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Contact Name
Zanastia Sukmayanti
Contact Email
zanassukma@gmail.com
Phone
+6289513739598
Journal Mail Official
inajemdperkeni@gmail.com
Editorial Address
Jl. Salemba 1, No. 22G, Kenari Senen DKI Jakarta – Indonesia
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
ISSN : 30483271     EISSN : 30631408     DOI : -
Core Subject : Health,
Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) is an open accessed online journal and comprehensive peer-reviewed medical journal published by the Indonesian Society of Endocrinology since 2024. Our main mission is to publish and disseminate research results that are relevant to current and future scientific development needs. InaJEMD is an open accessed online journal. We are welcome authors for original articles, case report, case series, case illustration, review articles, systematic review, and clinical practice. Authors are invited to submit articles that have not been published previously and are not under consideration elsewhere. Preparations of manuscript should follow the author guidelines of InaJEMD.
Articles 36 Documents
Trend Analysis of Clinical Characteristics of COVID-19 with Diabetes Based on Disease Severity Batari Retno Minanti; Soebagijo Adi Soelistijo; Agung Pranoto
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Diabetes Mellitus (DM) increases the risk of COVID-19's severity and mortality than those without DM. The aim of this study was to determine the characteristics and trends by disease severity of DM patients with COVID-19. Across-sectional study examining retrospective medical records was conducted in patients with diabetes mellitus who were confirmed to have COVID-19 by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). All adult patients (age > 18 years) with DM and COVID-19 registered and treated at the Surabaya Hajj General Hospital from May 2021 to the end of December 2021 were included in this study. Trends in each subject's characteristics are displayed in a graph with a trendline based on the severity of COVID-19. The highest proportionof disease severity of DM patients with COVID-19 is mild and moderate cases (72.2%), with 27.8% severe and critical cases. The average aged of the subjects was 56.38 ± 9.60 years. The age group with the highest proportion was 50-59 (42.6%). There are slightly more female than male patients (50.4% vs. 49.6%). The tendency is that the disease's severity increases with BMI, increasing HbA1C level, low sodium level, high chloride level, and high CRP and D-dimer levels. The pattern of clinical and laboratory features of DM patients based on the severity of COVID-19 infection shows the tendency for the disease severity worsens with increasing BMI, HbA1C level, low sodium level, high chloride level, and high CRP and D- dimer levels.
Diabetic Ketoacidosis as The First Manifestation of a Young Adult with Diabetes A Clinical Approach to Distinguish Different Types of Diabetes Mellitus M. Ikhsan Mokoagow; Anak Agung Arie Widiastuti; Jerry Nasarudin; Marina Epriliawati; Ida Ayu Made Kshanti; Nobian Andre; Adlina Hafidzati; Vania Tryanni
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Diabetic ketoacidosis (DKA) is an acute metabolic complication of diabetes. While it most commonly occurs in type 1 diabetes (T1DM), DKA can also occur in other types of diabetes. Encountering a case of DKA prompts further evaluation to determine the type of diabetes and manage patients accordingly. To establish a diagnosis of the type of diabetes in a case with an unusual presentation of DKA through a clinical approach. A 30-year- old male presented to the emergency department with sudden dyspnea. Laboratory examinations showed a blood glucose level of 506 mg/dL, a blood ketone level of 2.6 mmol/L, and a bicarbonate level of 5 mEq/L. Hishemoglobin A1c was 15.3%. He had not been previously diagnosed with diabetes mellitus. Studies have shown overlapping clinical and biochemical parameters of DKA among various types of diabetes. Following life-saving management, further clinical and laboratory evaluations should be performed. Measurement of autoantibody titer (i.e.: autoantibodies against glutamic acid decarboxylase, islet antigen-2, zinc transporter 8, and insulin) and c-peptide levels might help determine the type of diabetes in this patient. Establishing the diagnosis of a certain type of diabetes in young adults can be challenging. Based on clinical profile, a presumptive diagnosis of autoimmune diabetes, particularly latent autoimmune diabetes in adults (LADA), was made in this patient.
Transition of Care of Disorders of Sexual Development: A Twist of Two Cases with Ambiguous Genitalia Marshell Tendean; Nanny Natalia. M Soetedjo; Maya Kusumawati; Ervita Ritonga; Hikmat Permana
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Disorders of sexual development (DSD) is a congenital condition that requires an alteration in the development of chromosomal, gonadal, and anatomical sex is atypical. A report showed most of the patients in the 46XX DSD had congenital adrenal hyperplasia (CAH) at 69.23% followed by unknown under-virilization in the 46XY DSD group at 60.09%. Patient 1 diagnosed as DSD 46XX/non-classic congenital adrenal hyperplasia (NCAH) presented with primary amenorrhea, short stature, over-virilization (Prader 2), and 46XX karyotype. Laboratory examination showed elevated 17-hydroxyprogesterone (17OHP): 166.7 ng/ml (2.83 ng/ml), without salt wasting feature. Patient 2 diagnosed with DSD 46XY/type 2 5α -reductase deficiency (SAD) presented with cryptorchidism, under-masculinization (sinecker stage 3b), and 46XY karyotype. Laboratory examination showed elevated testosterone 613 ng/dL (4.6-38.3 ng/dL), decreased dihydrotestosterone (DHT) 11 ng/dL (>20 ng/dL), and elevated testosterone T/DHT ratio 55.73 (8-16). A deep understanding of pathophysiology, and approach to disease in each stage of life is important and warrants special treatment. Comprehensive multidisciplinary team management (MDT) is warranted in DSD management. Disease prognosis varies among each disorder: early detection, treatment compliance, and continuity of care are important to improve patient outcomes.
Does Severe Hypokalemia Worsen the Outcome of Diabetic Ketoacidosis Pamela Sandhya De Jaka; Dias Guita Alantus
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Hypokalemia is an uncommon finding in the initial evaluation of patients with DKA before insulin treatment. However, it can complicate the management of DKA and lead to a worse prognosis. Hypokalemia in DKA may result from a combination of factors, including kaliuresis, secondary osmotic diuresis, inadequate oral intake, and gastrointestinal losses such as vomiting. We report the case of a 31-year-old woman who recently experienced diabetic ketoacidosis with severe dehydration, severe hypokalemia, and sepsis. Unfortunately, her condition deteriorated, and she eventually went into cardiac arrest while receiving treatment in the emergency unit. This case highlights the challenges involved in providing therapy and managing complications that arise in patients, presenting a dilemma for healthcare providers
Diagnostic and Management of Idiophatic Panhypopituitarism A Case Report Ida Bagus Aditya Nugraha; Komang Agus Wira Nugraha; Anak Agung Gede Budhiarta; Ketut Suastika; Wira Gotera; Made Ratna Saraswati; I Made Pande Dwipayana; I Made Siswadi Semadi
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Hypopituitarism is marked by decreased secretion of one, several, or all anterior or posterior pituitary hormones. A rare disorder, panhypopituitarism indicates the loss of all the pituitary hormones but often is used in clinical practice to describe a patient's deficiency in growth hormone, gonadotropins, corticotropin, and thyrotropin in whom the posterior pituitary function remains intact. Hypopituitarism may occur because of diverse etiologies and lead to substantial morbidity and mortality. Despite advances in the diagnosis and management of pituitary disorders, hypopituitarism is still associated with increased long-term cardiovascular mortality. We report a rare case of a 22-year-old boy with idiopathic panhypopituitarism. The patient has deficiency of growth hormone, gonadotropin, corticotropin, and thyrotropin, yet the underlying etiology remains unknown in this patient because of lack of imaging data. This is very challenging to do prompt diagnosis and management of panhypopituitarism. The management is needing multiple hormonereplacement therapy, based on the result of pituitary hormone laboratory examination. Prompt treatment is needed to prevent further morbidity and mortality in this patient. hypothyroidism, growth hormon
Primary Adrenal Insufficiency due to Tuberculosis Infection Pitfalls in Diagnosis and Management Ira Laurentika; Em Yunir; Tri Juli Edi Tarigan; Agnes Stephanie; Robert Shinto; Taufik Agung
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Primary adrenal insufficiency (PAI) is a chronic condition in which both adrenal glands are not able to produce steroid hormones. In this article we reported a-20-year-old male with history of soft tissue tumor in thoracalregion and general hyperpigmentation of skin and mucous. Laboratory findings showed hypocortisolism and adrenal computed tomography (CT) scan showed bilateral enlargement of adrenal with multiple necrotic nodular lesion and calcification, suggesting adrenal metastasis or tuberculosis infection. The interferon gamma release assay (IGRA) and histopathology review of the specimen from soft tissue tumor in thoracal region showed confirmed the diagnosis of adrenal tuberculosis. Antituberculosis drugs were started, and hydrocortisone dose were frequently adjusted. Five months after therapy the patient is clinically improved with a minimal dose of steroid.
Pregnancy Following Recent Radioactive Iodine Ablation in Thyroid Cancer Patient A Case Report Robert Dwitama Adiwinoto; Soebagijo Adi Soelistijo; Hermina Novida; Agung Pranoto
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Well-differentiated thyroid carcinoma (DTC) is common among females of reproductive age. Pregnancy is associated with hormonal (TSH and HCG) and metabolic changes that might affect the thyroid gland. Informationregarding the outcome of babies born to mothers who have recently undergone radioactive Iodine-131 ablation (RAI) is scarce. A 24-year-old pregnant woman with a history of thyroid cancer was consulted by the obstetrics and gynecology for further evaluation. She complained of a lump under the left jaw, and a thyroid nodule was found from further examination. Postoperative pathology of the right thyroid tissue revealed follicular and solid variant papillary thyroid carcinoma. Postoperative Thyroglobulin (Tg) level before ablation was 16.14 ng/mL. Ablation with Iodine-131 of 100 mCi was performed. Whole-body scintigraphy (WBS) indicated remaining functional thyroid tissue in the right thyroid field and thyroid tissue metastases in the left supraclavicular area. The patient waspregnant 3 months after the radioablation. Fetomaternal examination results 6 months pregnancy revealed fetal biometry according to gestational age (31 – 32 weeks) with an estimated fetal weight of 1787 grams and fetal doppler was normal. The patient is treated with levothyroxine 125 μ g once daily, folic acid 400 μ g twice daily, calcium lactate twice daily, and aspirin 80 mg once daily. The TSH level was 0.01 (0.55 – 4.78) μ IU/mL and the fT4 was 1.14 (0.7 – 1.48) ng/dL. The latest thyroid ultrasound indicated no discrete mass in the thyroid fossa and non-specific lymphadenopathies. The baby was born normally, weighed 2680 grams, with normal thyroid function tests (neonatal TSH 1.02 μ IU/mL, fT4 2.6 ng/dL).
Hypokalemia Periodic Paralysis in Subtle Thyrotoxicosis with Renal Insufficiency Indah Sagitaisna Putri; Dadang Herdiana; Pipik Ripa’I; Miko Galastri
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Hypokalemia is one of the frequently observed electrolyte imbalances in clinical practice. The clinical manifestations range from asymptomatic to significant manifestation, such as paralysis. Here we report a case of 31-years-old female admitted to our emergency department with chief complaint of acute onset of paralysis in lower extremities. Vital signs showed slight tachycardia. The physical examinations were all normal. Motoric examination showed paraparesis in lower extremities with normal sensory function. Upon admission, laboratory tests showed severe hypokalemia (1.5 mmol/L) with renal insufficiency. The patient got hypokalemia corrected with both potassium oral supplementation and potassium infusion. Thyroid function tests showed hyperthyroidism and the diagnosis of thyrotoxic periodic paralytic (TPP) was made. This case report highlights the importance of early diagnosis and prompt treatment of hypocalemia in TPP patient.
Challenges in the Diagnosis and Management of Adrenal Insufficiency Febri Kurniawati; Sony Wibisono Mudjanarko; Soebagijo Adi Soelistijo; Agung Pranoto
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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Adrenal insufficiency (AI) is a rare endocrine condition. Primary adrenocortical insufficiency, or Addison diseases reduces the production of crucial hormones, including glucocorticoids, mineralocorticoids, and adrenal androgens. Due to the lack of proper cortisol response in adrenal crisis, it can be life-threatening during times of stress, emphasizing the need for a timely diagnosis. Despite this, diagnosing and managing AI still presents significant challenges. We report the case of a middle-aged woman who presented with complaints of weight loss, abdominalpain, lethargy, hyperpigmentation of the skin and mucosa, and a history of repeated hospitalizations for nausea, vomiting, dehydration, and hypovolemia. During the patient's previous hospitalization, Addison's crisis was suspected, and methylprednisolone therapy was administered, rendering the cortisol and ACTH assays inaccurate. The patient's condition subsequently improved. The subsequent monitoring revealed low cortisol levels, but an ACTH stimulation test was unavailable. The presence of pulmonary tuberculosis was indicated by a positive chest X-ray and IFN-Gamma Release Assay (IGRA) test. With a history of repeated hospitalizations, suspected Addison's crisis, hypoglycemia, mineralocorticoid involvement (hypotension, hyponatremia), and the presence of hyperpigmentation, a clinical diagnosis of primary adrenal insufficiency was made with limited conditions and testing tools. The patient was given anti-tuberculosis treatment and the lowest dose of hydrocortisone required to control the disease without causing side effects.
Artificial Intelligence for Managing Diabetes Mellitus in Indonesia Implementation Challenge in Resource-Limited Settings Veramita Augusta Arisandy; Shafira Maharani Malik
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
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The existence of Artificial Intelligence (AI) has shaped a significant transformation in healthcare. In the field of endocrinology, AI has been used in the treatment of diabetes mellitus which categorized as one of the leading causes of death in Indonesia. This study is based on a general article review that uncovered the function of AI and its utilization on diabetic care. Currently, AI has grown into a facility that plays a role in health care, such as screening, diagnosis, and recognizing problems. In the scope of diabetes, several AI-based methods and applications have been investigated and played a role in diabetes management such as monitoring blood sugar, setting therapy targets, and dietary adjustment in diabetic patients. Despite the sophistication of AI, there are still several potential risks and barriers, notably in Indonesia, where the limited resources still be an impediment to the use of advanced technology. Lack of data integration and limited accessibility are the common challenges to AI implementation in limited-resources areas. Nevertheless, the application of AI offers numerous prospective benefits, particularly in terms of convenience of use and its efficacy in diabetes management to optimize diabetes care with standardized digital data records, resource improvement, and workload decrease.

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