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Devi Oktafiani
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Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Published by Universitas Tadulako
ISSN : 23551933     EISSN : 25807390     DOI : https://doi.org/10.22487/mtj.v9i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Medika Tadulako merupakan jurnal ilmiah yag menerbitkan artikel hasil penelitian, literatur review, case report pada bidang Ilmu Kedokteran, Mikrobiologi, Biokimia, Anatomi, Pendidikan Kedokteran
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
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Search results for , issue "vol. 11 no. 1 (2026): maret" : 8 Documents clear
PLEURO-PULMONARY AMOEBIASIS WITH HISTORY OF CORONARY ARTERY BYPASS GRAFT PROCEDURE : A CASE REPORT Zevanya, Evita; Supono, Effie; Nagara, Clements; Iswanto
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/6r16w946

Abstract

Amoebiasis is defined as a parasitic infection caused by Entamoeba histolytica, an ubiquitous protozoan and more common in developing countries. Pulmonary is the second common site of extraintestinal amoeba infection after the liver. Most common causes of pulmonary amoebiasis are rupture of liver abscess, hematogenous spread, inhalation, or aspiration. A 49-year-old male experienced a mild cough with clear colour and right chest pain since got a coronary artery bypass graft (CABG) procedure a year before. Then he was admitted to hospital because of shortness of breath and lower right chest pain. Gastrointestinal symptoms were denied. The patient was diagnosed with pleuropulmonary amoebiasis. Thoracotomy and decortication surgery was performed on the patient because he did not respond to antimicrobial therapy. Complete and appropriate examinations are needed to diagnose patients with pleuro-pulmonary amoebiasis. All physicians in endemic areas or treat patients from endemic areas should be concerned about amoebiasis as a cause of pulmonary disease.
HUBUNGAN KADAR HEMOGLOBIN IBU HAMIL DENGAN BERAT BADAN LAHIR BAYI DI WILAYAH KERJA PUSKESMAS MAMBORO KOTA PALU TAHUN 2024 Dwiyulianti, Rizka; Sumarni; Suarayasa, Ketut; Oktafiani, Devi
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/rkqfkx02

Abstract

Angka kejadian anemia pada ibu hamil meningkat setiap tahunnya. Kadar hemoglobin yang rendah selama kehamilan dapat menyebabkan berbagai komplikasi, yaitu kelahiran prematur, hipoksia janin, dan berat badan lahir rendah. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar hemoglobin ibu hamil dengan berat badan lahir bayi di Wilayah Kerja Puskesmas Mamboro Kota Palu tahun 2024. Jenis penelitian ini adalah kuantitatif dengan desain penelitian observasional analitik menggunakan pendekatan cross sectional. Sampel diambil secara random dari rekam medis di Puskesmas Mamboro Kota Palu tahun 2024 sebanyak 69 responden. Kadar hemoglobin pada Ibu yang melahirkan tahun 2024 di Wilayah Kerja Puskesmas Mamboro Kota Palu rata-rata adalah normal (>11 g/dL) sebanyak 45 ibu (65,2%), terdapat 3 ibu (6,7 %) diantaranya melahirkan bayi dengan berat badan lahir rendah dan 42 ibu (93,3 %) melahirkan bayi dengan berat badan lahir normal. Ibu anemia sebanyak 24 ibu (34,8%), terdapat 17 ibu (70,8 %) diantaranya melahirkan bayi dengan berat badan lahir normal dan 7 ibu (29,2 %) melahirkan bayi dengan berat badan lahir rendah. Berdasarkan hasil penelitian ini didapatkan hubungan yang signifikan antar kadar hemoglobin ibu hamil dengan berat badan lahir bayi (p-value = 0,011).
A Systematic Literature Review Faktor-Faktor yang Memengaruhi Kejadian Tuberculosis Multidrug Resistance (TB MDR) Furqon, Muhammad Ikmaluddin; Setyawati, Tri
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/k4yn9p47

Abstract

Latar Belakang: Multidrug Resistant Tuberculosis (MDR-TB) menjadi tantangan besar dalam pengendalian TB di Indonesia. Pada tahun 2019, sekitar 2,4% kasus TB baru dan 13% kasus dengan riwayat pengobatan mengalami MDR-TB. Identifikasi faktor risiko penting untuk menentukan strategi pencegahan yang efektif. Tujuan: Mengetahui faktor-faktor yang memengaruhi kejadian MDR-TB di Indonesia. Metode: Penelitian ini menggunakan Systematic Literature Review (SLR) dengan pencarian literatur di Google Scholar menggunakan kata kunci terkait MDR-TB dan faktor risiko. Terdapat sembilan artikel observasional (2020–2025) yang memenuhi kriteria inklusi. Hasil: Faktor utama penyebab MDR-TB adalah riwayat pengobatan TB sebelumnya (gagal atau putus obat) dan ketidakpatuhan minum obat. Faktor lain yang berpengaruh meliputi gizi buruk, komorbiditas (terutama Diabetes Melitus), pendidikan rendah, dan kondisi sosial ekonomi rendah. Perilaku seperti merokok, stres, dan efek samping obat turut memperburuk kepatuhan. Faktor demografis seperti usia dan jenis kelamin tidak menunjukkan hubungan konsisten. Kesimpulan: MDR-TB bersifat multifaktorial. Pencegahan perlu difokuskan pada peningkatan kepatuhan pengobatan, penanganan kasus lama, serta perbaikan gizi, manajemen komorbid, dan kondisi sosial ekonomi.
THE EFFECT OF NBF (Neutral Buffered Formalin) 10% EARLY FIXATION ON UTERINE MESENCHYMAL CELL MORPHOLOGY IN A SIMPLE LABORATORY Rahmi, Mawar; Hutasoit, Gina Andyka; Fitriani, Junjun; Basry, Amirah
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/f5710y30

Abstract

An unoptimal duration of tissue fixation can cause degradation of cell morphology and reduce the accuracy of histopathological diagnosis. This study examined the effect of fixation duration using 10 percent Neutral Buffered Formalin on the morphology of uterine mesenchymal cells. The objective was to identify and compare their morphological characteristics after fixation for less than 2 weeks and more than 2 weeks and determine the optimal duration. A quasi-experimental design used 56 uterine leiomyoma samples divided into 2 fixation groups and processed with standard histopathology procedures using hematoxylin eosin staining. Morphological quality was evaluated based on nuclear color, cytoplasm, and cell membrane clarity using a 6-level assessment. Data were analyzed with descriptive statistics and a nonparametric comparative test. The group fixed for less than 2 weeks showed higher morphological values than the group fixed for more than 2 weeks, demonstrating clearer smooth muscle fibers, nuclei, and cytoplasm, while prolonged fixation produced shrunken nuclei and denser cytoplasm with reduced clarity. These findings indicate that fixation duration significantly influences the morphological quality of uterine mesenchymal cells, and fixation for less than 2 weeks yields superior morphology. This emphasizes the importance of appropriate fixation duration for producing reliable histopathological preparations.
HUBUNGAN POLIMORFISME GEN MELANOCORTIN 4 RECEPTOR (MC4R) RS17782313 TERHADAP DIABETES MELITUS : SEBUAH TINJAUAN NARATIF Siregar, Muhammad Rizky; Pupspasari, Anggelia; Maharani, Citra; Syauqy, Ahmad
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/c7hyc479

Abstract

Melanocortin 4 receptor (MC4R) plays a central role in appetite regulation and energy homeostatis. The rs17782313 polymorphism in the downstream region of MCR4 has been consistently associated with obesity, hyperglycemia and an increased risk of type 2 diabetes mellitus (T2DM), although the magnitude of the effect varies across ethnicities and study design. A largescale meta-analysis indicates that the C risk allele increases the risk of T2DM partially independent of BMI. Literature search on Pubmed, Scopus, Web of Science and Google Scholar; studies in English or Indonesian on the rs17782313 genotype were included, while non-journal publications and studies that did not present genotype data were not included in this review. Cross-ethnic evidence indicates that carriers of the C allele have a 6-10% increased risk of T2DM. In Korean population, the C allele was associated with higher fasting glucose and increase diabetes risk, with differences in effect according to sex and BMI. This was reinforced by a 2023 systematic review reporting an association between rs17782313 and increase BMI, waist circumference and glucose. The MC4R rs17782313 polymorphism is thought to act as a genetic susceptibility marker for DM, particularly T2DM. Large-scale cohort studies and functional studies are needed to confirm the causal relationship and clarify the interaction between genetic and environmental factors.
HUBUNGAN KADAR GLUKOSA DARAH DENGAN KEJADIAN HIPERTENSI: STUDI CROSS-SECTIONAL DI RS SYARIF HIDAYATULLAH JAKARTA Zulfa, Hilizza Awalina; Nofisah, Nur Lailatul; Nitalia, Mery; Hermawati, Luluk
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/asehgt73

Abstract

Hypertension is a condition characterized by an increase in systoic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg. One of the important risk factors for hypertension is elevated blood glucose levels (hyperglycemia). This study aimed to determine the association between random blood glucose levels and the occurence of hypertension at Syarif Hidayatullah Hospital, Jakarta. This study employed an observational analytic design with a cross-sectional approach. A total of 90 respondents were included using consecutive sampling, with inclusion criteria of patients aged >18 years who had complete medical records of random blood glucose and blood pressure measurements. Bivariate analysis was performed using the Chi-Square test. The result showed that 42.2% of patients with hyperglycemia had hypertension, while 31.1% had hyperglycemia without hypertension. Among patients with normal blood glucose levels, 7.8% had hypertension and 18.9% had neither hypertension nor hyperglycemia. The Chi-Square analysis demonstrated a significant association between random blood glucose levels and hypertension (p = 0.017) with an odds ratio (OR) odf 2.588, indicating that patients with hyperglycemia had appoximately 2.6 times higher risk of developing hypertension compared to normoglycemic patients. In conclusion, there is a significant association between elevated random blood glucose levels and the occurance of hypertension, suggesting that hyperglycemia is an important risk factor for hypertension.
Evaluasi Akurasi dan Presisi Titrasi Asam-Basa dalam Menentukan Konsentrasi Natrium Hidroksida Susiati, Asih Luklu; Jumrohwati; Alif, Nur Amalia
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/d42grb36

Abstract

Penelitian ini bertujuan untuk mengevaluasi tingkat ketepatan dan konsistensi metode volumetri dalam penentuan kadar larutan basa pada skala laboratorium dasar. Penelitian dilakukan secara kuantitatif eksperimental melalui pengukuran berulang sebanyak sembilan kali menggunakan prosedur netralisasi antara larutan natrium hidroksida dan asam klorida dengan indikator fenolftalein. Data dianalisis menggunakan perhitungan nilai rata-rata, standar deviasi, dan persentase variasi relatif untuk menilai konsistensi hasil, serta dibandingkan dengan nilai teoritis untuk menentukan tingkat ketepatan pengukuran. Hasil menunjukkan bahwa volume titran berada pada rentang yang relatif sempit dengan nilai rata-rata 5,26 mL dan menghasilkan konsentrasi 0,0526 M. Perbedaan terhadap nilai teoritis masih berada dalam batas yang dapat diterima untuk praktikum dasar. Temuan ini menunjukkan bahwa metode yang digunakan memiliki tingkat konsistensi dan ketepatan yang cukup baik serta layak diterapkan dalam kegiatan laboratorium pendidikan dengan tetap memperhatikan faktor teknis operasional.
ANALISIS TINGKAT STRES AKADEMIK TERHADAP KETERATURAN SIKLUS MENSTRUASI DAN DERAJAT DISMENORE PRIMER PADA MAHASISWI FAKULTAS KEDOKTERAN UNIVERSITAS TADULAKO Amran, Irwanto; Putrie, Intania Riska; White, I Putu Fery Immanuel; Nilawati
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/bs0amq82

Abstract

Background: Academic stress is one of the factors suspected to affect reproductive function, including menstrual cycle regularity and the severity of primary dysmenorrhea. However, empirical evidence among medical students still shows varied results. Objective: To analyze the relationship between academic stress levels and menstrual cycle regularity as well as the degree of primary dysmenorrhea among female students of the Faculty of Medicine, Tadulako University. Methods: This study is a quantitative research with a cross-sectional design involving 301 female medical students from class cohorts 2022–2024. Academic stress levels were measured using the PSS-10 questionnaire, menstrual cycle regularity was assessed through a menstrual questionnaire, and the degree of primary dysmenorrhea was measured using the WaLIDD instrument. The Chi-Square test was used to assess the relationship between stress levels and menstrual cycle regularity, while Spearman correlation was used to analyze the correlation with the degree of primary dysmenorrhea. Results: There was a non-significant relationship between academic stress levels and menstrual cycle regularity (p = 0.159), and a statistically non-significant correlation between academic stress levels and the degree of primary dysmenorrhea among female medical students at Tadulako University (p = 0.346; r = 0.054). Both variables showed a direction of association but were not statistically meaningful in medical students. Conclusion: There is a non-significant relationship between academic stress levels and menstrual cycle regularity as well as the degree of primary dysmenorrhea among 2022-2024 cohort female students of the Faculty of Medicine, Tadulako University.

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