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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 268 Documents
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Prodominance and Incidence of Pseudomonas Bacteria in Urinary Samples from Women with Chronic Urinary Tract Infections: Dominasi dan Insidensi Bakteri Pseudomonas pada Sampel Urin dari Wanita dengan Infeksi Saluran Kemih Kronis Saleem, Hanan Kareem
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.45

Abstract

Background; Chronic urinary tract infections in women are often associated with Pseudomonas aeruginosa, a significant pathogen causing recurrent and persistent infections. Aims of the study; To assess the predominance and incidence of Pseudomonas aeruginosa in urinary samples from women with chronic urinary tract infections. Methodology; A cross-sectional study at Al-Habbobi Teaching Hospital (10/11/2023–11/11/2024) examined bacterial infections in urinary samples from 1000 UTI patients (aged 35–45). Samples were cultured and analyzed for bacterial identification and antimicrobial susceptibility. Sociodemographic and clinical data were collected using questionnaires, ensuring ethical compliance and participant confidentiality. Result; The study included 1000 participants, with 60% in the 35–40 age group, 75% married, 60% having a college education, and 50% employed. Forty percent had a UTI history of 1–3 years. The most common bacteria in urine samples were Escherichia coli (45%), followed by Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (15%), and Enterococcus faecalis (7%). Infection rates of Pseudomonas aeruginosa were highest in patients with UTIs lasting 4–7 years (40.91%), followed by those with >7 years (36.36%) and 1–3 years (22.73%). The 35–40 age group had the highest prevalence of Pseudomonas (59.09%). Conclusions; The study concludes that Escherichia coli and Pseudomonas aeruginosa are the most prevalent bacteria in UTIs, with Pseudomonas being more common in patients aged 35–40 and with longer infection durations. Highlights: Chronic UTIs often involve Pseudomonas aeruginosa, causing persistent infections. Escherichia coli (45%) and Pseudomonas aeruginosa (22%) dominate UTI pathogens. Pseudomonas prevalence increases with age (35–40) and longer infection durations. Keywords: Escherichia coli, Pseudomonas aeruginosa, Urinary tract infections (UTIs), Chronic infections, Biofilms, Antibiotic resistance
Role of Clinical Chemistry in Hemodialysis: Assessment of Biochemical Markers and Electrolyte Imbalances: Peran Kimia Klinis dalam Hemodialisis: Penilaian Penanda Biokimia dan Ketidakseimbangan Elektrolit Al-Rubayee, Wasan T.
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.48

Abstract

Background; Chronic kidney disease (CKD) and renal failure are significant global health concerns, affecting millions of individuals and contributing to high morbidity and mortality rates. Aims of the study; This study aims to assess biochemical, inflammatory, and oxidative stress markers in renal failure patients to identify biomarkers and guide therapeutic strategies. Methodology; This case-control study, conducted between January 1, 2023, and January 1, 2024, included 100 renal failure patients and 50 healthy controls, aged 35-55 years. The participants’ gender distribution was 60% male and 40% female in the patient group, and 50% male and 50% female in controls. Renal function parameters (serum creatinine, BUN, GFR, urine output) were measured using an automated chemistry analyzer. Biochemical markers (potassium, calcium, phosphorus, PTH) were assessed with an electrolyte analyzer and immunoassay techniques. Inflammatory markers (CRP, TNF-α) and oxidative stress markers (MDA, GPx) were quantified using ELISA and spectrophotometric methods. Result; This study compared 100 renal failure patients and 50 healthy controls. Age differences were significant (p=0.045), with the renal failure group being older (53.2 ± 12.5 years). Gender, occupation, marital status, and smoking history showed no significant differences. Renal function parameters revealed significant differences: serum creatinine (7.4 ± 3.2 mg/dL vs. 0.9 ± 0.2 mg/dL, p<0.001), BUN (55.2 ± 19.1 mg/dL vs. 12.3 ± 4.5 mg/dL, p<0.001), GFR (15.6 ± 8.3 mL/min vs. 95.3 ± 10.2 mL/min, p<0.001), and urine output (450 ± 230 mL/day vs. 1600 ± 200 mL/day, p<0.001). Biochemical markers like potassium, calcium, phosphorus, and PTH also showed significant differences. Inflammatory and oxidative markers (CRP, TNF-α, MDA, GPx) had notable disparities, all with significant p-values. Conclusions; This study demonstrates significant differences between renal failure patients and healthy controls in renal function, biochemical markers, and inflammation. Renal failure patients had higher serum creatinine, BUN, and phosphorus levels, along with altered potassium, calcium, and PTH levels. Elevated inflammatory markers (CRP, TNF-α) and oxidative stress markers (MDA, GPx) suggest enhanced inflammation and oxidative stress Highlights: CKD study: Renal function, biochemical, inflammatory, oxidative stress markers analyzed. Significant differences in creatinine, BUN, GFR, CRP, TNF-α observed. Results highlight inflammation, oxidative stress in renal failure patients. Keywords: Renal failure, Biochemical markers, Inflammation, Oxidative stress, Serum creatinine, Parathyroid hormone
Evaluation of Histopathological Features and Some Immunological Markers in Diabetic Foot Ulcer Patients: Evaluasi Gambaran Histopatologi dan Beberapa Penanda Imunologi pada Pasien Ulkus Kaki Diabetes Faisal, Ahmed Nassir; Abbas, Abbas Muhsin
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.49

Abstract

Background; diabetic foot patients are affected by complications with any injury, more than healthy people, as a result of the delay in discovering the problem, as the patient’s lack of awareness of repeated injuries leads to complications with difficulty in treatment, these disorders are related to controlling the level of sugar in the blood. 39 samples of diabetic foot patients were collected from Al-Rifai General Hospital and the Diabetes Center in Nasiriyah city to conduct histological examinations. Aims of the study; the current study aims to characterize the histopathological features of diabetic foot ulcer cases. And assess immune and biochemical parameters associated with diabetic foot ulcer. In addition to evaluate the correlation between histopathological changes and immune responses. Methodology; Samples (blood, tissue specimen) were collected from diabetic patients with diabetic foot ulcer from Al-Rifai General Hospital and the Diabetic Center in in Nasiriyah city from April 2022 to september2022. Histopathological sections were prepared according to (Bancroft and Steven, 2008) , cytokines (TGF- β, IFN- γ and IL-17A) measured using the enzyme-linked immunosorbent technique ELISA. Result; the current study aims to demonstrate the histopathological changes associated with diabetic foot. results show purulent ulcer with a large gap between the edges of the lesion necrotic foci in the dermis tissue, Fibrin deposition with focal melanin pigmentation, degenerative changes with compaction of nuclei and extensive granulation formation in the dermis with inflammatory activity. The results showed a significant increase in the concentration of some cytokines (TGF- β, IFN- γ and IL-17A) and some Biochemical parameters such as (HbA1C and Triglycerides) in patients with diabetic foot compared to the healthy group. Conclusions; The present study concluded that the severity of diabetic foot ulcers is closely related to the high level of cytokines in diabetic patients with a preponderance in type 1 diabetes Highlights: tudy examines histopathological changes in diabetic foot ulcer patients. Findings show necrosis, inflammation, elevated cytokines (TGF-β, IFN-γ, IL-17A). Diabetic foot severity linked to cytokines and biochemical imbalances. Keywords: Diabetic foot, gangrene, ulcer, TGF- β, IFN- γ and IL-17A
Effectiveness of Entomopathogenic Fungi Against Adult Red Flour Beetles (Tribolium castaneum) (Coleoptera: Tenebrionidae): Efektivitas Jamur Entomopatogen Terhadap Kumbang Tepung Merah Dewasa (Tribolium castaneum) (Coleoptera: Tenebrionidae) Falhy, Majida Mohammad Abid; Azeez, Zahraa Falah
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.52

Abstract

The current study aimed to isolate some insect pathogenic fungi from the soil of wheat crops in different areas and test their effects on the adult stages of the red flour beetle Tribolium castaneum. Five species of fungi naturally infecting the flour beetle were recorded, and these genera were Beauveria bassiana and Metarhizium anisopliae, identified morphologically. Five local strains of insect pathogenic fungi were isolated, based on their macroscopic and microscopic characteristics. The concentrations of fungal spore suspensions affected the adults of the studied insect, with Beauveria bassiana being the most effective. The mortality rate of adults reached 93.33% when the highest concentration of the fungal suspension (17x108) was used after 10 days of treatment, while the mortality rate was 86.67% when using the suspension of Metarhizium anisopliae at the same concentration. One strain matched the species B. bassiana and four strains matched M. anisopliae. The identity of the strains was confirmed by amplifying and sequencing the ITS5-ITS4 region, and comparing the sequences to molecular databases and phylogenetic analyses. 99% identity values ​​were recorded with B. bassiana and M. anisopliae strains in molecular databases. Phylogenetic analyses confirmed that the sequences extracted from these strains fall within the group containing the reference sequences of B. bassiana and M. anisopliae, respectively, in the database. These results contribute significantly to the understanding of entomopathogenic fungi, which will aid in the development of biotechnological products in the field of biological control. Highlights: Soil fungi Beauveria bassiana and Metarhizium anisopliae infect red flour beetles. Fungal spore suspensions showed high mortality rates in beetle adults. Molecular analyses confirmed strains' identity, supporting biological control development. Keywords: Tribolium castaneum, entomopathogenic fungi, Beauveria bassiana. Metarhizium anisopliae. identification, contact toxicity
Probiotic Applications of Leuconostoc Mesenteroides: Antibacterial Activity Against MDR Pathogenic Bacteria: Aplikasi Probiotik Leuconostoc Mesenteroides: Aktivitas Antibakteri Terhadap Bakteri Patogen MDR Hammadi, Noor Alhuda Nadhim; Hasson, Shaimaa Obaid; Al-Awady, Mohammed Jabber
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.53

Abstract

Leuconostoc mesenteriodes is an important probiotic bacteria with impact characteristics and benefits for human health. Last year, probiotic bacteria were used as an alternative to traditional antibiotics in treat of different diseases especially in the broad distribution of MDR bacteria. L. mesenteriodes isolate was purchased from (Al-Amin Center for Research and Biotechnology\ Najaf, Iraq) and re-diagnosis using MRS media in anaerobic condition then diagnosis by vitek 2 system. The antibacterial activity of L. mesenteriodes was assessed using the agar well diffusion method against MDR pathogenic bacteria isolated from different clinical cases. The L. mesenteriodes crude was obtained by centrifuging the bacterial isolates. Five different concentrations of probiotic bacteria crude were tested against MDR pathogenic bacteria revealing the antibacterial activity of L. mesenteriodes crude concentrations (stock, 90%, 75%, 50% and 25% ) against MDR Staphylococcus aureus (22, 20, 20, 17, 14 mm), MDR Micrococcu. leuts (24, 23, 18, 16, 11 mm), MDR Proteus. mirabillis (22, 22, 18, 17, 14 mm), MDR Escherichia. coli (22, 20, 18, 12, 11 mm) and MDR Klebsiella pneumoniae were (20, 18, 14, 12, 11mm) an respectively. L. mesenteriodes probiotics improve antibacterial activity especially when used against multi-drug resistant bacteria Highlights: mesenteroides shows antibacterial potential against MDR pathogens. Tested using agar well diffusion with five crude concentrations. Effective against MDR bacteria strains including S. aureus, E. coli, and K. pneumoniae. Keywords: probiotic, L. mesenteriodes, MDR, Crud extract, pathogenic bacteria.
Molecular Characterization of Proton-Pumping NADH Family in Hydatids Isolated From Cattle: Karakterisasi Molekuler Keluarga NADH Pemompa Proton pada Hidatid yang Diisolasi dari Sapi Challoob, Maysoon Khazail; AL-Asadi , Sarmad Awad Mozan
Indonesian Journal on Health Science and Medicine Vol. 2 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.54

Abstract

Echinococcus granulosus mainly causes cystic echinococcosis and its energy from complex VI depends on NAD families. The study aimed to characterize and investigate these families in the E.granulosus G1 strain, as well as to genotype hydrophobic dehydrogenases. The results revealed the G1 strain has 21 subunits of proton-pumping NADH dehydrogenases distributed between the nuclear and mitochondrial genomes. Fifteen subunits (71.43%) were in the mitochondrial genome, and six subunits (28.57%) were in the nuclear genome. The hydrophobic NADI to NAD4L subunits were amplified using specifically designed primers and were 100% present in the protoscoleces and germinal layers of hydatids. They had 98.1-100% identities with their counterparts from the reference G1 strain. Phylogeny showed that hydrophobic subunits clustered with their counterparts in the G1 strain and were distant from their counterparts in G6 and G7 strains. The hydrophobic subunits were conserved between the protoscoleces and germinal layer of hydatids, as well as between individuals of the G1 strain. Additionally, all proton-pumping NADH dehydrogenases can be used in the diagnosis of the closely related strains G1 and G3. Highlights: granulosus G1 Strain: 21 NADH dehydrogenase subunits identified. Gene Location: 71.43% mitochondrial, 28.57% nuclear genomes. Diagnostic Use: Hydrophobic subunits differentiate G1/G3 strains from G6/G7. Keywords: E. granulosus, G1 strain, NADH family, hydatids, hydrophobic
Comparative Study of Serum Electrolytes in Diabetic and Non-Diabetic People of Different Age and Gender from Basrah Province, Iraq: Studi Perbandingan Elektrolit Serum pada Penderita Diabetes dan Non-Diabetes dengan Usia dan Jenis Kelamin yang Berbeda dari Provinsi Basrah, Irak Hassan, Saged S.; Salman, Nader A.; Hussein, Shahla A.
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.55

Abstract

The present study aimed at investigating differences in the levels of the most important blood electrolytes in diabetic patients of different age and gender and compare it with levels recorded in normal control group from Basrah Province. The theoretical hypothesis of the research relay on the possible impact of hyperglycemia caused by this disease on the osmotic status and electrolyte distribution between extra- and intracellular fluids. Blood samples were collected from 50 diabetic patients ranging in age from 27 to 62 years and are registered in the Diabetes Department of Al-Faiha’a Educational Hospital in Basrah and compared with 50 control group of nearly same ages. The sample include both males and females. Results of the present investigation revealed significant differences in electrolyte levels between diabetic and non-diabetic groups. Both Na+ and Cl- showed a significant decrease in diabetes patients suggesting the occurrence of hyponatrmia and hypochloromia cases respectively. On contrary K+ ion showed a significant elevation in diabetes patients compared with control which reflects hyperkalemia cases. No significant changes were noticed in the case of serum Ca++ and phosphorus. Results were discussed in view of the findings of other studies on the osmotic status of diabetic patients Highlights: Analyzed electrolyte differences in diabetic vs. non-diabetic individuals. Compared Na+, Cl-, K+, Ca++, and phosphorus levels in 100 participants. Significant hyponatremia, hypochloremia, and hyperkalemia found in diabetic patients. Keywords: Serum Electrolytes, Diabetes, Age, Gender , Basrah.
Interactive Effects of Agrivoltaic Shading, Irrigation, and Biofertilizers on the Chemical Composition of Lettuce Leaves (Lactuca sativa L.): Pengaruh Interaktif Peneduh Agrivoltaic, Irigasi, dan Pupuk Hayati terhadap Komposisi Kimia Daun Selada (Lactuca sativa L.) Khudhair, Manar Ali; Sahib, Mohammed R.; AL-Agele , Hadi A.
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.56

Abstract

The agrivoltaic system is one of the most efficient approaches to sustainability, optimizing agricultural land for simultaneous food production and electricity generation. This technique decreases water usage by providing shade to soil and vegetation, therefore reducing evaporation and prolonging soil moisture retention relative to open-field farming. This study sought to examine the impact of shaded versus unshaded cultivation, irrigation levels (100% and 50%), and biofertilizer application on the concentration of chemical characteristics in plant leaves. The findings demonstrated that both shaded and unshaded cultivation markedly enhanced leaf concentrations of chlorophyll, and carbohydrates. Biofertilizer, consisting of a mixture of Trichoderma and mycorrhiza, markedly improved chlorophyll and carbohydrates levels in leaves. Nonetheless, irrigation levels exhibited no substantial impact on the leaf concentrations of flavonoids, nitrates, or carbs. The combination of shaded cultivation with biofertilizer led to substantial enhancements in chlorophyll, flavonoids, carbs, and nitrate levels. The combination of shaded cultivation and irrigation markedly increased the levels of chlorophyll, flavonoids, nitrates, and carbohydrates. Furthermore, the interaction between irrigation and biofertilizer demonstrated notable enhancements in chlorophyll and nitrate levels. Ultimately, the triple combination of shade, irrigation, and biofertilizer significantly influenced all examined parameters, resulting in elevated levels of chlorophyll, flavonoids, nitrates, and carbohydrates in leaf tissues. Highlights: Agrivoltaics optimize land, reducing evaporation and boosting soil moisture retention. Shade and biofertilizer enhance chlorophyll, flavonoids, carbohydrates, and nitrate levels. Combined shade, irrigation, and biofertilizer significantly improve all leaf chemical parameters.. Keywords: Agrivoltaic system, bio-fertilization, drip irrigation, deficit irrigation, chemical traits
Effectiveness of Green Synthesized ZnO Nanoparticles Against MDR Resistant Klebsiella Pneumoniae Isolated From Diabetic Foot on Some Virulence Factors Genes Expression: Efektivitas Nanopartikel ZnO Hasil Sintesis Hijau Terhadap Klebsiella pneumoniae Resisten MDR yang Diisolasi dari Kaki Diabetes pada Beberapa Ekspresi Gen Faktor Virulensi Al-Mousawi, HaiderTurky Mousa; Jadooa, Mustafa Muhammed; Al-bderee, Nadhim Mushtaq
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.57

Abstract

Diabetic foot ulcers are a major public health problem and are quite costly for diabetic patients. Besides, patients with diabetic foot ulcers often have a poor quality of life. Most of the main complications of diabetic foot ulcers are the bacterial infection that leads to gangrene when different types of antibiotics fail to prevent bacterial infections. The research proposed in this study aims to determine the most effective synthesis type of Zinc oxide nanoparticles (ZnO NPs) and study its effect on some virulence factor genes expressions. Research includes the isolation and identification of several bacterial species by biochemical tests, as well as confirmation by the Vitek system and molecular diagnostics. Out of 100 swabs, 26 samples were found to be contaminated with bacteria Klebsiella pneumoniae is one the main virulence factor that develops of diabetic foot ulcers. The biological production of Zinc Oxide was using bacteria Pseudomonas aeruginosa. The characterization of the Zinc Oxide products was using the Ultra-violet Visible spectrophotometer, Fourier transform infrared spectroscopy, Scanning electron microscopy, X-Ray diffraction spectrum very small crystals with a large spherical shape were formed, with a size of 13.5 nm. The genes were included as the bacterial virulence factors coding genes, MagA of gene Klebsiella pneumoniae, which are responsible for the production of exotoxins that cause sepsis, necrosis, tissue necrosis and non-healing. The expression of MagA genes the different before and after treatment with ZnO NPs. The mRNA for both genes was extracted alongside the mRNA for 16SrRNA acting as housekeeping gene. All mRNAs were converted to cDNA through RT-PCR technique and then measure the expression by qPCR. The expressions of MagA genes for the biological product nanomaterial, bacterial nanomaterial, were significant for all the isolates with P<0.01. In conclusion from the foregoing the biological nanoparticles product was more sufficient for inhibition of most isolates. Highlights: Diabetic foot ulcers worsen by bacterial infections, causing severe complications. ZnO nanoparticles synthesized biologically; bacterial virulence gene expression analyzed. ZnO nanoparticles significantly inhibited K. pneumoniae virulence with P<0.01. Keywords: K. pneumoniae, P. aeruginosa, ZnO NPs, Mucoviscosity associated a gene (MagA) and gene expression
The Relationship Between Toxoplasmosis and Prostate Cancer Patients: Hubungan Antara Toksoplasmosis dan Pasien Kanker Prostat Shihab, Raghad N.; Sulaiman , Evan H.; El Abdeen, Atheer Abd elqader Zain
Indonesian Journal on Health Science and Medicine Vol. 1 No. 3 (2024): Desember
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.58

Abstract

Background: Toxoplasmosis is one of the most common global life-threatening diseases among immunocompromised persons. It is not only a disease, but also a contributing factor to several pathological disorders, such as prostate cancer. Objectives. The purpose of the presented work is determining the prevalence regarding toxoplasmosis in Iraqi cancer patients and to connect that prevalence with the type of malignancy. Patients and Methods: This study included 115 male patients (75 with prostatic tumors and 40 with normal prostate glands) from Al-Amal National Hospital for Cancer Management was enrolled between December 15, 2023and July 1, 2024. Results: The study's results showed that prostate cancer patient group with the toxoplasmosis had the greatest IgG antibody level, measuring 52.64±1.16 UI/ml. The control group had 0.306±0.05 UI/ml. According to CMIA, all groups had seronegative IgM antibody levels. However, the mean PSA of the patients in this study was 66.72±0.51 ng/ml, compared to 2.48 ±0.04 ng/ml for the healthy control groups. Measuring IL-10 levels in samples were done by ELISA method showed a group of prostate cancer patients with toxoplasmosis has highest level 19.36 ±0.15 pg/ml, while the healthy control group has the lowest level of the same assay 12.78 ±0.13 pg/ml. However, illustrated that prostate cancer patient group with toxoplasmosis higher level significantly (P≤0.01) of IFNγ in comparation of the group of healthy control. Conclusion: Prostate inflammation is caused by the common parasite T. gondii, which encysts and causes chronic inflammation in prostate of any species, according to this work. The anti-inflammatory cytokines IL-10 and IFNγ were linked to an increased risk of prostate cancer infected with toxoplasmosis. Highlights: Toxoplasmosis contributes to prostate cancer risk via chronic inflammation. Analyzed IgG, PSA, IL-10, and IFNγ in prostate cancer patients. Elevated IL-10, IFNγ indicate toxoplasmosis increases prostate cancer susceptibility. Keywords: Toxoplasma gondii; IgM, IgG, Prostate cancer

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