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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 56, No. 1" : 15 Documents clear
Front Matter Vol. 56, No. 1 March (2020) Matter, Front
Folia Medica Indonesiana Vol. 56, No. 1
Publisher : Folia Medica Indonesiana

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Differences of Indirect MAR Test in the Unexplained Infertile and Fertile Couples Ramadhona, Nur Hafiz; Hinting, Aucky; Lunardhi, Hamdani
Folia Medica Indonesiana Vol. 56, No. 1
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Infertility is the inability of a partner to get pregnant after regular sexual intercourse without contraception for 12 months. Based on the cause, male infertility is caused by genetic, hormonal, infectious, sexual, and unexplained infertility. However, many infertile couples are classified into unexplained infertility without an antisperm antibody (ASA) immunological examination. This study aimed to prove that couples classified as unexplained infertility can be caused by ASA wives. This was an observational study with a cross sectional study design. The sample consisted of 2 groups, in which the first group consisted of 36 fertile couples and the second group consisted of 35 unexplained infertility couples. All samples were carried out indirect MAR test to obtain the ASA value of the wife. If the wife's ASA value was >40%, the ASA results were positive. Conversely, if the ASA value was <40%, the ASA results were negative. From these 2 groups, there was a statistically significant difference (p<0.0001) that the wife's ASA value in the unexplained infertility group was significantly higher than that in the fertile group. This study concluded that the positive ASA results from the indirect MAR test were significantly found in the unexplained infertility sample.
Profile of Secondary Glaucoma at a Tertiary Hospital in East Java Komaratih, Evelyn; Rindiastuti, Yuyun; Primitasari, Yulia
Folia Medica Indonesiana Vol. 56, No. 1
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Glaucoma is the leading cause of irreversible blindness. The aim of this study was to review the profile of secondary glaucoma cases visiting a tertiary hospital in East Java. This is retrospective observational study, completed case records of new patients with secondary glaucoma who presented to glaucoma clinic from January 2014 to April 2016 were included. Out of the 363 case records screened, 66 cases were found to eligible for inclusion. The evaluation included a detailed history and examination performed including vision, anterior segment examination, intraocular pressure (IOP), gonioscopy, and fundus evaluation. Diagnosis of secondary glaucoma was made on the basis of presence of a secondary cause for presence of raised IOP. 66 cases were eligible for inclusion in the study, most of the cases was occurred in the range age 21-50 years. The male female ratio was 1.3:1. Frequent causes of secondary glaucoma were lens factor 30.8%, steroid induced 29.5%, uveitic 20.5%, neovascular15.4%, and surgical complication 3.8%. Most patients with secondary glaucoma have poor vision < 0.1 with high IOP at presentation. Assessment and early detection of underlying cause is the key guide to treatment strategy.
Profile of Colorectal Tumor in Gastroentero-Hepatology Center, Department of Internal Medicine, Dr Soetomo Hospital, Surabaya Thamrin, Husin; Ilmiah, Khafidhotul; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56, No. 1
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Colorectal cancer has became burden in the world.The latest study shows that colorectal cancer is the third most common cancer in men and second most common cancer in women globally. There are difference characteristic of epidemiology in every countries. Moreover, there is no study that represents epidemiology of colorectal cancer in Indonesia yet, especially in East Java. The aim of this study was to describe colorectal tumor profile by age and gender in Gastroentero-Hepatology Center, Dr Soetomo Hospital. This study has received a certificate of Ethical Clearance No.273/Panke.KKE/IV/2015, a descriptive retrospective study. We collected data using medical records, and patients who have been colonoscopy examination and suspected colorectal tumor were included. There were 201 patients, divided to 100 males and 101 females. The peak of incidence was on 51-60 years old group, but on the 31-40 years old incidence of colorectal tumor was increased. The youngest patient was 17 years old. And tumors are more likely develop in distal area, especially in rectum. This study shows a different characteristic profile of colorectal tumor, where tumor is developed at young people and there is no significant difference between male and female for the incidence.
Comparison between Early and Late Drain Released after Modified Radical Mastectomy Surgery through Observation over Proportion of Percutaneous Aspiration Technique of Seroma Production in Surgical Polyclinic of Dr. Soetomo Hospital, Surabaya Parlindungan, Putra Gelar; Ishardyanto, Hantoro
Folia Medica Indonesiana Vol. 56, No. 1
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Surgery is the most frequent indication and major therapy in the management of malignancy of breasts. Drain is one method to drainage the seroma formed after the modified radical mastectomy surgery. The drain-release protocol varies in each hospitals. This study aimed to compare the proportion of percutaneous aspiration in patients with early drain release with late drain release in postoperative MRM patients. The present study is a prospective cohort study comparing the proportion of percutaneous aspiration in 30 patients with early drain released with 30 patients with late drain release in Dr. Soetomo hospital The recording of the proportion of aspiration actions was conducted serially on days 3, 7, 10, and 14 after drain release. Recording of age, nutritional status (BMI), tumor histopathology type, stage, shoulder mobilization time, obliterant usage, wound infections surgery, flap necrosis and hematom were analyzed to find out if there was any effect on seroma event In our study we did not find the difference in serum aspiration proportions both in the early and late drain observation group. Age factor, nutritional status (BMI), histopathology type, stage, shoulder mobilization time, obliterant use, presence of surgical wound infection, flap necrosis and hematom did not differ significantly statistically to seroma events. Statistically, there was no difference in the proportion of percutaneous aspiration in a group of observed patients with early and late drain release. Late drain release can be avoided to potentially harm the patient in decreasing the lives' quality of the patients.
Role of Age, Sex, and Body Mass Index on Blood Pressure among Students of St. Hendrikus High School, Surabaya, Indonesia Andajani, Susilowati
Folia Medica Indonesiana Vol. 56, No. 1
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The purpose of this study was to analyze the influence of age, sex, Body Mass Index (BMI), and nutritional status on blood pressure in class X and XI students, SMAK St. Hendrikus, Surabaya, Indonesia. The sample of students in class X and XI of SMAK St. Hendrikus Surabaya in 2013. The sample size was 150 students. The sampling technique was consecutive sampling. The independent variables were age, sex, BMI, and nutritional status, while the dependent variable was blood pressure. Data were analyzed by Pearson correlation test, Spearman, and Chi Square statistical test with ?=0.05. The level of risk was calculated by epi info program. Most students (40.7%) were 16 years old, those with pre-hypertension (systolic) 26.7%, grade 1 systolic hypertension by 1.3%, diastolic pre-hypertension 25.3% and grade 1 diastolic hypertension by 6.7%. Age did not have significant influence (p=0.623) on systolic blood pressure, but had a significant influence (p=0.002) on diastolic blood pressure. Male sex significantly influenced systolic (p=0.002, RR 5.36 95% CI 2.2320-12.8649) and diastolic (p <0.001, RR 1.95 95% CI 1.1272-3 , 3719) blood pressure. BMI had significant influence (p <0.001) on blood pressure. Nutritional status had significant influence on systolic blood pressure (p=0.002), with overnutrition status with RR 2.28, 95% CI 1.3983-3.7104. Nutritional status had significant influence on diastolic blood pressure (p <0.001), and with overnutrition status with RR 2.73, 95% CI 1.8143-4.1179. In conclusion, the trend for pre-hypertension to grade 1 diastolic hypertension increases with age and age has an influence on diastolic blood pressure. The risk of males to have pre-hypertension to grade 1 systolic hypertension is 5.36 times that of females, and the risk to have pre-hypertension to grade 1 diastolic hypertension is 1.95 times that of women. The higher the BMI, the higher the systolic and/or diastolic blood pressure.
The Use of Oral Antibiotics to Prevent Surgical Site Infection on Postoperative Modified Radical Mastectomy Patients in Dr. Soetomo General Hospital, Surabaya Hadi, Norman; Ishardyanto, Hantoro
Folia Medica Indonesiana Vol. 56, No. 1
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Surgical operations on modified radical mastectomy are considered clean procedures by the Centers for Disease Control and Prevention (CDC) wound classification system. Despite this, higher than expected Surgical Site Infection (SSI) rates are reported, varying from 1 % to 26 % across the literature. Some surgeons also prescribe postoperative prophylaxis for postoperative modified radical mastectomy patients to prevent infection despite its lack of proven efficacy. The aim of this study is to analyze the use of oral antibiotics to prevent Surgical Site Infection (SSI) on postoperative modified radical mastectomy patients in Dr. Soetomo General Hospital. This study was double-blinded randomized control trial of 60 postoperative modified radical mastectomy patients (2 groups) during the period of December 2017 to March 2018. Samples were prospectively divided into two groups (random sampling), in group A (n=30) patients received single dose prophylactic antibiotics and continued with oral antibiotics postoperative (Cefadroxil 2 x 500 mg) during 7 days and in group B (n=30) patients received single dose prophylactic antibiotics and continued without postoperative antibiotics (placebo). Both groups were evaluated clinically for surgical site infection up to 30 days. There was no statistically significant difference in both groups {p=1 (p>0.05)}. There was no incidence of surgical site infection in both groups during the 30-day follow-up period (days 3, 7, 14 and 30). There was no difference in the surgical site infection rate among those who received oral postoperative antibiotics prophylactic and without antibiotics (placebo) on postoperative modified radical mastectomy patients in Dr. Soetomo General Hospital. Because of the potential adverse events associated with antibiotic use, further evaluation of this practice is required.
Ratio of CD68/CD163 in Breast Carcinoma with and without Axillary Lymph Node Metastatic Wiratama, Priangga Adi; Sandhika, Willy
Folia Medica Indonesiana Vol. 56, No. 1
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Tumor and its microenvironment can interact each other. Macrophage is part of tumor microenvironment. New drugs targeting specific superficial receptor of macrophage or cytokine of macrophage polarization have been found. Therefore, macrophage phenotype and its ratio of M1/M2 macrophage need to be identified. This identification could lead us to prognose breast cancer and monitor its therapy. Analytical observational study with cross sectional approach, conducted on paraffin block sample of breast carcinoma from Anatomical Pathology Laboratory of Dr. Soetomo General Hospital. The samples divided into four groups based on nodal metastasis staging (N0, N1, N2, and N3) and stained with antibody against CD68 and CD163. The ratio of CD68 and CD163 were analyzed with Anova test. There were difference expression of CD68 as M1 macrophage marker in various axillary node metastasis groups (p=0.015). There were difference ratio of CD68 as M1 macrophage marker and CD163 as M2 macrophage marker in various axillary node metastasis groups (p=0.005). There were difference ratio of macrophage M1 and macrophage M2 between N0 and N3 group, N2 and N3 group also.
Comparison of Irisin Serum Healthy Untrained Males on Treadmill Exercises by Increasing Gradually Speed Vs Inclination Uda'a, Budiyanto; Tinduh, D; Masduchi, HR; Laswati, Laswati; Wibisono, S; Soenatalina, Soenatalina; Theodora, S
Folia Medica Indonesiana Vol. 56, No. 1
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Aerobic exercise can improve cardiorespiratory fitness in young people. Irises released into the bloodstream function to execute regulation of energy metabolism, triggering browning white adipose, which is useful in mitochondrial biogenesis. The American College of Sport Medicine (ACSM) recommends moderate intensity cardiorespiratory fitness training with a frequency of 3-5 times a week, duration of 20-60 minutes, using a treadmill. Study subjects (n = 20) were divided randomly into 2 groups, namely the moderate intensity Treadmill training group with gradual speed improvement and gradual inclination increase. Serum slices are measured on the first and last day of exercise. There was an increasing of irisin serum in the moderate intensity Treadmill training group by increasing gradually speed after 2 weeks of exercise, both 30 minutes pre-exercise (p = 0.02) and 1 hour post exercise (p = 0.01). Medium intensity Treadmill training with 2 weeks gradual speed increase with frequency 3 times a week can increase serum slice in men, healthy untrained young men.
Structural Model of Maternal Behavior in Community Setting to Prevent Low Birth Weight in East Nusa Tenggara, Indonesia Anggrahini, Simplicia Maria; Notobroto, Hari Basuki; Irwanto, Irwanto; Suryawan, Ahmad
Folia Medica Indonesiana Vol. 56, No. 1
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Low birth weight (LBW) is still a magnitude problem in Indonesia with a multifactorial causes. Studies revealed that one of cause of LBW-infants birth is mother's behavior in treating her pregnancy, including traditional pregnancy care practices. The purpose was to develop the structural model on community setting that might describe the LBW infants-birth. A case-control study on 50 post-partum mothers with LBW and 50 with normal birthweight infants was held in Kupang, East Nusa Tenggara, Indonesia, November 2016 - May 2017. Mother who have spontaneous birth, singleton, and received integrated ANC were inlcuded. Several data such as maternal characteristics, pregnancy knowledge, perceived behavioral control (PBC), maternal health status, obedience to traditional pregnancy care, were collected using questionnaire and medical records tracing. Statistical analysis was performed using path analysis from SmartPLS 3.2.7 and considered significant path when the coefficients were not zero with P value <0.05. Outer and inner model analysis showed two significant paths, both are come from maternal characteristic that influence the LBW infants-birth through pregnancy knowledge (0.489, P=0.000) and PBC (0,425, P=0,000). In the first path, PBC affect maternal health status (0.217, P=0.021) which in turn will cause LBW (0.201, P=0.001). The second path, PBC affect the obedience to traditional pregnancy care (0.474, P=0.000) and then influence to LBW (0.316, P=0.000). As conclusion, maternal characteristics, pregnancy knowledge, PBC, maternal health status, and obedience to traditional pregnancy care are key points that might be used as a significant variables in preventing LBW-infants birth.

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