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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Articles 17 Documents
Search results for , issue "Vol. 57, No. 3" : 17 Documents clear
Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Anggraini, Nutria Widya Purna; Sulistyowati, Sri; Bachnas, Muhammad Adrianes; Yuliantara, Eric Edwin; Prabowo, Wisnu; Budihastuti, Uki Retno
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Preeclampsia is hypertension in pregnancy that affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
Validity and Reliability of WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) Type 12 Questions Indonesian Version on Back Pain Rijanti, Kusumawardhany Airlangga; Subadi, Imam; Kurniawati, Patricia Maria
Folia Medica Indonesiana Vol. 57, No. 3
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The study was to prove the validity and reliability of the WHODAS 2.0 Indonesian version questionnaire in patients with back pain. This study was an observational cross-sectional study conducted in 2018. The study included the filling of WHODAS 2.0 Indonesian version, Indonesian version of Oswestry Disability Index (ODI) questionnaire, Wong-Baker Scale, conducted at Department of Rehabilitative Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, against 82 respondents with back pain. Each respondent was given informed consent. The validity of the WHODAS 2.0 Indonesian version questionnaire was measured using Pearson's test on the correlation of WHODAS 2.0 Indonesian version questionnaire and Oswestry Disability Index questionnaire with r >0.3 (0.862). WHODAS 2.0 Indonesian version questionnaire and Wong-Baker Scale had r >0.3 (0.449–0.785). The reliability of the WHODAS 2.0 Indonesian version questionnaire was measured using Pearson's correlation test with r >0.3 (0.764–0.866). WHODAS 2.0 Indonesian version's internal reliability was tested using Cronbach-Alfa Test with alpha >0.6 (0.634–, 853). In conclusion, the WHODAS 2.0 - Indonesian version is a valid and reliable questionnaire for patients with back pain.
Clinical and Radiological Study of Patients With Skull Base Fracture After Head Injury Oktavian, Puguh; Romdhoni, Achmad Chusnu; Dewanti, Linda; Fauzi, Asra Al
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Traumatic brain injury (TBI) is the largest contributor to morbidity and mortality in various parts of the world. Skull base fracture (SBF) is one of the many manifestations that can occur in cases of mild to severe TBI. With varying patterns of TBI, it was necessary to review the characteristics of SBF, clinical manifestations, cerebrospinal fluid leakage, and complications. The data were taken from the medical records of SBF patients who were treated at RSUD (Regional Public Hospital) Dr. Soetomo in the period January 2014 - July 2019. Then, the data obtained were written on the collection sheet and analyzed descriptively using RKward. It was found that SBF most often occurs due to severe TBI (60.14%). 77.7% of SBF patients were male and 35.1% of all patients aged 15-24 years. The most frequent cause was traffic accidents (86.5%). The anterior cranial fossa (ACF) was the most frequently fractured part of the skull base (30.4%). There was a significant relationship between the severity of TBI with the occurrence of CSF leakage and complications. About 33 patients (22.3%) had complications such as pneumocephalus and 9 patients (6.1%) had meningitis. Complications in the form of brain abscess and hydrocephalus in 1 (0.7%) patient each. SBF often occurred in men of productive age 15-24 years. The ACF was the most frequently fractured part. The majority were caused by traffic accidents accompanied by severe brain injuries. The most common complications were pneumocephalus, meningitis, brain abscess, and hydrocephalus.
Front Matter Vol. 57 No. 3 September 2021 Matter, Front
Folia Medica Indonesiana Vol. 57, No. 3
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Characteristics of Obstructive Anuria Patients in a Tertiary Hospital in East Java, Indonesia Wicaksono, Fandy; Rizaldi, Fikri; Soebadi, Doddy M
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Obstructive uropathy is an obstruction of urinary passage which may lead to anuria, a condition where urine production is less than 50 to 100 ml in 24 hours. The varying etiologies and underlying pathophysiology among different cases based on different demographics can make it difficult for physicians to decide the proper management. Therefore, we aimed to evaluate the clinical profile and management of anuria patients in Dr. Soetomo General Academic Hospital over a four-year period. This was a descriptive study with a retrospective approach evaluating all patients with anuria admitted from January 2016 to December 2019. Patient data taken from the medical record were presented descriptively. A total of 176 patients were obtained. Only 161 patients were included. Most of the patients were female (n=100, 62.11%) aged 51 to 60 years old (n=63, 39.1%). Postrenal obstruction due to urinary stone was the most frequent etiology (n=86, 53.4%). Consequently, some patients developed hydronephrosis, which was mostly dominated by the bilateral (n=130, 80.8%) and severe types (n=75, 46.6%). A total of 129 patients (80.1%) underwent hemodialysis. Most of the patients were treated with definitive treatment (n=46, 38.7%). Normalization of renal function mostly occurred in patients who underwent percutaneous nephrostomy (PNS) before giving a definitive treatment.
Prevalence and Population at Risk for Noise Induced Hearing Loss (NIHL) in Adolescent Students Yusni, Yusni; Ikbal, Ikbal; Meutia, Firdalena
Folia Medica Indonesiana Vol. 57, No. 3
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Noise-Induced Hearing Loss (NIHL) is a global health problem, often underestimated, and leads to permanent hearing loss. The prevalence of NIHL in adolescents has increased in line with the increasing use of cell phones. This study aimed to determine the prevalence of NIHL and analyze the population at risk (age, gender, and school) in adolescent students. The study design was a cross-sectional study. A total of 510 students consisting of female, n=288 and male, n=222; junior high school, n=203 and senior high school, n=307 were used as research subjects. This study was conducted on August-October 2015 at Darul Ihsan School, Banda Aceh, Indonesia. An audiometry examination was performed to determine the diagnosis of NIHL. Data analysis was using descriptive analysis and independent sample t-test(p<0.05). The results of this study were the prevalence of NIHL in adolescents aged 11-20 years was 18.88%. The highest percentage of NIHL was at the age of 15 years (34.57%). The number of NIHL was significantly higher (p=0.000*) in males (24.32%) compared to females (9.37%). The prevalence of NIHL was significantly higher (p=0.00*) in senior high school children (26.11%) compared to that in junior high school children (9.12%). In conclusion, the highest prevalence of NIHL was at the age of 15 years. NIHL was more common in male than in female students. NIHL was higher in high school students compared to junior high school students. The NIHL was related to age, gender, and school level.
Ethanol Extract of Marigold Flower (Tagetes Erecta L.) Decreases The Total Cholesterol, Low Density Lypoprotein (LDL), Malondialdehyde (MDA), and Apoliprotein B (APOB) on Hyperlipidemia Rat Models Kresnapati, I Nyoman Bagus Aji; Khaerunnisa, Siti; Safitri, Indri
Folia Medica Indonesiana Vol. 57, No. 3
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This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW (P1), ethanol extract of gemitir flowers (Tagetes erecta L.) 200 (P2), 400 BW (P3), and 800 mg/kgBW (P4). On day 51, the total cholesterol, LDL-C, MDA, and ApoB blood serum levels were checked. The results showed total cholesterol, Low-Density Lipoprotein (LDL), Malondialdehyde (MDA), and Apolipoprotein B (ApoB) given ethanol extract of gemitir flowers 200 and 400 mg/kgBW (P2) had a significant reduction (P < 0.05). Giving ethanol extract of gemitir flower (Tagetes erecta L.) could reduce levels of total cholesterol, LDL, MDA, and Apo B.
Bladder Chondrosarcoma in A Male: A Rare Case Report Tamrin, Muhammad Husni; Djatisoesanto, Wahjoe
Folia Medica Indonesiana Vol. 57, No. 3
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Chondrosarcoma is a rare variant of bladder tumor and one of the rare types of soft tissue sarcoma. This case happened on a 36-year-old male who complained of lumps in his lower abdomen, accompanied by difficulties in passing urine and painful urination, without hematuria. We performed TURBT and histopathological examination showed low-grade chondrosarcoma. The patient was diagnosed with low-grade bladder chondrosarcoma. The patient was treated for chemotherapy and radiotherapy. However, after undergoing one cycle of chemotherapy, the patient refused to continue the therapy.
Duplication and Multiseptate Urinary Bladder: A Rare Case Report Zulfikar, Muhammad Fawzi; Djatisoesanto, Wahjoe; Tarmono, Tarmono
Folia Medica Indonesiana Vol. 57, No. 3
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The multiseptate bladder is a congenital bladder anomaly that is very rare and often accompanied by other congenital abnormalities. This condition could result in intravesical obstruction and kidney failure in more serious conditions. A 3-year-old girl without any complaint was consulted by the Pediatric Surgery Department with postoperative cloacal type malformation anorectal (MAR) postero-sagittal anorecto-vagino-urethroplasty (PSARVUP) + sigmoidectomy. Magnetic Resonance Imaging (MRI) of the pelvis showed the appearance of four interconnected multiple fluid lesions. Cystoscopy was performed and found many septa with varied positions and forms. From the cystography during the operation, it was seen duplication of the right and left bladder. There was no further operative treatment in the field of urology because no urinary tract obstruction and normal renal function were found in this study.
Modified Cantwel-Ransley Reconstruction of Continent Penile Epispadias In Children: A Case Report Nadhir, Ahmad; Tarmono, Tarmono
Folia Medica Indonesiana Vol. 57, No. 3
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Epispadias as an isolated embryologic defect is a rare anomaly, with an incidence of 1 in 117.000 males. Isolated epispadias with continence is a very rare condition comprising less than 10% of all epispadias cases. Epispadias is a closure defect of the dorsal wall of the urethra. The biggest challenges for epispadias treatment are creating adequate penile length, straightening the severely curved penis, and creating a penopubic angle for allowing comfortable penetration of the penis. An 11-year-old boy underwent surgery for his continent penile epispadias in Dr. Soetomo General Academic Hospital. The surgical technique chosen for this patient was Modified Cantwell-Ransley repair. The dressing was opened on the 3rd day after the operation. The urethral catheter was removed on the 10th day. The patients underwent regular follow-up examinations for 6 months and were evaluated for subjective and objective outcomes. There was no post-operative fistula or urethral narrowing requiring urethral dilatation. The Uroflowmetry and post voiding residual ultrasound result was good. The cosmetic appearance of the penis was satisfying. Outcomes related to sexual activity were not evaluated because the patient had no sexual activity yet.

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