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INDONESIA
Jurnal Penelitian Saintek
Published by Universitas Negeri Yogyakarta
ISSN : 14123991     EISSN : 25287036     DOI : 10.21831
Core Subject : Science,
Decision Sciences, Operations Research & Management
Arjuna Subject : -
Articles 10 Documents
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Search results for , issue "Vol 25, No 2 (2020)" : 10 Documents clear
OPTIMASI MEDIA KULTUR IN VITRO ANGGREK Dendrobium nobile BERBASIS PUPUK DENGAN PENAMBAHAN AIR KELAPA DAN VITAMIN B1 Ayu Purnamasari; Ratnawati Ratnawati; Aloysius Suyitno; Lili Sugiyarto; Ixora Sartika Mercuriani
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34267

Abstract

Tujuan penelitian ini adalah mengetahui pengaruh kombinasi penambahan air kelapa dan vitamin B1 terhadap pertumbuhan anggrek Dendrobium nobile serta mengetahui konsentrasi vitamin B1 yang optimum untuk pertumbuhan anggrek pada media kultur in vitro berbasis pupuk. Penelitian ini merupakan penelitian eksperimen dengan menggunakan rancangan tersarang (nested design) dengan faktor I adalah perlakuan air kelapa (dengan air kelapa dan tanpa air kelapa) dan faktor II adalah variasi konsentrasi vitamin B1 (0 ml.L-1, 0,25 ml.L-1,0,5 ml.L-1, dan 1 ml.L-1). Sampel yang digunakan adalah bibit anggrek D. nobile umur 11 bulan dalam kultur in vitro yang mempunyai keseragaman karakter pertumbuhan. Data penelitian ini dianalisis menggunakan analisis ragam (Anova) metode rancangan tersarang dan uji Least Significant Difference (LSD). Hasil penelitian menunjukkan bahwa penambahan air kelapa memberikan pengaruh yang signifikan terhadap pertambahan diameter batang dan berat basah tanaman sedangkan penambahan vitamin B1 memberikan pengaruh yang signifikan terhadap pertambahan jumlah daun, jumlah akar, dan panjang akar anggrek. Konsentrasi vitamin B1 yang optimum untuk pertumbuhan anggrek adalah 0,5 ml.L-1 baik pada media yang mengandung ataupun tidak mengandung air kelapa.OPTIMATION FERTILIZER BASED IN VITRO CULTURE MEDIA COCONUT WATER AND B1 VITAMIN ADDITION FOR Dendrobium nobileThis study was aimed at determining the effect of the coconut water and vitamin B1 as a combination on the growth of Dendrobium nobile orchids and determining the optimum concentration of vitamin B1 for orchid growth in fertilizer-based in vitro culture media. This study was an experimental study using a nested design which factor I was the treatment of coconut water (with and without coconut water) and factor II was the variation in the concentration of vitamin B1 (0 ml.L-1, 0.25 ml. L-1, 0.5 ml.L-1, and 1 ml.L-1). The samples used were 11 months old D. nobile orchid seeds in in vitro culture which had simultaneous growth characters. The data were analyzed using Anova, nested design method and Least Significant Difference (LSD) test. The results show that the addition of coconut water has a significant effect on the increase in stem diameter and plant wet weight. The addition of vitamin B1 has a significant effect on the increase in the number of leaves, the number of roots, and the length of the orchids. The optimum concentration of vitamin B1 for orchid growth is 0.5 ml.L-1 both in media with or without coconut water.
ANALISIS KESERAGAMAN PENDINGINAN PRODUK PLASTIK INJEKSI MOLDING DENGAN VARIASI SISTEM PENDINGIN Angger Bagus Prasetiyo; Fauzun Fauzun; Azhim Azyratul Azmi; Rizqi Ilmal Yaqin; Sigit Haryo Pranoto
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34574

Abstract

Tujuan dari penelitian ini adalah untuk dapat menganalisis keseragaman pendinginan produk plastik injeksi molding dengan variasi sIstem pendingin menggunakan metode Computational Fluid Dynamics (CFD). Variasi sistem pendinginan ini dimaksudkan untuk mengetahui pengaruh sistem pendingin terhadap keseragaman pendinginan produk plastik. Studi kasus pada penelitian ini menggunakan produk tempat teh sachet. Material produk plastik yang digunakan adalah Polypropylene yang dipanaskan dengan suhu 490°K. Pembuatan Computer-Aided Design (CAD) produk dilengkapi dengan sistem pendingin pada masing-masing variasi. Desain gambar mold disederhanakan menjadi bagian cavity dan core dengan menggunakan Software Solidwork 2015. Fluida pendingin menggunakan air dan mold-nya menggunakan material steel. Boundary condition pada produk plastik mengggunakan pressure inlet. Hasil simulasi menunjukkan bahwa penggunaan metode CFD variasi sistem pendinginan yang diusulkan mampu menganalisis keseragaman pendinginan produk plastik injeksi molding. Penggunaan conformal cooling channel system dengan menggunakan metode CFD menghasilkan penurunan temperatur yang lebih seragam dibandingkan dengan penurunan temperatur pada straight cooling channel. Pada penelitian ini, variasi pendingin conformal cooling channel lebih baik dibandingkan dengan straight cooling channel.SIMULTANEOUS COOLING ANALYSIS OF INJECTION MOLDING PLASTIC PRODUCTS WITH COOLING SYSTEM VARIATIONSThis study was aimed at analyzing the simultaneous cooling process of injection molding plastic products with a variety of cooling systems using the Computational Fluid Dynamics (CFD) method. This cooling system variation was intended to determine the effect of the cooling system on simultaneous coolling process of plastic products. This case study used a tea sachet product. The plastic product material used was Polypropylene. It heated at a temperature of 490 ° K. The manufacture of Computer-Aided Design (CAD) products was equipped with a cooling system in each variation. The mold drawing design was simplified into cavity and core parts by using Solidwork 2015 Software. Water was used as the cooling fluid while steel material was used as the mold. A pressure inlet was used as a boundary conditions for the plastic products. The simulation results show that the used of CFD method in cooling system is able to analyze the simultaneous cooling of injection molding plastic products. The use of conformal cooling channel system using CFD method produces more simultaneous temperature drop compared to the straight cooling channel. In this study, conformal cooling channel variation is better than straight cooling channel 
SINTESIS HIDROGEN PEROKSIDA PADA PENGOLAHAN AIR KOLAM RENANG MENGGUNAKAN METODE ELEKTRODISINFEKTAN Suyanta Suyanta; Fika Deni Utari
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34336

Abstract

Penelitian ini bertujuan untuk mengetahui potensial dan waktu optimum proses elektrodisinfektan air kolam renang serta mengetahui kualitas air kolam renang berdasarkan parameter kadar hidrogen peroksida, pH dan TDS setelah proses elektrodisinfektan berdasarkan Peraturan Menteri Kesehatan Republik Indonesia No. 32/MENKES/PER/VI/2017. Optimasi potensial listrik menggunakan variasi 2, 4, 6, 8 dan 10 volt. Optimasi waktu yang digunakan adalah variasi 0,5; 1; 2; 3; dan 4 jam. Sampel dianalisis untuk mengetahui kadar hidrogen peroksida, pH dan TDS air kolam renang berturut-turut menggunakan metode spektrofotometri UV-Vis, pH meter dan TDS meter. Berdasarkan penelitian potensial optimum proses elektrodisinfektan sebesar 10 volt, sedangkan waktu optimum selama 4 jam dengan hidrogen peroksida yang dihasilkan sebesar 68,05 mg/L. Kualitas air kolam renang berdasarkan Peraturan Menteri Kesehatan RI dikatakan baik karena memenuhi standar kualitas air kolam renang yaitu kadar hidrogrn peroksida kurang dari 0,3%, pH antara 7-7,8 serta nilai TDS air kolam renang turun dari 219 menjadi 216.THE SYNTHESIS OF HYDROGEN PEROXIDE IN SWIMMING POOL WATER TREATMENT USING ELECTRODISINFECTANT METHODThis study was aimed at determining the potential and the optimum time for the electrodisinfectant process of swimming pool water and determining the quality of swimming pool water based on the parameters of hydrogen peroxide, pH, and TDS levels after the electrodisinfectant process based on the Regulation of the Minister of Health of the Republic of Indonesia No. 32/MENKES/PER/VI/2017. The electric potential optimizations used were 2, 4, 6, 8 and 10 volts. The time optimizations used were 0.5; 1; 2; 3; and 4 hours. The samples were analyzed using  UV-Vis spectrophotometric methods, pH meter and TDS meter to determine hydrogen peroxide levels, pH and TDS of swimming pool water. The result shows that the optimum potential for the electrodisinfectant process is 10 volts, while the optimum time for 4 hours with hydrogen peroxide is 68.05 mg / L. The quality of swimming pool water based on the Minister of Health Regulation is categorized as good quality. The quality of the water meets the swimming pool water quality standards. The hydrogen peroxide level is less than 0.3%; the pH is between 7-7.8; and the TDS value of swimming pool water drops from 219 to 216.
PREDIKSI TOTAL PADATAN TERLARUT BUAH MELON GOLDEN MENGGUNAKAN VIS-SWNIRS DAN ANALISIS MULTIVARIAT Yuda Hadiwijaya; Kusumiyati Kusumiyati; Agus Arip Munawar
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34487

Abstract

Penelitian ini bertujuan untuk memprediksi total padatan terlarut buah melon golden (Cucumis melo L.) menggunakan Vis-SWNIRS dan analisis multivariat. Terdapat 82 sampel buah melon golden dipilih untuk dianalisis di Laboratorium Hortikultura, Fakultas Pertanian, Universitas Padjadjaran. Nirvana AG410 spectrometer dengan rentang panjang gelombang 300 sampai 1050 nm digunakan untuk pengambilan data spektra pada sampel buah melon utuh. Metode koreksi spektra yang digunakan yaitu Standard Normal Variate (SNV), Multiplicative Scatter Correction (MSC), dan Orthogonal Signal Correction (OSC). Pemodelan kalibrasi dilakukan menggunakan Partial Least Squares Regression (PLSR). Hasil penelitian menunjukkan bahwa penggunaan metode koreksi spektra OSC menampikan model kalibrasi terbaik dibandingkan spektra original dan 2 spektra lainnya yang telah dikoreksi. Koefisien determinasi pada spektra OSC memperlihatkan nilai R2 tertinggi yaitu 0,99. Di samping itu, nilai ratio performance to deviation (RPD) yang diperoleh sebesar 3,40. Hal ini membuktikan total padatan terlarut buah melon golden dapat diprediksi dengan akurasi yang tinggi menggunakan Vis-SWNIRS dan analisis multivariat.PREDICTION OF TOTAL SOLUBLE SOLIDS OF GOLDEN MELON USING Vis-SWNIRS AND MULTIVARIATE ANALYSISThis study was aimed at predicting the total dissolved solids of golden melon (Cucumis melo L.) using Vis-SWNIRS and multivariate analysis. There were 82 golden melon fruit samples selected for analysis at the Horticulture Laboratory, Faculty of Agriculture, Padjadjaran University. Nirvana AG410 spectrometer with a wavelength range of 300 to 1050 nm was used to collect spectral data on intact melon fruit samples. The spectra correction methods used were Standard Normal Variate (SNV), Multiplicative Scatter Correction (MSC), and Orthogonal Signal Correction (OSC). Calibration modeling was carried out using Partial Least Squares Regression (PLSR). The results show that the use of the OSC spectra correction method presents the best calibration model compared to the original spectra and 2 other corrected spectra. The coefficient of determination on the OSC spectra shows the highest R2 value, namely 0.99, besides that the ratio performance to deviation (RPD) value obtained is 3.40. This proves that the total dissolved solids of golden melon can be predicted with high accuracy using Vis-SWNIRS and multivariate analysis.
PEMANFAATAN EKSTRAK DAUN URTICA DIOICA L. SEBAGAI ANTI-AGING ALAMI DALAM SEDIAAN KRIM Siti Maimunah; Zuhairiah Nasution; Amila Amila
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34296

Abstract

Penelitian ini bertujuan untuk memformulasikan ekstrak daun jelatang dalam sediaan krim dan menguji efektivitas  anti-aging nya. Penelitian ini dilakukan di Laboratorium Kimia Farmasi Universitas Sari Mutiara Indonesia pada bulan Juni-Agustus 2020. Alat yang digunakan adalah skin analyzer and moisture checker. Sampel daun jelatang diperoleh dari Hutan Sibolangit, Sumatera Utara. Uji iritasi terhadap enam orang sukarelawan menggunakan krim ekstrak jelatang dengan konsentrasi tertinggi yaitu 0,5%. Pengujian aktivitas anti-aging menggunakan 18 sukarelawan wanita berusia 19-22 tahun. Parameter yang diukur meliputi kadar air, jumlah pori dan kerutan. Distribusi data dianalisis dengan Shapiro-Wilk Test dan dilanjutkan dengan Kruskal-Walls Test dan Mann-Whitney Test. Hasil penelitian ekstrak etanol daun Jelatang dapat diformulasikan dalam bentuk sediaan krim tipe A/M yang homogen, dengan pH 6, viskositas 28.000 cps, tidak menimbulkan iritasi dan stabil dalam penyimpanan selama 28 hari. Hasil analisis dengan skin analyzer menunjukkan perubahan kondisi kulit menjadi lebih baik yaitu kadar air bertambah, pori dan kerutan berkurang. Sediaan krim dengan konsentrasi 0,5% menunjukkan efektivitas  anti-aging terbaik.THE UTILIZATION OF URTICA DIOICA L. LEAVES EXTRACT AS A NATURAL  ANTI-AGING IN CREAM PREPARATIONThis study was aimed at formulating Nettle leaf extract in a cream formulation and testing its anti-aging effectiveness. This research was conducted at the Pharmaceutical Chemistry Laboratory of Sari Mutiara Indonesia University in June-August 2020. The tools used were skin analyzer and moisture checker. Nettle leaf samples were obtained from the Sibolangit Forest, North Sumatra. The irritation test of six volunteers used nettle extract cream with the highest concentration of 0.5%. The anti-aging activity test used 18 female volunteers aged 19-22 years. Parameters measured include moisture content, number of pores and wrinkles. The data distribution was analyzed using the Shapiro-Wilk Test and followed by the Kruskal-Walls Test and the Mann-Whitney Test. The results show that the ethanol extract of Nettle leaves can be formulated in a homogeneous type A / M cream dosage form, with a pH of 6, a viscosity of 28,000 cps, non-irritating and stable in storage for 28 days. The results of the analysis with the skin analyzer showed that the skin condition changed for the better, namely increased water content, reduced pores and wrinkles. Cream preparations with a concentration of 0.5% show the best anti-aging effectiveness.
APLIKASI SISTEM INFORMASI PELAYANAN HAJI DAN UMRAH BERBASIS AUGMENTED REALITY/VIRTUAL REALITY Ali Anton Senoaji; Winih Wicaksono; Endah Kusumaningrum
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34389

Abstract

Tujuan dari penelitian yaitu membangun aplikasi sistem informasi dan pelayanan ibadah haji dan umrah yang mampu menciptakan lingkungan virtual yang interaktif dengan basis Augmented Reality/Virtualy Reality (AR/VR). Metode yang digunakan dalam penelitian ini adalah jenis penelitian dan pengembangan (RD), yaitu mengembangkan Aplikasi Haji Pintar yang dibuat oleh Ditjen. PHU Kementrian Agama Republik Indonesia. Hasil penelitian menunjukkan bahwa calon/jamaah haji/umrah mengatakan aplikasi AR/VR ini mampu menciptakan lingkungan virtual yang interaktif. Terbukti ada 51% responden termotivasi untuk menunaikan ibadah haji/umrah. Pengembangan aplikasi sistem informasi pelayanan ibadah haji dan umrah dengan basis AR/VR menurut 82% responden mengatakan dalam kategori Layak. APPLICATION OF THE INFORMATION SYSTEM OF HJI AND UMRAH SERVICES BASED ON AUGMENTED REALITY/VIRTUAL REALITYThe purpose of this research is to build an information system application and services for Hajj and Umrah that can create an interactive virtual environment based on Augmented Reality/Virtualy Reality (AR/VR). The method used in this research is a type of research and development (RD), which is building/developing a Smart Hajj Application made by the Directorate General. PHU of the Ministry of Religion of the Republic of Indonesia. The results showed that the pilgrims/pilgrims said that the AR/VR application was able to create an interactive virtual environment. It is proven that 51% of respondents are motivated to carry out the Hajj/Umrah pilgrimage. Development of information system applications for Hajj and Umrah services based on AR/VR according to 82% of respondents said it was in the Eligible category.
ANALISIS PADA SISTEM INFORMASI AKADEMIK MAHASISWA MENGGUNAKAN METODE SYSTEM USABILITY SCALE Wresni Anggraini; Reski Mai Candra; Widad Ulfika Sari
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.28763

Abstract

Penelitian ini bertujuan untuk mengidentifikasi permasalahan pada Sistem Informasi Akademik Mahasiswa (SIAM), mengetahui tingkat usability-nya, dan memberikan rekomendasi perbaikan SIAM. Penelitian ini dilakukan di Universitas Muhammadiyah Riau mulai Februari hingga Juli 2019. Tahap awal pengumpulan data dilakukan dengan melakukan observasi langsung terhadap objek penelitian yaitu Sistem Informasi Akademik Mahasiswa (SIAM) UMRI. Sampel diambil menggunakan metode random sampling. Sebanyak 4.623 mahasiswa aktif pengguna SIAM Universitas Muhammadiyah Riau terpilih menjadi sampel dalam penelitian ini. Penelitian ini dilakukan dengan menggunakan metode System Usability Scale (SUS) untuk mengetahui tingkat usability, mengidentifikasi permasalahan, dan memberi rekomendasi perbaikan SIAM. Hasil penelitian menunjukan bahwa SIAM sudah acceptable atau dapat diterima oleh penggunanya dan memiliki skala nilai C+ dan memiliki rating good; dan fitur SIAM belum dirancang dengan baik; dan SIAM memiliki banyak inkonsistensi. Beberapa rekomendasi perbaikan dari beberapa pihak diharapkan dapat dijadikan sebagai rujukan bagi tim pengembang sistem dalam melakukan perbaikan usability system sehingga SIAM memiliki tingkat usability yang tinggi dan dapat mencapai kepuasan pengguna.(THE ANALYSIS ON STUDENTS ‘ACADEMIC INFORMATION SYSTEM USING USABILITY SCALE SYSTEM)This study was aimed at identifying the problems in the Student Academic Information System (SAIS), determining the level of usability, and providing recommendations for the improvement of SAIS. This study was conducted at Muhammadiyah Riau University from February to July 2019. The initial stage of data collection was carried out by direct observation of the research object, namely the UMRI SIAS. In determining the sample, from the random sampling, the 4,623 active students were taken a part in SAIS, Muhammadiyah University of Riau. This study was conducted using the System Usability Scale (SUS) method to determine the level of usability, identify problems, and provide recommendations for improvements to SIAS. The results show that SIAS is acceptable and feasible to its users. SIAS got C+ (good) rating scale since its functions and features are not well designed and has many inconsistencies. Some recommendations for improvement from several parties are expected to be used as a reference for the system development team in improving the usability of the system so that SIAS get a higher level of usability and can achieve user satisfaction.
STUDI AWAL DISTRIBUSI TEMPERATUR ELEMEN BAHAN BAKAR REAKTOR CEPAT BERPENDINGIN GAS Balya Lutviana Laila Saro; Fiber Monado; Menik Ariani
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.27744

Abstract

Tujuan dari penelitian ini adalah menganalisis desain reaktor berdasarkan aspek termal hidrolik dan melakukan perhitungan distribusi temperatur elemen bahan bakar pada kondisi tunak. Perhitungan dilakukan secara komputasi dengan menggunakan MATLAB (MATrix LABoratory). Metode yang digunakan ialah studi literatur dan perhitungan komputasi. Studi awal distribusi temperatur elemen menggunakan bahan bakar reaktor cepat berpendingin gas atau Gas-cooled Fast Reactor (GFR). GFR ini didesain dengan bahan bakar uranium metal (U-10%wtZr), pendingin Helium (He), kelongsong stainless steel 316 (SS316) dan daya 500 MWt. Untuk menghitung distribusi temperatur elemen bahan bakar maka akan digunakan dengan asumsi distribusi kerapatan daya di dalam bahan bakar merata ke segala arah baik untuk arah radial maupun aksial dan transfer panas berlangsung pada keadaan tunak untuk 1 kanal pendingin.Perhitungan distribusi temperatur elemen bahan bakar pada kondisi tunak dilakukan dengan menggunakan  persamaan-persamaan yang diadaptasi dari Duderstadt dan Hamilton. Hasil penelitian ini menunjukan bahwa reaktor berada dalam batas aman dengan temperatur maksimum berada di bawah nilai titik leleh bahan bakar, sehingga dari keadaan ini dapat menunjang keamanan pengoperasian reaktor.PRELIMINARY STUDY OF THE  ELEMENT TEMPERATURE DISTRIBUTION OF GAS-COOLED FAST REACTORThe study was aimed at analyzing the design of the reactor based on thermal-hydraulic aspects and calculating the temperature distribution of the fuel element under steady conditions. The calculations were done computationally using MATLAB (MATrix LABoratory). The method used was the study of literature and computational calculations. Preliminary studies of the temperature distribution of the elements using a Gas-cooled Fast Reactor (GFR). The GFR is designed with uranium metal fuel (U-10% wtZr), Helium cooler (He), 316 stainless steel cladding (SS316) and 500 MWt power. To calculate the temperature distribution of the fuel element, assuming the distribution of the power density in the fuel is evenly distributed in all directions. All directions for both radial and axial direction and heat transfer took place under steady-state for 1 cooling channel. The calculation of the temperature distribution of the fuel element under steady-state performed using equations adapted from Duderstadt and Hamilton. The results of this study indicate that the reactor is within safe limits with maximum temperatures below the value of the melting point of the fuel.  The conclusion was it is able to support the safety of the reactor operation.
SINTESIS ANALOG KURKUMIN 2,6-BIS-(E)-4-HIDROKSI-3-METOKSI BENZILIDIN)-SIKLOHEKSA-1-ON BERBAHAN DASAR VANILIN DENGAN KATALIS HCl Rahma Diyan Martha; Tutik Dwi Wahyuningsih; Chairil Anwar
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.34106

Abstract

Tujuan penelitian ini memodifikasi gugus β-diketon sehingga dapat meningkatkan stabilitas dari analog kurkumin.Metode yang digunakan yaitu sintesis senyawa analog kurkumin berbahan dasar vanillin sebagai sumber benzaldehida dan sikloheksanon sebagai sumber keton dengan katalis asam (HCl). Dianalisis dengan KLT dan instrumentasi FTIR,direct-MS,1H NMR dan 13C NMR. Dari hasil analisis titik leleh, KLT, FTIR, direct-MS, 1H- dan 13C-NMR, bahwa senyawa target telah terbentuk berupa padatan warna kuning kehijauan, memiliki titik leleh 210-212 °C dan rendemen 53,00% serta hasil KLT terdapat spot baru yang berfluorosensi. Sehingga, dapat disimpulkan bahwa senyawa analog kurkumin (2,6-bis-((E)-4-hidroksi-3-metoksibenzilidin)-sikloheksa-1-on) dapat disintesis melalui kondensasi aldol menggunakan starting material vanilin sebagai sumber benzaldehida dan sikloheksanon sebagai sumber keton dengan katalis asam (HCl).THE SYNTHESIS OF CURCUMINE ANALOGUE 2,6-BIS-(E)-4-HIDROKSI-3-METOKSI BENZILIDIN)-SIKLOHEKSA-1-ON FROM VANILIN WITH HYDROCLORIDE ACID CATALYSTThe aim of this study was to modify the β-dicetone group so as to increase the stability of the curcumin analogue. The method used is the synthesis of a curcumin analogue compound based on vanillin as a source of benzaldehyde and cyclohexanone as a source of ketones with an acid catalyst (HCl). Analyzed by TLC and FTIR instrumentation, direct-MS, 1H NMR and 13C NMR. From the analysis of melting point, TLC, FTIR, direct-MS, 1H- and 13C-NMR, that the target compound has been formed in the form of a greenish yellow solid, has a melting point of 210-212 ° C and a yield of 53.00% and the results of TLC are new fluorescent spot. Thus, it can be concluded that the curcumin analogue compound (2,6-bis - ((E) -4-hydroxy-3-methoxy benzylidine) -cyclohexa-1-on) can be synthesized through aldol condensation using vanillin as a source of benzaldehyde and cyclohexanone. as a source of ketones with an acid catalyst (HCl).
AKTIVITAS ANTIDIABETES METABOLIT SEKUNDER BAKTERI ENDOFIT ASAL KULIT KAYU MANIS Purbowatiningrum Ria Sarjono; Hendra Dwipa Rifky Mahardika; Nies S. Mulyani; Ngadiwiyana Ngadiwiyana; Nor Basid Adi Prasetyawibowo; Ismiyarto Ismiyarto
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.32892

Abstract

Penelitian ini bertujuan untuk mengisolasi bakteri endofit yang bersimbiosis dengan kulit kayu manis, mendapatkan data kemampuan inhibisi enzim α-glukosidase dari metabolit sekunder isolat bakteri endofit yang didapatkan, serta mendapatkan informasi mengenai kandungan kimia dari metabolit sekunder isolat bakteri endofit yang didapat. Bahan yang digunakan pada penelitian ini terdiri atas sampel kulit kayu manis (Cinnamomum burmanii) yang didapatkan dari daerah Kopeng, Kabupaten Semarang. Metode yang digunakan dalam sterilisasi adalah metode klorin. Pengamatan morfologi koloni dilakukan dengan pewarnaan gram sedangkan Uji Inhibisi α-glukosidase dari metabolit menggunakan metode dari Sancheti. Aktivitas antidiabetes diuji menggunakan metode penghambatan enzim α-glukosidase. Hasil yang diperoleh pada penelitian ini adalah lima isolat bakteri memiliki yang bentuk beragam yakni streptobacillus (isolat C1, isolat C4, dan isolat C5), diplobacillus (isolat C2), dan diplococcus (isolat C3). Kemampuan inhibisi α-glukosidase tertinggi dihasilkan oleh metabolit sekunder isolat C5 yakni sebesar 45,634% pada konsentrasi 100 ppm. Penapisan fitokimia pada penelitian ini menunjukkan bahwa metabolit sekunder isolat C5 yang memiliki daya inhibisi tertinggi mengandung senyawa flavonoid, tanin, kuinon dan saponin.ANTIDIABETIC ACTIVITY FROM SECONDARY METABOLIM ENDOPHYTIC BACTERIA BARKThis study was aimed at isolating endophytic bacteria symbiotic with cinnamon bark, obtaining data on the inhibition ability of α-glucosidase enzymes from secondary metabolites of endophytic bacterial isolates obtained, and obtaining information on the chemical content of secondary metabolites of endophytic bacterial isolates obtained. The materials used in this study consisted of the samples of cinnamon bark (Cinnamomum burmanii) obtained from Kopeng, Semarang. The method used in sterilization was the chlorine method. Colony morphological observations were carried out by using gram staining, while the α-glucosidase inhibition test of metabolites used the Sancheti method. The antidiabetic activity was tested using the α-glucosidase enzyme inhibition method. The results show that five bacterial isolates had various forms, namely streptobacillus (isolate C1, isolate C4, and isolate C5), diplobacillus (isolate C2), and diplococcus (isolate C3). The highest α-glucosidase inhibition ability was produced by secondary metabolites of isolate C5, namely 45.634% at a concentration of 100 ppm. Phytochemical screening in this study showed that the secondary metabolites of isolate C5 which had the highest inhibitory power contained flavonoids, tannins, quinones and saponins.

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