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Jurnal Kedokteran Diponegoro
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ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 1,040 Documents
THE EFFECT OF TURMERIC EXTRACT (Curcuma longa) ON THE IMPROVEMENT OF MUSCLE MASS IN SWISS DIABETES MELITUS MICE SKELETAL MUSCLE INDUCED BY STREPTOZOTOCIN Alfin Ihza Trimahendra; Yora Nindita; Vega Karlowee; Muhamad Thohar Arifin; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.964 KB) | DOI: 10.14710/dmj.v9i3.27510

Abstract

Backgrounds. Diabetes mellitus is a degenerative disease that has various complications. One of neglected diabetes mellitus complication is skeletal muscle atrophy. Turmeric and java turmeric extracts were need to be clarified due to those effect as antihyperglycemic agent which might affected muscle atrophy as one of diabetes mellitus complication. Aim. To compared the efficacy of turmeric and java turmeric extract on reducing the progression of skeletal muscle atrophy in streptozotocin-induced diabetes mellitus. Methods. We conducted experimental animal studies with a post test only control group design using 25-30 grams male Swiss mice aged 12 weeks. Diabetes mellitus was induced by streptozotocin (STZ) administration. All 28 samples were randomly divided into 4 groups : control + PBS, control + STZ, STZ + turmeric, and STZ + java turmeric groups. Before treatment, blood glucose and body weight were examined on 3rd day. Blood glucose, body weight, hindlimb muscle weight, and muscle diameter results were examined after treatment (on 21st day). Data was analyzed with statistical software after all procedures were done. Results. STZ + turmeric group showed insignificant decreased in blood sugar levels (p=0.107). Control + STZ group showed significantly reduced hindlimb muscle weight compared to other groups. Hindlimb muscle weight was significantly ameliorated by STZ + turmeric extract (p=0.048). There were no significant improvement on skeletal muscle diameter among groups. Conclusion. The administration of turmeric extract improved hindlimb muscle weight but may not mediated by glucose lowering effect in streptozotocin induced diabetic mice.
RIGHT VENTRICULAR AND PULMONARY HYPERTENSION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND RESTRICTIVE LUNG DISEASE Valencia Fabiana; Dwi Lestari Partiningrum; Bernardus Parish Budiono; Fathur Nur Kholis
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.557 KB) | DOI: 10.14710/dmj.v9i3.27498

Abstract

Background: Chronic lung disease is frequently associated with lung vascular lesion. We evaluated the structural-functional related changes of right ventricle under CLD with or without PH at RSUP dr. Kariadi, Semarang. Methods: We studied patients at RSUP dr. Kariadi who underwent routine evaluation that included resting spirometry and echocardiography. Patients with either COPD or RLD were studied, exclusion were made for patients with valvular heart disease and congestive heart disease. This study was performed during May through June of 2019 (n = 20). PASP, RVD, RVWT, TAPSE and spirometry values were analyzed for the association between PASP and RVD, RVWT, TAPSE, TAPSE/PASP ratio and FVC, FEV1, FEV1/FVC. Results: Thirteen (65%) of 20 patients who underwent echocardiography and spirometry evaluation were male and their average age were 55 years old. Mean PASP was 49.30 mmHg (range 2–111 mmHg). Ninety five percents patients had restrictive spirometry and 5% patients had moderate-severe mixed spirometry. The majority of the population of the study sample is dominated by a very severe degree of restriction spirometry. Out of the 20 subjects, 15 subjects (75%) had a diagnosis of COPD and 10 subjects (50%) had a history of pulmonary TB. In this study, 75% subjects had right ventricular dilatation, 85% subjects had right ventricular hypertrophy, and 15% subjects had decreased right ventricular systolic function (low TAPSE). The majority of structural and functional abnormalities of the right heart are found on patients with very severe degree of restriction spirometry. There were 13 subjects (65%) pulmonary hypertension, with the most findings being severe pulmonary hypertension as many as 8 subjects (40%). As many as 14 subjects (70%) had high TAPSE / PASP ratio.Conclusions: PH prevalence in patients with CLD is significantly associated with spirometry values. PH severity degree in patients with CLD is not significantly associated with spirometry values.Key words: spirometry; pulmonary hypertension; right heart echocardiography.
THE EFFECT OF THE ACIDITY OF FERMENTED MILK AGAINST THE HARDNESS OF NANOHYBRID COMPOSITE RESIN Hanny Tiara A Sinaga; Diah Ajeng Purbaningrum; Ariosta Ariosta; Dwi Retnoningrum
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29336

Abstract

Background : The hardness of nanohybrid composite resin can decrease due to the acidic condition of the oral cavity. The acidic condition of the oral cavity can cause continuous degradation in composite resin. Fermented milk is a beverage that is widely sold in the market and is good for consumption however this beverage has the acid potential of hydrogen (pH) which can reduce the composite resin toughness. Aim : To determine the acidity effect of fermented milk on the hardness of nanohybrid composite resin. Method: Experimental study with a post test control group design. There were 27 samples of nanohybrid composite resin. One time immersion for three seconds in each group of beverages namely Milk, Cimory, and Yakult. After 15 days, a composite resin hardness test was performed using a Micro Vickers Hardness Tester with a load of 100 grams for 10 seconds. Statistical tests using One Way ANOVA. Results: The nanohybrid composite resin exhibited significant reduction in hardness between three beverage groups. Post hoc LSD test showed that there were significant differences between Milk with Yakult (p = 0.006) and Cimory with Yakult (p = 0.008) while Milk with Cimory (p = 0.907) did not have significant. Conclusions : There is a effect of fermented milk influences the hardness. There is a significant difference between Milk and Yakult and between Cimory and Yakult and there is no significant difference between Milk and Cimory.
THE EFFECT OF ANTLIONS EXTRACT TOWARDS BLOOD GLUCOSE LEVEL OF MALE SWISS MICE INDUCED BY STREPTOZOTOCIN Rizky Indra Puspito; Santoso Jaeri; Y.L Aryoko Widodo; Andrew Johan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29681

Abstract

ABSTRACTBackground: Diabetes mellitus is a disease that is included in the group of metabolic diseases, characterized by hyperglycemia that occurs due to abnormal insulin secretion. Generally, treatment of diabetes mellitus uses insulin injection and Oral Hypoglycemic Drugs (OHD). In addition there are also animals are trusted by public in healing diabetes mellitus. Antlions (Myrmeleon sp)  is a useful animal to treat diabetes mellitus. The body of antlions contains sulfonylureas which is a substance that stimulates insulin secretion in pancreatic beta cells. Aim: The objective of this research was to analyze the effect of antlions extract on blood glucose level of male swiss mice induced by streptozotocin Methods: This research was a pure experimental laboratory study and the design used is the Pre Test and Post Test Control Group Design, which is done by comparing the results of observations in the control and treatment groups after the action was done. Sampling was done using the simple random sampling technique. The sample size used in this study amounted to 30 mice. The data obtained were analyzed using ANOVA test with a confidence level of 95%. Results: The administration of antlions extract could lower (p<0.05) blood glucose levels in male Swiss mice after 28 days of treatment. The administration of antlions extract with doses of 14 mg/kgBW and 56 mg/kgBW significantly lowered blood glucose levels in male Swiss mice as evidenced by p=<0.001 and p=0.034. Whereas the administration of antlions extract with a dose of 28 mg/kgBW was less significant in lowering blood glucose levels in male Swiss mice (p=0.210). Conclusion: The administration of antlions extract (Myrmeleon sp.) with a dose of 14 mg/kgBW had the best effect on lowering blood glucose levels in male Swiss mice after 28 days of treatment. Keywords: diabetes mellitus, blood glucose, antlions
THE EFFECT OF COFFEE BREWING METHODS ON TOOTH DISCOLORATION Rizki Nurida Rahmawati; Nadia Hardini; Lusiana Batubara
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29331

Abstract

Background: The color of teeth in each individual varies greatly in which it is influenced by the color of dentin and enamel. The most frequent tooth discoloration that happened is caused by extrinsic stains like coffee. Coffee consumption habits are increasing along with the level of creativity in serving coffee. Nowadays, coffee with conventional methods like black/Turkish coffee and manual brewing methods such as drip brewing and espresso become popular coffee that are fancied by Indonesian people. Exposure to chromogenic substances and the acidic nature of coffee can cause the formation of pores in enamel and facilitate the deposition of dyes, which cause the color changes. Aim: The aim of this research was to analyze the effect of brewing methods on tooth discoloration. Method: This research was a true experimental study with a pre-post test control group design. Twenty eight post-extracted first premolar teeth samples divided into 4 groups for drip, espresso, black coffee and control by implementing random allocation. All samples were immersed in each coffee brewing group for 3 hours, 6 hours, and 9 hours. The teeth color was measured using a Chromameter based on the CIE L*a*b system. Statistical tests used Kruskal Wallis and Mann-Whitney test. Result: The Kruskal Wallis test showed differences in the color change ∆a * between the four groups (p < 0.05). Mann-Whitney test indicated a significant difference between the treatment group (drip, espresso, and black coffee group) and the control group (p < 0.05). Conclusion: Drip coffee, espresso and black coffee brewing methods can affect tooth discoloration, especially affects the red discoloration. But there is no difference in the effect of the drip, espresso, and black coffee brewing methods on tooth discoloration.
BRONKHOPNEUMONIA AS COMORBIDITIES OF CMV INFECTION : STUDY CASE ON 1 YEAR 9 MONTHS OLD BOY Wulan Widiasmaran; Ayu Anggraini Kusumaningrum; Fitri Amalia; Dimas Tri Anantyo
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.28187

Abstract

Background. Pneumonia is an acute lung parenchyma inflammation, which includes the alveoli and tissues. According to RISKESDAS 2018, pneumonia prevalence of children under five years old in Indonesia has increased from 1.6% in 2013 to 2% in 2018. Cytomegalovirus infection (CMV) is the most common congenital infection and causes high morbidity in newborns. The purpose of this case is to report a case in Semarang and conduct a discussion of pneumonia cases and a history of CMV infection so that proper treatment can immediately start.Method. Anamnesis carried out on February 1, 2020, at Government Hospital in Semarang. Data obtained from allonamnesis with the patient's mother, physical examination, supporting examinations, and medical records of patients. Case. Patient of a boy aged one year nine months that come to the ER with a chief complaint of fever and cough.Discussion. A boy aged one year nine months with fever and cough complaints about five days before entering the hospital. Sputum culture examination revealed the presence of Klebsiella pneumonia, then treated with cefoperazone sulbactam. The patient had a history of cytomegalovirus infection but not optimally treated because of the high avidity value.Conclusion. Patient has diagnosed with bronchopneumonia et causa Klebsiella pneumonia.
Difference in Profiles of Oxidative Stress Marker (MDA) in STEMI and NSTEMI Kaninta Nuga Sekunda; Ariosta Ariosta; Charles Limantoro; Andreas Arie Setiawan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29673

Abstract

ABSTRACT Introduction: Acute Myocardial Infarction (AMI) results in necrosis of the myocardium due to blockage in the coronary artery. AMI is classified into two categories, STEMI and NSTEMI. AMI is a multifactorial condition closely related to the increase in production of reactive oxygen species (ROS). As the end product of lipid peroxidase, Malondialdehyde (MDA) is often used as a biomarker for oxidative stress. Purpose: To prove the difference between profiles of oxidative stress marker (MDA) in STEMI and NSTEMI. Methods: An observational analytic study with a cross-sectional study approach done in Dr. Kariadi Central Public Hospital and Diponegoro National Hospital, Semarang, Central Java, between April and September 2020. Subjects were diagnosed by the presence of chest pains and an increase in CKMB and troponin levels. The study was conducted on 47 subjects consisting of 20 STEMI samples and 27 NSTEMI samples. Serum MDA was examined using the TBARS method. Data were analyzed by a computer program. Results: Mean serum MDA in STEMI and NSTEMI was 0,22 ± 0,12 μmol/L and 0,82 ± 0,92 μmol/L respectively. From the statistical analysis, results showed that the difference in serum MDA concentrations between STEMI and NSTEMI were significant (p = 0,007). Conclusion: Malondialdehyde concentration in NSTEMI was significantly higher than in STEMI. It is suggested that further research be done to know which type of MDA is more accurate, to understand the effect of lipid profile towards STEMI and NSTEMI, and to put patient’s medical history into consideration. Key Words: Acute Myocardial Infarction, Reactive Oxygen Species, Oxidative Stress, Malondialdehyde
ASSOCIATION BETWEEN 25-HYDROXYVITAMIN D LEVELS AND GROWTH PARAMETERS IN THALASSEMIA WITH REPEATED BLOOD TRANSFUSION Najma Khairani Harahap; Mulyono Mulyono; Yetty Movieta Nency; Nyoman Suci Widyastiti
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 6 (2020): DIPONEGORO MEDICAL JOURNAL (Jurnal Kedokteran Diponegoro)
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v9i6.29325

Abstract

Background. Blood transfusion is a therapeutic choice for thalassemia with anemia. Hemosiderosis is the side effects of blood transfusions which cause impaired liver function, leads to low vita­min D levels in plasma. The low level of vitamin D cause delay in physical growth. The aim is to determine the relation between 25-hydroxyvitamin D levels and growth parameters in thalassemia with repeated blood transfusion history. Method. In this analytical cross-sectional study, thalassemia patients with repeated blood transfusion and ages 0-18 years old were recruited. This research was held in Semarang, Purwodadi, and Rembang from May to September 2019. Thalassemia patients who met the criteria were measured the 25-hydroxyvitamin D level, physical activity and the growth parameters (weight, height, and body mass index). Results. Forty thalassemia patients aged 6-18 years old were recruited in this study. The percentage of boys are 47.5% and girls are 52.5%. Most of subject had high ferritin serum (87.5%) and low vitamin D level (87.5%). Growth parameters from the patients were 52.5% weight-for-age <5 percentile, 45% height-for-age <5 percentile and 25% BMI-for-age underweight. There isn’t significant result in 25-hydroxyvitamin D with growth parameters, and a significant result between physical activity and height-for-age (p=0.027), but not with weight-for-age and BMI-for-age. Conclusion. The 25-hydroxyvitamin D do not associate with growth parameters significantly in thalassemia with repeated blood transfusion but physical activity has significant association with height-for-age.
BARRIERS TO THE IMPLEMENTATION OF ISONIAZID PREVENTIVE THERAPY AMONG CHILDREN UNDER FIVE YEARS OLD IN CLOSE CONTACT WITH SPUTUM SMEAR-POSITIVE TB PATIENTS Tirsa Hizkia Saverina Nugroho; Anindita Soetadji; Dea Amarilisa Adespin; Stefani Candra Firmanti
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29456

Abstract

Background: The implementation of isoniazid preventive therapy (IPT) among children under five years old in close contact with sputum smear-positive TB patients is still low. Only 21,7% of children implemented the IPT in Central Java in 2017. Assessment of the barriers to IPT implementation needs to be carried out in the control of child TB cases.Objective: To analyze the barriers to IPT implementation among children under five years old in close contact with sputum smear-positive TB patients.Methods: A cross-sectional study was conducted among children (age <5 years) in close contact with sputum smear-positive TB patients. Data were collected from KRMT Wongsonegoro Hospital, Dr. Adhyatma, MPH Hospital, Puskesmas Kedungmundu, and Puskesmas Bandarharjo. Structured questionnaires were used to obtain sociodemographic information and to identify associated barriers to IPT implementation. The data were analyzed using Fisher’s exact test.Results: The majority (93,3%) of the total subject (75) of this study did not implement the IPT. The results of the bivariate analysis showed that distance to health facilities (p=0.024), perceived barriers (p=0.016), and cues to action (p=0.001) had a significant association as barriers to IPT implementation. Meanwhile age (p=0.622), gender (p=2.121), education level (p=0.073), economic level (p=0.521), knowledge level (p=0.166), and perceived threats (p=0.316) had no significant association as barriers to IPT implementation.Conclusion: IPT implementation rate is low. The barriers were distance to health facilities, perceived barriers, and cues to action.
THE DIFFERENCE OF MEAN PLATELET VOLUME AND PLATELET COUNT IN CORONARY HEART DISEASE PATIENTS WITH ACUTE CORONARY SYNDROME AND NON ACUTE CORONARY SYNDROME Aditya Paelo Rizki Sikumbang; Indranila Kustarini Samsuria; Novi Anggriyani; Charles Limantoro
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29460

Abstract

Background: Coronary Heart Disease (CHD) is currently one of main causes and the first death in developed and developing countries, including Indonesia. CHD appeared with the clinical appearance of asymptomatic, stable angina pectoris until acute coronary syndrome. ACS is a progressively CHD and takes parameters that describe the process pathogenesis. MPV and platelet count are two parameters in the complete blood count which reflect the activity of platelets in CHD.Objective: This study is to investigate the differences Mean Platelet Volume and Platelet Count in CHD with ACS compared to non ACS.Methods: A cross-sectional study was conducted with collecting data from the medical records of patients with CHD who underwent treatment in the dr. Kariadi General Hospital Medical Center Semarang, the period of January - December 2019. Eighty subjects of 20 non-ACS patients and 60 ACS patients were included in this study which is Mean Platelet Volume and Platelet Count in hematology laboratory were analyzed. The Independent T-test were used for comparing the group means.Results: MPV was found to be higher significantly among ACS patients as compared to non ACS, 9,43 ± 0,3868 fl vs 9,43 ± 0,3868 fl (p-value<0.01) while Platelet Count was lower significantly among ACS patients as compared to non ACS, 282,63 ± 75,084 109/L  vs 322,30 ± 41,980 109/L.Conclusion: There were significantly differences in Mean Platelet Volume and Platelet count between patients with ACS and non ACS.

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