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Asian Journal of Fertility, Endocrinology, and Reproduction
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Jl. Simpang Danau Maninjau Selatan 1 No. 14, Sawojajar, Malang, East Java, Indonesia, 65139
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INDONESIA
Asian Journal of Fertility, Endocrinology, and Reproduction
Published by Pusat Pelatihan Profesional Kesehatan
ISSN : 31644554     EISSN : 31644538     DOI : -
Core Subject : Health, Science, Social,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences
The Asian Journal of Fertility, Endocrinology, and Reproduction (AJFER), first launched in 2025, is a peer-reviewed and open-access scientific journal dedicated to advancing knowledge in the fields of fertility, endocrinology, and reproduction health published by the Pusat Pelatihan Profesional Kesehatan, Indonesia. AJFER provides a platform for the dissemination of high-quality, evidence-based research and professional discourse in the field of reproductive health. Encompassing original research articles, review papers, case reports, and clinical as well as basic science studies. The journal embraces a broad interdisciplinary scope within reproductive medical sciences, including but not limited to: Obstetrics and Gynecology, Reproductive Endocrinology, Andrology, Embryology, Urology, Reproductive Medicine, Reproductive genetics, and public health in reproductive care. To ensure timely dissemination of scientific contributions, AJFER maintains four times a year publication schedule, issuing four editions per year (for every three months: January, April, July, and Oktober). All manuscripts submitted to AJFER undergo a comprehensive double-blind peer review system. Accepted articles are promptly published with open-access availability. By embracing this interdisciplinary approach, AJFER aims to bridge clinical practices research, and policymaking to improve reproductive health outcomes in Asia and beyond.
Arjuna Subject : -
Articles 18 Documents
 1   2 
Comparative Effectiveness of Hormone Suppression Therapy and Surgery in Postmenopausal Endometriosis: A Systematic Review Elviara Martha Tinova Suprapto; Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.34

Abstract

Introduction: Postmenopausal endometriosis is a rare condition that presents diagnostic and therapeutic challenges, requiring evidence from various study designs. This systematic review evaluates the quality of available case reports and interventional studies to determine the reliability of evidence supporting hormonal suppression therapy and surgical management in postmenopausal endometriosis. Case Presentation: Risk of bias was assessed using the JBI Critical Appraisal Checklist for Case Reports and the Cochrane RoB 2 tool for randomized or quasi-experimental studies. Each domain was evaluated to determine methodological rigor and reporting completeness. Result: Included studies demonstrated that hormonal and surgical therapies offer varying degrees of effectiveness in managing postmenopausal endometriosis. Retrospective findings showed that menopausal hormone therapy may reduce symptoms, although adjustments to dose or regimen were sometimes required due to recurrence. Randomized and comparative trials evaluating different hormonal regimens reported symptom improvement without significant changes in metabolic parameters, although stimulation of residual endometriotic tissue remained a consideration. Controlled trials comparing hormonal therapy with surgical intervention indicated that treatment decisions should be individualized and carefully monitored. Case reports consistently documented favorable outcomes following surgical removal of lesions, with long-term follow-up showing no recurrence in several patients. Reports of medical therapy, including aromatase inhibition with supportive bone-protective treatment, demonstrated reductions in lesion activity and stabilization of bone density. Overall, both medical and surgical approaches were associated with symptom relief and stable clinical outcomes, with no major complications reported across studies. Conclusion: Evidence on treatment effectiveness in postmenopausal endometriosis remains limited by methodological weaknesses in interventional studies. While case reports support the potential benefits of surgical and hormonal therapies, more rigorous prospective studies are needed to strengthen clinical recommendations.
Incidental Cutaneous Endometriosis Discovered During Cesarean Section: A Case Report Elviara Martha Tinova Suprapto; Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.35

Abstract

Introduction: Cutaneous endometriosis is a rare form of extragenital endometriosis characterized by the presence of endometrial tissue within the skin, most commonly associated with previous gynecologic or obstetric surgical scars, particularly cesarean section. The diagnosis is often challenging due to nonspecific clinical manifestations and variable symptomatology. Case Presentation: A 31-year-old woman, gravida 2 para 1, with a history of cesarean section 14 years prior, underwent a repeat cesarean section for the same indication of cephalopelvic disproportion. During the second pregnancy, the patient did not report any palpable abdominal mass or menstrual abnormalities, except for mild dysmenorrhea. Intraoperatively, a well-defined mass was incidentally identified within the subcutaneous fat layer, firmly attached to the fascia, measuring 4.7 × 2.9 × 2.7 cm. The mass appeared yellowish with partially brownish areas and had a firm–elastic consistency. Complete surgical excision was performed. Histopathological examination revealed adipose and connective tissue containing nodular aggregates of decidualized cells, with no evidence of malignancy. Postpartum follow-up for three months showed complete resolution of symptoms without recurrence. Conclusion: Cutaneous endometriosis may present as an incidental intraoperative finding and can remain asymptomatic, particularly during pregnancy due to decidualization. A prior history of cesarean section is a significant risk factor. Complete surgical excision remains the treatment of choice and is associated with excellent clinical outcomes. Increased awareness of this rare entity is essential to ensure accurate diagnosis and appropriate management.
Cell-Based Regenerative Therapy for Premature Ovarian Failure: A Systematic Review and Meta-Analysis of Hormonal and Follicular Outcomes Nabila Khairunisa Azzahra; Sutrisno; Leny Silviana Farida
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.36

Abstract

Introduction: Premature ovarian insufficiency (POI) is associated with impaired ovarian function and hormonal imbalance, and this meta-analysis evaluates whether cell-based regenerative therapy improves hormonal and follicular outcomes in animal models. Methods: This systematic review and meta-analysis followed PRISMA 2020 guidelines. PubMed and Scopus were searched (December 2025) for in vivo animal studies of POI/POF comparing cell-based regenerative therapy with untreated controls. A random-effects model was used to pool outcomes, reported as mean difference (MD) with 95% confidence intervals (CI). Heterogeneity was assessed using I² statistics. Risk of bias was evaluated using the SYRCLE risk-of-bias tool. Results: Meta-analysis demonstrated that cell-based regenerative therapy significantly reduced follicle-stimulating hormone (FSH) levels (MD -1.79; 95% CI -3.06 to -0.51) and significantly increased estradiol (E2) levels (MD 19.67; 95% CI 17.17 to 22.17) compared with untreated POI controls. In addition, a significant increase in total follicle count was observed in treated groups (MD 31.93; 95% CI 18.08 to 45.78). Considerable heterogeneity was noted in some outcomes, reflecting variability in animal models and intervention protocols. Conclusion: Cell-based regenerative therapy improves hormonal and follicular outcomes in animal models of premature ovarian insufficiency, supporting its potential as a regenerative treatment strategy.
A Comprehensive Systematic Review and Meta-Analysis: Unraveling the Efficacy of Soy Isoflavones in Managing Urinary Incontinence among Menopausal Women Recavery Dwi Wulandari; Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 3 (2026): July 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i3.37

Abstract

Introduction: Urinary incontinence (UI) is a common and distressing condition that affects a significant proportion of menopausal women worldwide. Endogenous estrogen levels diminish during menopause, which can lead to weakening pelvic floor muscles and urogenital changes, and is a factor in the onset or exacerbation of UI symptoms. Previous studies have investigated the impact of soy isoflavones on various menopausal symptoms, including hot flashes and bone health, and their role in mitigating urinary incontinence remains an area of ongoing research. Methods:  This review is a systematic review. An inclusive, methodical search was conducted through PubMed, ScienceDirect, and Google Scholar to identify relevant studies. The selected studies were analyzed in Review Manager V.5.4 using a random-effects model to estimate the odds ratios with 95% confidence intervals. Results:  The discovery between the two studies showed that the soy isoflavone group achieved a significantly greater improvement than the placebo group, with a mean difference of 192.94 (95% CI 0.0, 2284.63; p < 0.00001). Nonetheless, it should be noted that the significance of the result is insubstantial due to the incompatible comparison groups across the studies. Conclusion:  This review on soy isoflavones and urinary incontinence in menopausal women discovered a positive tendency, but there is no statistical significance due to the conflicting studies.
Flavonoids Extract of Phaleria macrocarpa Fruit Extract Ameliorated Inflammation Markers In Endometriosis Mice Models Sutrisno Sutrisno; Maharani Maharani; Gema Alya Salsabila; Ani Khoirinda; Leni Ria Ariana; Ana Paramita Prastiwi; Maria Antonia Barbara Batu Mali
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.38

Abstract

Introduction: Endometriosis is an abnormal endometriosis growth in the outside of uterus, which performed pelvic pain and high inflammatory markers. This study investigated the potential endometriosis therapeutic agents of flavonoid compounds from P. macrocarpa in decreasing IGF-1, IL-33, IL-2, IL-10, IFN-Ɣ, and MUC1 levels in the endometriosis mice model. Methods: Forty female mice, weight 20 – 30 grams, 6 – 8 weeks old, were classified into 8 groups (Normal, Endometriosis (EM), EM +3.75; EM + 7.5; EM +11.25; EM + 15; EM + DNG; and EM + LA). Endometriosis mice models were induced by injecting cyclosporin, followed by adenomyosis tissue that was injected intramuscularly and ethynyl estradiol. Endometriosis mice were treated as group as for 14 days. The peritoneal fluid of all animal models was collected and analyzed by using ELISA. Result: Administrated of PME 7.5 mg/mice/day for 14 days increase IL-10. The PME decreased IL-2 significantly and improved the IL-2 levels as well as normal mice. PME also reduced IL17A, IGF1, IL-33 and lowered IL-4, IFN y, and Mucin1 levels. Conclusion: Phaleria macrocarpa fruit extract altered inflammation marker protein of endometriosis mice model for 14 days and potentially for endometriosis therapeutic agents.
5-O-methyl genistein of Phaleria macrocarpa Revealed a Potential Therapeutic Compound for Endometriosis Sutrisno; Maharani Maharani
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.39

Abstract

Introduction: Endometriosis is a gynecological disease characterized by pelvic pain and high inflammation in women. Phaleria macrocarpa fruit contains six flavonoids involved Eriodictyol, Glycitin, 5-O-methylgenistein, Catechin 7-O-beta-D-xyloside, 8-Prenylnaringenin, and Naringenin. In vivo experiment performed that flavonoid from Phaleria macrocarpa fruit potential as therapeutic agents for endometriosis. However, the mechanism of flavonoids from Phaleria macrocarpa was limited information. This study performed the endometriosis therapeutic mechanism of flavonoids from Phaleria macrocarpa through molecular docking. Methods In silico experiment was carried out of this study, canonical SMILES of six identified flavonoids from Phaleria macrocarpa were predicted the anti-inflammatory, antineoplastic, and antioxidant properties. Then, the highest biological properties was redocked with AKT, COX-2, AHR, and ESR by using Molegro Virtual Docker version 5.0. Result: According to the bioactivity prediction, six flavonoids of Phaleria macrocarpa performed antiinflammatory property ranged 0.599 – 0.751, low anti-inflammatory intestinal NSAID agent, and antineoplastic (uterine, cervical, and ovarian cancers). 5-O-methylgenistein showed highest breast cancer – resistant protein inhibitor. Molecular docking performed interaction of 5-O-methylgenistein and inhibited COX-2, AHR, ESR, and AKT. 5-O-methylgenistein induced apoptosis by caspase – 3 interactions. A proposed mechanism of 5-O-methylgenistein in endometriosis was reducing pain, inducing apoptosis, preventing cancer cell initiation, inhibiting proliferation and oncogenic cell. Conclusion: 5-O-Methylgenistein performed a promising plant constituent for endometriosis therapy.
The Role of Botanical Interventions to the Inflammatory Environtment of Endometriosis Desease Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 2 (2026): April 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i2.40

Abstract

Endometriosis stands as one of the most complex, pervasive, and physically taxing conditions encountered in modern gynecological medicine. Clinically, it is fundamentally defined and recognized as a chronic, estrogen-dependent inflammatory disease. The defining pathological hallmark of this condition—the insidious and aberrant growth of endometrial-like tissue outside the normal confines of the uterine cavity—sets into motion a relentless cycle of physiological disruption. Patients suffering from this disease frequently present with a debilitating complaint, such as severe symptoms, most notably persistent pelvic pain, intense dysmenorrhea, and painful dyspareunia. Furthermore, the disease is intricately and tragically linked to profound infertility challenges, a culmination of factors that lead to a severely impaired overall quality of life for the affected individuals.
Maternal Mortality in Indonesia: When Will It End? Sutrisno Sutrisno
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 3 (2026): July 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i3.72

Abstract

Maternal mortality in Indonesia remains a critical public health concern, frequently drawing public attention through social media but requiring deeper systemic analysis. This editorial argues that maternal death is rarely due to biology alone; rather, it reflects the simultaneous failure of multiple protective mechanisms within the health system. Although Indonesia's maternal mortality ratio has declined by roughly 45% since 1990, progress has stagnated since 2015, and conflicting national estimates point to problems in case detection and reporting rather than genuine improvement. Significant geographic inequality persists, with mortality rates in eastern Indonesia and Sulawesi far exceeding those in Java–Bali, driven partly by extreme disparities in distance to hospital care. The COVID-19 pandemic did not create these vulnerabilities but revealed them, as provincial performance against national targets deteriorated sharply in 2021. Meanwhile, the causes of maternal death are shifting: traditional obstetric emergencies such as hemorrhage and sepsis have declined proportionally, while hypertensive disorders and non-obstetric complications—linked to chronic disease—have risen substantially. The editorial stresses that service coverage alone does not guarantee effective care, since antenatal visits and facility births can fail to detect danger or respond appropriately. Maternal mortality is instead shaped by layered determinants—immediate clinical causes, intermediate social and access barriers, and distant governance failures—a pattern mirrored in perinatal mortality data. The author calls for a standardized, accountable Maternal Death Surveillance and Response system, stronger emergency obstetric networks, equitable workforce distribution, and transparent reporting. Ultimately, meaningful progress requires systemic reform and sustained moral commitment, not incremental policy gestures or modest statistical improvement.

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