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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 16 Documents
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Search results for , issue "Vol. 59, No. 1" : 16 Documents clear
The Effect of Binahong (Anredera cordifolia (Ten.) Steenis) Leaf Ethanolic Extract on the Reduction of Blood Uric Acid Levels in Hyperuricemic Male White Wistar Rats (Rattus norvegicus) Anugerah, Panji; Rahman, Safrizal
Folia Medica Indonesiana Vol. 59, No. 1
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Abstract

Highlights: • Antioxidant flavonoid compounds can be found in binahong leaf extract. • Binahong leaf extract is as effective as allupurinol in reducing uric acid levels. Abstract: Binahong (Anredera cordifolia (Ten.) Steenis) is empirically used to treat burns, rheumatism, gout, typhoid, and stroke. Binahong leaves contain flavonoids that have an antioxidant effect. This study aimed to identify and test binahong leaf flavonoid compounds' antioxidant properties in reducing uric acid levels. This study began by producing binahong leaf extract and then identifying the flavonoid content with a phytochemical test. The results indicated that the binahong leaf extract contained antioxidant flavonoid compounds. The data were followed by testing flavonoid activity in lowering uric acid levels. This study used male white Wistar rats, of which the uric acid was induced by chicken liver juice. The animals used in the test were 25 rats divided into five groups (i.e., negative control group, positive control group, and treatment groups with dose I, dose II, and dose III). In each group, there were five male white rats. This study was a laboratory experiment using a pre-test post-test design with control groups (pre-test post-test control group design), where the grouping was done based on a randomized group design. By using statistical tests, the results obtained showed that there was a significant decrease of uric acid levels in the positive control group and the treatment group. In conclusion, binahong leaf ethanolic extract can reduce blood uric acid levels induced by chicken liver juice in male white Wistar rats.
Nutritional Knowledge and Body Mass Index among Students at Novena University, Ogume, Nigeria Andrew, Udi Onoriode; Godswill, Okoro Ogheneyebrorue; Mamerhi, Enaowho Taniyowho; Boma, Douglas
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • Interviews were conducted on the correlation between nutritional knowledge and BMI among students at Novena University, Ogume, Nigeria. • Most of the students had adequate nutritional knowledge and a low obesity prevalence rate. Abstract: Body mass index (BMI), which is calculated using height and weight, is a rough indicator of body fat. This study aimed to investigate whether there is a significant correlation between nutritional knowledge and BMI among students at Novena University, Ogume, Nigeria. This study was done using a cross-sectional survey. Interviews were conducted with 50 participants from the sample, whose nutritional knowledge and weight status were assessed. The results showed that the students' BMI ranged from 15 to 39, with a mean and standard deviation of 23.93±5.46 cm. There was a positive correlation between the students' nutritional knowledge and their BMI. In conclusion, the majority of Novena University students are knowledgeable about obesity, which likely accounts for their low obesity prevalence rate.
Anxiety Disorder among Older Adults with Visual Impairment in Ekiti, Nigeria: Implications for the Potential Opportunity to Mitigate the Impact of the Disability and Prevent Psychological Harm Aina, Felix Olukayode; Ajayi, Iyiade Adeseye; Omotoye, Joseph Olusola; Agbesanwa, Tosin Anthony; Dada, Mobolaji Usman; Fadare, Joseph Olusesan; Ajite, Olumide Kayode; Prajjwal, Priyadarshi
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: Anxiety is an important morbidity among visually impaired older adults. There is potential for stakeholders to specifically channel their interventions towards particular IVI domains in order to reduce anxiety prevalence. Abstract: Visual impairment is a significant morbidity among adults globally. It has negative impacts on work force participation and productivity, as and well as higher depression and anxiety disorder rates. In the case of older adults, vision impairment can contribute to social isolation and a greater likelihood of early entry into nursing or care homes. This hospital-based, cross-sectional study was designed to determine anxiety disorder's prevalence among the study population and which Impact of Visual Impairment (IVI) domain is most correlated with anxiety disorder. The study was carried out at the Ophthalmology Clinic of the Ekiti State University Teaching Hospital, Ado Ekiti, Nigera. Questionnaires were used to collect information from 115 respondents. Information sought included sociodemographic information, anxiety status, and visual impairment's impact on daily functions. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety disorder, while the IVI scale was used to assess the impact of visual impairment. The IVI scale is an instrument used for determining the impact of visual impairment under three domains: (reading and accessing information, mobility and independence, and emotional well-being). Anxiety disorder was detected in 10.4% of all the respondents, and the IVI's mobility and independence domain of IVI was most strongly correlated with anxiety disorder.
Screen Time and Dry Eye Disease During Distance Learning among the Class of 2019 Medical Students at a University in Jakarta, Indonesia Bernadette, Karen; Rasyid, Meriana
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • There is a correlation between screen time and dry eye disease among medical students due to distance learning during the pandemic. • This study's findings can lead researchers to conduct further studies to investigate and prevent DED. Abstract: Dry eye disease (DED), also known as dry-eye syndrome, is commonly caused by a lack of tears or excessive evaporation. It affects 334 million people worldwide. According to global epidemiological research, the DED prevalence in adults and the elderly is roughly 5-50%. Research has revealed that DED prevalence and epidemiology are more typically connected to aging. However, extended exposure to digital screens is an external DED risk factor to be aware of, especially in this digital technology era and amidst the COVID-19 pandemic. These two situations are expected to increase the number of DED sufferers in the younger age groups, such as elementary, high school, and university students. The ongoing COVID-19 pandemic has compelled a shift in learning and teaching methods in order for education to proceed. However, the digitization era and the COVID-19 pandemic can double the DED risk, particularly among medical students. This study's objective was to determine how remote learning affected DED prevalence among the class of 2019 medical students at Universitas Tarumanagara, Jakarta, Indonesia, in the COVID-19 pandemic. Data were collected from 144 respondents using a Google Forms questionnaire. According to the statistical test results, there was a 2.4-fold increase in screen time during the COVID-19 pandemic compared to the pre-pandemic period. The results demonstrated a significant relationship between screen time and DED among the class of 2019 medical students at Universitas Tarumanagara. These findings are predicted to be of interest to academics and students, as their frequent engagement with computer displays and smartphones will continue to increase due to technological advancements. Furthermore, researchers may use the findings as a reference in conducting DED-related research.
The Impact of Social Stigma on Child Patients with Cleft Lip and Palate Ariani, Yuni; Astarini, Diska
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: 1. Awareness of social stigma impact on children with cleft lip and palate is lacking in various areas. 2. Identifying social stigma's influence on children with cleft lip is important to help surgeons prioritize resource allocation and provide further evidence in incorporating quality of life. Abstract: Social rejection still happens to a large number of children who have cleft lip and palate. Stigma has a detrimental impact on children with cleft in the aspects of education, employment, marriage, and community acceptance, which can be exacerbated by barriers to high-quality child care. A literature study related to this topic was conducted by searching for articles from 2018 to October 2021 through three databases (i.e., PubMed, Embase, and Medline). The term used for the literature search was "cleft", which generated results that were sorted alphabetically and by relevance. This yielded 15 articles that focused on social stigma's influence on cleft lip and palate patients. In conclusion, the articles generally reported that the awareness of social stigma impacts on children with cleft lip and palate are lacking in various areas. It is important to identify social stigma's influence on children with cleft lip. This can help surgeons prioritize resource allocation and provide further evidence in incorporating quality of life measures into the treatment outcome assessment.
Five Single-Nucleotide Polymorphisms in the PITX2 Gene as Risk Factors for Atrial Fibrillation Putra, Rendra Mahardhika; Dharmadjati, Budi Bakti; Pikir, Budi Susetyo; , Irma Maghfirah; Isaridha, Ilma Alfia; Arnindita, Jannatin Nisa
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • A genetic variable has been identified as an atrial fibrillation risk factor. • Rs2200733 is a type of SNP that increases atrial fibrillation risk, whereas rs3853445, rs6838973, and rs17570669 have the reverse effect. Abstract: Atrial fibrillation (AF) is a highly prevalent arrhythmia. The involvement of molecular mechanisms in increased AF risk remains uncertain. However, the paired-like homeodomain transcription factor 2 or pituitary homeobox 2 (PITX2) gene has been linked to AF development. A comprehensive search was carried out to identify all eligible case-control studies in order to assess the association between five single-nucleotide polymorphisms (SNPs) in the PITX2 gene and the risk of AF. This meta-analysis employed the Review Manager (RevMan) software version 5.3 (Cochrane). There were 13 clinical studies, with a total of 11,961 subjects, that met the inclusion criteria. These subjects consisted of 4,440 patients with AF and 7,521 controls. The meta-analysis of five SNP types in the PITX2 gene was done using crude odds ratios (ORs). This revealed that rs2200733 increased the risk of AF (OR=1.80; 95% CI=1.53-2.11; p=0.0005; I2=80%). On the other hand, the other three SNPs decreased the risk of AF, namely, rs385344 (OR=0.75; 95% CI=0.59-0.95; p=0.002; I2=85%), rs6838973 (OR=0.64; 95% CI=0.51-0.81; p=0.0001; I2=73%), and rs17570669 (OR=0.80; 95% CI=0.65-0.98; p=0.03; I2=70%). However, there was no significant association between rs10033464 and AF (OR=1.21; 95% CI=0.97-1.50; p=0.13; I2=83%). In conclusion, depending on the type, SNPs in the PITX2 gene correlate with AF risk factors, either by alleviating or reducing the risk.
The Use of STRONGkids, Total Lymphocyte Count, and Serum Albumin to Identify the Risk of Hospital Malnutrition in Children Rusti, Hafiza Amadhin; Widjaja, Nur Aisiyah; Irawan, Roedi; Setiawan, Ariandi
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • Medium- and high-risk STRONGkids scores are related with low total lymphocyte count and serum albumin, which are related to hospital malnutrition, albeit indirectly. • The use of STRONGkids with total lymphocyte count and serum albumin can detect the risk of hospital malnutrition in children. Abstract: Hospital malnutrition occurs in hospitalized patients who do not consume enough food while their nutritional requirements increase. It occurs particularly in children who have undergone gastrointestinal surgery. Despite the lack of a universal instrument for detecting hospital malnutrition, various parameters can be considered to assist in its identification. STRONGkids has demonstrated its efficiency in detecting malnutrition risk in children. Total lymphocyte count (TLC) and serum albumin are biochemical markers that are related to infection and protein leakage, which can worsen hospital malnutrition. The research objective was to analyze the correlation between STRONGkids and biochemical markers (TLC, serum albumin) to identify hospital malnutrition in children who underwent gastrointestinal surgery. This was a retrospective cross-sectional observational study utilizing medical records. The statistical analysis was conducted using SPSS 21. This study included 37 subjects, with a 24.32% hospital malnutrition incidence rate. The subjects were divided into two groups: hospital malnutrition (n=9) and non-hospital malnutrition (n=28). The STRONGkids of both groups at admission demonstrated a significant difference, while the albumin and TLC did not. The significantly different STRONGkids scores of both groups at admission correlated negatively with the length of hospital stay (LOS), body weight reduction, TLC, and albumin. Those parameters also did not correlate with hospital malnutrition. However, hospital malnutrition increased the risk of low albumin and TLC at discharge by 2.951 and 5.549 times, respectively. In conlusion, TLC and serum albumin cannot be used as independent markers for hospital malnutrition, but STRONGkids can be used in conjunction with TLC and serum albumin to identify hospital malnutrition risk.
Front Matter Vol.59 No.1 [3/2023] Indonesiana, Folia Medica
Folia Medica Indonesiana Vol. 59, No. 1
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Back Matter Vol.59 No.1 [3/2023] Indonesiana, Folia Medica
Folia Medica Indonesiana Vol. 59, No. 1
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Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise Melbiarta, Rezy Ramawan; Kalanjati, Viskasari P.; Herawati, Lilik; Salim, Yusuf; Othman, Zulhabri
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. • The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models' spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group's (HCD+MIE) SA to the control group's SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.

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