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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 1,055 Documents
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APPROPRIATE USAGE OF ANTIBIOTICS AND ITS COST-EFFECTIVENESS Ivana Shafira Putri; Rebriarina Hapsari; V. Rizke Ciptaningtyas
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29330

Abstract

Background: Inappropriate use of antibiotics not only cause resistance, but also indirectly increase morbidity, mortality, and prolong the length of stay, which can lead to increased health care costs. Pneumonia is one of the infectious diseases with a high prevalence in Indonesia. It requires various antibiotic treatment that makes the antibiotic selection need to be considered in both clinical terms and cost-effectiveness. Aim: This study aimed to determine the association between the quality of antibiotic and cost-effectiveness in hospitalized pneumonia patients at Diponegoro National Hospital Semarang in the period 2015 - 2019. Methods: A cross-sectional study was performed in fifteen patients with community-acquired pneumonia (CAP). The medical records as samples were retrospectively obtained by total sampling method. The categories of antibiotic quality (appropriate and inappropriate) were determined according to the Gyssens criteria and analyzed using a cost-effectiveness table. The outcome measure was length of stay (LOS).  Results : Mean LOS, mean antibiotic cost, and median total direct hospital cost of appropriate and inappropriate antibiotic quality respectively 3,27 days versus 6 days (p = 0.275), 123,302 IDR versus 286,000 IDR (p = 0.020), and 3,317,100 IDR versus 3,878,600 IDR (p = 0,602). Based on the cost-effectiveness table, the position of appropriate antibiotic quality was in column G (dominant), while the position of inappropriate antibiotic quality was in column C (dominated).  Conclusions: The appropriate usage of antibiotics was more cost-effective than inappropriate. There was a significant differences of LOS between both categories.
THE EFFECT OF GLYCOLIC ACID AND VITAMIN C TOPICAL IN FRECKLES EFFICACY Tiffani Sandradewi Wignjosoesastro; Widyawati Widyawati; Rahmat Sugianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29346

Abstract

Abstract Background: Freckles are small dark-spot hyperpigmentation on the face, upper body, and back of the hands. This hyperpigmentation develops as a result of melanocyte activity by the combination of genetic predisposition located on the basal layer and sun exposure. Glycolic acid and vitamin C are widely used as a depigmentation agent. The component of vitamin C is unstable, hence, it is often used more effective when it binds to other depigmentation agents, such as glycolic acid to develop better depigmentationObjective: The aim of this study was to prove the efficacy of combination of glycolic acid and vitamin C in freckles.Methods: True experimental study with one group pre and post-test group design. Fifteen freckles patients with inclusion and exclusion criteria received combination therapy of glycolic acid and vitamin C topical for 30 days. Clinical evaluation using Freckles Refinement Score and photography was recorded before and after therapy. The statistical analyses used was Wilcoxon test.Results: There was a significant value (p = 0.000) for improvement of the Freckles Refinement Score after received the combination of glycolic acid and vitamin C topical.Conclusion: The combination of glycolic acid and vitamin C was effective for Freckles. 
THE DIFFERENCES IN TROPONIN I AND CK-MB VALUES IN ACUTE MYOCARDIAL INFARCTION PATIENTS WITH ST ELEVATION AND WITHOUT ST ELEVATION Paulus Rio Kurniawan; Andreas Arie Setiawan; Charles Limantoro; Ariosta Ariosta
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29601

Abstract

Background: Acute myocardial infarction includes STEMI and NSTEMI. In STEMI and NSTEMI, an increase in cardiac biomarkers especially troponin I and CK-MB are affected by the ischemic process. In STEMI thrombus blocks the entire artery lumen while in NSTEMI thrombus does not block the entire artery lumen. This can lead to different ischemic processes. Aim: To prove the differences in troponin I and CK-MB values in acute myocardial infarction patients with ST-elevation and without ST- elevation. Methods: An observational analytic study using a cross-sectional design was conducted between April and September 2020. The total sample of the study was 48 samples, consists of 25 samples with STEMI and 23 samples with NSTEMI. The normality test was analyzed using  Shapiro-Wilk test. The difference test was analyzed using Mann-Whitney test. Results: Mean troponin I values of STEMI and NSTEMI patients were 30.40 ± 20.79 ng/mL; 1.38 ± 1.76 ng/mL, respectively. Mean CK-MB values in STEMI and NSTEMI patients were 386.12 ± 319.70 U/L; 42.39 ± 27.54 U/L, respectively. There were statistically significant differences in troponin I and CK-MB values (p respectively 0.00; 0.00) in STEMI patients compared to NSTEMI patients. Conclusion: There were differences in troponin I and CK-MB values between STEMI and NSTEMI patients. The troponin I and CK-MB values in STEMI patients were higher than in NSTEMI patients.
ANTIOXIDANT EFFECT OF LONGAN PERICARP EXTRACT IN PARACETAMOL-INDUCED IN RATS Nabilah Saniyya Wahyudi; Lusiana Batubara; Endang Sri Sunarsih; Eva Annisaa'
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29324

Abstract

Background: Oxidative stress is a condition which were free radicals harm biological molecules, like lipid, protein, and DNA. Consume paracetamol can increase oxidative stress, which can cause increased level of AST and ALT serum. Longan pericarp (Dimocarpus longan L.) is one of natural ingredients that contain phenolic and flavonoids as an antioxidant to prevent oxidative stress. This study aims to prove the effect of longan pericarp (Dimocarpus longan L.) on AST and ALT serum levels of Wistar rats induced paracetamol. Methods: Experimental research with post-test only control group design. Thirty males wistar aged 2-3 months weighing 140-250 grams randomly divided into 5 groups. Group K1 was normal control group. Group K2 was induced by paracetamol 2000 mg/kgBW. Group P1, P2, P3 were induced by paracetamol 2000 mg/kgBW administered by longan shell extract (Dimocarpus longan L.) in multilevel dose 5 mg/200 gBW, 10 mg/200 gBW, and 15 mg/200 gBW. Blood samples in each group were collected to measure AST and ALT serum levels of wistar rats. Results: There were signifficant differences groups of AST serum. There were signifficant difference groups of K1-K2 (p=0,000), K2-P2 (p=0,041), and K2-P3 (p=0,010). There were signifficant differences groups of ALT serum. There were signifficant differences groups of K1-K2 (p=0,001), K2-P2 (p=0,032), and K2-P3 (p=0,006).  Conclusions:  The longan pericarp extract can lower the AST and ALT serum levels of Wistar rats induced by paracetamol.
IN VITRO TESTING OF CLOVE EXTRACTS IN INHIBITING AND KILLING STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI Nadia Dwi Rahmawati; Tri Nur Kristina; Endang Sri Lestari; Hardian Hardian
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29420

Abstract

Background: Diarrhea that could be caused by Staphylococcus aureus and Escherichia coli can be prevented by increasing hand hygiene using alcohol-based hand rub, but frequent use might cause skin irritation. Replacing alcohol with herbs could avoid this side effect. Cloves have been proved to have antibacterial properties. However, most researches used complex extraction methods that might not be applicable on a household scale.Objective: To prove that clove extracts have ability to inhibit and to kill S. aureus and E. coli.Methods: This is an experimental study by using post-test only control group design. Clove extract was obtained with simple aqueous maceration. Samples were Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 allocated into six groups: clove extracts at concentrations of 12.5%, 25%, 50%, 100% respectively; 70% alcohol as a positive control; and aquadest as a negative control. Each group was given 5 repetitions of intervention. MIC was measured with dilution method, while MBC with streak method. Negative controls were only used to monitor the quality of this work.Results: MIC of S. aureus was started at 50% concentration of clove extract, while MBC of S. aureus was started at 25 % concentration of the same extract. MIC and MBC of E. coli was both started at 25% concentration of clove extract. MIC and MBC of 100% concentration of clove extract were equal with 70% alcohol.Conclusion: Concentration of 100% clove extracts have similar ability with 70% alcohol to inhibit and to kill S. aureus and E. coli. Keywords: Clove Extracts, Escherichia coli, MBC, MIC, Staphylococcus aureus
The Difference of Length of Stay, Surgical Site Infection, Post Surgical Pain, and Bile Leak in Laparoscopic Cholecystectomy and Open Cholecystectomy Dilla Putri; Santoso Jaeri; Agung Aji Prasetyo; Sigit Adi Prasetyo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29402

Abstract

Background: The incidence of cholesistolithiasis is increased  due to the changes of diet to the western diet. The cholecystectomy is one of the treatments for cholecystolithiasis. It can be divided into laparoscopic cholecystectomy and laparotomy cholecystectomi. The previous study demonstrated that the laparoscopic cholecystectomy was better than laparotomy cholecystectomy for postoperative length of stay, surgical site infection, postoperative pain, and bile leak in cholecystolithiasis, but there is no official data  and research yet in Indonesia Objective: To determine the difference of  postoperative length of stay, surgical site infection, postoperative pain, and bile leak in laparoscopic cholecystectomy and laparotomy cholecystectomy.Methods: An analytic observational study with cross sectional design. Subject was patient who had undergone laparoscopic or laparotomy cholecystectomy from Dr Kariadi Hospital, Semarang and RSND Semarang during period of 2013 to 2019. The Mann Whitney-U test was used to determine the difference of length of stay as well the Chi Square test for determining the difference of surgical site infection, postoperative pain, and bile leak among both groups.Results: 34 (41.5%) men and 48 (58.5%) women with an age avarage of  49.84 ± 13.54 years were included. There were a significant difference between laparoscopic and laparotomy cholecystectomy in cholecystectolithiasis cases on postoperative hospital stay (p = 0.000), postoperative pain (p = 0.000), surgical site nfection (p = 0.000), and bile leak ( p = 0.013).Conclusion: Laparoscopic cholecystectomy was better than open cholecystectomy in postoperative hospital stay, surgical site infection, postoperative pain, and bile leak for cholecystolithiasis cases. Keywords: bile leak , cholecystetomy, cholecystolithiasis, laparoscopy, laparotomy
The Effect of High Intensity Interval Training (HIIT) on Reaction Time Study Among Medical Student in Semarang Chikita Dian Rahma Saphira; Sumardi Widodo; Arinta Puspita Wati; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29283

Abstract

Background: Reaction time is a cognitive-motoric connection that is important in making quick decisions. Due to the lack of time, medical student has low physical activity.  High Intensity Interval Training (HIIT) is a strong and intense exercise interspersed with low intensity exercise that does not require much time. It has been known that can improve cognitive function.Objective: To determine the effect of HIIT on an individual’s reaction time.Methods: Quasi-experimental research with pre-test and post-test groups design. The research subjects were 29 medical students of Diponegoro University, woman, normal IMT, 18-22 ages, has no neurologic deficit. The control group instructed not to do any physical exercises (n=15) and the experimental group was given an intervention of HIIT exercises that consists of warm-up, core, and cool-down movements for 6 weeks (n=14). Reaction time scores before and after were measured using the Attention Network Test (ANT). The significance of the data was analyzed using the paired sample t-test the independent sample t-test.Results: A significant decrease in reaction time scores (p=0,007) in both the experimental and control groups. A significant difference in reaction time scores (p=0.007) between the experimental group before and after the intervention was 592,07±74,82 to 517,21±56,77 milisecond. A significant difference in reaction time scores (p=0.024) between the control group before and after the intervention was 611,73±78,93 to 574,06±47,06 milisecond.Conclusion: HIIT for 6 weeks has been proved to reduce reaction time scores.  Keywords: High Intensity Interval Training, Physical Exercise, Reaction Time, Attention Network Test.
MELATONIN CAN NOT SIGNIFICANTLY INCREASE PLATELET COUNT Tania Meysavira Fawzi; Lusiana Batubara; Asih Budiastuti; Taufik Eko Nugroho
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29492

Abstract

Background: Burn injury defines as skin or tissue damage caused by heat, radioactivity, electricity, or chemicals. Burn injury have an impact on physiological homeostasis. Burn injury will cause an increase in free radicals, it can also cause changes in the platelet count. Melatonin has been proposed as burn supportive therapy because it acts as an antioxidant that can eliminate free radicals. Melatonin can increase the number of the platelets through the mechanism of increasing megakaryocyte fragmentation and modulating the cytokines involved in platelet production. Aim: Proving the effects of melatonin supplementation on the number of platelets in male Wistar rats with third degree of burn injury. Methods: This research was an experimental with randomized control group pre-post test design. Samples are 12 healthy male Wistar rats then randomly divide into two groups, control and experimental group. Each rat was induced 30% burn injury under anesthesia. Rats in control group were given placebo at 0, 8, and 16 hours after burn injury, while rats in experimental group were treated with melatonin intraperitoneal at 0, 8 and 16 hours after burn injury. Blood samples were collected from the retroorbital sinuses at 0, 3, and 24 hours. Data were analyzed statistically by Paired t-Test and Independent t-Test. Results: In control group, the number of platelets at 0-3 hours (p=0,024) and 0-24 hours (p=0,039) showed a significant decrease in platelet count. In experimental group, the number of platelets at 0-3 hours (p=0,047), 0-24 hours (0,015), 3-24 hours (p=0,04) showed a significant decrease in platelet count.Conclusions: Melatonin administration did not cause a significant increase of platelets number. Keywords: Burns, Platelet count, Melatonin
The Comparison Between Plyometrics and Aerobic Exercises toward Medical Students of Diponegoro University Iin Atika Situngkir; Endang Ambarwati; Endang Kumaidah; Sumardi Widodo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29274

Abstract

ABSTRACTIntroduction: Sedentary life style had become one of factors causing health problem for someone in general. To avoid that condition we could apply some exercises regularly. Exercise can improve concentration, memory, and intellectuals. The sports enjoyed today are Plyometrics and Aerobics. Both sports proved beneficial in improving cognitive function, including concentration. The purpose of this study is to find out comparison between Plyometric and Aerobic towards concentration level.Methods: This research applied quasi-experimental study with pre and post-test design. There were subjects divided into three groups were control group, Plyometrics group and Aerobics group. Medical students of Diponegoro University were taken as subjects of the research which consist 39 males. Intervention is given for 6 weeks. Each week consists of two meetings. The indicator of this research focused on concentration level measured by using Digit Symbol Substitution Test (DSST), measured before and after 6 weeks exercise. Statistical analysis of this study using Paired t-test.Results: There was a significant difference in concentration measurement results between treatment and control groups (p=0.00). Treatment group concentration scores improved better than control group. The DSST score on Plyometrics exercises was 60.00±5.08 and after intervention to 78.00±2.30. The DSST score on Aerobic exercises was 58.76±4.88 and after intervention to 63.07±5.88. Plyometrics exercises are shown to have better effects in increased concentration compared to Aerobic exercises.Conclusion Plyometric and Aerobic exercise were able to enhance concentration level with the highest result achieved by Plyometric group.
The Correlation between Mean Aterial Pressure and Bleeding Volume with The National Institute of Health Stroke Scale (NIHSS) Score for Intracerebral Hemmorhage Patients Shonia Syvafiftyan Rosaline; Hermina Sukmaningtyas; Arinta Puspita Wati; Sukma Imawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29315

Abstract

Introduction: Intracerebral hemorrhage refers to primary, spontaneous, and non-traumatic bleeding that occurs in the brain parenchyma. Intracerebral hemorrhage accounts for approximately 10-20% of all stroke. The most common risk factor for non-traumatic hemorrhagic stroke is hypertension. The increase in Mean Arterial Pressure leads to the incidence of intracerebral hemmorhage. The NIHSS is a systematic assessment tool that quantitatively measures stroke associated with neurologic deficits. Neurological deficits that occur in intracerebral hemorrhage occur because blood enters the brain parenchyma. The incoming blood was measured by the Automatic Volume Method (software volume evaluation), namely the calculation of volume by computer software on the CT Scan tool.Aim: To determine the correlation between Mean Arterial Pressure and bleeding volume with NIHSS score in intracerebral hemorrhage patients.Methods: The research design used in this study was cross sectional. The sample of this study was 40 research subjects using purposive sampling, this study has independent variables, namely Mean Arterial Pressure and bleeding volume, while the dependent variable is the NIHSS score (National Institute of Health Stroke Scale). This study conducted an analysis using Spearman's.Results: : The results of this study indicate that there is no significant relationship between bleeding volume and NIHSS score (p = 0,157, r = 0,228) and there is no significant relationship between MAP and NIHSS score (p = 0,268, r = -0,179)Conclusion: There is no statistically significant relationship between Mean Arterial Pressure and bleeding volume with the NIHSS scoreKeywords: Mean Arterial Pressure, Bleeding Volume, National Institute of Health Stroke Scale, Intracerebral Hemorrhage

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