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All Journal Majalah Farmaseutik Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Prosiding University Research Colloquium Journal of Engineering Science and Technology Management Business and Economic Publication Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis Multicore International Journal of Multidisciplinary (MIJM)
Besan, Emma Jayanti
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Pengembangan Sediaan Lip Balm Berbasis Ekstrak Buah Bit (Beta vulgaris L.): Evaluasi Mutu Fisik dan Potensi SPF Besan, Emma Jayanti; Setyowati, Endang; Fadel, Muhammad Nurul; Firdyansyah, Diah Aprilia
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.100424

Abstract

Lip balm merupakan sediaan pelembab bibir untuk melindungi bibir. Buah bit (Beta vulgaris L) berfungsi sebagai antioksidan dan memiliki pontensi sebagai radikal bebas.Tujuan penelitian ini untuk menganalisis stabilitas fisik lip balm dan penentuan nilai SPF dari ekstrak buah bit. Penelitian ini dibuat lip balm dengan 3 formula ekstrak buah bit konsentrasi yang berbeda yaitu F1(5%), F2(10%), F3(15%). Jenis penelitian ini adalah eksperimental. Metode ekstraksi menggunakan metode maserasi dengan pelarut etanol 70%. Sediaan lip balm dilakukan uji mutu fisik meliputi uji organoleptik, uji homogenitas , Uji pH dan selanjutnya dilakukan penentuan nilai SPF dengan metode in vitro menggunakan spektrofotometri UV-VIS. Data uji pH dan nilai SPF dianalisis menggunakan metode Kruskal Wallis untuk melihat pengaruh konsentrasi ekstrak. Berdasarkan uji Kruskal Wallis didapatkan hasil bahwa konsentrasi ekstrak buah bit berpengaruh terhadapat uji mutu fisik dan penentuan nilai SPF sediaan lip balm. Hasil uji organoleptik ke-3 formula memenuhi kriteria. Uji homogenitas ke-3 formula homogen. Uji pH ketiga formula memiliki rentang stabil pH-5 memenuhi syarat. Nilai SPF F1(5%) 1,47 F2(10%) 2,80 F3(15%) 2,96 formula F2 dan F3 memenuhi syarat SPF 2-4(Minimal). Ketiga formula memenuhi spesifikasi dan stabil uji mutu fisik pada masa simpan 14 hari. Perbedaan konsentrasi dapat mempengaruhi hasil nilai SPF, nilai spf tertinggi pada konsentrasi 15%. Ketiga formula dapat diketahui uji mutu fisik yaitu organoleptik, homogenitas, dan pH.
ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
UJI EFEKTIVITAS ANTIBAKTERI KRIM EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP PERTUMBUHAN BAKTERI Pseudomonas aeruginosa Fadel, Muhammad Nurul; Besan, Emma Jayanti; Hamzah, Hasyrul; Prasetyawan, Fendy
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Desember 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i2.643

Abstract

Infeksi bakteri masih menjadi masalah kesehatan yang signifikan. Sejumlah bakteri yang bersifat resisten dapat menyebabkan infeksi bakteri salah satunya bakteri Pseudomonas aeruginosa. Salah satu Tanaman yang memiliki aktivitas antibakteri yaitu tanaman Kersen (Muntingia calabura L.) terutama pada daunya dimana beberapa penelitian dinyatakan mengandung zat Saponin, Tanin, flavonoid dan Akaloid. Tujuan dari penelitian ini untuk mengetahui aktivitas antibakteri krim ekstrak etanol Daun Kersen (Muntingia calabura L.) terhadap pertumbuhan bakteri Pseudomonas aeruginosa. Penelitian yang dilakukan adalah penelitian eksperimental laboratorium. Metode untuk mengujian aktivitas antibakteri melalui metode difusi cakram dengan formulasi 0%, 5%, 10%, 15%, dan gentamicin. Metode menganalisis data menggunakan One Way Anova untuk mengetahui perbedaan data. Hasil uji aktivitas antibakteri krim terhadap bakteri Pseudomonas aeruginosa dengan konsentrasi 5% daya hambat sebesar 17,33 mm kategori kuat, 10% daya hambar sebesar 19,00 mm kategori kuat, dan 15% daya hambat 22,66 mm kategori sangat kuat.Berdasarkan penelitian dapat disimpulkan bahwa krim ektrak etanol Daun Kersen (Muntingia calabura L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Pseudomonas aeruginosa.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
PENINGKATAN KESEHATAN HOLISTIK MELALUI EDUKASI PEMBUATAN SIROP HERBAL “SiHebat” KEPADA MASYARAKAT Fadel, Muhammad Nurul; Besan, Emma Jayanti; Rosnarita, Intan Adevia; Yuliasari, Aulia Wahyu; Besan, Ulfa Nabila
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2093

Abstract

The diversity of herbal plants around us is a potential that has not been optimally utilized. The Nasyiatul Aisyiyah Branch Leadership for the 2024 period requires socialization and education related to health as part of filling the routine monthly religious study activities. This community service program aims to provide education to the Nasyiatul Aisyiyah group in Getas Pejaten, Kudus Regency, regarding the production process and utilization of "SiHebat" herbal syrup based on local plants such as ginger, turmeric, temulawak, and lemongrass, which have various health benefits. Educational activities are carried out through the delivery of material using power point presentation media, with a participatory method that includes a pre-test, material presentation, presentation of herbal syrup making material, and a post-test. The results of the activity showed a significant increase in participants' understanding of the use of herbal plants for health, as indicated by an increase in the average post-test score compared to the pre-test. In addition to providing education, this program also aims to encourage community independence in utilizing local natural resources and opening up business opportunities based on herbal products, in addition it can be used by the community as a reference for developing a product that can increase independence, especially in entrepreneurship. The success of the program is measured through the enthusiasm of the participants, increased knowledge, and the ability to instill the making of herbal syrup, from the results of the Pre-test and Post-test, an increase in community knowledge was obtained in understanding starting from raw materials, efficacy and how to make and rules for using efficacious herbal syrup. From the results of community service in making efficacious herbal syrup, it can provide information and benefits to the community in developing innovations in making herbal preparations, especially in making herbal syrup and in the future this program can be further developed through product diversification and joint research to optimize the benefits of herbal plants for public health.
Formulation and Antibacterial Activity Testing of Face Mist Made from Red Betel Leaf (Piper Crocatum Ruiz and Pav.) Ethanol Extract Against Propionibacterium Acnes Anggraeni, Ira; Rahmawati, Riana Putri; Besan, Emma Jayanti
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.571

Abstract

Purpose: This study aimed to formulate and evaluate the antibacterial activity of face mist containing ethanol extract of red betel leaf (Piper crocatum Ruiz & Pav.) against Propionibacterium acnes, with the hypothesis that higher extract concentrations enhance antibacterial efficacy. Research Method: A quantitative experimental design was conducted using three formulations with extract concentrations of 15%, 25%, and 35%, alongside positive (clindamycin 300 mg) and negative (base face mist) controls. Samples were obtained from Kayen Village, Pati Regency, Indonesia. Physical evaluations included organoleptic, homogeneity, pH, and spreadability tests, while antibacterial activity was assessed using the disc diffusion method. Data were analyzed with Shapiro–Wilk, Levene’s, One-Way ANOVA, and LSD Post Hoc tests. Results and Discussion: All formulations met physical quality standards. Antibacterial testing showed inhibition zones of 7.57 mm (moderate) for 15%, 10.67 mm (strong) for 25%, and 13.47 mm (strong) for 35%, with higher concentrations producing greater inhibition. Positive control exhibited a 37.60 mm (very strong) inhibition zone, while the negative control showed no activity. Implications: Red betel leaf extract demonstrates potential as a natural antibacterial ingredient in acne treatment formulations. The 35% concentration was optimal but still less effective than clindamycin. Future research should focus on optimizing formulation stability, enhancing sensory appeal, and exploring synergistic combinations to improve efficacy.
Formulation and Antioxidant Activity Test of Micellar Water Extracted from Mangosteen Fruit Peel (Garcinia mangostana L.) Using the DPPH Method with Variations in the Concentration of PEG-7 Glyceryl Cocoate as a Surfactant Andriyani, Yunita; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.588

Abstract

Purpose: This study aims to determine the effect of PEG-7 glyceryl cocoate at concentrations of F1 0.2%, F2 0.4%, and F3 0.6% on the physical stability and cleaning power of micellar water preparations containing mangosteen peel extract. The best formulation was then tested for its antioxidant activity using the DPPH method. Research Method: This study used a laboratory experimental method. The variations in PEG-7 glyceryl cocoate concentration used in the micellar water extract of mangosteen peel were F1 (0.2%), F2 (0.4%), F3 (0.6%), and negative control F0 (0%). Evaluations were conducted on physical stability tests (organoleptic, pH, homogeneity, and viscosity) and cleaning power. The best micellar water formulation was then tested for antioxidant activity using the DPPH method. The test results were analyzed using a One-Way ANOVA test. Results and Discussion: The results of testing F3 micellar water, with the highest concentration of PEG-7 glyceryl cocoate, demonstrated that it was the best formula and exhibited the best cleaning ability. The results of the analysis using one-way ANOVA showed a p-value of < 0.05. The antioxidant activity of F3 was determined to have an IC50 of 103.81 μg/ml, which falls within the moderate category. Implications: The results of this study indicate that PEG-7 glyceryl cocoate at a concentration of 0.6% can be used as a surfactant in micellar water preparations of mangosteen peel extract. Further research is needed to determine the long-term stability of the preparation.
Analisis Cost-Benefit Terapi Simvastatin dengan Atorvastatin pada Pasien Dislipidemia di Apotek 71 Kota Kediri dengan Pendekatan Human Capital Method Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Fadel, Muhammad Nurul; Besan, Emma Jayanti; Astutik, Widhi; Arifin, Chandra; Rofiq, Abd; Rhomah, Eka Hayati
Business and Economic Publication Vol. 3 No. 2 (2025): Business and Economic Publication
Publisher : Fakultas Ekonomi Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/bep.v3i2.1571

Abstract

This study aims to analyze the cost-benefit of simvastatin therapy compared to atorvastatin in dyslipidemia patients at Apotek 71 Kediri City using the Human Capital Method. Using a cross-sectional study design, this study analyzed 60 patients (30 simvastatin users, 30 atorvastatin users). Productivity loss data was collected through a patient self-report questionnaire and valued monetarily using the assumption of a uniform daily wage. Results showed that direct costs of simvastatin were lower (IDR 75,000/month) than atorvastatin (IDR 210,000/month), but lost productivity in the simvastatin group was higher (IDR 384,000) than atorvastatin (IDR 180,000). The Net Benefit value of simvastatin therapy was -Rp 39,000 with a Benefit Cost Ratio (BCR) of 0.91, while atorvastatin produced a Net Benefit of +Rp 210,000 with a BCR of 1.54. The difference in Net Benefit was statistically significant based on an independent t-test (p=0.002). Thus, atorvastatin is more economically efficient than simvastatin because it provides higher productivity benefits despite higher direct costs.
Uji Aktivitas Antioksidan Fraksi n-Heksan, Etil Asetat dan Air Ektrak Etanol Daun Pisang Kepok (Musa paradisiaca L.) dengan Metode DPPH (1,1 dipheniyl-2- picrylhidrazyl) Fadel, Muhammad Nurul; Besan, Emma Jayanti; Apriliani, Fitri; Djamal, Julia Megawati; Sholekhah, Nihayatus
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia merupakan negara tropis yang mempunyai keragaman flora yang berpotensi besar untuk dikembangkan dalam pengobatan tradisional. Salah satu tumbuhan yang terdistribusi secara luas di Indonesia dan memiliki aktivitas antioksidan yaitu daun pisang kepok (Musa Paradisiaca L.). Daun pisang memiliki kandungan senyawa flavonoid, polifenol, tannin, alkoloid, dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas antipksidan dari fraksi n-heksan, fraksi etil asetat, dan fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) dengan metode DPPH. Penelitian ini menggunakan jenis penelitian eksperimental. Metode pembuatan ekstrak menggunakan maserasi dengan pelarut etanol 70%. Setelah didapatkan ekstrak dilanjutkan dengan proses fraksinasi dengan pelarut n-heksan, etil asetat, dan air. Hasil dari fraksi diuji aktivitas antioksidannya dengan metode DPPH menggunakan alat spektrofotometri UV- Vis. Aktivitas antioksidan dari berbagai fraksi dinyatakan dalam bentuk nilai IC50. Hasil skrinning fitokimia ekstrak etanol 70% daun pisang kepok (Musa Paradisiaca L.) mengandung senyawa flavonoid, alkoloid, tanin, saponin, dan polifenol. Hasil penelitian ini diperoleh bahwa uji aktivitas antioksidan yang dinyatakan dengan nilai IC50 pada fraksi n-heksana, fraksi etil asetat, fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) berturut-turut yaitu: 53,87 ppm, 12,96 ppm, dan 34,11 ppm. Fraksi etil asetat, fraksi air, dan kontrol positif vitamin C memiliki aktivitas antioksidan sangat kuat, sedangkan fraksi n-heksan memiliki aktivitas antioksidan kuat.
Antibacterial Potential of Ethanol Extract Cream of Kersen Leaves (muntingia Calabura L) Against Pseudomonas Aeruginosa Fadel, Muhammad Nurul; Besan, Emma Jayanti; Ridwanto, Muhammad
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5187

Abstract

Bacterial infections remain a substantial health concern. Several resistant microorganisms can induce bacterial infections, including Pseudomonas aeruginosa. Some research indicate that Kersen leaves (Muntingia calabura L), due to its flavonoids, tannins, and saponins that have undergone clinical testing, possess antibacterial characteristics. This study seeks to evaluate the antibacterial efficacy of a 96% ethanol extract cream derived from Kersen leaves (Muntingia calabura L) against the proliferation of Pseudomonas aeruginosa bacteria. The research performed was experimental in a laboratory setting. The procedure for evaluating antibacterial efficacy via the disc diffusion method utilising formulations of 0%, 5%, 10%, 15%, and gentamicin. The technique of data analysis employing One Way ANOVA to discover differences in data. The antibacterial activity of the cream against Pseudomonas aeruginosa was tested, yielding a 5% inhibition of 17.33 mm (strong category), 10% inhibition of 19.00 mm (strong category), and 15% inhibition of 22.66 mm (very strong category). The research concludes that a 96% ethanol extract cream of Kersen leaves (Muntingia calabura L) possesses the potential to suppress the growth of Pseudomonas aeruginosa bacteria.
Co-Authors Andriyani, Yunita Anggraeni, Ira Astutik, Widhi Ayuningsih, Safitri Besan, Ulfa Nabila Chandra Arifin Dahbul, Nura Ali Dameria, Gempita Hutami Endang Setyowati Faisal Akhmal Muslikh Faradila, Fatarani Febriana, Laela Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Hamzah, Hasyrul Hasriyani Hasriyani, Hasriyani Julia Megawati Djamal Kadir, Mujtahid Bin And Mildawati, Ratna Muhammad Nurul Fadel Nurul Huda Oktadiana, Isma Rahmawati, Izda Rahmawati, Riana Putri Rhomah, Eka Hayati Ridwanto, Muhammad Rofiq, Abd Rosnarita, Intan Adevia Salmasfattah, Novyananda Salmasfattah, Novynanda Saputri, Ardiani Maulina savitri, Lisa Setyaningrum, Intansari Sholekhah, Nihayatus Tsamrotul Ilmi Yuliasari, Aulia Wahyu Yuneka Saristiana