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Winni Maharani
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Jl. Hariangbanga No. 2, Kota Bandung, 40132, West Java, Indonesia
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Global Medical and Health Communication
Published by Universitas Islam Bandung
ISSN : 23019123     EISSN : 24605441     DOI : https://doi.org/10.29313/gmhc.v13i2
Core Subject :
Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, health communication, health promotion, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.
Arjuna Subject : -
Articles 45 Documents
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Clinical Factors of Linezolid-associated Toxic Optic Neuropathy in Drug-resistant Tuberculosis Patients Dwi Indira Setyorini; Zen Ahmad; Zen Hafy; Devi Azri Wahyuni; Subandrate Subandrate; Ella Amalia
Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i2.9676

Abstract

Linezolid remains a key component in drug-resistant tuberculosis (DR-TB) regimens but is associated with toxic optic neuropathy (TON). Although mitochondrial dysfunction has been implicated in linezolid-induced neurotoxicity, the contribution of mitochondrial DNA (mtDNA) variants remains uncertain, with limited data from Indonesian populations. This study aimed to evaluate clinical risk factors and mitochondrial DNA polymorphisms associated with linezolid-related TON in DR-TB patients. This cross-sectional analytical study was conducted at Dr. Mohammad Hoesin Hospital in Palembang from January to March 2025 and involved 51 DR-TB patients receiving linezolid therapy, selected through consecutive sampling. Demographic and clinical data were collected, and mtDNA polymorphisms (G3010A and A2706G) were examined using PCR-RFLP, chosen based on previous studies linking these variants to linezolid toxicity in Asian and African populations. TON was identified in 22 of 51 patients (43.1%) based on standardized ophthalmological criteria. Diabetes mellitus (PR=2.078, 95% CI=1.191–3.624, p=0.03) and treatment regimen (PR=12.469, 95% CI=1.821–85.398, p=0.00) demonstrated statistically significant associations with TON, whereas age (p=0.635), sex (PR=0.713, 95% CI=0.384–1.322, p=0.29), HIV status (PR=1.600, 95% CI=0.672–3.809, p=0.40), and DR-TB type (PR=1.438, 95% CI=0.735–2.812, p=0.28) were not associated. All subjects had a wild-type genotype for G3010A and a mutant-type genotype for A2706G, precluding any association analysis for these variants. In conclusion, diabetes mellitus and individual treatment regimens were associated with linezolid-induced TON in this study. In contrast, the investigated mtDNA polymorphisms (G3010A and A2706G) showed no variability; thus, no relationship could be evaluated. Larger prospective studies with expanded genetic markers and multivariate adjustment are warranted to characterize susceptibility factors for linezolid-associated TON better.
Older Adults’ Experiences of Medical Rehabilitation for Knee Osteoarthritis: A Qualitative Study Yenni Limyati; Julia Windi Gunadi; Christian Edwin; Teresa Lucretia; Ardo Sanjaya; Jerremilie Jerremilie
Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i2.9845

Abstract

Knee osteoarthritis (KOA) is a major cause of disability among older adults. Yet, qualitative evidence on the experience of medical rehabilitation within hospital-based, nationally insured health systems such as Indonesia's remains limited. This study aims to explore how older adults with KOA described their experience of undergoing medical rehabilitation at a hospital-based outpatient clinic in Indonesia. A qualitative exploratory-interpretive design was used. Semi-structured interviews were conducted with 10 older adults (6 women, 4 men; median age 68 years, range 61–84) undergoing medical rehabilitation for KOA at a teaching hospital rehabilitation clinic in Bandung, Indonesia. Data were analyzed using reflexive thematic analysis. Three themes were generated: (1) navigating uncertainty toward controlled self-management of pain and procedures, including initial apprehension toward unfamiliar or invasive modalities such as dry needling; (2) restoring functional roles in daily and religious life, particularly movements associated with prayer and agricultural work; and (3) support networks and systemic barriers, including family and peer support alongside administrative barriers related to insurance referral renewal and cross-clinic scheduling conflicts. These barriers recurred across participants but were not universal. In conclusion, older adults' experience of KOA rehabilitation extended beyond pain relief to the restoration of culturally and religiously meaningful roles, supported by family, peer, and clinical relationships within a system shaped by administrative constraints specific to the Indonesian insurance context. These findings may inform more individualized, patient-centered rehabilitation planning in similar hospital-based settings.
Clinical Factors Associated with Active Tuberculosis among Participants in Community-based Active Case Finding in Purwakarta District: A Cross-sectional Study Cindra Paskaria; Aurel Dion Mazzarello Kiswanto; Abram Pratama
Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i2.10224

Abstract

Active case finding (ACF) is one of the key strategies to achieve tuberculosis elimination targets. ACF activity has been carried out in the Purwakarta District, which has a high number of tuberculosis cases. This study aims to examine the participants' characteristics, clinical conditions, and associated risk factors. This study uses quantitative methods with a cross-sectional approach. Data for this study were derived from a routine ACF initiative conducted by the District Health Office in the villages of Cibogo Girang, Citeko Kaler, and Sindang Sari between September and October 2023. The study subjects consisted of people who participated in ACF. Distribution and frequency of demographic characteristics, clinical symptoms, and risk factors were calculated and compared between tuberculosis and non-tuberculosis patient groups. Binary logistic regression analysis was applied to examine associations. 365 participants attended the ACF sessions and successfully identified 35 cases of active tuberculosis. More than half of the ACF participants experienced clinical symptoms of tuberculosis. Still, there was no statistically significant difference in proportion between participants diagnosed with tuberculosis and those not, except for the symptom of night sweats (p=0.005) with an odds ratio of 3.07 (1.40-6.75). In conclusion, there was no difference in the proportion of risk factors between the two groups. The ACF in Indonesia's rural communities, combined approaches, can successfully uncover a substantial number of hidden tuberculosis cases. The specific association of night sweats with tuberculosis contributes to the clinical understanding of its presentation and should be factored into screening algorithms.
Effect of Staurogyne elongata Leaf Extract on Macrophages, Fibroblast Proliferation, Collagen Deposition, and Excisional Wound Closure in BALB/c Mice Florence Meliawaty; Juni Handajani; Heni Susilowati; Poerwati Soetji Rahajoe; Euis Reni Yuslianti; Mistli Nur Robbani; Zahra Noor Aflina; Sallimah Nur’idzati
Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i2.10276

Abstract

A wound is a disruption of tissue integrity caused by physical, chemical, thermal, microbiological, or immunological injury, resulting in structural and functional alterations of the skin. Wound healing is a complex process involving inflammatory, proliferative, and remodeling phases. Macrophages regulate inflammation and phagocytosis, whereas fibroblasts contribute to tissue repair through collagen synthesis. Reundeu (Staurogyne elongata) leaf extract possesses antibacterial and antioxidant properties that may enhance wound healing. This study aims to evaluate the effects of Staurogyne elongata leaf extract on macrophages, fibroblast proliferation, collagen deposition, and excision wound healing in BALB/c mice. This study was conducted at the Universitas Jenderal Achmad Yani laboratories in Cimahi from October 17, 2025, to January 27, 2026. It evaluated the effects of S. elongata leaf extract on wound healing rate, macrophage and fibroblast counts, and collagen density in mouse excision wounds. A post-test-only control group design was used. Forty mice were assigned to five groups: a negative control, a positive control (0.5% chlorhexidine), and treatment groups receiving extracts at 6.25%, 12.5%, and 25%. Tissue samples were collected on days 0, 1, 3, and 7. Wound healing was assessed by wound area reduction. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests (p≤0.05). The 6.25% extract group showed the highest wound healing rate and wound closure on day 7. The highest macrophage count was observed in the 25% extract group on day 3, whereas the highest fibroblast count and collagen density were found in the 12.5% and 25% extract groups on days 3 and 7. In conclusion, these findings suggest that S. elongata leaf extract promotes wound healing by enhancing macrophage activity, fibroblast proliferation, collagen deposition, and tissue regeneration in mice.
Counterpressure Therapy for Active Phase Labor Pain in Bengkulu City Dika Nafisyatul Mumayyizah; Dara Himalaya; Rini Mustikasari Kurnia Pratama; Fitri Ramadhaniati; Yetti Purnama; Deni Maryani
Global Medical & Health Communication (GMHC) Vol. 14 No. 2 (2026): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v14i2.10456

Abstract

Labor pain is a common concern during childbirth, particularly as uterine contractions become more intense during the active phase of labor. Non-pharmacological approaches such as counterpressure may provide supportive pain management during labor. This study aimed to examine changes in labor pain intensity before and after counterpressure therapy among women in the active phase of the first stage of labor at a clinic in Bengkulu City. A quantitative quasi-experimental study with a single-group pretest-posttest design was conducted among 22 women with cervical dilatation of 4–6 cm. Participants were selected using purposive sampling during December 12–31, 2025. Pain intensity was assessed using the Numeric Rating Scale before and after the intervention. The mean pain intensity score was 4.9545 before the intervention and 3.5000 after the intervention, with a mean difference of 1.4545 points. The Shapiro-Wilk test indicated a non-normal data distribution (p<0.001); therefore, the Wilcoxon signed-rank test was used, which showed a statistically significant difference between pre-intervention and post-intervention pain scores (p=0.007). In conclusion, these findings indicate a within-group change in reported labor pain intensity following counterpressure therapy among women in the active phase of the first stage of labor at a clinic in Bengkulu City. However, because the study did not include a control group, the observed change cannot be interpreted as definitive evidence of the intervention's causal effect.

Page 5 of 5 | Total Record : 45

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