The extract obtained by remaceration contained flavonoids, phenolics, tannins, saponins, and steroids/triterpenoids. Thin-layer chromatography indicated the presence of terpenoids, flavonoids, essential oils, and saponins. Quantitative analysis showed flavonoid, phenolic, tannin, and sterol contents of 34.86 ± 1.11 mg RE/g, 5.14 ± 0.15 mg GAE/g, 0.99 ± 0.01%, and 0.072 ± 0.0004 mg CE/g, respectively. Antioxidant IC₅₀ values were 209.55 ± 9.10 ppm for DPPH and 220.18 ± 4.23 ppm for FRAP. The Liebermann–Burchard assay showed cholesterol inhibition with an IC₅₀ of 96.11 ppm. GC-MS tentatively identified several compounds, while molecular docking suggested favora
Immunostimulatory Effect of Cayratia trifolia L. Domin on Granulocytes and Natural Killer Cells in Tuberculosis-Induced Rats Muhammad Ilyas Y Ilyas Y; Wa Ode Salma; Mubarak Mubarak; Nasrudin Nasrudin; Parawansah Parawansah; Fadhliyah Malik; Asriullah Jabbar; Asniar Pascayantri; Esti Badia; Sernita Sernita; Nirwati Rusli; Lukman La Basy
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.433

Abstract

Pulmonary tuberculosis (TB) remains a major public health problem in Indonesia and a leading cause of death from infectious diseases, partly because of impaired host immunity. Galing (Cayratia trifolia L. Domin) has been reported to exert immunomodulatory effects in bacterial infections. This study evaluated the immunostimulatory effect of galing leaf and stem extracts on granulocytes and natural killer (NK) cells in a TB-induced rat model. Leaf and stem extracts were administered orally to 28 Wistar rats at doses of 400 and 500 mg/kg body weight for seven days, followed by induction with TB ESAT-6 antigen. Granulocyte counts were measured using a hematology analyzer, whereas NK cells were quantified by ELISA. Galing extract significantly increased granulocyte and NK cell expression compared with the negative control (p<0.05). These findings indicate that galing extract has potential as an immunostimulatory agent in pulmonary TB by enhancing granulocyte and NK cell responses.
Antidiabetic Effects of Miana (Coleus atropurpureus) Leaf Ethanol Extract on Blood Glucose and Pancreatic-Renal Histopathology in Diabetic Rats Tien Wahyu Handayani; Mariyani Mariyani; Joni Tandi; Cecilya Caroline; Magfirah Magfirah
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.445

Abstract

This study evaluated the antidiabetic potential of ethanol extract of miana leaves (Coleus atropurpureus Benth.) and its protective effects on pancreatic and renal tissues in streptozotocin-induced diabetic rats. Thirty male Wistar rats were allocated to six groups: normal control, negative control (diabetes + Na-CMC), positive control (diabetes + glibenclamide), and three groups receiving miana extract at 150, 200, or 250 mg/kg body weight. Diabetes was induced by intraperitoneal streptozotocin injection (40 mg/kg body weight). Phytochemical screening detected flavonoids, alkaloids, tannins, and saponins. On day 28, 250 mg/kg produced the greatest blood glucose reduction (102 ± 9 mg/dL), numerically lower than glibenclamide (123 ± 25 mg/dL), although not statistically significant (p = 0.248). Histopathological analysis showed pancreatic and renal protection, with damage scores of 0.8 ± 0.447 and 0.4 ± 0.548, respectively. These findings indicate that 250 mg/kg was the most effective dose in this model.
Antibacterial Activity of Esterified Trigona laeviceps Hive Waste Extract against Skin-Associated Bacteria Mighfar Syukur; Ahmad Fuad Masduqi; Yuliana
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.446

Abstract

Stingless bee (Trigona laeviceps) hive waste contains bioactive compounds, including flavonoids, phenolics, terpenoids, and organic acids, with potential antibacterial activity. This study aimed to enhance its antibacterial activity through esterification using methanol and ethanol. The extract was obtained by sonochemical extraction with 96% ethanol and reacted with methanol or ethanol using H₂SO₄ as a catalyst. Esterification products were characterized by FTIR and GC–MS. Antibacterial activity against Staphylococcus aureus and Propionibacterium acnes was evaluated at 10%, 15%, and 20% using the agar well-diffusion method. Alcohol variation affected the chemical profile and antibacterial activity. The ethanol ester showed the largest inhibition zones at 20%, measuring 1.97 ± 0.24 mm against S. aureus and 1.90 ± 0.10 mm against P. acnes. These findings suggest that esterification may improve the value of stingless bee hive waste as a natural antibacterial candidate.
Bioassay-Guided and In Silico Identification of α-Amylase Inhibitors from Abelmoschus esculentus Fruit Christina Astutiningsih; Syifaur Rohmah; Novy Dwi Susilowati
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.447

Abstract

Diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia. Inhibition of α-amylase is one therapeutic strategy for controlling postprandial blood glucose levels. This study aimed to identify active compounds responsible for α-amylase inhibitory activity in Abelmoschus esculentus fruit using a bioassay-guided and in silico approach. Methanol extract, fractions, and subfractions were evaluated in vitro for α-amylase inhibition. The most active subfraction was characterized by LC–MS and further analyzed by molecular docking and ADMET prediction. Subfraction 2 showed the strongest inhibitory activity, with 74.2634 ± 4.7091% inhibition. LC–MS identified nine compounds, four of which showed favorable binding affinity and interaction patterns with α-amylase: 2-hydroxy-7-methoxycadalene, N-E-coumaroyl tyramine, homovanillic acid, and quercetin. These findings suggest that A. esculentus fruit contains bioactive compounds with potential α-amylase inhibitory activity.
Cytotoxic Interaction Between Cisplatin and Eclipta alba Extract in HeLa Cervical Cancer Cells Putri Awaliah Aldina; Surawalia Said; Muhammad Ilham Hamzah; Nur Afiq Zaky Ananda; Fityatun Usman; Zulkifli Zulkifli; Widya Hardiyanti; Nurfadilah Nurfadilah; Andi Ulfah Magefirah; Lukman Lukman
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.449

Abstract

Cervical cancer remains a major cause of cancer-related mortality among women worldwide. Cisplatin is a first-line chemotherapeutic agent, but its use is limited by resistance and dose-dependent toxicity. This study evaluated the cytotoxic interaction between cisplatin and Eclipta alba extract in HeLa cervical cancer cells. Ethanolic maceration yielded 17.38 g of extract, corresponding to 10.22%. Thin-layer chromatographic screening indicated flavonoids, coumarins, and triterpenoid saponins, while LC–MS/MS tentatively identified eclalbasaponin I, wedelolactone, pinoquercetin, luteolin, and quercitrin. Cytotoxicity was assessed using the MTT assay. The IC₅₀ values were 1.15 ± 0.16 µg/mL for cisplatin and 598.29 ± 42.89 µg/mL for the extract. Under fixed sub-IC₅₀ cisplatin conditions, 0.42 µg/mL, the extract IC₅₀ decreased to 64.97 ± 5.41 µg/mL. Combination index values below 1 suggested synergistic interaction under fixed-dose conditions, indicating a potential dose-sparing strategy requiring further validation.
Optimization of Green Tea Leaf Extract Serum Using Xanthan Gum and Carbopol Nuzul Fajriani; Ratih Dyah Pertiwi; Hanifah Zahra
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.458

Abstract

Green tea leaves (Camellia sinensis) contain polyphenolic compounds with antioxidant potential and can be developed into topical serum preparations. This study aimed to optimize the combination of xanthan gum and carbopol in a green tea leaf ethanol extract serum using the Simplex Lattice Design method. Serum formulations were prepared using different proportions of xanthan gum and carbopol, then evaluated for viscosity, spreadability, adhesiveness, pH, organoleptic properties, and physical stability using a cycling test. The optimum formulation consisted of 55% xanthan gum and 45% carbopol, with a desirability value of 1.0. Verification showed that the predicted and observed responses were not significantly different. The optimum formula met the initial physical quality requirements; however, the cycling test showed changes in viscosity, spreadability, and adhesiveness. These findings indicate that xanthan gum and carbopol can be optimized to produce green tea extract serum, although further stability improvement is required.

Page 19 of 20 | Total Record : 193

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