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INDONESIA
Health Science Journal of Indonesia
Published by Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan
ISSN : 20877021     EISSN : 23383437     DOI : https://doi.org/10.22435/hsji
Core Subject : Health,
Dentistry Health Professions Nursing Public Health
Health Science Journal of Indonesia is a journal developed to disseminate and discuss the scientific literature and other research on the development of health. This journal is intended as a medium for communication among stake holders on health research such as researchers, educators, students, practitioners of Health Office, Department of Health, Public Health Service center, as well as the general public who have an interest in the matter. The journal is trying to meet the growing need to study health. Vision: Becoming a notable national journal in the field of health research and towards a reputable international journal. Mission: Providing scientific communication media in health research in order to advance science and technology in related fields. Organizes scholarly journal publishing in health research with an attempt to achieve a high impact factor in the development of science and technology.
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 95 Documents
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Do the acute lymphoblastic leukemia and non-hodgkin lymphoma patients have a worse prognosis of COVID-19 infection in children?: a case report Nadirah Rasyid Ridha; Bahrul Fikri; Rahmawaty Rahimi; Amiruddin Laompo; Conny Tanjung; Dasril Daud; Nasrum Massi
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4467

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a contagious disease caused by a new type of Coronavirus namely Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Children with tumors or autoimmune diseases are more susceptible, because of suppression of their immune system, chemotherapy, radiotherapy, or surgery on tumors. Case presentation: We present the clinical features 3 Acute Lymphoblastic leukemia and 1 Non-Hodgkin lymphoma patients who were infected with COVID-19 since July to August 2020 in our hospital. These were the first four cases identified as COVID-19 positive in Dr Wahidin Sudirohusodo Hospital. Case 1, 2, and 4 were diagnosed as moderate and common type of COVID-19, while case 3 was classified as severe type. They may be transmitted COVID-19 infection during hospitalization. All cases were recovered from COVID-19 after a combination therapy against virus, bacteria, and also respiratory support. Conclusion: Our case series of four pediatric cancer patients showed a good outcome after prompt treatment, suggesting that malignancy in children may not be a contributor factor for COVID-19 recovery. Keywords: COVID-19; acute lymphoblastic leukemia; non-hodgkin lymphoma; children Abstrak Latar belakang: Covid-19 (Coronavirus disease 2019) adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Anak yang menderita kanker atau penyakit autoimun lebih rentan tertular karena penurunan system kekebalan tubuh, dampak kemoterapi, radioterapi, atau operasi tumor. Penyajian kasus: Kami melaporkan 3 pasien leukemia limfoblastik akut dan 1 pasien limfoma non-Hodgkin yang terinfeksi Covid-19 sejak Juli-Agustus 2020. Kasus tersebut adalah 4 kasus pertama yang teridentifikasi Covid-19 di Rumah Sakit Dr. Wahidin Sudirohusodo. Kasus 1,2, dan 4 terdiagnosis positif Covid -19 derajat sedang, sedangkan kasus 3 tergolong berat. Mereka kemungkinan terinfeksi Covid-19 saat perawatan. Semua kasus dinyatakan sembuh dari Covid-19 setelah pemberian obat anti virus, antibiotik, dan alat bantu pernapasan. Kesimpulan: Serial kasus dari 4 pasien kanker anak dengan outcome yang baik setelah pengobatan yang cepat mengindikasikan bahwa penyakit keganasan pada anak kemungkinan bukan faktor yang berkontribusi dalam kesembuhan Covid-19. Kata kunci: COVID-19; leukemia limfoblastik akut; limfoma non-hodgkin; anak
Helmet use behavior and its relation to head injury of road traffic accident in Indonesia (Basic Health Research, 2018) Lusianawaty Tana; Delima Delima; Nunik Kusumawardani; Lely Indrawati
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4655

Abstract

Background: Nationally, the prevalence of injuries tends to increase from 7.5% in 2007, 8.2% in 2013, and 9.2% in 2018. The main cause of injuries is motorcycle accidents (40.6%), which most occur on the highway (42.8%). This is a further analysis of Indonesia Basic Health Research (Riskesdas) 2018 data, to assess the role of sociodemography on helmet use behavior and head injuries due to traffic accident. Methods: The 2018 Basic Health Research was a cross-sectional research, based on data from individuals aged 5 years old and above, who analyzed with helmet use behavior and the incidence of head injuries due to traffic accident as dependent variables. The independent variables consist of sociodemographic characteristics, the role of individual in accident, and the impact of the accident. The data were analyzed by bivariate and multivariate, and taking into account the complex sample in 5% confidence level. Results: The results showed that 44.4% from 19122 individuals aged five years old and above had good behavior in using helmets. The determinants of helmet use behavior were age, gender, education, occupation, economic status, location and area of residence (adjusted OR 1.15—4.5; p≤0.02). The result from14.1% of respondents who had a head injuries caused by traffic accidents. The risk of head injuries due to traffic accidents was 1.17 times (95% CI 1.02—1.35; p 0.03) in the unhelmeted group compared to the helmeted group. Conclusion: Helmet use behavior is connected with the reduction of head injuries due to traffic accidents. Counseling and monitoring of helmet use is need to be improved, especially for the youth category. Keywords: head injury, traffic accident, helmet use Abstrak Latar belakang: Secara nasional, prevalensi cedera cenderung meningkat dari 7,5 % pada tahun 2007, 8,2 % pada 2013, dan 9,2 % pada 2018. Penyebab utama dari cedera adalah kecelakaan bermotor (40,6 %), dan kebanyakan terjadi di jalan raya (42,8 %). Ini merupakan analisis lanjut data Riset Kesehatan Dasar (Riskesdas) 2018 untuk menilai peran sosiodemografi terhadap perilaku penggunaan helm dan hubungan perilaku penggunaan helm dengan cedera kepala akibat kecelakaan lalu lintas. Metode: Riskesdas 2018 adalah riset potong lintang. Data individu umur 5 tahun ke atas dianalisis dengan perilaku penggunaan helm dan kejadian cedera kepala akibat kecelakaan lalu lintas sebagai variabel terikat. Variabel bebas terdiri dari karakteristik sosiodemografi, peran individu dalam kecelakaan, dan dampak kecelakaan. Data dianalisis secara bivariat dan multivariat dengan memperhitungkan complex sample dan 5 % tingkat kepercayaan. Hasil: Hasil menunjukkan bahwa 44,4% dari 19.122 individu umur 5 tahun ke atas mempunyai perilaku yang baik dalam menggunakan helm. Determinan perilaku penggunaan helm adalah umur, jenis kelamin, pendidikan, pekerjaan, status ekonomi, lokasi dan area tempat tinggal (adjusted OR 1,15—4,5; p≤0,02). Sejumlah 14,1% individu mengalami cedera kepala akibat kecelakaan lalu lintas. Risiko cedera kepala pada individu yang tidak menggunakan helm sebesar 1,17 kali (95% CI 1,02—1,35; p 0,03) dibandingkan dengan individu yang menggunakan helm. Kesimpulan: Perilaku penggunaan helm berhubungan dengan penurunan cedera kepala akibat kecelakaan lalu lintas. Penyuluhan dan pemantauan penggunaan helm perlu ditingkatkan terutama pada kelompok remaja. Kata kunci: cedera kepala, kecelakaan lalu lintas, penggunaan helm
Stigma during COVID-19 pandemic among healthcare workers in greater Jakarta metropolitan area: a cross-sectional online study Ika Saptarini; Novianti Novianti; Anissa Rizkianti; Iram Barida Maisya; Suparmi Suparmi; Ginoga Veridona; Ning Sulistiyowati; Sudikno Sudikno
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4754

Abstract

Background: COVID-19, which started in Wuhan, has become a global pandemic leading to a new global risk to human health. Lack of information or misinformation about COVID-19 can lead to stigmatization, including for health workers. This study aims to determine the stigmatization among health workers during the COVID-19 pandemic within the Greater Jakarta Metropolitan Area. Methods: This study was a cross-sectional study conducted online using Google Forms in the Jabodetabek area. The questionnaire’s link was distributed through social media, including Whatsapp, Facebook, Twitter, and Instagram. The study sample is health workers who live in Jabodetabek and carry out health practices. Stigma is measured using four dimensions: personalized stigma, disclosure concerns, public attitudes, and negative self-image. Result: The negative self-image dimension is the dimension most felt by health workers. More than half of health workers agreed that during the COVID-19 pandemic, they put their families at risk because of their status as health workers. The stigma of health workers who work in hospitals is higher than that of non-hospital health workers, such as health centers, clinics, and laboratories. Conclusion: There was any stigmatization among healthcare workers in Greater Jakarta Metropolitan Area. Stigmatization was higher among healthcare workers who work in hospitals compared to those who work in non-hospitals. Some efforts should be made to reduce stigmatization among health workers, such as provide correct information to the public, equip health personnel with adequate personal protective equipment, and give incentives periodically to the health workers. Keywords: Stigma, COVID-19, healthcare workers, Greater Jakarta Metropolitan Area Abstrak Latar belakang: COVID-19 yang bermula dari Wuhan telah menjadi pandemi global yang mengancam kesehatan umat manusia. Kurangnya informasi atau informasi yang salah mengenai COVID-19 dapat menyebabkan adanya stigmatisasi termasuk terhadap tenaga kesehatan. Penelitian ini menilai adanya stigmatisasi terhadap tenaga kesehatan selama pandemi COVID-19 di wilayah Jabodetabek. Metode: Penelitian ini merupakan penelitian potong lintang dan dilakukan secara daring menggunakan Google Form di wilayah Jabodetabek. Tautan pengisian kuesioner disebarkan melalui media sosial seperti Whatsapp, Facebook, Twitter dan Instagram. Sampel studi adalah tenaga kesehatan yang tinggal di Jabodetabek dan melakukan praktik kesehatan. Stigma diukur menggunakan empat dimensi yaitu personized stigma, disclosure concerns, concerns about public attitudes dan negative self-image. Hasil: Dimensi negative self-image merupakan dimensi yang paling dirasakan oleh tenaga kesehatan. Lebih dari separuh tenaga kesehatan setuju bahwa selama pandemi COVID-19 mereka membahayakan keluarga mereka karena status mereka sebagai tenaga kesehatan. Stigma pada tenaga kesehatan yang bekerja di rumah sakit lebih tinggi disbanding tenaga kesehatan yang bekerja bukan di rumah sakit seperti puskesmas, klinik dan laboratorium. Kesimpulan: Terdapat stigmatisasi pada petugas kesehatan di jabodetabek. Stigmatisasi lebih tinggi di antara petugas kesehatan yang bekerja di rumah sakit dibandingkan dengan mereka yang bekerja tidak di rumah sakit. Beberapa upaya yang perlu dilakukan untuk mengurangi stigmatisasi di kalangan petugas kesehatan, seperti memberikan informasi yang benar kepada masyarakat, melengkapi tenaga kesehatan dengan alat pelindung diri yang memadai, dan memberikan insentif kepada mereka secara berkala. Kata Kunci: Stigma, COVID-19, tenaga kesehatan, jabodetabek
The correlation of structural and binding affinity of insulin analog to the onset of action for diabetic therapy Galuh Wening Permatasari; Didik Huswo Utomo; Dian Laila Purwaningroom; Djoko Soeatmadji
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4783

Abstract

Background: These days, insulin analog production has been improved and becoming popular. The advantages of insulin analog have been extensively reviewed in terms of effectiveness compared to human insulin. Each of the insulin analog industries has claimed their safety and efficacy based on in vivo and in vitro to overcome type 2 diabetes. Hereby, we report on the identification of highly effective analog-based insulin on structure and binding affinity computationally, to confirm its potential and give a broader point of view to insulin analog users. Methods: Five types of insulin analogs, Aspart, Glargine, Detemir, Lispro and Degludec, were analyzed. We grouped and clustered the sequence by alignment to identify the closeness and sequence similarity between samples, continued by superimposing analysis and undertaking binding affinity identification utilizing of a docking analysis approach. Results: Lispro had the least sequence similarity to other types, close to Aspart (96%) and Glargine (90.5%), while Detemir and Degludec showed 100% similarity we decide to only use Degludec for the next analysis. Furthermore, Lispro, Aspart, and Glargine exhibited structural similarity strengthened by the lack of significant difference in the RMSD data. Importantly, Aspart had the highest binding affinity score (-66.1 +/- 7.1 Kcal/mol) in the docking analysis to the insulin receptor (INSR) and similar binding site areas to human insulin. Conclusion: Our finding revealed that the strength of insulin analogs towards insulin receptors is identic with its rapid mechanism in the human body. Keywords: computation, docking, insulin analog, sequence similarity, structure Abstrak Latar belakang: Saat ini, produksi analog insulin meningkat dan menjadi popular. Keuntungan analog insulin telah ditinjau secara ekstensif dalam hal efektivitas dibandingkan dengan insulin manusia. Masing-masing industri analog insulin mengklaim keamanan dan kemanjurannya berdasarkan in vivo dan in vitro untuk mengatasi diabetes tipe 2. Kami melaporkan identifikasi insulin analog yang efektif berdasarkan struktur dan afinitas pengikatan secara komputasi, untuk mengonfirmasi potensi serta memberikan sudut pandang yang lebih luas kepada pengguna insulin analog. Metode: Lima jenis analog insulin, Aspart, Glargine, Detemir, Lispro, dan Degludec, dianalisis. Kami membandingkan dan mengelompokkan urutan tersebut dengan penyelarasan untuk mengidentifikasi kedekatan dan kesamaan urutan antar sampel dilanjutkan dengan superimposing analysis dan melakukan identifikasi binding affinity menggunakan pendekatan analisis docking. Hasil: Lispro memiliki kemiripan sekuen paling rendah dengan jenis lainnya, mendekati Aspart (96%) dan glargine (90,5%), sedangkan Determir dan Degludec menunjukkan kemiripan 100% sehingga kami menggunakan Degludec untuk analisis selanjutnya. Selain itu, Lispro, Aspart, dan Glargine menunjukkan kesamaan struktural yang diperkuat oleh rendahnya nilai signifikansi pada data RMSD. Perlu digarisbawahi bahwa Aspart memiliki skor afinitas pengikatan tertinggi (-66.1 +/- 7.1 kkal / mol) dalam analisis docking ke reseptor insulin (INSR) dan memiliki area pengikatan yang serupa dengan insulin manusia. Kesimpulan: Penemuan kami mengungkapkan bahwa kekuatan insulin analog sejalan dengan laju mekanismenya di dalam tubuh manusia Kata kunci: komputasi, docking, insulin analog, kemiripan sekuen, struktur
Performance of the tariff method and physicians in determining stroke as the cause of deaths using verbal autopsy in areas with a limited number of physicians: cases in Indonesia Endang Indriasih; Meiwita Budiharsana
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4805

Abstract

Background: Physician-certified verbal autopsy (PCVA) is the primary method used to determine the cause of death in Indonesia, although it is very costly and problematic to use in areas where physicians are not widely available with most deaths occur at home. The Tariff method has been piloted to obtain an alternative approach that does not require a physician to determine the cause of death. This validation study presents how the Tariff captures the correctness and distinctiveness of stroke symptoms to the PCVA. Methods: Medical records of 298 adult deaths that occured in four teaching hospitals in the Jakarta from January 1, 2015 to March 2017 were collected prospectively. Verbal Autopsy (VA) was applied using the 2014 WHO instrument diagnosed by a trained physician (PCVA) and by Tariff method. The validity of the VA was assessed by comparing the PCVA diagnoses with the Tariff diagnoses, referring to the best standard. Results. Sensitivity, specificity and positive predictive value (PPV) of VAs using physician’s diagnosis (PCVA) for stroke were 73.9%, 73.5% and 93.4% respectively. The corresponding sensitivity, specificity and positive predictive value (PPV) of VAs diagnosed by the Tariff method were 75%, 61% and 91%. The negative predictive values (NPV) of both techniques were low, 35.6% and 32.6% respectively. Conclusion: The performance of the Tariff method for stroke was almost similar with PCVA, and with a narrower variation, or more consistent than PCVA. Therefore, the Tariff method is a potential alternative to be used on a large scale, because the difficult geographical conditions where physician are not widely available for causes of deaths with distinct signs and symptoms. Keywords: verbal autopsy, sensitivity, specificity, determining cause of death, physician, tariff method Abstrak Latar Belakang: Autopsi verbal yang disertifikasi oleh dokter (PCVA) merupakan metode utama yang digunakan untuk memastikan penyebab kematian di Indonesia. Meskipun sangat mahal dan bermasalah untuk digunakan di daerah di mana dokter tidak banyak tersedia dan sebagian besar kematian terjadi di rumah. Metode Tarif telah diujicobakan untuk mendapatkan pendekatan alternatif yang tidak memerlukan dokter untuk menentukan penyebab kematian. Studi validasi ini menyajikan bagaimana Tarif menangkap kebenaran dan kekhasan gejala stroke dibandingkan dengan PCVA. Metode: Rekam medis dari 298 kematian orang dewasa yang terjadi di empat rumah sakit studi di wilayah Jakarta pada 1 Januari 2015 hingga Maret 2017 dikumpulkan secara prospektif. Autopsi verbal (AV) dilakukan dengan menggunakan instrumen WHO 2014 yang didiagnosis oleh dokter terlatih (PCVA) dan metode Tarif. Validitas AV dinilai dengan membandingkan diagnosis PCVA dengan diagnosis metode Tarif, mengacu pada baku mutu. Hasil. Sensitivitas, spesifisitas dan nilai prediksi positif (PPV) dari AV dengan diagnosis dokter (PCVA) untuk stroke adalah 73,9%, 73,5% dan 93,4%. Sensitivitas, spesifisitas, dan nilai prediksi positif (PPV) yang sesuai dari AV yang didiagnosis dengan metode Tariff adalah 75%, 61% dan 91%. Nilai prediksi negatif (NPV) dari kedua teknik itu rendah, masing-masing 35,6% dan 32,6%. Kesimpulan: Untuk stroke, kinerja metode Tarif hampir sama dengan PCVA, dan dengan variasi yang lebih sempit, atau lebih konsisten dibandingkan PCVA. Oleh karena itu, untuk penyebab kematian dengan tanda dan gejala yang berbeda, metode Tarif merupakan alternatif potensial untuk digunakan dalam skala besar, di Indonesia dimana banyak wilayah dengan geografis sulit dan dokter tidak selalu tersedia. Kata kunci: autopsi verbal, sensitifitas, spesifisitas, penentuan penyebab kematian, dokter, metode tariff
First experience of using favipiravir in the first healthcare worker patient with moderate case of Coronavirus Disease 2019 (COVID-19) at Sulianti Saroso Infectious Disease Hospital, Jakarta, Indonesia: a case report Pompini Agustina Sitompul; Nina Mariana; Adria Rusli
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i1.4879

Abstract

Background: During the early period of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, there was no approved and definitive drug available for the treatment of COVID-19. Favipiravir, chloroquine, hydroxychloroquine was used for re-purposing drugs while their efficacy and safety remained a major concern for healthcare workers. Clinical trial to assess efficacy and safety were ongoing. Case presentation: We present here the case of a 38-year-old woman, the first case of a healthcare worker diagnosed with COVID-19 who had moderate type, including first experience treatment with favipiravir in Sulianti Saroso Infectious Disease Hospital, Jakarta, Indonesia. We present the clinical characteristics, chest X-ray, clinical laboratory profiles, the treatment process with favipiravir and hydroxychloroquine as well as the clinical outcome of moderate type COVID-19 patient. Conclusion: This case highlights that considering the use of emergency intervention outside of clinical trial in the COVID-19 population, the informed patient consent has been given and the use of emergency intervention was monitored. Keywords: COVID-19, favipiravir, medical worker, case report, Jakarta Abstrak Latar belakang: Periode awal pandemi Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), belum terdapat obat yang disetujui dan pasti tersedia untuk pengobatan COVID-19. Favipiravir, chloroquine, hydroxychloroquine digunakan sebagai obat dengan indikasi baru yang sementara efektifitas dan keamanannya menjadi perhatian para petugas medis. Penyajian kasus: Disini kami melaporkan kasus wanita umur 38 tahun, merupakan kasus pertama seorang tenaga kesehatan Rumah Sakit terdiagnosis Coronavirus Disease 2019 (COVID-19) dengan penggunaan terapi favipiravir untuk pertama kalinya di Rumah Sakit Pusat Infeksi Sulianti Saroso, Jakarta, Indonesia. Berikut ini kami gambarkan karakteristik klinis, hasil foto thorak, profil laboratorium dan proses terapi menggunakan favipiravir and hidroxychloroquine serta hasil akhir pada kasus COVID-19 derajat sedang. Kesimpulan: Kasus ini menggaribawahi bahwa pertimbangan penggunaan kegawatdaruratan obat antivirus diluar uji klinis pada populasi pasien COVID-19, pasien telah memberikan persetujuan dan penggunaan obat-obat tersebut dimonitor. Kata kunci: Covid-19, favipiravir, tenaga kesehatan, laporan kasus, Jakarta
Front Matter HSJI Volume 12 no.1 2021 hsji author
Health Science Journal of Indonesia Vol 12 No 1 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Front Matter HSJI Volume 12 no.1 2021
The importance of hospital re-accreditation: improving the timeliness of laboratory critical value reporting Wahyu Febrianto; Menis Rahmawati; I Gede Sastrawan; Tita Hariyanti
Health Science Journal of Indonesia Vol 12 No 2 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i2.3315

Abstract

Background: Patient safety is the main issue in healthcare services nowadays. Delaying to inform the critical value of laboratory results is a significant source of harm for the patient. The aim of this study is to compare the timeliness of laboratory critical value reporting before and after re-accreditation as one of the service quality indicators in Hospital X. Methods: This study was done by using observational cross-sectional in Hospital X on January - February 2020 with total sampling method of critical value reporting to the responsible clinician that originated from Intensive Care Unit (ICU), Verlos Kamer (VK), and inpatient ward (IW) 1-6 from January-December 2019. The timeliness of reporting was counted since the laboratory result was obtained until received by the responsible clinician within £ 30 minutes and categorized as "On time" or "Late". Results: During 2019, there were 816 reporting which has been done before re-accreditation (511) and after re-accreditation (305) with 17 kinds of tests. The most reported test was platelet with 349 (before re-accreditation) and 101 (after re-accreditation), whilst SGOT/SGPT and albumin were the fewest one. The lowest timeliness of reporting percentage was 76,00% (February), whilst the highest was 98,48% (November). The timeliness of reporting's percentage was 84,34% (before re-accreditation) and 94,43% (after re-accreditation). The statistical analysis result revealed Pearson Chi-Square correlation was 18,535 with significance 0,000 and 3,145 odds ratio which shows that re-accreditation could significantly increase the timeliness of critical value reporting three times. Conclusion: This result showed that re-accreditation could affect the timeliness of laboratory critical value reporting to the responsible clinicians. Keywords: re-accreditation, critical value, laboratory, patient safety, hospital Abstrak Latar belakang: Keselamatan pasien merupakan isu utama dalam pelayanan kesehatan. Tertundanya komunikasi hasil nilai kritis laboratorium merupakan sumber bahaya yang signifikan terhadap pasien. Penelitian ini bertujuan untuk membandingkan ketepatan waktu pelaporan nilai kritis laboratorium sebelum dan setelah reakreditasi sebagai salah satu indikator mutu di RS X. Metode: Penelitian dilakukan dengan cara observasional dengan metode cross sectional di RS X pada Januari - Februari 2020 dengan total sampling laporan nilai kritis kepada Dokter Penanggung Jawab Pasien (DPJP) yang berasal dari ruang Intensive Care Unit (ICU), Verlos Kamer (VK), dan ruang rawat inap 1 – 6 sejak Januari – Desember 2019. Ketepatan waktu pelaporan dihitung sejak hasil pemeriksaan didapatkan hingga diterima oleh DPJP dalam waktu £ 30 menit dan dinyatakan sebagai "Tepat Waktu" atau "Terlambat". Hasil: Selama tahun 2019, terdapat 816 pelaporan yang dilakukan sebelum akreditasi (511) dan setelahnya (305) dengan 17 jenis pemeriksaan. Pemeriksaan trombosit menjadi yang paling banyak dilaporkan yaitu 349 (sebelum akreditasi) dan 101 (setelah akreditasi), sedangkan SGOT/SGPT dan albumin menjadi yang paling sedikit. Persentase ketepatan waktu pelaporan paling rendah adalah 76,00% (Februari) sedangkan yang paling tinggi adalah 98,48% (November). Persentase ketepatan waktu pelaporan didapatkan 84,34% (sebelum akreditasi) dan 94,43% (setelah akreditasi). Hasil analisis statistik didapatkan korelasi Pearson Chi-Square 18,535 dengan signifikansi 0,000 dan Odds ratio 3,145 menunjukkan re-akreditasi mampu meningkatkan kemungkinan ketepatan waktu pelaporan nilai kritis sebesar tiga kali lipat. Kesimpulan: Hal ini menunjukkan bahwa re-akreditasi mampu mempengaruhi ketepatan waktu pelaporan nilai laboratorium kritis kepada DPJP. Kata kunci: re-akreditasi, nilai kritis, laboratorium, keselamatan pasien, rumah sakit.
Interferon gamma concentration in diabetes mellitus and dyslipidemia patient Nelly Marissa; Marlinda Marlinda; Maulidar Maulidar; Veny Wilya; Nur Ramadhan; Zain Hadifah
Health Science Journal of Indonesia Vol 12 No 2 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i2.4290

Abstract

Background: Patient with diabetes mellitus (DM) occurs chronic inflammation by characterized a decreased concentration of various cytokinin types. This causes changes in the body’s immunity so that can be easier in having an infection. One of the most important cytokines against infection is IFN-γ. This study aimed to determine IFN-γ concentration in DM and dyslipidemia patients. Metode: An amount of 234 people who received treatment at the health center in Banda Aceh in 2019 were included in this study. From each respondent, 5 ml of blood was taken to check fasting blood glucose, triglycerides, high-density lipoproteins (HDL), and interferon-gamma (IFN-γ). Test of fasting blood glucose, triglycerides, HDL was carried out using the colorimetric enzymatic method. The IFN-γ protein concentration was examined using the sandwich enzyme-linked immunosorbent assay (ELISA) technique. Result: IFN-γ concentration in the non-DM group was higher than in the DM group. There was a significant difference between the average IFN-γ concentration in the non-DM group compared with the DM group (p = 0.000). All DM patients had increased fasting blood glucose, most had hypertriglycerides, but HDL levels were normal. The fasting blood glucose group <126 mg / dl had a higher IFN-γ concentration than the group with fasting blood glucose levels ≥126 mg / dl. There was a significant difference in the concentration of IFN-γ between the two groups (p = 0.000). The group with triglyceride levels <150 mg / dl had lower IFN-γ levels than the group with triglyceride levels ≥ 150 mg / dl. There was a significant difference between the average IFN-γ concentration between those groups (p = 0.000). The fasting blood glucose levels ≥126 mg / dl and triglycerides levels ≥ 150 mg / dl had higher IFN-γ concentration than the group who had fasting blood glucose levels ≥126 mg / dl and triglycerides levels < 150 mg / dl. Conclusion: There are differences in IFN-γ concentrations in people with DM, increased fasting blood glucose and dyslipidemia compared to normal people. Keywords: IFN-γ, diabetes mellitus, dyslipidemia Abstrak Latar belakang: Penderita diabetes mellitus (DM) dan dyslipidemia mengalami inflamasi kronik yang ditandai dengan perubahan konsentrasi berbagai sitokin. Hal ini yang menyebabkan perubahan imunitas tubuh sehingga mudah mengalami infeksi. Salah satu sitokin yang paling berperan terhadap infeksi adalah interferon gamma (IFN-γ). Penelitian ini bertujuan untuk memeriksa konsentrasi IFN-γ pada penderita DM dan dislipidemia. Metode: Sebanyak 234 orang yang melakukan pengobatan di puskesmas di Kota Banda Aceh pada tahun 2019 diikutsertakan dalam penelitian ini. Dari setiap responden dilakukan pengambilan darah sebanyak 5 ml untuk dilakukan pemeriksaan kadar gula darah puasa (KGD P), trigliserida, high density lipoprotein (HDL), dan inrferon- gamma (IFN-γ). Pemeriksaan KGD, trigliserida, HDL dilakukan dengan metode enzimatik kolorimetrik. Pemeriksaan konsentrasi protein IFN-γ menggunakan teknik sandwich Enzyme-linked immunosorbent assay (ELISA). Hasil: Konsentrasi IFN-γ pada kelompok non-DM lebih tinggi dibandingkan dengan kelompok DM. Terdapat perbedaan bermakna antara rata-rata konsentrasi IFN-γ pada kelompok non-DM dibandingkan dengan kelompok DM (p=0,000). Semua penderita DM mengalami peningkatan KGD P, sebagian besar mengalami hipertrigliserida, namun kadar HDL normal. Pada kelompok KGD P <126 mg/dl memiliki konsentrasi IFN-γ yang lebih tinggi dibandingkan dengan kelompok dengan KGD P ≥126 mg/dl. Terdapat perbedaan bermakna perbedaan konsentrasi IFN-γ antar kedua kelompok tersebut (p=0,000). Kelompok dengan kadar trigliserida <150 mg/dl memiliki kadar IFN-γ lebih rendah dibandingkan dengan kelompok dengan kadar trigliserida ≥ 150 mg/dl. Terdapat perbedaan bermakna antara rata-rata konsentrasi konsentrasi IFN-γ antar kedua kelompok tersebut (p=0,000). Pada kelompok KGD P ≥126 mg/dl dan trigliserida ≥ 150 mg/dl memiliki kadar IFN-γ yang lebih tinggi dibandingkan dengan kelompok KGD P ≥126 mg/dl namun trigliserida <150 mg/dl. Terdapat perbedaan bermakna antara rata-rata konsentrasi konsentrasi IFN-γ antar kedua kelompok tersebut (p=0,000). Kesimpulan: Terdapat perbedaan konsentrasi IFN-γ pada orang dengan DM, peningkatan KGD P dan dislipidemia dibandingkan dengan orang normal. Kata kunci : IFN-γ, diabetes mellitus, dislipidemia.
The relationship of smoking duration, sleep disorders, and nutritional status of Indonesian adult men: data analysis of the 2014 Indonesian Family Life Surve Relawantria Harlianti; Trias Mahmudiono; Dominikus Raditya Atmaka; Siti Helmyati; Mira Dewi; Cindra Tri Yuniar
Health Science Journal of Indonesia Vol 12 No 2 (2021)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i2.5243

Abstract

Background: In Indonesia, the prevalence of smoking is increasing from year to year and can cause various health problems, such as sleep disorders and affect a person's nutritional status. So, in this study, the relationship between smoking duration, sleep disturbances, and nutritional status in men aged 26–45 years will be investigated using secondary data from the 2014 Indonesia Family Live Survey (IFLS). Methods: The 2014 secondary data from the fifth waves of the IFLS were used for analysis. All 5,379 data of men aged 26–45 years who provided anthropometric, smoking duration, and sleep disorders were included in the study. The Chi-Square test was used to examine the relationship between smoking duration, sleep disorders, and nutritional status in men aged 26 – 45 years. Furthermore, the Multinomial Logistics Regression test is carried out to determine the variables that have the strongest influence. Results: Based on the results of statistical tests conducted, it was found that the majority of respondents had a smoking duration of 11-20 years, of which 27.2% of respondents did not experience sleep disorders and 25.4% had sleep disorders. The nutritional status of respondents with a smoking duration of 11-20 years is normal as many as 35% of respondents and at least 0.5% of respondents have underweight nutritional status with smoking duration <5 years. Furthermore, the test results of the relationship between smoking duration and sleep disturbances obtained p-value = 0.03 and the relationship between smoking duration and nutritional status obtained p-value <0.01. Conclusion: Smoking duration was associated with sleep disorder and overweight nutritional status in men aged 26 – 45 years. Keywords: smoking duration, sleep disorder, nutritional status, tobacco use, sleeping sickness Abstrak Latar belakang: Di Indonesia, prevalensi merokok semakin meningkat dari tahun ke tahun dan dapat menyebabkan berbagai permasalahan kesehatan, seperti gangguan tidur serta mempengaruhi status gizi seseorang. Sehingga pada penelitian ini akan diteliti hubungan antara durasi merokok, gangguan tidur, dan status gizi pada pria berusia 26–45 tahun menggunakan data sekunder dari Indonesia Family Live Survey (IFLS) tahun 2014. Metode: Analisis dari data sekunder gelombang kelima IFLS tahun 2014. Semua 5.379 data pria berusia 26–45 tahun yang memiliki kelengkapan data antropometri, kebiasaan merokok, dan gangguan tidur diikutkan dalam penelitian. Uji Chi-Square digunakan untuk menguji hubungan antara durasi merokok, gangguan tidur, dan status gizi pada pria berusia 26 – 45 tahun. Selanjutnya uji Regresi Logistik Multinomial dilakukan untuk mengetahui variabel yang memiliki pengaruh paling kuat. Hasil: Berdasarkan hasil dari uji statistik yang dilakukan, didapatkan bahwa mayoritas responden memiliki durasi merokok selama 11-20 tahun, dimana sebanyak 27.2% responden tidak mengalami gangguan tidur dan 25.4% mengalami gangguan tidur. Status gizi paling banyak yang dimiliki oleh responden dengan durasi merokok selama 11-20 tahun adalah normal sebanyak 35% responden dan yang paling sedikit sebanyak 0.5% responden memiliki status gizi underweight dengan durasi merokok <5 tahun. Selanjutnya hasil uji hubungan antara durasi merokok dengan gangguan tidur didapatkan nilai p-value=0.03 dan hubungan antara durasi merokok dengan status gizi didapatkan nilai p-value<0.01. Kesimpulan: Durasi merokok berhubungan dengan gangguan tidur dan status gizi overweight pada laki-laki usia 26 – 45 tahun. Kata kunci: durasi merokok, gangguan tidur, status gizi, penggunaan tembakau, penyakit tidur

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