African Journal of Biochemistry and Molecular Biology Research
African Journal of Biochemistry and Molecular Biology Research aims to publish high-quality, peer-reviewed research that advances biochemical and molecular understanding of living systems while supporting interdisciplinary developments across the life sciences. • Biochemical Advancement: disseminate rigorous studies in fundamental and applied biochemistry, including molecular mechanisms, metabolism, enzymes, membranes, and biomolecular interactions. • Molecular and Cellular Inquiry: encourage research in molecular biology, genetic and cellular regulation, pathogen biology, and biologically relevant analytical methods. • Life-Science Integration: promote interdisciplinary work linking biochemistry and molecular biology with biotechnology, physiology, microbiology, pharmacology, pathology, and health science. • Scientific Relevance and Application: support research that contributes to biomedical, environmental, agricultural, nutritional, and translational scientific problems. AJBMBR welcomes original research papers and related scholarly contributions in biochemistry, molecular biology, and associated life-science fields, especially studies with strong methodological grounding and clear scientific relevance. • Core Biochemistry: macromolecular biochemistry, enzymology, membrane biochemistry, nutritional biochemistry, reproductive and developmental biochemistry, and biochemical regulation of cellular processes. • Molecular and Biomedical Sciences: molecular biology, medical and clinical biochemistry, pathology, pharmacology, physiology, microbiology, parasitology, malariology, and related disease-oriented biosciences. • Biotechnology and Bioinformatics: biotechnology, computational biology, bioinformatics, molecular data analysis, and applied laboratory innovation. • Health and Natural Product Sciences: phytomedicine, food science, health science, toxicology, and biophysics relevant to biomolecular or physiological understanding. • Environmental and Applied Biosciences: environmental biochemistry and other biochemical applications connected to biological systems, sustainability, and applied life-science research.
Articles
103 Documents
<![CDATA[Unlocking the Potential of Carica papaya L.: A Comprehensive Review on Its Antiviral Activity and Therapeutic Role in Dengue Management ]]>
<![CDATA[Dluya Samuel Thagriki]]>
<![CDATA[ African Journal of Biochemistry and Molecular Biology Research Vol 3 No 3 (2026): African Journal of Biochemistry and Molecular Biology Research ]]>
Publisher : <![CDATA[Darul Yasin Al Sys ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.58578/ajbmbr.v3i3.11641
<![CDATA[Dengue is a rapidly expanding global health problem for which no specific antiviral therapy is currently available, leaving disease management largely supportive and symptomatic. Severe thrombocytopenia is a major clinical concern in dengue infection, while prophylactic platelet transfusion can be costly and may not always be readily accessible. Carica papaya leaf juice (CPLJ) has been used off-label in the management of dengue fever and dengue haemorrhagic fever and has been reported to increase platelet counts in thrombocytopenic children and adults with minimal adverse effects. This review synthesizes evidence on the antiviral activity and therapeutic potential of CPLJ and C. papaya leaf extracts in the treatment and recovery of dengue-infected patients. It examines recent findings from in vitro and in vivo studies, documented clinical trials, traditional applications, and research on the phytochemicals, amino acids, and other bioactive constituents of C. papaya leaves. The reviewed evidence indicates that CPLJ and its extracts may inhibit dengue virus activity, increase platelet counts, and support recovery among patients with dengue fever and dengue haemorrhagic fever. These findings suggest that C. papaya leaves represent a promising natural source of bioactive compounds for developing supportive or antiviral interventions against dengue virus infection. Nevertheless, further rigorous pharmacological and clinical investigations are required to establish standardized formulations, therapeutic dosages, mechanisms of action, safety profiles, and clinical efficacy.]]>
<![CDATA[Extraction and Application of Natural Dye from African Locust Bean (Parkia biglobosa) Pod on Nylon Fabrics ]]>
<![CDATA[Andema Aaron Kanadi]]>;
<![CDATA[Abdulkadir Junior Bilyamin]]>;
<![CDATA[Joshua Yakubu]]>;
<![CDATA[Lunsti John]]>;
<![CDATA[Akinterinwa Ayo]]>;
<![CDATA[Peter Micheal Dass]]>
<![CDATA[ African Journal of Biochemistry and Molecular Biology Research Vol 3 No 3 (2026): African Journal of Biochemistry and Molecular Biology Research ]]>
Publisher : <![CDATA[Darul Yasin Al Sys ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.58578/ajbmbr.v3i3.11793
<![CDATA[Growing environmental and health concerns regarding synthetic dyes have increased interest in natural colorants as potentially more sustainable alternatives. This study aimed to extract and optimize a natural dye from Parkia biglobosa pods and evaluate its application to nylon fabrics. The dye was extracted through maceration, producing a yield of 23.76%. The optimum dyeing conditions for treated and untreated nylon were concentrations of 1% and 1.5%, temperatures of 60 and 70 °C, and dyeing times of 30 and 40 min, respectively. The extract was applied using pre-, meta-, and post-mordanting techniques with copper sulfate, ferrous sulfate, and potassium aluminum sulfate as mordants. The resulting fabrics exhibited shades ranging from light and dark brown to black, with pre-mordanting producing the most visually attractive shades. However, the dyed nylon fabrics demonstrated poor colorfastness to sunlight and washing, with ratings ranging from 1 to 3. Neither mordanted nor unmordanted fabrics exhibited antibacterial activity against B. subtilis or S. Typhi (inhibition zone: 0.00 ± 0.00 mm). In contrast, all dyed fabrics showed varying antifungal activity against P. notatum. Treated nylon dyed with copper sulfate produced the largest inhibition zone (1.0 ± 0.00 mm), whereas untreated nylon dyed with potassium aluminum sulfate produced the smallest (0.3 ± 0.00 mm). These findings demonstrate the potential of P. biglobosa pods as a source of natural dye for nylon fabrics, particularly when applied through pre-mordanting. Nevertheless, the poor colorfastness and limited antimicrobial performance indicate that further optimization is necessary before practical textile application.]]>
<![CDATA[Protective Effects of Methanolic Extracts of *Calotropis gigantea* Leaves, Stem Bark and Roots against Diabetes-Induced Hepatic and Renal Dysfunction in Streptozotocin-Induced Albino Rats ]]>
<![CDATA[Mercy iliya Tumba]]>;
<![CDATA[Isaac John Umaru]]>;
<![CDATA[Chinedu Imo]]>
<![CDATA[ African Journal of Biochemistry and Molecular Biology Research Vol 3 No 3 (2026): African Journal of Biochemistry and Molecular Biology Research ]]>
Publisher : <![CDATA[Darul Yasin Al Sys ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.58578/ajbmbr.v3i3.11830
<![CDATA[Calotropis gigantea is widely used in traditional medicine, but comparative evidence concerning the antidiabetic and organ-protective effects of its different anatomical parts remains limited. This study evaluated the phytochemical constituents and therapeutic effects of methanolic extracts derived from the leaves, stem bark, and roots of C. gigantea in streptozotocin (STZ)-induced diabetic albino rats. Plant materials were air-dried, pulverized, extracted through cold maceration in methanol for 72 hours, and concentrated using a rotary evaporator. Phytochemical constituents were characterized by gas chromatography–mass spectrometry (GC–MS). Thirty-six male albino rats were randomly allocated to six groups: normal control, diabetic control, metformin-treated (100 mg/kg), and leaf-, stem-bark-, and root-extract-treated groups (100 mg/kg each). Treatments were administered for 14 days. Fasting blood glucose, liver and kidney function indices, and lipid profiles were assessed, alongside histopathological examination of liver and kidney tissues. GC–MS identified several bioactive constituents, including 7-octen-2-ol, α-terpineol, and D-limonene. Diabetes induction increased fasting blood glucose from 4.93 ± 0.25 to 16.14 ± 0.98 mmol/L, with concentrations remaining elevated in untreated diabetic rats. All extracts significantly reduced blood glucose, while the root extract produced the greatest reduction, from 15.37 ± 1.10 to 8.93 ± 1.94 mmol/L, comparable to the response observed with metformin. The root and leaf extracts produced the strongest improvements in renal function indices. The leaf extract yielded the most pronounced reductions in alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities and improved the lipid profile by reducing serum triglyceride and cholesterol concentrations while increasing high-density lipoprotein concentrations. Histopathological findings corroborated the biochemical results, demonstrating reduced hepatic and renal tissue damage in treated animals. These findings indicate that C. gigantea extracts, particularly those obtained from the roots and leaves, possess antidiabetic, hepatoprotective, nephroprotective, and lipid-modulating potential, supporting their further pharmacological evaluation for managing diabetes-associated complications.]]>
