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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 1,055 Documents
 73   74   75   76   77 
QUALITY OF LIFE AMONG TUBERCULOSIS PATIENTS WITH AND WITHOUT DIABETES MELLITUS BEFORE AND AFTER ANTI-TB DRUGS ADMINISTRATION Ksatriaputra, Alesandro; Kholis, Fathur Nur; Ngestiningsih, Dwi; Hariyana, Bambang
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29334

Abstract

Background : Increased TB prevalence with and without diabetes mellitus affects the quality of life of the patients. Appropriate action on TB patients was needed in health status improvement and quality of life of the patients. SF-36 questionnaire as an instrument to assess the quality of life. Aim : To compare Quality of Life (QoL) between TB with diabetes mellitus patients and TB without diabetes mellitus patients before and after the treatment of tuberculosis. Methods : A cross-sectional design was performed in this study by collecting data from the medical record of patients in Kariadi Hospital Semarang who were diagnosed with tuberculosis. Research subjects were 44 people with 22 TB with diabetes mellitus patients and 22 TB without diabetes mellitus patients. The direct approach was carried out using the SF-36 questionnaire. The SF-36 questionnaire was filled out using telephone interview. All questions were scored on a scale from 0 to 100, with 100 represents the highest level of function with interpretation the higher the score the higher the level of function, and vice versa. Statistical tests use Wilcoxon Test and Independent Samples T test. Results : Wilcoxon test on quality of life of TB patients with and without diabetes mellitus before and after treatment of tuberculosis was significant (p = 0.0040). Mean improvement in quality of life difference before and after treatment of tuberculosis in TB without diabetes mellitus patients (p = 41.72) was more significant than TB with diabetes mellitus patients (p = 26.38). Conclusion : There was a significant difference in quality of life between TB with and without diabetes mellitus patients before and after the treatment of tuberculosis as indicated by the SF-36 questionnaire score. TB without diabetes mellitus patients have more significant changes in quality of life compared to TB with diabetes mellitus patients.
ANTIHYPERURICEMIC EFFECT OF RED GINGER POWDER AND LIME JUICE COMBINATION IN WISTAR RATS INDUCED HYPERURICEMIA Eva Susanty Purba; Chikita Dian Rahma Saphira; Salma Yasmine Azzahara; Edwin Basyar; Muflihatul Muniroh; Ainun Rahmasari Gumay
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29374

Abstract

Background: Hyperuricemia is an abnormally high level of uric acid in the blood. Ginger and lime are natural ingredients that contain antioxidants and anti-inflammatory which could reduce blood uric acid levels. This study aims to prove the effect of red ginger powder and lime juice combination on uric acid levels of Wistar rats induced hyperuricemia.Methods: Experimental research with pre and post-test only control group design. Thirty Wistar male rats, aged 2-3 months, weighed 150-350 grams randomly divided into 5 groups. Group C1 was normal control group. Group C2 was induced by single intraperitoneal injection of potassium oxonate (300mg/kgBW). Group T1, T2, T3 were induced by potassium oxonate and orally administered by combination of red ginger powder (300, 600, 1200 mg/200gBW) and lime juice (2ml/150gBW). Blood samples in each group will be collected in 1 hour after treatment. Uric acid levels were measured using the TBHBA uric acid method.Results: Uric acid level in T1, T2, and T3 group was significantly lower than C2 group (p<0,05). The most effective dose to reduce uric acid levels was 1200mg/200gBW red ginger in combination with 2ml/150gBW lime juice (T3 group).Conclusion: Red ginger powder and lime juice may reduce the blood uric acid levels in Wistar rats induced hyperuricemia.
THE EFFECT OF VCO TO THE GROWTH OF CANDIDA ALBICANS ON DENTURE BASIS OF ACRYLIC RESIN Vivi Indah Fatmasari; Rebriarina Hapsari; Nadia Hardini; Endang Sri Lestari
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29329

Abstract

Background: Acrylic resin was a material of denture base which frequently used, but it still had a weakness that it was porous, then, it was often the breeding ground of Candida albicans. Virgin coconut oil (VCO) contained fatty acid which was effective to hamper the growth of C.albicans. Objective: This research was to identify the effect of VCO on the growth of C.albicans on acrylic resin denture. Methods: This research was an experimental laboratory research which exerted post-test control group design. The total sample 24 which were divided into 3 groups of treatment and 1 group of control. The treatment covered acrylic plates soaking which have been contaminated with C.albicans suspension into VCO in concentration level 25%, 50%, 75%, and sterile aquades for 8 hours. The acrylic plate was vibrated to knock out C.albicans and was then continued by colony counting on the media of Sabouraud Dextrose Agar (SDA). The statistic test employed Kruskal-Wallis and continued to the Post-Hoc test which employed Mann-Whitney. Findings: The VCO in concentration level 25%, 50%, and 75% affected to inhibit the growth of C.albicans. In the Kruskal-Wallis test, it was found a significant difference between the number of C.albicans on the control group and the VCO in concentration level 25%, 50%, and 75% (p<0,05). The Post-Hoc Mann-Whitney test indicated no significant difference between VCO in concentration level 25% and 50%, 25% and 75%, also 50% and 75% (p>0,05). Conclusion: The VCO in concentration level 25%, 50%, and 75% affected was able to hamper the growth of C.albicans. Further, there was no significant difference in each VCO concentration.
MEDICAL PROBLEM, CONCEQUENCES TO ORAL CARE IN GERIATRIC PATIENT Nadia Hardini; Oedijani Santoso
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29985

Abstract

Introduction: Oral and maxillofacial tissue status has a significant impact on the systemic health of elderly patients. Elderly patients without oral diseases are rare to find by dentists. Literature Review: Prevention and treatment for caries and periodontal diseases should be done for elderly patients, except in particular conditions when its not worth the risks treatments. Although the relationship between oral diseases and systemic diseases is still controversial and unresolved, it can be assumed that elderly patients have a greater risk of acute and chronic oral infections due to the use of various drugs and medical disorders, impaired immune function, age related impaired kidney, liver and cardiovascular dysfunction. Conclusion: While on duty, dentists who provides care to elderly patients, must know the medical history and systemic review, and understands general medical problems that affects oral care of the elderly.Keyword : medical problem, elderly, oral treatment
THE DIFFERENCE OF HISTOPATHOLOGICAL IMAGE OF THE WISTAR RAT’S KIDNEY ADMINISTERED WITH GRADUAL DOSAGE OF PYRETHROID Diaz Almayang; Saebani Saebani; Tuntas Dhanardhono; Endang Ambarwati; Ika Pawitra Miranti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29537

Abstract

Background: Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the active substances in pyrethroid widely used is cypermethrin. The effects of cypermethrin intoxication on the kidneys, especially in humans, are little to be studied. This study aims to determine the difference in the histopathological image of the Wistar rat’s kidney.Method: The experimental research of the post-test only control group design involved 24 male Wistar rats divided into 4 groups randomly, the control (not given cypermethrin), treatments of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Cypermethrin are given orally for 14 days. After the rats were terminated, the kidney were processed to be paraffin-embedded tissues and stained with HE. Tubular injuries were examined using 400x magnification of light microscope and focused on closure of tubular lumen as well as proteinaceous cast inside the lumens.Results: The results of this study showed that the means of histopathological damage to the kidneys increased from control group to 500 mg/kgBW treatment group. Statistical analysis with One way ANOVA showed significant differences (p<0.001), continued with Post hoc games Howell test, there was a significant differences between control group with 250 mg/kgBW treatment group and 500 mg/kgBW treatment group, and between 125 mg/kgBW treatment group with 250mg/kgBW treatment group and 500 mg/kgBW treatment group. There was no significant difference between the control group with 125 mg/kgBW group and 250 mg/kgBW treatment group with 500 mg/kgBW treatment group.Conclusion: There is a significant difference in renal histopathological  image due to exposure to pyrethroid (cypermethrin) in gradual doses. The image of kidney damages can result in tubules injury  which include: albuminous degeneration with narrowing of the tubular lumen and hyaline cast. The means of tubular injury rate will increase with increasing dose of pyrethroid.
DETERMINATION OF DENGUE VIRAL INFECTION SEVERITY IN PEDIATRIC BASED ON PHYSICAL EXAMINATION AND LABORATORY TESTS: A CASE STUDY OF A 7 MONTHS OLD BABY WITH DENGUE HAEMORRHAGIC FEVER Muhammad Ghaza Syahputra; Ayu Anggraini Kusumaningrum; Dewi Apriani; Dimas Tri Anantyo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29323

Abstract

Background: Dengue viral infection can infect people of all ages, including infants less than 1-year-old. The Disease severity of dengue infection consists of asymptomatic infection and symptomatic infection. The symptomatic infection has varying degrees of severity: undifferentiated fever, dengue fever, DHF, and Dengue Shock Syndrome (DSS). Method: The data obtained by interviewing the patients' parents for the symptoms and patients' medical records for information on the treatments and examinations.  Case: A 7 months old baby arrived at the hospital with a continuous abrupt 3 days fever, the condition is accompanied by watery stool two times a day, vomiting once a day.  Discussion: The patient arrived at the hospital with a continuous abrupt 3-day fever. The results of the physical examination showed a positive tourniquet test and palpable liver. The laboratory test results showed that the patient has thrombocytopenia, and the chest x-ray results showed that the patient has pleural effusion. Conclusions: The patient was diagnosed with DHF without shock and sent home after the patient got fluid therapy, supportive, and symptomatic treatments. 
THE EFFECT OF STRATIFIED DOSES OF CURRY LEAF EXTRACT (MURRAYA KOENIGII) ON TOTAL CHOLESTEROL AND TRIGLYCERIDES IN MALE SPRAGUE-DAWLEY RATS INDUCED BY HIGH FAT FEED Muhammad Iqbal Reynaldi; Santoso Santoso; Kusmiyati Tjahjono
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29256

Abstract

Background: High level of total cholesterol and tryglicerides in the blood can cause atherosclerosis. Curry leaves are often used by the society to reduce total cholesterol and trygliceride levels in the blood, but no studies have examinded the effective dosage of curry leaf extract to reduce total cholesterol and triglyceride levels.Aim: This study aims to determine the effect of giving curry leaf extract (Murraya koenigii) on cholesterol and triglyceride levels of male Sprague-Dawley rats induced by high fat feed.Methods: This study was a true experimental study with a pre-post test with randomized control group design. The subjects of the study were male Sprague-Dawley rats induced by high fat feed for 10 days. Cholesterol and triglyceride levels were measured by enymatic methods. Then, the data were analyzed using paired t test and for P3 group total cholesterol using the Wilcoxon test to analyze the differences in total cholesterol and triglyceride levels between before and after given the curry leaf extract, Repeated Anova test to analyzed the differences between groups which was then followed by post hoc bonferoni and One Way Anova to analyze the differences in total cholesterol and triglyceride levels between groups.Results: There was no significant differences in total cholesterol levels between before and after given the curry leaf extract at a dose of 200 mg/KgBW, 300 mg/KgBW, and 400 mg/KgBW (p= 0.641 for the P1 group, p= 0.385 for the P2 group and p= 0.398 for the P3 group). In contrast to triglyceride levels, there were differences in triglyceride levels before and after administration of curry leaf extrcat at a a dose of 300 mg/KgBW (p= 0.012), while the other groups were not significant.Conclusion: The stratified doses of curry leaf extract (Murraya koenigii) in this study could not reduce cholesterol level and triglyceride levelKeywords: Curry leaf extract; Dyslipidemia; Total Cholesterol; Triglyceride 
The Comparation Between Plyometrics and Aerobic Exercise on Medical Student’s Mood in Diponegoro University Karoni Karoni; Muflihatul Muniroh; Marijo Marijo; Endang Kumaidah
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29379

Abstract

Background: Physical activity is important to do because a sedentary lifestyle is one of the causes of various health problems in the world. One of the importance of physical activity is to improve mental health, quality of life and well-being. Physical activity significantly has a positive impact on a person's mood. Plyometrics and aerobic exercises are popular physical activities, but comparing the effects of both in improving cognitive function, especially in the mood domain, has never been done. Objective: To analyze mood differences between the group with plyometrics exercise and the group with aerobic exercise in students of the Faculty of Medicine, Diponegoro University.Methods: This study is an experimental study with parallel 3 groups pre and post-test design. The research subjects were 45 UNDIP medical students who were selected by purposive sampling and grouped into 3 groups randomly. The untreated control group (n = 15), the plyometrics treatment group (n =15), and the aerobic treatment group (n = 15). The treatment group did physical activity for 6 weeks. Mood levels were measured before and after the intervention using the Profile Of Mood States (POMS). The better a person's mood, the lower the Total Mood Disorder (TMD) score is obtained.Results : TMD scores (pre-test to post-test) in the plyometrics (p <0.001) and aerobic (p = 0.001) groups both experienced a significant decrease. However, there was no significant difference between the TMD post-test scores in the plyometrics treatment group and the aerobic treatment group.Conclusion: Plyometrics and aerobic exercise has a similar effect on improving mood score.
COMPARISON BETWEEN LAPARATOMY AND LAPARASCOPY COLORECTAL CANCER FOR LENGTH OF HOSPITAL, SURGICAL SITE INFECTION AND INTRAPERITONEUM ADHESION Ahmad Wasil; Saekhol Bakri; Yan Wisnu; Abdul Mughni
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29335

Abstract

Colorectal cancer (CRC) is the development of cancer from the colon or rectum. There are two kinds of surgery which are laparotomy and laparoscopy. This course of action had a significant effect on the length of stay, surgical site infection, and intraperitoneal adhesion. The purpose of this study is to find out the comparison between laparotomy and colorectal cancer laparoscopy with the length of stay, surgical site infection and intraperitoneal adhesion. The researcher used a cross sectional design. The sample for this study was taken from the medical record data of colorectal cancer patients in Dr. Kariadi Semarang from 2013 to 2018. The data were collected using purposive sampling technique. There were 57 samples that included inclusion and exclusion criteria with 28 details of laparoscopy and 29 samples of laparotomy. Numeric-scale data were tested for normality of data by Kolmogorov-Smirnov and found abnormal data using the Mann Whitney test. Nominal scale data were processed using the non-parametric Chi-Square test and it significant if p<0.05. There is a difference in length of stay and frequency of occurrence of surgical site infections and intraperitoneal adhesion between laparotomy and laparoscopy.
MELASMA SHOW UP IN CONTRACEPTIVE PILLS ACCEPTORS Cahya Novenita Azzahra; Widyawati Widyawati; Liza Afriliana; Julian Dewantiningrum
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29436

Abstract

AbstractIntroduction : Melasma is one of the most common hyperpigmentation disorders among womans, the common hyperpigmentation patches which commonly found on face especially on sunlight exposured area. One of the factors causing melasma is the use of oral contraceptives which cause the buildup of the hormones estrogen and progesterone on the skin.Objectives : Thus, the aim of the study is to analyze the association between duration of contraceptive pills use and melasma.Methods : This study used a cross-sectional design. The research was conducted in May-July 2020. The subjects were 36 womans aged 30-55 years old and oral contraceptive acceptors that qualify inclussion criteria and not eligible exclussion criteria. The data was collected primarily using questionnaires. Physical examinations were done through observation with a photo of the respondents. Data analysis using the Chi Square test with a significance value p <0,05.Results : Based on the results of this study, the significance of 0.017 less than 0.05 which indicates a relationship between variables duration of contraceptive pills use and melasma. Conclusions : This study shows a association between duration of contraceptive pills use and melasmaKeywords : melasma, contraceptive pills.

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