cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Samsul A Rahman Sidik Hasibuan
Contact Email
mimp@journal.marasofipublishing.co.id
Phone
+62812-6345-3310
Journal Mail Official
mijm@journal.marasofipublishing.co.id
Editorial Address
Jl. Pimpinan Gg. Perkauman No. 7, Desa/Kelurahan Sei Kera Hilir I, Kec. Medan Perjuangan, Kota Medan, Provinsi Sumatera Utara, Kode Pos: 20233
Location
Kota medan,
Sumatera utara
INDONESIA
Multicore International Journal of Multidisciplinary (MIJM)
Published by Marasofi International Media and Publishing
ISSN : -     EISSN : 3108933X     DOI : https://doi.org/10.64123
Core Subject : Economy, Health, Education, Social, Engineering,
Economics, Econometrics & Finance Education Engineering Health Professions Social Sciences
Multicore International Journal of Multidisciplinary (MIJM) aims to foster intellectual exchange and collaboration across various academic disciplines, promoting knowledge that transcends traditional boundaries and contributes to the development of society and science. Scope includes (but is not limited to): 1. Interdisciplinary research integrating science, technology, and humanities 2. Multidisciplinary innovation in education, economics, and society 3. Applied science and technology for public benefit 4. Social science and behavioral research with cross-field implications 5. Health sciences and public policy 6. Sustainability and development studies 7. Cultural studies, philosophy, and ethical innovation 8. Computational models in social and human behavior
Arjuna Subject : Umum - Umum
Articles 5 Documents
 1 
Search results for , issue "Vol. 1 No. 2 (2025): November" : 5 Documents clear
Pharmacokinetics and Druglikeness of Amoxicillin Drug using SwissADME Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Rhomah, Eka Hayati; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.3

Abstract

Amoxicillin, a widely utilized semi-synthetic penicillin derivative, remains a cornerstone in treating various bacterial infections. Despite its extensive clinical application, a comprehensive in silico assessment of its pharmacokinetic and "druglikeness" properties using modern computational tools can provide valuable complementary insights. This study employed the SwissADME web platform to meticulously analyze the computed descriptors, physicochemical characteristics, ADME profile, druglikeness, and medicinal chemistry aspects of amoxicillin. The chemical structure of amoxicillin, represented by its SMILES string, was retrieved from the PubChem database and subsequently input into SwissADME for analysis. The results indicate that amoxicillin possesses a molecular weight of 365.40 g/mol and a hydrophilic nature, as evidenced by its consensus LogP value of -0.39 and high water solubility predictions. Its Topological Polar Surface Area (TPSA) is 158.26 Ų, and it contains 4 hydrogen bond donors and 6 hydrogen bond acceptors. While the in silico prediction for gastrointestinal (GI) absorption was "Low" (likely due to the high TPSA and hydrophilicity, suggesting reliance on active transport mechanisms in vivo), amoxicillin fully complies with Lipinski's Rule of Five, indicating good oral bioavailability potential. Furthermore, it is predicted not to permeate the Blood-Brain Barrier (BBB) and shows no inhibitory activity against major CYP450 enzymes (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4) or P-glycoprotein, minimizing potential drug-drug interactions. The absence of PAINS and Brenk alerts signifies a clean chemical profile regarding assay interference and toxicity flags. Although some stricter druglikeness filters were violated due to its polar nature, amoxicillin's overall in silico profile, combined with its established clinical efficacy, highlights the complex interplay of physicochemical properties and biological transport mechanisms. This study reaffirms amoxicillin's favorable attributes from a computational perspective, serving as a valuable reference for understanding established antibiotics and guiding future antimicrobial design.
A Comparative Study of the Effectiveness of the Circular Economy Approach in China and the Community-Based Approach in Indonesia in Plastic Waste Management Rizka Saputro Nugroho; Muhammad Musyarrof Bik
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.1

Abstract

Plastic waste remains a pressing global environmental challenge, with countries adopting various approaches to address it. This study aims to compare the effectiveness of China's circular economy (CE) strategy and Indonesia's community-based (CB) approach in managing plastic waste. Employing a qualitative comparative method, the research analyzes policy frameworks, case studies, and secondary data from both countries. The results reveal that China’s CE model, supported by centralized policy integration and technological innovation, achieves a recycling rate of 31%, demonstrating national scalability and efficiency. Conversely, Indonesia’s CB model promotes grassroots participation and behavioral change but faces limitations in policy consistency and scalability, with recycling rates ranging between 11–15%. Despite these differences, both approaches offer complementary strengths. China showcases systemic and industrial coordination, while Indonesia highlights the value of community engagement. This study recommends a hybrid strategy that combines China’s policy-driven structure with Indonesia’s participatory initiatives to create a more inclusive and sustainable plastic waste management model. The findings encourage policymakers and international agencies to promote knowledge exchange and develop integrated frameworks that balance regulation with public involvement.
Preventing And Mitigating Session Hijacking Using Zero Trust Architecture Santhoshkumar S; Arunarani S
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.2

Abstract

Session hijacking remains a critical threat in modern cybersecurity, allowing attackers to impersonate legitimate users by exploiting stolen session tokens. Conventional perimeter-based security frameworks often fail to prevent such attacks due to their reliance on static authentication. This study proposes a Zero Trust Architecture (ZTA) approach to prevent and mitigate session hijacking through continuous authentication, device trust verification, and micro-segmentation. A comprehensive dataset—including real-world attack traces, simulated penetration tests, and ZTA implementation logs—was used to evaluate the system's performance. The core components include risk-based access control, short-lived device-bound tokens, and behavioral analytics. Results demonstrate that the proposed model effectively blocks invalid or replayed tokens and untrusted devices, achieving a 100% detection rate in simulated hijacking scenarios. Compared to traditional methods, ZTA significantly reduces the session attack surface and improves resistance against MITM attacks. While challenges remain in user experience and legacy system compatibility, the security benefits justify implementation in cloud and hybrid enterprise environments. It is recommended that organizations adopt ZTA as a foundational security strategy to counter evolving session-based threats.
Strengths and Weaknesses of MSMEs in the Digital Era: Challenges and Opportunities for Transformation Towards Sustainable Competitiveness Dwi Yanti Octaviani; Mila Kamelia Putri; Mashudi
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.4

Abstract

This study aims to analyze the dynamics of Micro, Small, and Medium Enterprises (MSMEs) in responding to the rapid advancement of digital technology. The primary focus is to identify the internal strengths and weaknesses of MSMEs, as well as to evaluate external challenges and opportunities in the digitalization process to achieve long-term competitive advantage. Employing a qualitative approach through literature review and secondary data analysis, the study highlights operational flexibility and product innovation as key strengths of MSMEs. However, limitations in financial access, low levels of digital literacy, and infrastructure gaps remain significant barriers. Globalization and shifting consumer behavior further underscore the urgency for digital adaptation among MSMEs. On the other hand, digitalization presents significant opportunities such as market expansion, increased operational efficiency, and the enhancement of data-driven strategies. This article offers strategic recommendations, including improving digital literacy, gradual technological integration, and fostering collaboration within the digital ecosystem, to sustainably strengthen MSME competitiveness.
The Effect of Corn Husk Waste Addition in Paper Production on Surface Texture and Printability Dianta Mustofa Kamal; Nadiah Tsabitah; Nayla Nazneen
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.5

Abstract

Indonesia, as an agrarian country with abundant corn production, generates a significant volume of corn husk waste. This study aims to evaluate the effect of corn husk waste addition on the physical characteristics of recycled paper, particularly surface texture and print quality. Corn husk waste was selected due to its high cellulose content and wide availability in Indonesia. The papermaking process involved delignification using NaOH, bleaching with H₂O₂, and blending recycled paper pulp with corn husk fibers. The test results show that corn husk fibers increase paper thickness and tensile strength, while providing a rougher but still functional surface texture. Printing tests indicated that ink absorption remained adequate, although minor spreading was observed in rougher areas. Overall, the resulting paper has potential as an eco-friendly alternative for simple applications such as handicrafts and non-commercial printing.

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 2 No. 1 (2026): May Vol. 1 No. 2 (2025): November Vol. 1 No. 1 (2025): May