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Science Get Journal
Published by CV. Get Press Indonesia
ISSN : -     EISSN : 30626595     DOI :  http://doi.org/10.69855/science
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Physics
A Peer Reviewed Research Science Get Journal e-ISSN: 3062-6595 Science Get Journal is an Open Access and Anonymous Reviewer/Anonymous Author journal. The field of Science is a vehicle for scientific communication in the field of Science which covers the cross-fields of Mathematics, Physics, Chemistry, Biology, Geography and Mathematics,  Natural Sciences Education and Social Sciences. Science Get Journal is published by Get Press Indonesia. Science Get Journal is used to publish research published every month January, April, July, and October. The Science Get Journal template can be downloaded here (Click). Information about article submission: Articles sent by the author (author) will be seen and read by the editor, if there are still discrepancies with the applicable template and do not comply with the scope of Science Get Journal then the article will be returned to the author. If it is appropriate, the article will be forwarded to the Science Get Journal reviewer for a review process carried out by the Science Get Journal reviewer. A total of two reviewers within a two week period of evaluating the article.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol 3 No 1 (2026): January, 2026" : 9 Documents clear
Synthesis and Characterization of Graphene Oxide-Based Composite Membranes for Enhanced Seawater Desalination Process Efficiency Andi Haslinah; Lieza Corsita; Setiarto Pratigto; Indah Tri Rizky; Adianti Putri Alitonang
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.354

Abstract

Graphene oxide (GO) is a promising nanomaterial for membrane-based desalination due to its tunable interlayer structure and abundant surface functionalities. This study synthesized and characterized a graphene oxide titanium dioxide (GO–TiO₂) composite membrane via vacuum-assisted filtration to enhance seawater desalination performance. Characterization using XRD, FTIR, SEM, and contact angle analysis confirmed uniform TiO₂ incorporation, which expanded GO interlayer spacing from 0.77 nm to 0.90 nm, increased hydrophilicity, and improved structural stability. Forward osmosis (FO) tests using 3.5 wt% NaCl feed solution showed that the GO–TiO₂ membrane achieved over 99% salt rejection and a 125% increase in water flux compared to pristine GO membranes. TiO₂ acted as a nano-spacer and hydrophilic agent, reducing GO restacking and facilitating water transport. These results indicate that the GO–TiO₂ composite membrane offers enhanced permeability, selectivity, and durability, making it a promising candidate for sustainable seawater desalination.
Engineering Structure and Stability of Next-Generation Perovskite Materials for Optimization of Photovoltaic Solar Cell Efficiency Anugrah; Rismen Sinambela
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.371

Abstract

Perovskite solar cells (PSCs) are a promising next-generation photovoltaic technology due to their high power conversion efficiency (PCE) and facile fabrication. However, structural instability, environmental sensitivity, and operational degradation limit their practical applications. This study investigates the effects of compositional and interfacial engineering on PSC performance and stability. Three perovskite types mixed-cation, interface-modified, and anti-perovskite were fabricated and characterized in terms of crystallinity, morphology, optical absorption, and electrical performance. Mixed-cation perovskites exhibited superior crystallinity, homogeneous morphology, broad optical absorption, the highest PCE (21.0 ± 0.3%), and 86.7% efficiency retention after 500 hours. Interface-modified PSCs enhanced Voc and fill factor, whereas anti-perovskites showed the lowest performance due to poor crystallinity and secondary phase formation. These findings indicate that combining cation/anion compositional engineering with interface modification is an effective strategy for developing high-performance and stable PSCs, offering insights for next-generation photovoltaic device optimization
Evaluation of Microplastic Content in Human Circulatory System and Its Potential Impacts on Systemic Health Kun Mardiwati Rahayu; Mila Sari; Pratiwi Ratih Halimatus Sya'diah
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.357

Abstract

Given the escalating global production of plastics and the absence of regulatory frameworks addressing internal human exposure, microplastic contamination has emerged as an urgent environmental and public health policy concern.Using micro Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy, MPs were detected in 76.0% of samples collected from 50 healthy adults, with an average concentration of 3.15 ± 1.25 particles/mL and a mean particle size of 5.8 ± 2.1 μm. Polyethylene terephthalate (PET) and polypropylene (PP) were the dominant polymer types, while fragments and fibers represented the most common morphologies. Correlation analyses revealed significant positive associations between total MP concentration and inflammatory biomarkers C-reactive protein (r = +0.415, p = 0.003) and interleukin-6 (r = +0.288, p = 0.043) as well as oxidative stress marker malondialdehyde (r = +0.350, p = 0.013), suggesting that MPs may contribute to subclinical systemic inflammation and oxidative imbalance. These findings provide empirical evidence supporting the systemic circulation of MPs and their potential role as low-grade biological stressors that could influence vascular homeostasis. Further longitudinal and mechanistic studies are warranted to elucidate causal pathways, characterize nanoplastic fractions, and establish standardized analytical protocols. This research underscores the growing necessity to treat microplastic exposure as a critical environmental and public health issue.
Study on Material Innovation and Electrochemical Performance in Solid-State Battery Technology for Sustainable Energy Applications Herlina Rahim; Rozlinda Dewi; Venny Yusiana; Rismen Sinambela
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.373

Abstract

Solid-state batteries (SSBs) have gained strong attention for their higher safety, greater energy density, and improved electrochemical stability compared to liquid-electrolyte lithium-ion batteries, although challenges remain in optimizing ionic conductivity, interfacial resistance, and cycling stability. This study investigates the synthesis, structural characteristics, and electrochemical performance of the argyrodite solid electrolyte Li₆PS₅Cl (LPSC), produced via high-energy mechanical milling and integrated into a prototype SSB using a Li-metal anode and NMC811 cathode. XRD analysis confirmed the formation of the cubic argyrodite phase, while SEM revealed a homogeneous particle morphology conducive to efficient ion transport. Electrochemical impedance spectroscopy (EIS) showed an ionic conductivity of 1.87 × 10⁻³ S/cm at 25°C, which increased to 3.41 × 10⁻³ S/cm after annealing at 550°C. Galvanostatic cycling at 0.1C demonstrated stable capacity retention of 92.5% after 50 cycles, indicating strong interfacial contact between the LPSC electrolyte and NMC811 cathode. Comparative evaluation with recent SSB literature shows that the optimized LPSC electrolyte achieves performance levels comparable to state-of-the-art sulfide-based electrolytes due to improved crystallinity and reduced grain-boundary resistance. These results highlight the potential of mechanically milled LPSC as a promising solid electrolyte for next-generation SSB applications.
Integration of Photocatalysis and Membrane Technology as a Hybrid System for Microplastic Degradation in Wastewater Sri Rahayu Dwi Purnaningtyas; Mila Sari; Eka Cahya Muliawati
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.411

Abstract

Microplastic contamination in wastewater poses a serious threat to aquatic ecosystems and human health due to its persistence and limited removal by conventional treatment processes. This study evaluates a hybrid photocatalytic membrane reactor (PMR) integrating TiO₂-based photocatalysis with membrane filtration for the removal and degradation of polyethylene (PE), polypropylene (PP), and polyester (PET) microplastics. Photocatalytic membranes were fabricated via phase inversion using polyethersulfone (PES) and characterized by SEM, XRD, contact angle, porosity, and water flux measurements.TiO₂ incorporation significantly increased membrane hydrophilicity and permeability while maintaining the asymmetric structure and anatase crystallinity. The hybrid PMR achieved microplastic removal efficiencies above 99% for all polymers, outperforming membrane-only filtration and standalone photocatalysis. FTIR and SEM analyses confirmed oxidative polymer chain scission, while mineralization efficiencies reached 8.7%, 11.3%, and 18.9% for PE, PP, and PET, respectively. The degradation followed apparent first-order kinetics, with PET showing the highest rate constant. Hydroxyl radicals were identified as the dominant reactive species. The PMR also exhibited mitigated membrane fouling, stable performance over five cycles, and negligible TiO₂ leaching. The specific energy consumption ranged from 0.38 to 0.46 kWh m⁻³ with an estimated operational cost of USD 0.42–0.53 per m³. These findings demonstrate the technical and economic feasibility of the hybrid PMR for advanced microplastic treatment.
Exploration of CRISPR-Cas9 Gene Editing System Utilization for Targeted Induction of Apoptosis in Cancer Cells Resti Ariani; Eka Cahya Muliawati; Zola Efa Harnis
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.436

Abstract

The CRISPR-Cas9 gene editing system represents a powerful approach for precision targeting of genetic determinants involved in cancer cell survival. This study evaluated the ability of CRISPR-Cas9 to induce apoptosis in cancer cells through targeted disruption of anti-apoptotic genes. Acute myeloid leukemia (HL-60 and KG-1) and anaplastic thyroid cancer (8505C and C643) cell lines were used to knockout BIRC5 (survivin) and MADD using specific single-guide RNAs. Efficient genome editing was achieved, with indel formation exceeding 50% across all models. Targeting BIRC5 and MADD significantly reduced cell viability to 39.8–54.6% of control levels and induced substantial apoptosis. Total apoptotic populations reached 52.8–60.1% following BIRC5 knockout and 45.3–50.6% following MADD knockout. Apoptosis induction was confirmed by caspase-3/7 activation, increased Sub-G1 accumulation, and cleavage of apoptosis-related proteins, indicating activation of the intrinsic apoptotic pathway.Notably, BIRC5 disruption consistently produced stronger pro-apoptotic effects than MADD across all cancer models. Overall, these findings highlight the therapeutic potential of CRISPR-Cas9–mediated targeting of anti-apoptotic genes as a promising strategy for precision oncology and for overcoming resistance to conventional cancer therapies.
Development of Deterministic-Stochastic Mathematical Models for Predicting Zoonotic Disease Transmission Dynamics in Tropical Regions Khairunnisa Fadhilla Ramdhania
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.437

Abstract

Leptospirosis is a re-emerging zoonotic disease involving complex interactions between humans, animal reservoirs, and the environment. This study investigates leptospirosis transmission using a coupled human–rodent SIR–SIR model under deterministic and stochastic frameworks. The basic reproduction number ( ) was derived analytically to determine invasion thresholds. Deterministic analysis shows that when , the disease persists and converges to an endemic equilibrium. In contrast, stochastic simulations reveal substantial variability in transmission dynamics and demonstrate the possibility of disease extinction even under conditions that deterministically predict persistence. Sensitivity analysis identifies the rodent-tohuman transmission rate and human recovery rate as key parameters influencing . These findings highlight the limitations of purely deterministic models and emphasize the importance of stochastic approaches for capturing realistic zoonotic disease dynamics. The proposed framework provides insights for developing integrated control strategies combining reservoir management, environmental intervention, and early treatment.
Modified Cellulose Membranes Show High Performance for Oil–Water Separation in Wastewater Treatment Ian Kurniawan
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.440

Abstract

Efficient separation of oil–water emulsions is critical for environmental protection and industrial wastewater treatment. In this study, cellulose membranes were surface-modified by introducing hydrophilic functional groups to enhance hydrophilicity, permeability, and antifouling performance. The modified membrane exhibited a significant decrease in water contact angle from 46.3° to 12.8°, indicating markedly improved wettability. FTIR and XRD analyses confirmed successful surface modification without altering the crystalline structure of cellulose. Compared to the pristine membrane, the modified membrane showed increased porosity (78.6%) and water uptake (126.4%), leading to enhanced pure water flux (3,420 L·m⁻²·h⁻¹) and stable oil–water emulsion flux (2,680 L·m⁻²·h⁻¹), with an oil rejection efficiency exceeding 99%. The membrane also demonstrated superior antifouling performance, with a flux recovery ratio of 91.3%, and maintained high separation efficiency over multiple filtration cycles, indicating excellent reusability and operational stability. These results demonstrate that surface modification is an effective strategy for developing high-performance and sustainable cellulose membranes for oil–water separation in wastewater treatment applications.
The Application of CRISPR-Based Genetic Engineering for the Elimination of Harmful Inherited Diseases in Human Embryos Eka Cahya Muliawati
Science Journal Get Press Vol 3 No 1 (2026): January, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v3i1.446

Abstract

CRISPR-Cas9 genome editing offers a theoretical approach for preventing inherited diseases by correcting pathogenic mutations at the embryonic stage. This study presents a simulation-based assessment of CRISPR-Cas9–mediated correction of the pathogenic CAG repeat expansion in the Huntingtin (HTT) gene using a human embryo model. The analysis evaluated predicted editing efficiency, early developmental outcomes, unintended genomic modifications, and Huntingtin protein expression. Simulation results indicated that precise genetic correction was achieved in 42.7% of embryos, while a substantial proportion exhibited mosaic or partial editing. CRISPR-edited embryos showed a modest improvement in predicted blastocyst formation compared to untreated mutant controls but remained inferior to wild-type embryos. Unintended genomic alterations, including off-target edits and large deletions near the target site, were observed in a notable subset of embryos. Protein expression analysis suggested partial restoration of normal Huntingtin localization in successfully corrected embryos.These findings indicate that although CRISPR Cas9 mediated germline correction is theoretically feasible, persistent mosaicism and safety concerns currently limit its clinical applicability. Germline genome editing should therefore remain restricted to carefully regulated research settings.

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