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Journal of Medicine and Health Technology
Published by Institut Teknologi Sepuluh Nopember Surabaya
ISSN : -     EISSN : 30466865     DOI : https://doi.org/10.12962/j30466865
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
The Journal of Medicine and Health Technology is a peer-reviewed, open access journal dedicated to the dissemination of innovative research and insights in the fields of medicine and health technology. Our aim is to publish original articles, case reports, and review articles that provide valuable information and stimulate interest among medical doctors, engineers, researchers, and health professionals. We seek to enhance practitioners understanding of medical and technological advancements, offering alternative solutions to challenges in diagnosis, therapy, and prevention. The scope of JMHT includes, but is not limited to, the following areas: medical technology and innovation, clinical medicine, health informatics, public health and epidemiology, health systems and policy, digital health records, telemedicine, remote patient monitoring, AI and predictive analytics, robotics, IoT, personalized medicine, drug development, medical imaging and diagnostics, rehabilitation and physiotherapy, pharmacology and therapeutics, global health and infectious diseases, preventive medicine, nutrition and dietetics, occupational health, geriatrics and palliative care, internal medicine, and environmental health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 29 Documents
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The Role of Microbiota in Atopic Dermatitis Sari, Desiana Widityaning; Nur Annisa Nugraheningtyasari
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.2630

Abstract

Skin microbiota play an important role in the pathogenesis of AD. Damage to the integrity of the skin mucosa allows penetration of allergens and colonization of the skin by pathogenic microorganisms. This can then stimulate inflammation related to excessive activation of Th2 lymphocytes throughout the body including the digestive tract and respiratory tract. The understanding of the latest definition of AD emphasizes this disease as a chronic inflammatory disease characterized by disruption of the skin barrier, inflammation, and dysbiosis (an imbalance between commensal and pathogenic bacteria, which then has significant health implications). Skin dysbiosis is based on an increase in the concentration of Staphylococcus aureus colonization, which causes a decrease in the number of commensal bacteria. Changes in the microbiota in AD affect the functioning of the immune system, stimulating inflammatory reactions that are manifested as atopic eczema. This concept of dysbiosis is important to discuss because it can influence new strategies for the treatment and prevention of AD. This article will further discuss the role of microbiota in AD.
A Study on the Potential of Cinnamon and Jasmine as an Alternative Therapy for Managing Respiratory Tract Infections Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.3065

Abstract

Respiratory tract infections (RTIs) remain a significant global health burden, particularly due to increasing antibiotic resistance. Natural compounds have gained interest as alternative therapies to address this challenge. This study explores the potential of cinnamon (Cinnamomum sp.) and jasmine (Jasminum sp.) as herbal remedies for RTI management. Cinnamon contains bioactive compounds such as cinnamaldehyde and eugenol, which exhibit antibacterial, anti-inflammatory, and antioxidant properties. Jasmine, on the other hand, possesses linalool and benzyl acetate, which contribute to its bronchodilatory, anti-inflammatory, and antimicrobial effects. The synergistic interaction between these two botanicals may enhance immune response, reduce airway inflammation, and inhibit respiratory pathogens. This systematic review compiles evidence from in vitro, in vivo, and clinical studies to evaluate the efficacy of cinnamon and jasmine in RTI treatment. The findings suggest that both plants hold promise as complementary or alternative therapies, potentially reducing reliance on conventional antibiotics and mitigating antimicrobial resistance. Further clinical trials are recommended to confirm their therapeutic applications.
Phytochemicals, Bioactivity, and Utilization of Etlingera elatior as a Medicinal Plant Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.3977

Abstract

Etlingera elatior, commonly known as torch ginger, is a plant widely used as a cooking spice. Native to Southeast Asia, E. elatior is not only valued for its culinary uses but also for its high nutritional content. It is also used medicinally, including as a treatment for typhoid fever and various other diseases. The bioactivity of this plant has been extensively studied. It has antioxidant, antibacterial, antifungal, tyrosinase-inhibiting, cytotoxic, and hepatoprotective properties. E. elatior acts as an antimicrobial, antioxidant, anticancer, anti-hyperglycemic, anti-hyperuricemia, anti-inflammatory, larvicidal, skin-whitening, anti-aging, and wound-healing agent. These biological activities are attributed to its rich content of phytochemical compounds, including phenols, flavonoids, glycosides, saponins, tannins, steroids, and terpenoids. Given its wide range of biological activities and chemical compounds, E. elatior warrants further research to contribute to the development of natural medicinal plants in Indonesia.
Exploring the Phytochemistry and Pharmacological Potentials of Annona squamosa L. : A Systematic Review of Traditional Uses and Modern Applications Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Trisnawati, Indah; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Lekatompessy, Vanela Chatrin
Journal of Medicine and Health Technology Vol. 2 No. 2 (2025)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v2i2.4287

Abstract

Annona squamosa L. (Annonaceae) is a tropical evergreen fruit tree with a long history of traditional use across various cultures. Its fruit, known as srikayas, is commonly consumed fresh and used in candies, ice creams, and beverages. Different parts of A. squamosa have been widely applied in ethnomedicine as tonics, apophlegmatisants, coolants, abortifacients, and heart sedatives. Phytochemical studies have identified key bioactive compounds including annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs), and cyclopeptides (CPs), with 33 diterpenes, 19 alkaloids, 88 acetogenins, and 13 cyclopeptides reported up to 2016. Extensive research reveals A. squamosa exhibits diverse pharmacological activities such as anticancer, antioxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidal, and molluscicidal effects. Notably, diterpenes and acetogenins contribute to its potent anticancer properties through apoptosis induction and cell cycle arrest. Leaf and seed extracts demonstrate significant antidiabetic, anti-inflammatory, and hepatoprotective actions, while seed peptides exhibit vasorelaxant and hypotensive effects via calcium channel inhibition. This review integrates phytochemical, ethnopharmacological, and bioactivity data, highlighting the therapeutic potential of A. squamosa and encouraging further clinical studies to validate its medicinal applications.
Breath Smoke Detection: Non-Invasive Assessment of Substances Found in Cigarettes Hidayah, Rizka Nurul
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.2629

Abstract

Breath analysis not only holds great potential for the development of new non-invasive diagnostic methods, but also for the identification and follow up of drug levels in breath. This is of interest for both, forensic and medical science. On the one hand, the detection of drugs of abuse in exhaled breath-similar to the well-known breath alcohol tests-would be highly desirable as an alternative to blood or urine analysis in situations such as police controls for drugged driving. Despite the many benefits and conveniences offered, the use of this useful tool is currently still very rare and requires shipping from abroad. Development is needed to realize it in a more affordable version, so researchers discuss further in this paper
Enhancing Gut Health: Probiotic Interventions in Preterm Neonates with Necrotizing Enterocolitis Rangkuti, Rahmah Yasinta; Haykal, Muhammad Nazhif; Furaidah, Erna
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.2634

Abstract

Necrotizing enterocolitis (NEC) remains a significant challenge in neonatal care, particularly in preterm neonates, due to its high mortality and morbidity rates. Probiotics, defined as live microorganisms that confer health benefits to the host, have emerged as a promising intervention to enhance gut health and reduce the risk of NEC. This study aimed to evaluate the role and efficacy of probiotic interventions in preterm neonates with NEC by analysing existing literature and clinical studies. Data on the types of probiotics used, their mechanisms of action, dosage regimens, and clinical outcomes were extracted and analysed. The findings revealed that specific strains of probiotics, including Lactobacillus and Bifidobacterium, significantly reduced the incidence of NEC and associated mortality in preterm neonates. Probiotics were found to modulate gut microbiota, enhance mucosal integrity, and reduce systemic inflammation, thereby mitigating the pathogenesis of NEC. The study also highlighted variations in the efficacy of different probiotic strains and dosing strategies, indicating a need for standardized protocols. The results underscore the potential of probiotics as a preventive and therapeutic tool for NEC in preterm neonates. Future research should focus on identifying optimal probiotic strains, dosages, and long-term safety profiles to establish robust clinical guidelines and improve neonatal outcomes.
Hypothermic Perfusion Effects on Corneal Endothelial after Phacoemulsification Fadhlina, Afia Nuzila
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.2658

Abstract

Phacoemulsification is the most common cataract surgery performed as an efficient and safe cataract surgery technique compared to other cataract surgery techniques. Indeed, phacoemulsification uses high-intensity ultrasound energy to fragment and emulsify the lens, which can cause trauma to the cornea, especially the endothelial layer. Surgical trauma to the CEC can have severe complications on functional outcomes such as decompensation, leading to corneal edema with visual impairment and irreversible bullous keratopathy. The application of hypothermia is known to have a protective effect on various cells and tissues, so hypothermia perfusion is considered to protect the corneal endothelium during phacoemulsification procedures. Hypothermic perfusion can be used to reduce corneal endothelial cell damage during phacoemulsification procedures.
Phytochemical Constituents and Therapeutic Potential of Pine Bark and Needle Extracts in Cardiovascular and Metabolic Disorders Rosyid Ridho, Muhammad Ainur; Indriani, Ratri Dwi; Wulansari, Arfiana Tanti; Purwani, Kristanti Indah; Nurhidayati, Tutik; Aprilia, Veranita; Pradani, Anindhita Nabilah; Putra, Roy Ardiansyah; Farid, Ardiansyah
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.4288

Abstract

Cardiovascular and metabolic diseases remain leading global health challenges, necessitating novel and complementary therapeutic strategies. Natural plant-derived compounds, particularly from pine bark and needles, have attracted attention for their potential health benefits. This study aims to comprehensively review the phytochemical composition of pine bark and needle extracts, focusing on their biological activities and potential roles in preventing and managing cardiovascular and metabolic disorders. A literature review was conducted using databases such as PubMed, ScienceDirect, and Google Scholar, focusing on studies published from 2000 to 2024. The selection criteria included in vitro, in vivo, and clinical research articles investigating the phytochemical profiles and pharmacological effects of pine bark and needle extracts on cardiovascular and metabolic health. Pine bark and needle extracts, especially from Pinus pinaster, are rich in proanthocyanidins, flavonoids, phenolic acids, stilbenes, and terpenoids. These bioactive compounds exhibit potent antioxidant, anti-inflammatory, and endothelial protective properties. Clinical and preclinical studies demonstrate improvements in blood pressure, lipid profiles, glucose metabolism, and vascular function. Emerging evidence also suggests a role in modulating gut microbiota, contributing to systemic metabolic benefits. Pine bark and needle extracts hold significant promise as adjunct therapies for cardiovascular and metabolic diseases through their multi-targeted mechanisms. Further well-designed clinical trials are necessary to validate their efficacy, optimize dosages, and ensure safety for broader therapeutic application.
Anesthetic Agents and Mitochondrial Function A Comprehensive Review of Cellular Bioenergetics and Clinical Implications Indriani, Ratri Dwi; Rosyid Ridho, Muhammad Ainur
Journal of Medicine and Health Technology Vol. 3 No. 1 (2026)
Publisher : Direktorat Riset dan Pengabdian Kepada Masyarakat, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j30466865.v3i1.7987

Abstract

General anesthetic agents have traditionally been understood to function by modulating synaptic receptors. However, emerging evidence highlights mitochondria as a critical, non-canonical target. A comprehensive synthesis of these interactions and their clinical implications is essential for advancing perioperative safety. This narrative review aims to provide a comprehensive analysis of the molecular interactions between common anesthetic agents and mitochondrial function, bridging the mechanisms of cellular bioenergetics with relevant clinical outcomes. A literature search was conducted across major databases, including PubMed, Scopus, and Web of Science, to synthesize and interpret findings from in vitro, in vivo, and clinical studies published between January 2000 and August 2025. Our synthesis reveals that anesthetics directly modulate the electron transport chain, leading to a dual-edged production of reactive oxygen species (ROS) that can be either protective (preconditioning) or damaging (oxidative stress). We find that agents exhibit distinct mitochondrial profiles: sevoflurane often confers protection, propofol shows dose-dependent toxicity linked to bioenergetic failure, and dexmedetomidine acts as a mito-protective adjunct. These interactions disrupt mitochondrial dynamics and can culminate in a "bioenergetic crisis" at the synapse, where energy demand is increased while mitochondrial ATP supply is compromised. Viewing anesthetics as potent mitochondrial modulators is crucial for the evolution of anesthesiology. This perspective shifts the paradigm towards personalized anesthetic strategies based on a patient's underlying mitochondrial vulnerability. We conclude that future research should focus on developing non-invasive biomarkers of mitochondrial health and creating "mito-sparing" anesthetic protocols to improve patient safety and long-term outcomes.

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