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All Journal Majalah Farmaseutik Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Prosiding University Research Colloquium Journal of Artificial Intelligence and Digital Business Journal of Engineering Science and Technology Management Business and Economic Publication JUKEJ: Jurnal Kesehatan Jompa Journal of Innovative and Creativity IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis Multicore International Journal of Multidisciplinary (MIJM)
Besan, Emma Jayanti
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Pengembangan Sediaan Lip Balm Berbasis Ekstrak Buah Bit (Beta vulgaris L.): Evaluasi Mutu Fisik dan Potensi SPF Besan, Emma Jayanti; Setyowati, Endang; Fadel, Muhammad Nurul; Firdyansyah, Diah Aprilia
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.100424

Abstract

Lip balm merupakan sediaan pelembab bibir untuk melindungi bibir. Buah bit (Beta vulgaris L) berfungsi sebagai antioksidan dan memiliki pontensi sebagai radikal bebas.Tujuan penelitian ini untuk menganalisis stabilitas fisik lip balm dan penentuan nilai SPF dari ekstrak buah bit. Penelitian ini dibuat lip balm dengan 3 formula ekstrak buah bit konsentrasi yang berbeda yaitu F1(5%), F2(10%), F3(15%). Jenis penelitian ini adalah eksperimental. Metode ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Sediaan lip balm dilakukan uji mutu fisik meliputi uji organoleptik, uji homogenitas , Uji pH dan selanjutnya dilakukan penentuan nilai SPF dengan metode in vitro menggunakan spektrofotometri UV-VIS. Data uji pH dan nilai SPF dianalisis menggunakan metode Kruskal Wallis untuk melihat pengaruh konsentrasi ekstrak. Berdasarkan uji Kruskal Wallis didapatkan hasil bahwa konsentrasi ekstrak buah bit berpengaruh terhadapat uji mutu fisik dan penentuan nilai SPF sediaan lip balm. Hasil uji organoleptik ke-3 formula memenuhi kriteria. Uji homogenitas ke-3 formula homogen. Uji pH ketiga formula memiliki rentang stabil pH-5 memenuhi syarat. Nilai SPF F1(5%) 1,47 F2(10%) 2,80 F3(15%) 2,96 formula F2 dan F3 memenuhi syarat SPF 2-4(Minimal). Ketiga formula memenuhi spesifikasi dan stabil uji mutu fisik pada masa simpan 14 hari. Perbedaan konsentrasi dapat mempengaruhi hasil nilai SPF, nilai spf tertinggi pada konsentrasi 15%. Ketiga formula dapat diketahui uji mutu fisik yaitu organoleptik, homogenitas, dan pH.
ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

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Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
UJI EFEKTIVITAS ANTIBAKTERI KRIM EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP PERTUMBUHAN BAKTERI Pseudomonas aeruginosa Fadel, Muhammad Nurul; Besan, Emma Jayanti; Hamzah, Hasyrul; Prasetyawan, Fendy
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Desember 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i2.643

Abstract

Infeksi bakteri masih menjadi masalah kesehatan yang signifikan. Sejumlah bakteri yang bersifat resisten dapat menyebabkan infeksi bakteri salah satunya bakteri Pseudomonas aeruginosa. Salah satu Tanaman yang memiliki aktivitas antibakteri yaitu tanaman Kersen (Muntingia calabura L.) terutama pada daunya dimana beberapa penelitian dinyatakan mengandung zat Saponin, Tanin, flavonoid dan Akaloid. Tujuan dari penelitian ini untuk mengetahui aktivitas antibakteri krim ekstrak etanol Daun Kersen (Muntingia calabura L.) terhadap pertumbuhan bakteri Pseudomonas aeruginosa. Penelitian yang dilakukan adalah penelitian eksperimental laboratorium. Metode untuk mengujian aktivitas antibakteri melalui metode difusi cakram dengan formulasi 0%, 5%, 10%, 15%, dan gentamicin. Metode menganalisis data menggunakan One Way Anova untuk mengetahui perbedaan data. Hasil uji aktivitas antibakteri krim terhadap bakteri Pseudomonas aeruginosa dengan konsentrasi 5% daya hambat sebesar 17,33 mm kategori kuat, 10% daya hambar sebesar 19,00 mm kategori kuat, dan 15% daya hambat 22,66 mm kategori sangat kuat.Berdasarkan penelitian dapat disimpulkan bahwa krim ektrak etanol Daun Kersen (Muntingia calabura L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Pseudomonas aeruginosa.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
PENINGKATAN KESEHATAN HOLISTIK MELALUI EDUKASI PEMBUATAN SIROP HERBAL “SiHebat” KEPADA MASYARAKAT Fadel, Muhammad Nurul; Besan, Emma Jayanti; Rosnarita, Intan Adevia; Yuliasari, Aulia Wahyu; Besan, Ulfa Nabila
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2093

Abstract

The diversity of herbal plants around us is a potential that has not been optimally utilized. The Nasyiatul Aisyiyah Branch Leadership for the 2024 period requires socialization and education related to health as part of filling the routine monthly religious study activities. This community service program aims to provide education to the Nasyiatul Aisyiyah group in Getas Pejaten, Kudus Regency, regarding the production process and utilization of "SiHebat" herbal syrup based on local plants such as ginger, turmeric, temulawak, and lemongrass, which have various health benefits. Educational activities are carried out through the delivery of material using power point presentation media, with a participatory method that includes a pre-test, material presentation, presentation of herbal syrup making material, and a post-test. The results of the activity showed a significant increase in participants' understanding of the use of herbal plants for health, as indicated by an increase in the average post-test score compared to the pre-test. In addition to providing education, this program also aims to encourage community independence in utilizing local natural resources and opening up business opportunities based on herbal products, in addition it can be used by the community as a reference for developing a product that can increase independence, especially in entrepreneurship. The success of the program is measured through the enthusiasm of the participants, increased knowledge, and the ability to instill the making of herbal syrup, from the results of the Pre-test and Post-test, an increase in community knowledge was obtained in understanding starting from raw materials, efficacy and how to make and rules for using efficacious herbal syrup. From the results of community service in making efficacious herbal syrup, it can provide information and benefits to the community in developing innovations in making herbal preparations, especially in making herbal syrup and in the future this program can be further developed through product diversification and joint research to optimize the benefits of herbal plants for public health.
Analisis Cost-Benefit Terapi Simvastatin dengan Atorvastatin pada Pasien Dislipidemia di Apotek 71 Kota Kediri dengan Pendekatan Human Capital Method Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Fadel, Muhammad Nurul; Besan, Emma Jayanti; Astutik, Widhi; Arifin, Chandra; Rofiq, Abd; Rhomah, Eka Hayati
Business and Economic Publication Vol. 3 No. 2 (2025): Business and Economic Publication
Publisher : Fakultas Ekonomi Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/bep.v3i2.1571

Abstract

This study aims to analyze the cost-benefit of simvastatin therapy compared to atorvastatin in dyslipidemia patients at Apotek 71 Kediri City using the Human Capital Method. Using a cross-sectional study design, this study analyzed 60 patients (30 simvastatin users, 30 atorvastatin users). Productivity loss data was collected through a patient self-report questionnaire and valued monetarily using the assumption of a uniform daily wage. Results showed that direct costs of simvastatin were lower (IDR 75,000/month) than atorvastatin (IDR 210,000/month), but lost productivity in the simvastatin group was higher (IDR 384,000) than atorvastatin (IDR 180,000). The Net Benefit value of simvastatin therapy was -Rp 39,000 with a Benefit Cost Ratio (BCR) of 0.91, while atorvastatin produced a Net Benefit of +Rp 210,000 with a BCR of 1.54. The difference in Net Benefit was statistically significant based on an independent t-test (p=0.002). Thus, atorvastatin is more economically efficient than simvastatin because it provides higher productivity benefits despite higher direct costs.
Uji Aktivitas Antioksidan Fraksi n-Heksan, Etil Asetat dan Air Ektrak Etanol Daun Pisang Kepok (Musa paradisiaca L.) dengan Metode DPPH (1,1 dipheniyl-2- picrylhidrazyl) Fadel, Muhammad Nurul; Besan, Emma Jayanti; Apriliani, Fitri; Djamal, Julia Megawati; Sholekhah, Nihayatus
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Indonesia merupakan negara tropis yang mempunyai keragaman flora yang berpotensi besar untuk dikembangkan dalam pengobatan tradisional. Salah satu tumbuhan yang terdistribusi secara luas di Indonesia dan memiliki aktivitas antioksidan yaitu daun pisang kepok (Musa Paradisiaca L.). Daun pisang memiliki kandungan senyawa flavonoid, polifenol, tannin, alkoloid, dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas antipksidan dari fraksi n-heksan, fraksi etil asetat, dan fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) dengan metode DPPH. Penelitian ini menggunakan jenis penelitian eksperimental. Metode pembuatan ekstrak menggunakan maserasi dengan pelarut etanol 70%. Setelah didapatkan ekstrak dilanjutkan dengan proses fraksinasi dengan pelarut n-heksan, etil asetat, dan air. Hasil dari fraksi diuji aktivitas antioksidannya dengan metode DPPH menggunakan alat spektrofotometri UV- Vis. Aktivitas antioksidan dari berbagai fraksi dinyatakan dalam bentuk nilai IC50. Hasil skrinning fitokimia ekstrak etanol 70% daun pisang kepok (Musa Paradisiaca L.) mengandung senyawa flavonoid, alkoloid, tanin, saponin, dan polifenol. Hasil penelitian ini diperoleh bahwa uji aktivitas antioksidan yang dinyatakan dengan nilai IC50 pada fraksi n-heksana, fraksi etil asetat, fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) berturut-turut yaitu: 53,87 ppm, 12,96 ppm, dan 34,11 ppm. Fraksi etil asetat, fraksi air, dan kontrol positif vitamin C memiliki aktivitas antioksidan sangat kuat, sedangkan fraksi n-heksan memiliki aktivitas antioksidan kuat.
Prediction of Scabertopin from Tapak Liman (Elephantopus scaber) for Antileukemic Saristiana, Yuneka; Prasetyawan, Fendy; Salmasfattah, Novynanda; Ilmi, Tsamrotul; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.5

Abstract

Leukemia remains a significant global health challenge, necessitating the exploration of novel therapeutic agents with improved efficacy and safety profiles. Elephantopus scaber (commonly known as Tapak Liman) is a medicinal plant traditionally used for various ailments, including cancer. Scabertopin, a sesquiterpene lactone isolated from E. scaber, has attracted scientific interest due to its potential antileukemic properties. This study aims to predict the antileukemic activity of Scabertopin through an in silico approach. The compound's chemical structure was retrieved in SMILES format from the PubChem database and analyzed using the PASS (Prediction of Activity Spectra for Substances) online tool. The prediction results indicated a high probability of antileukemic activity, with a Pa (probability of activity) value of 0.822 and a Pi (probability of inactivity) value of 0.004. These findings suggest a strong likelihood that Scabertopin exhibits antileukemic effects, supporting its potential as a candidate for further pharmacological and clinical investigations. The use of computational prediction tools provides an efficient and cost-effective preliminary screening method for identifying promising bioactive compounds from natural sources. This study contributes valuable insights into the therapeutic potential of Scabertopin and highlights the importance of traditional medicinal plants in drug discovery for leukemia treatment.
Pharmacokinetics and Druglikeness of Amoxicillin Drug using SwissADME Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Rhomah, Eka Hayati; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.3

Abstract

Amoxicillin, a widely utilized semi-synthetic penicillin derivative, remains a cornerstone in treating various bacterial infections. Despite its extensive clinical application, a comprehensive in silico assessment of its pharmacokinetic and "druglikeness" properties using modern computational tools can provide valuable complementary insights. This study employed the SwissADME web platform to meticulously analyze the computed descriptors, physicochemical characteristics, ADME profile, druglikeness, and medicinal chemistry aspects of amoxicillin. The chemical structure of amoxicillin, represented by its SMILES string, was retrieved from the PubChem database and subsequently input into SwissADME for analysis. The results indicate that amoxicillin possesses a molecular weight of 365.40 g/mol and a hydrophilic nature, as evidenced by its consensus LogP value of -0.39 and high water solubility predictions. Its Topological Polar Surface Area (TPSA) is 158.26 Ų, and it contains 4 hydrogen bond donors and 6 hydrogen bond acceptors. While the in silico prediction for gastrointestinal (GI) absorption was "Low" (likely due to the high TPSA and hydrophilicity, suggesting reliance on active transport mechanisms in vivo), amoxicillin fully complies with Lipinski's Rule of Five, indicating good oral bioavailability potential. Furthermore, it is predicted not to permeate the Blood-Brain Barrier (BBB) and shows no inhibitory activity against major CYP450 enzymes (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4) or P-glycoprotein, minimizing potential drug-drug interactions. The absence of PAINS and Brenk alerts signifies a clean chemical profile regarding assay interference and toxicity flags. Although some stricter druglikeness filters were violated due to its polar nature, amoxicillin's overall in silico profile, combined with its established clinical efficacy, highlights the complex interplay of physicochemical properties and biological transport mechanisms. This study reaffirms amoxicillin's favorable attributes from a computational perspective, serving as a valuable reference for understanding established antibiotics and guiding future antimicrobial design.
Uji Aktivitas Antioksidan Ekstrak dan Fraksi-Fraksi Herba Suruhan (Peperomia Pellucida L.) dengan Metode DPPH Besan, Emma Jayanti; Fadel, Muhammad Nurul; Dahbul, Nura Ali; Dameria, Gempita Hutami; Prasetyawan, Fendy
IJF (Indonesia Jurnal Farmasi) Vol 9, No 1 (2024): IJF (Indonesia Jurnal Farmasi)
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v9i1.2421

Abstract

Tanaman suruhan (Peperomia pellucida L.) merupakan tanaman yang secara empiris digunakan masyarakat dalam dunia pengobatan, berkaitan dengan kandungan antioksidannya yaitu flavonoid, alkaloid, tanin, saponin dan polifenol. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan fraksi n-heksan, etil asetat dan air dari ekstrak etanol herba suruhan dengan metode penangkapan radikal DPPH. Herba suruhan diekstraksi menggunakan etanol 70%, difraksinasi dengan n-heksan, etil asetat dan air dan dilakukan analisis antioksidan menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa masing-masing fraksi memiliki aktivitas antioksidan dengan nilai IC50 untuk fraksi n-heksan, etil asetat, air dan vitamin C berturut-turut adalah 74,44; 16,98; 38,26; 10,84 µg/mL. Hasil analisis statistika tidak ada perbedaan yang signifikan antara fraksi n-heksan, etil asetat dan air dari ekstrak etanol herba suruhan dengan kontrol positif vitamin C. Aktivitas antioksidan terbaik terdapat pada fraksi etil asetat.
Co-Authors Astutik, Widhi Ayuningsih, Safitri Besan, Ulfa Nabila Chandra Arifin Dahbul, Nura Ali Dameria, Gempita Hutami Endang Setyowati Etikasari, Ria Faisal Akhmal Muslikh Faradila, Fatarani Febriana, Laela Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Hamzah, Hasyrul Handayani, Ratna Fitriana Hasriyani Hasriyani, Hasriyani Intan Adevia Rosnarita Julia Megawati Djamal Kadir, Mujtahid Bin And Lisa Savitri Mildawati, Ratna Mudik, Edo Muhammad Nurul Fadel Nurul Huda Oktadiana, Isma Rahmawati, Izda Rahmawati, Riana Putri Rhomah, Eka Hayati Rofiq, Abd Salmasfattah, Novyananda Salmasfattah, Novynanda Saputri, Ardiani Maulina Sari, Fatika Setyaningrum, Intansari Sholekhah, Nihayatus Tsamrotul Ilmi Yuliasari, Aulia Wahyu Yuneka Saristiana