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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,040 Documents
 72   73   74   75   76 
CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY Maria Hotmaida Carolina Munthe; Novi Kusumaningrum; Amallia Nuggetsiana Setyawati; Astika Widy Utomo; Santoso Santoso
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29955

Abstract

Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.Objective: To determine the correlation between serum IL-23 levels and AV severity in men.Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.
THE COMPARISON BETWEEN PLYOMETRICS EXERCISE WITH AEROBIC EXERCISE TOWARDS DECISION-MAKING IN YOUNG ADULTS Azzahara, Salma Yasmine; Ambarwati, Endang; Kumaidah, Endang; Widodo, Sumardi
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29333

Abstract

Background: Lack of physical activity in individual has a big impact towards brain as if in the cognitive parts of the brain, especially decision making and memory. The relation between physical activity and cognitive ability is related to angiogenesis and neurogenesis that is more optimal in individuals who do their physical activity routine. Plyometrics and Aerobic exercise are proven to have a positive effect on the body, but there has been no further research on the comparison of the two sports.  Aim: to understand the comparison between plyometrics exercise with aerobic exercise towards decision-making in young adults . Methods: This study used quasi experimental design pretest and posttest. The subjects were 39 aged, all of whom are students of Fakultas Kedokteran Universitas Diponegoro. Subjects divided into 3 groups as control, Plyometrics exercise, and Aerobic exercise. Decision-making score measured by IOWA Gambling Task (IGT). Data’s significance was analyzed with paired t-test.  Results: There was significant difference in decision-making score before (pre-test) and after (post-test) Plyometrics and Aerobic exercise (p<0,05). Nevertheless, higher score was found in experimental group 1 which is the Plyometrics exercise (p=0,000). Furthermore, there was significant difference towards decision-making score in experimental and control group (p<0,05). Conclusion: Plyometrics and Aerobic exercise increase decision-making score for young adults. A more significant increase was found in the Plyometrics group (p=0,000).
THE ASSOCIATION OF DIABETES DURATION WITH THE SEVERITY OF DIABETIC RETINOPATHY Intan Lamy Manao; Hesti Triwahyu Hutami; Fifin Luthfia Rahmi; Arnila Novitasari Saubig
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29942

Abstract

Background: The prevalence of diabetic patients is increasing over the years. It will increase the incidence of microvascular complications due to prolonged hyperglycemia in diabetic patient. Diabetic retinopathy is one of microvascular complication which is one of the leading causes of blindness in the world. Prolonged hyperglycemia in diabetic patient cause toxicity to the retina which cause nerve and vascular damage and death to the retina. In this study was analyzed the association of diabetes duration with the severity of diabetic retinopathy associated with many cases of delay in diagnosing diabetes recentlyObjective: This study aims to investigate the association of diabetes duration with the severity of diabetic retinopathyMethods: A cross-sectional design was performed by collecting data from the medical records of diabetic patients who were diagnosed with diabetic retinopathy in Diponegoro National Hospital in July-December 2019 using purposive sampling method. Research subjects were 51 patients who fulfilled the inclusion and exclusion criteria. The data were analyzed using non-parametric Chi Square test with p < 0.05 was considered statistically significant.Results: Prevalence was more in the age group of 51-60 years (45,1%), female (58,8%), diabetics <5 years (41,2%), and PDR (72,6%). Chi Square analysis shows no statistically significant association between duration of diabetes with the severity of diabetic retinopathy (p = 0,881)Conclusion: There was no statistically significant association between duration of diabetes with the severity of diabetic retinopathy
THE EFFECT OF CORIANDER LEAVES EXTRACT ON THE DEGREE OF WISTAR RATS LIVER MICROSCOPIC DAMAGE WAS GIVEN MERCURIC CHLORIDE ORALLY Ardiani, Zefania Regina; Sudaryanto, Sudaryanto; Istiadi, Hermawan; Hadi, Hadi
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29328

Abstract

Background Mercury is a heavy metal that is widely used in various aspects of human life. However, mercury exposure can damage the liver. The high antioxidant found in coriander leaves is expected to be a solution to the problem in preventing liver damage due to mercury exposure. Aim Proving that administration of coriander leaf extract can reduce the degree of wistar rats liver microscopic damage due to mercury exposure. Methods Experimental study with post test only control group design for 14 days, used 24 male Wistar rats, divided randomly into 4 groups : C (-), C (+) (given mercury orally 10 mg / kgBW), X1 ( given mercury orally 10 mg / kgBW and coriander leaf extract 100 mg / kgBW) and X2 (given mercury orally 10 mg / kgBW and coriander leaf extract 200 mg / kgBW). On the 15th day, rats were terminated, the livers were harvested, microscopic preparations were made and stained with Hematoxylin-Eosin. Observed with a magnification of 400x in 5 different fields of view of each sample and were assessed using Manja Roenigk's score. Results Were obtained normal, mild damage, moderate damage, and severe damage respectively in the group: C (-): 80%, 20%, 0%, 0%; C (+): 0%, 3%, 67%, 30%; X1: 47%, 33%, 17%, 3%; X2: 77%, 23%, 0%, 0%. Spearman test found significant correlation (p = 0,000) with storng correlation ( r = 0.781) and the direction between the two variables is negative (-) . Kruskal Wallis test found significant differences (p = 0,000). Continued Mann Whitney test found significant differences between groups C (-) with C (+) (0,000), C (-) with X1 (0.004), C (+) with X1 (0,000), C (+) with X2 (0,000) ), and X1 with X2 (0.007) and the difference is not significant between C (-) and X2 (0.756). Conclusion Giving coriander leaves extract can reduce the degree of microscopic damage of Wistar rat liver due to mercury exposure.
IN VITRO ANTIMICROBIAL ACTIVITY OF COCONUT SHELL LIQUID SMOKE AGAINST Candida albicans AND Lactobacillus acidophilus ATTRIBUTING TO ENDODONTIC TREATMENT FAILURE Isniya Nosartika; Nadia Hardini; Tyas Prihatiningsih
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29958

Abstract

L. acidophilus bacteria and C. albicans fungi are the most common microorganisms isolated from the oral cavity of patients suffering from post-treatment of root canal endodontic infections. Chlorophenol Camphor menthol (ChM) is one of the antimicrobials used for root canal sterilizer but it still has many flaws. Coconut shell liquid smoke (CS-LS) is a natural product that has an antimicrobial activity and non-toxic chemical compounds for humans. This study aims at determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of L. acidophilus bacteria and C. Albicans fungi and comparing the antimicrobial activity between CS-LC with commercial root canal sterilization. The MIC and MBC of CS-LS were measured using 10 different concentrations ranging from 10-100%. MIC was determined by the broth dilution method. All concentration was cultured on each agar media to determine its MBC. The data were analyzed using the comparative test of Kruskall-Wallis with post-hoc Mann-Whitney. MIC and MBC of C. albicans were 10% of CSLS. Meanwhile, L. acidophilus has the MIC with a 50% concentration of CSLS and MBC with a 60% concentration of CS-LS. No significant difference in CS-LS and ChKM was found. Thus, CS-LS has a potential for endodontic treatment failure. Further research should be conducted to know other potential uses of CS-LS in dentistry.
THE EFFECT OF “PERMATA-KU” EXERCISES ON THE IMPROVEMENT OF COMPUTER VISION SYNDROME SCORE Made Ayu Kusuma Dewi; Fifin Luthfia Rahmi; Arnila Novitasari Saubig; Hari Peni Julianti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29524

Abstract

Background : Most human activities cannot be separated from the use of computers. Long-term and uncontrolled use of computers can lead to Computer Vision Syndrome (CVS). According to the Ministry of Health of the Republic of Indonesia (KEMENKES) CVS can be handled with ergonomics use of computers resultantly reducing the impact of computer exposure. Education on ergonomics use of computer and PERMATA-KU exercise is expected to improve CVS scores.Research Purpose : Proving the effect of PERMATA-KU exercises toward CVS score improvementMethod : Research subjects are divided into treatment group and control group, each group consists of 15 people. The treatment group received education about the ergonomics use of computer and PERMATA-KU exercises while the control group received education on the ergonomics use of computers. The measurement’s instrument is the CVS questionnaire. The dependent variable of the study was the CVS score and the independent variable of the study was the type of treatment. Statistical test with Wilcoxon, paired t test, unpaired t test, Mann whitney and chi square. Meaning value p <0.05.Result : There was a significant difference in CVS scores before and after the intervention in the treatment group (p = 0.001) and the control group (p = 0.006). There was a significant difference in delta CVS scores between the treatment group and the control group (p=0,008). There was a significant difference in CVS scores after the intervention in the treatment group and the control group (p=0,017). There was no significant difference in the incidence of CVS after the intervention between the treatment group and the control group (p = 0.259).Conclusion : There is an effect of "PERMATA-KU" exercise on the improvement of CVS scores.
ENFORCEMENT OF MEDICAL DISCIPLINE VIOLATIONS IN INDONESIA Wibiansyah, Kukuh Tri; Wahyudi, Firdaus; Bhima, Sigid Kirana Lintang; Dhanardhono, Tuntas
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29322

Abstract

Background: The medical profession is closely related to human values and professionalism, but in practice, there are still doctors who breach the medical discipline principles. Method:  This is a descriptive study to outline the enforcement outcome. Samples were taken from data of breach of medical discipline in 2014-2018 which were uploaded on the website of the Indonesian Medical Council (KKI) combined with interviews reports. Result: The average complaint  of breach is 40.6 complaints per year. The percentage of the case completion compare to the number of complaints each year was 82% in 2015, 103% in 2016, 217% in 2017, and 126% by 2018. Total number of decision from medical discipline council trial in 2018 was 49 cases, consists of 4 cases from 2014, 5 cases from 2015, 21 cases from 2016, 16 cases from 2017, and 3 cases of complaints submitted in 2018.  Of the verdict from the trial, 15 decision considered as interlocutory verdict and 34 cases as final decision. The period of handling of medical disciplinary breach requires 1 to 2 years. Conclusion: The enforcement of medical discipline violations experienced progressive resolution annually, with 2017 as the peak year. The performance was influenced by alteration in the management board and the enactment of new council regulations.
THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) ON SHORT-TERM MEMORY AMONG MEDICAL STUDENT OF DIPONEGORO UNIVERSITY Nadia Ayu Octaviani; Sumardi Widodo; Arinta Puspita Wati; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29279

Abstract

Background: High Intensity Interval Training (HIIT) is an aerobic exercise consisting of high intensity of physical exercise interspersed with low intensity of physical exercise. HIIT has been known that can improve cognitive function. Medical students has low physical activity that can affect on cognitive function including short-term memory. Short-term memory is important in learning process which can affect on academic performance. Objective: To determine the effect of High Intensity Interval Training (HIIT) on an individual’s short-term memory. Methods: This study used quasi experimental pretest and posttest design. The research subjects were 29 female students of the Faculty of Medicine, Diponegoro University with the average age of 19-22 years with normal BMI, divided in 2 groups. Experimental group (n=14) was instructed to do 6 weeks of HIIT (3 times a week) and control group (n=15) was instructed to not to do any exercises. Short-term memory was measured with Scenery Picture Memory Test (SPMT). The significance of the data was analyzed with paired sample t-test and independent sample t-test. Results : A significant increase (p<0.001) in memory score before and after HIIT, from 18.07±1.49 to 20.21±1.37. The posttest memory score of HIIT group (20.21±1.37) was significantly (p=0.034) higher than the control group (18.67±2.23). Meanwhile, the memory score at the pretest between the 2 groups was no significant differences (p=0.621). Conclusion: HIIT can improves short-term memory.Keywords: High Intensity Interval Training (HIIT), Short-term Memory, Scenery Picture Memory Test (SPMT).
Comparison Of Plyometrics And Aerobic Exercises On Attention Levels In Young Adults Kinanti Maura Sandradewi; Endang Kumaidah; Yosef Purwoko; Marijo Marijo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29286

Abstract

Background. Plyometrics and aerobic training is a form of exercise that is easily applicable to all people. Plyometrics and aerobic trainings are proven to improve attention level in previous study.Objective. The aim of this study is to compare the effect of plyometrics training and aerobic training on attention level of young adults.Methods. A quasi-experimental study with pre and post test&control group design. The subjects were 54 male, with age range from 18 to 23 years old. Subjects were divided into 3 groups: C (control), EP1 (plyometrics training), and EP2 (aerobic training; with of 20meters multistage shuttle test design) . Both EP groups was given training for 6 weeks, twice a week. The attention level was measured using Attention Networks Test.Results. After 6-weeks of training, attention score in both of experimental groups were better than the control group. In EP1, all of the attention level component which was alerting, orienting, and executive increases significantly (p<0,01). In EP2, only alerting (p<0,01) and executive (p=0,01) increase significantly. Plyometrics training is proven to increase the attention level better than aerobic training, with significant increase in alerting (p=0,012), orienting (p=0,016), and executive (p=0,02)Conclusion. Plyometrics training is proven to increase attention level better than aerobic training in young adults.
The Effect of Various Concentrations of Liquid Smoke with Time Differences on the Viability of Candida albicans Nahla Nahla; Endang Sri Lestari; Nadia Hardini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.30112

Abstract

Background: Dentures that are rarely cleaned will trigger the growth of Candida albicans, which is a fungus known to be a major cause of opportunistic infections of the oral cavity. Liquid smoke is a chemical produced by distillation of smoke from combustion, containing phenol, carbonyl and carboxylic acids that are effective in killing fungi.Objective: To determine the effect of various concentrations of liquid smoke with different periods of time on the viability of Candida albicans.Methods: This was an experimental laboratory research with post-test only control group design. This study used Candida albicans colonies as samples with 6 different treatment concentrations of liquid smoke (100%, 50%, 25%, 12.5%, and 6.25%) and different periods of time (5 and 15 minutes), with 5 duplications.Results: The Kruskal-Wallis test on the MIC (Minimum Inhibitory Concentration) showed that there are significant differences (p <0.001) in the experimental groups, while the test on the MBC (Minimum Bactericidal Concentration) also showed the same result (p <0.001). The Mann-Whitney test stated that there was a significant difference between liquid smoke concentrations of 12.5% with positive control. The lowest concentration that could inhibit the growth of Candida albicans is 12.5%. At 24 hours incubation with 5 and 15 minute soaking time, the MBC of Candida albicans was 100% with 15 minute soaking time.Conclusions: Liquid smoke affected the growth of Candida albicans, characterized by MIC at a concentration of 12.5% and MBC at a concentration of 100% with a 15-minute soaking time.

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