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Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Published by Lembaga Pengembangan Kinerja Dosen
ISSN : 2809235X     EISSN : 28092090     DOI : 10.55606
Core Subject : Health,
Medicine & Pharmacology Nursing Public Health
Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan diterbitkan 3 (tiga) kali dalam satu tahun yaitu Edisi Januari, Mei, dan September. Jurnal Ilmiah Kedokteran dan Kesehatan menyajikan hasil penelitian dan tinjauan pustaka sehingga jurnal ini bermanfaat bagi dokter, pengambil kebijakan, tenaga kesehatan, dosen serta mahasiswa yang tertarik dengan publikasi ilmiah terkait Ilmu Kedokteran dan Kesehatan
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 481 Documents
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Kajian Kimia Medisinal Ciprofloxacin: Mekanisme Kerja, Antibakteri, dan Pola Resistensi Bakteri Saeful Amin; Fuza Khoirun Nisa; Yosi Setiawati; Muhammad Akbar Alfi Fauzan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3923

Abstract

Ciprofloxacin is a fluoroquinolone antibiotic that is widely used in the treatment of various bacterial infections. This study aims to analyze the mechanism of action of ciprofloxacin from a medicinal chemistry perspective, evaluate its antibacterial effectiveness against pathogenic bacteria, and identify the developing resistance patterns. The method used is a literature study by reviewing various relevant scientific literature. The results of the study indicate that ciprofloxacin works by inhibiting the enzymes DNA gyrase and topoisomerase IV, which play an important role in bacterial DNA replication and transcription, causing DNA fragmentation and bacterial cell death. Ciprofloxacin shows high antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Vibrio cholerae. However, resistance to ciprofloxacin continues to increase, mainly due to target gene mutations, increased expression of efflux pumps, and changes in porin structure. A deep understanding of the structure-activity of ciprofloxacin is important in the development of new derivatives that are more effective and able to overcome resistance. This study provides important insights into the innovation of more robust antimicrobial drug design.
Tinjauan Kimia Medisinal Senyawa Fenol dari Ekstrak Daun dan Biji Pepaya (Carica papaya) sebagai Anti Kanker Devi Wulandari; Saeful Amin; Nida Atsila Anamareri; Atiqoh Azizah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3926

Abstract

Purpose: The aim of this study is to measure the total phenolic content in papaya (Carica papaya L.) leaf and seed extracts and to evaluate their potential as anticancer agents based on their antioxidant activity. Methodology/approach: Location & Materials: Papaya leaves and seeds were sourced from Manoko, Bandung. Extraction: The samples were washed, dried at 45°C, powdered, and extracted with 70% ethanol using the reflux method. Analysis: Total phenolic content was measured using a UV-Vis spectrophotometer at 761 nm after reacting extracts with Folin-Ciocalteu reagent and sodium carbonate. Results were compared to a gallic acid standard curve. Supporting Methods: Literature review on medicinal chemistry and anticancer drug development, as well as qualitative analysis using thin-layer chromatography (TLC) for main phenolic compounds. Results/findings: Papaya leaf and seed extracts contain significant phenolic compounds, including flavonoids and phenolic acids. These phenolics contribute to antioxidant activity, which helps protect cells from oxidative damage linked to cancer. Previous studies show papaya leaf extract can act as an immunomodulator and anticancer agent, while papaya seed contains benzyl isothiocyanate, which inhibits cancer cell growth. Limitations: The study only measures total phenolic content and does not isolate or identify individual active compounds. Anticancer activity is inferred from phenolic content and literature, not directly tested in vivo or in clinical trials. Contribution: This research provides scientific evidence that papaya leaves and seeds are promising natural sources of phenolic compounds with antioxidant and potential anticancer properties. The findings support further research in pharmacy, medicinal chemistry, and oncology, especially for developing plant-based anticancer agents.
Rancang Bangun Alat Fiksasi Pemeriksaan Emergency Radiologi pada Ekstremitas Bawah Chusnul Fadilah Sahudin; Ildsa Maulidya Mar'athus Nasokha; Retno Wati
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3928

Abstract

Lower extremity injuries, especially femur and cruris fractures, are quite common in Indonesia. In emergency cases, lateral radiographic examinations with horizontal beam directions often experience distortion and object cutting due to difficulties in placing the cassette. Therefore, a fixation device is needed that can support the position of the cassette and the examination object to produce optimal radiographs. This study used an experimental approach with a design and construction method. Data collection was carried out through functional and performance tests of the fixation device at the Klaten Islamic Hospital, as well as an assessment using a checklist questionnaire to three experienced radiographers. The fixation device was successfully designed in an L shape, made of iron plate with additional foam for patient comfort. The results of the functional test showed a success rate of 90%, met the criteria for feasibility (> 75%), indicating that the fixation device was able to support the cassette and object stably and minimize distortion in emergency radiographic examinations of the lower extremities. The design and construction of this fixation device is effective in improving the quality of emergency radiographic examinations of the femur and cruris. This device is feasible to use with potential improvements in the aspect of ease of mobility for more optimal use in the future.
Studi Kasus Repeat (Pengulangan) Radiograf dengan Modalitas Digital Radiography (DR) di Instalasi Radiologi RSUD Dr. Soehadi Prijonegoro Sragen Yunita Yunita; Ayu Mahani; Muhammad Za'im
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3929

Abstract

Repeat analysis is a systematic method for analyzing radiographic images repeatedly to identify and reduce errors in digital processing. This method is part of the quality assurance (QA) and quality control (QC) program which aims to ensure optimal quality radiographic results. According to the Decree of the Minister of Health Number 129/Menkes/SK/II/2008 concerning the standard for repeat radiographic images <2%. This study aims to determine the factors that cause repeat photos and how to prevent repeat photos at Dr. Soehadi Prijonegoro Sragen Hospital. This research method uses qualitative with a case study approach to analyze repeat radiographs using Digital Radiography (DR) at the Radiology Installation of Dr. Soehadi Prijonegoro Sragen Hospital. The study was conducted from September 2024 to March 2025. The population includes all radiographic images with DR modality, while the sample is the result of repeat radiographic images. Data were collected through direct observation, interviews with three radiographers and one radiology specialist, and documentation. The average percentage of repeat X-ray photos on digital radiography modality in October 2024 was 1954 examinations with 122 repeats with a percentage of 6.24%, in November 2024 was 2206 examinations with 70 repeats with a percentage of 3.17%, in December 2024 was 2622 examinations with 16 repeats with a percentage of 0.61%. The percentage of repeats on digital radiography (DR) modality that occurred at Dr. Soehadi Prijonegoro Sragen Hospital exceeded the standards set by the Minister of Health with repeat results> 2% in October and November 2024. The factors causing repeats are due to positioning, patient movement, exposure factors, artifacts and equipment. The suggestion to minimize repeats that occur is to increase the accuracy of the radiographer in conducting the examination.
Pengaruh Kualitas Tidur terhadap Nilai Hemoglobin pada Remaja Putri Elyn Arlinda; Dyah Artini; Siti Nurhayati
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3933

Abstract

Anemia is a condition where a person has a hemoglobin value below normal (12 gr/dl). The prevalence of anemia is around 30% of women of childbearing age, namely 15-49 years old, suffer from anemia. In Indonesia, data on anemia sufferers shows 32%. The prevalence of anemia in DIY shows that the results of Riskesdas in 2013 amounted to 37.1% of adolescent girls experiencing anemia, and further increased in the 2018 Riskesdas results, namely 48.9% experiencing anemia. Anemia has a negative impact on adolescent girls, namely a decrease in immune system function, easy fatigue, disrupting physical, cognitive, psychological growth and development, and reducing learning concentration which can affect learning achievement. Factors causing anemia can be caused by sleep quality. Good sleep will help the body's biological process to regenerate erythrocyte cells in producing gemoglobin. This study uses a quantitative correlation research design with purposive sampling technique with inclusion and exclusion criteria. The number of samples in this study were 30 adolescent female respondents. Statistical analysis used is chi-square with a p value <0.5. The results of this study indicate that the majority of adolescent girls experience poor sleep quality as many as 18 adolescent girls (60%) and as many as 21 adolescent girls (70%) have abnormal hemoglobin values. Chi-square test obtained a value of p = 0.001 <0.5 which means that sleep quality can affect hemoglobin levels in adolescent girls
Karakterisasi Aktivitas Antioksidan Ekstrak Etanol Bawang Lanang (Allium sativum L.) Melalui Uji DPPH Shinta Nursifa; Saeful Amin; Olivia Fauzi Syalamatul Syalamatul Putri; Firli Nimah Dinda Azqiah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3940

Abstract

Purpose: This study aimed to evaluate the antioxidant activity and identify secondary metabolite compounds of the ethanol extract from lanang onion bulbs (Allium sativum L.) against DPPH free radicals. Methodology/approach: Extraction was performed by maceration using 95% ethanol, followed by fractionation with n-hexane, ethyl acetate, and water. Antioxidant activity was tested qualitatively by thin-layer chromatography (TLC) and quantitatively by the DPPH method using a UV-Vis spectrophotometer. Phytochemical screening was carried out to identify bioactive compound content. Results/findings: The ethanol extract and ethyl acetate fraction exhibited strong antioxidant activity with IC₅₀ values of 13.85 ppm and 7.27 ppm, respectively. Phytochemical tests revealed the presence of flavonoids, saponins, alkaloids, tannins, steroids, and triterpenoids in each fraction. Limitations: This study was limited to in vitro testing and did not include comprehensive toxicity or in vivo analysis. Contribution: This research contributes to the development of natural antioxidants in pharmacology, phytochemistry, traditional medicine, and functional food industries. The results are useful for researchers, academics, and herbal or health-related industries.
Peran Senyawa Bioaktif Tumbuhan untuk Penyakit Degeneratif : Tinjauan Kimia Medisinal Agis Difa Maharan; Saeful Amin; Nova Noor Fauzan; Nova Sopiyanti
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3959

Abstract

Degenerative diseases, such as Alzheimer's, diabetes mellitus, and cancer, are global health challenges whose prevalence increases with increasing life expectancy. Phytochemicals, bioactive compounds found in plants, have shown potential in preventing and inhibiting the development of these diseases. Compounds such as flavonoids, polyphenols, and glucosinolates have antioxidant, anti-inflammatory, and neuroprotective activities that can protect these body cells from oxidative damage and chronic inflammation. This study suggests that consuming phytochemical-rich foods, such as cruciferous vegetables, pigmented fruits, and certain spices, contributes to a reduced risk of degenerative diseases.
Tinjauan Kelengkapan Pengisian Formulir Permintaan Informasi Medis di Rumah Sakit Permata Pamulang Ima Rusdiana; Holidah Holidah; Tasya Kamila
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3966

Abstract

The medical information request form is the consent given by the patient or their closest family after receiving a complete explanation regarding the medical action that will be carried out on the patient. The aim of this study was to analyze the completeness of filling out medical information request forms. The method used in this research is descriptive research using a sample of 50 medical information request forms. The sampling technique used in this research was total sampling. The results of the research showed that filling in the patient's identity at Gem Pamulang Hospital was almost completely complete with a percentage of 98% and almost nothing was incomplete with a percentage of 2%, almost half of the important reports were complete with a percentage of 29.5 and more than half were incomplete with the percentage is 70.5% and the author authentication is partially complete with a percentage of 24%, and most of it is incomplete with a percentage of 76%.
Faktor Risiko Maternal yang Memengaruhi Kejadian Preeklamsia di RSU Rahmad Hidayah Provinsi Sumatera Utara Marta Armita Silaban; Dear Megawati Situmorang
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.3982

Abstract

The Development of the Research and Health Agency of the Ministry of Health explained that the largest cause of AKI in Indonesia is 32.4% hypertension and/or preeclampsia and 20.3% of postpartum hemorrhage. Hypertension in pregnancy is the main cause of direct death in Indonesia at this time. Severe preeclampsia is a condition where blood pressure is >160/110 mmHg at >20 weeks gestational age without seeing proteinuria and accompanied by involvement of other organs. Preeclampsia is also still a problem, 10% of pregnant women worldwide suffer from preeclampsia, and is the cause of 76,000 maternal deaths and 500,000 infant deaths 566 each year. The purpose of this study is to find out the maternal risk factors that affect the incidence of preeclampsia at Rahmad Hidayah Hospital. The research method used a cross sectional with a sample of 60 mothers. The results of the study were that there was a correlation between the maternal age variable and the incidence of preeclampsia with a value of p=0.004 (α<0.05); There was a correlation between the maternal parity variable and the incidence of preeclampsia with a value of p=0.019 (α<0.05); There was a correlation between the variable history of hypertension/preeclamsia and the incidence of preeclampsia with a value of p=0.000 (α<0.05).
Faktor-faktor yang Memengaruhi Kejadian Preeklampsia di RS Bhayangkara Polda Riau Provinsi Riau Tahun 2024 Damayanty S; Ufi Alfianingsih; Erin Padilla Siregar; Novita Andriani Br. Manjorang; Ika Damayanti Sipayung; Ade Rachmat Yudiyanto
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.3984

Abstract

The number of maternal deaths based on documentation of the family health program at the Ministry of Health, Indonesia had 4,627 deaths in 2020. This figure increased compared to 2019 which amounted to 4,221 deaths. Based on the cause, most maternal deaths in 2020 occurred due to bleeding (1,330 cases), pregnancy-related hypertension (1,110 cases), and circulatory system disorders (230 cases). Preeclampsia is associated with risk factors, including age; women over 40 are more likely to experience preeclampsia, as are mothers who are pregnant with many children. Using quantitative, using numerical data through retrospective surveys with cross-sectional studies. The population of all mothers who experienced preeclampsia in 2023-2024 amounted to 60 people, the research sample Total Sampling 60. The results of statistical tests showed that p.value = 0.004 and α = 0.05, where the value of P.value (0.004) <α (0.05), so it can be concluded that there is a relationship between maternal age and the incidence of Preeclampsia. The results of statistical tests showed that p.value = 0.019 and α = 0.005, where the value of P.value (0.019) <α (0.005), so it can be concluded that there is a relationship between maternal parity and the incidence of Preeclampsia. Based on the results of the statistical test, it was found that p.value = 0.000 and α = 0.05, where the value of P.value (0.000) < α (0.05), so it can be concluded that there is a relationship between maternal nutritional status and the incidence of preeclampsia. The results of the statistical test showed that p.value = 0.120 and α = 0.05, where the value of P.value (0.120) < α (0.05), so it can be concluded that there is no relationship between maternal gestational age and the incidence of preeclampsia.

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