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Sinergi International Journal of Psychology
Published by YAYASAN SINERGI KAWULA MUDA
ISSN : -     EISSN : 3025552X     DOI : https://doi.org/10.61194/psychology
Core Subject : Health, Education, Social,
Education Health Professions Social Sciences
Sinergi International Journal of Psychology is a research publication platform aimed at global lecturers and researchers 1. Applied Psychology & Clinical Psychology 2. Developmental and Educational Psychology 3. Experimental and Coginitive Psychology, 4. General Psychology, 5. Neuropsychology and Physiological Psychology, 6. Social Psychology,
Arjuna Subject : Psikologi - Psikologi (Lain-Lain)
Articles 52 Documents
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Delirium in Bipolar Disorder as a Triggering Factor to Cognitive Decline: A Case Report and Neuroprogression Insight Ahadiah, Hayyunah Rohmatul; Syadza, Lailatus; Shafly, Moch Syafirul Nur; Asikah; Algristian, Hafid
Sinergi International Journal of Psychology Vol. 3 No. 4 (2025): November 2025
Publisher : Yayasan Sinergi Kawula Muda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61194/psychology.v3i4.784

Abstract

Bipolar disorder is a major contributor to global disability, affecting not only mood regulation but also cognitive function, and its impact is often exacerbated by metabolic comorbidities such as type 2 diabetes mellitus, hypertension, and dyslipidemia. These comorbid conditions can lead to poorer clinical outcomes and increase the risk of neuropsychiatric complications such as delirium and cognitive impairment, which are frequently overlooked in clinical practice. This article aims to describe and analyze the case of a 31-year-old male with a history of bipolar disorder who presented with a hyperglycemic crisis and pneumonia, followed by the onset of acute delirium and subsequent cognitive decline. Through a descriptive clinical approach, the patient’s medical and psychiatric history, laboratory findings, and treatment course are reviewed to explore the complex interaction between mood disorders and metabolic dysfunction. The analysis reveals a strong link between metabolic dysregulation and worsening neuropsychiatric outcomes. This case underscores the importance of early detection and an integrated, multidisciplinary management approach to prevent long-term cognitive deterioration in patients with psychiatric disorders accompanied by metabolic conditions, offering important implications for future clinical practice.
Hormonal Influence on Mood Dysregulation: A Case of Bipolar Disorder with Endometriosis Sakdyah, Halimatus; Septina, Egy Atthahirah; Pramesta, Linda Ramadhanty; Ikhsan, Muhammad; Shafira , Alsa; Nurhayati , Endi; Algristian, Hafid
Sinergi International Journal of Psychology Vol. 3 No. 4 (2025): November 2025
Publisher : Yayasan Sinergi Kawula Muda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61194/psychology.v3i4.829

Abstract

Bipolar disorder often coexists with gynecological conditions such as endometriosis, presenting clinical challenges due to overlapping hormonal and neuropsychiatric influences. The impact of hormonal therapy on mood stability in women with affective disorders remains underexplored. We report the case of a 30-year-old woman with bipolar II disorder, stable for nearly two years on lamotrigine, who developed mood destabilization after initiating hormonal treatment for stage III endometriosis. Sequential regimens—dienogest, norethisterone, and ethinylestradiol–levonorgestrel—were temporally associated with new or worsening mixed affective symptoms, including agitation, insomnia, irritability, and emotional lability, despite adherence to mood stabilizers. Her Hamilton Depression Rating Scale score increased from 9 to 21 within three months, with laboratory evaluation showing elevated estradiol and suppressed luteinizing hormone, supporting a hormone-related mechanism. A structured literature review (PubMed, Scopus, Google Scholar, 2000–2024) identified limited but consistent evidence that synthetic progestins may exacerbate psychiatric symptoms in mood-vulnerable populations through neuroendocrine and neurotransmitter modulation. This case underscores the importance of recognizing hormonally induced mood dysregulation in women with pre-existing psychiatric disorders and highlights the need for proactive management strategies. We recommend pre-treatment psychiatric screening, structured and longitudinal mood monitoring throughout hormonal therapy, and close interdisciplinary collaboration between gynecology and psychiatry to optimize outcomes. Integrated care approaches may reduce the risk of mood destabilization, enhance safety, and improve quality of life for women facing the dual burden of bipolar disorder and endometriosis.

Page 6 of 6 | Total Record : 52

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