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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 150   151   152   153   154 
The correlation between TAM,MVD, VEGF andMMP-9 expressions among various histological progression, histological grading and staging of breast cancer Irianiwati, Harijadi Surendra Prabawa, Yulius Hermanto Angelina Septiana, Brian Arditya M
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Breast cancer may progress from an atypical lesion. Angiogenesis has an important role in thegrowth, invasion and metastasis of breast cancer, which can be reflected through the microvasculardensity (MVD). Tumor associated macrophages (TAMs) are stromal cells that can produce proangiogenicfactor such as vascular endothelial growth factor (VEGF), and induce matrixmetalloproteinase-9 (MMP-9) for degrading extracellular matrix and basement membrane.Angiogenesis in breast cancer progression and its relationship with histological grading as wellas its staging need to be defined and thus, cancer therapy and prognosis can be determinedmore accurately. The aim of this study was to investigate the correlation between TAM, MVD,VEGF and MMP-9 expressions among fibrocystic lesion, atypical lesion and breast cancer, andits correlation with histological grading and staging of breast cancer. Using a cross-sectionalstudy, a total of 50 paraffin embedded tissues of fibrocystic lesion, atypical lesion and breastcancer were chosen in this study. Those specimens were stained immunohistochemically withmonoclonal antibody (MoAb) anti CD68, von Willebrand factor (vWF), VEGF and MMP-9. Theexpressions of VEGF and MMP-9 were counted from the mean numbers of positive tumor cells.TAMs were counted from numbers of macrophages which expressed CD-68. MVDs were countedfrom numbers of microvessels whose endothelial cells expressed vWF, using the AverageMicrovessels Count ( AMC) method. The correlation of both markers and different type of breastlesions were analyzed by using Pearson correlation. There were statistically significant correlationsbetween TAM (r=0.760; p=0.000), MVD (r=0.659; p=0.000), and MMP-9 (r=0.518; p=0.000),among several breast lesions and histological grade of breast cancer. The highest of theirexpressions was found in the poor grade of cancers. There were statistically significant correlationsbetween TAM (r=0.581; p=0.000), VEGF (r=0.443; p=0.001) and MVD (r=0.566; p=0.000)among fibrocystic, atypical lesion and stage II - III of breast cancer. VEGF expression was notsignificantly correlated with several histological grade of breast cancer and the highest of itsexpression was only found in atypical lesion. This study has suggested that TAM, MVD, VEGFand MMP-9 expressions might play an important role in the histological progression, histologicalgrading and staging of breast cancer. The highest expression of VEGF in atypical breast lesionsupported the fact that angiogenic switch already started in the early stage and grade of breastcancer.
Retrospek Dan Prospek Penelitian Anthropologi Ragawi Dan Biologi Manusis Di Indonesia. T. Jacob T. Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 02 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : Penelitian Anthropologi Ragawi
Daytime transmission of filariasis caused by nonperiodic form of Brugia Malaya among Dayak indigenous inhabitants in East Kalimantan. FA Sudjadi FA Sudjadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In addition to the previously known of subperiodic and periodic form, the nonperiodic form of B. malayi Lichtenstein was recently reported from East Kalimantan as a new filarial different subspecies. The morphology or natural habitat of filarial parasite was recently described. This paper reports daytime transmission of the disease found in highly endemic area of Dayak, indigenous inhabitants of Krayan area, Long Ikis district, Pasir regency, East Kalimantan. To show such transmission, the microfilaria carrier was followed by daily activities at daytime. When the carrier was at work in the forest, the wild mosquitoes landing and feeding on him were collected, then reared in a laboratory until 14 days. The remains alive of mosquitoes were then morphologically identified and dissected. Infective larvae were recovered from 2 dissected mosquito species, Mansonia bonnae and Mansonia uniformis. Out of 131 alive mosquitoes dissected, 15 (consisting of 10 Ma.bonneae or 13,0% and 5 Ma. uniformis or 11,6%) were found infectious, from which 23 recovered and 11 filarial larvae respectively. Totally, 34 infective B.malayi larvae recovered: 24 larvae from the head and another 10 from the thorax.Key words: Brugia malayi - nonperiodic form - daytime transmission - Mansonia bonnae - Mansonia uniformis
Serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal Erna Kristin, Mohammad Hakim, Sri Kadarsih Soejono, Lukman Hakim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The prevalence of iron deficiency anemia in pregnant women is estimated to be higher than nonpregnant women. Ironsupplementation program has been proven clinicallyto improvethe hemoglobin (Hb)level of pregnant women. The absorption of iron is affected by food, therefore iron has to be given 2 hours after meal. However, in practice, iron was given shortly after meal. The physiologicalchange in pregnant women affects drug absorption, distribution, and eliminationphases. Objective: To understand serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in trimester 2 pregnant women with iron deficiency anemia. Method: The research design was a phase IIclinical trial. Subjects were 24 trimester 2 pregnant women with iron deficiency anemia, classified into two groups, who were treated as follows: The first group was consisted of 12 women with irondeficiency anemia, treated with twice-a-day ferrous sulphate tablet @300 mg orally,given shortly after meal for 12 weeks; the second group was consisted of 12 women with iron deficiency anemia, treated with twice-a-day ferrous sulphate tablet @300 mg orally, given 2 hours after meal for 12 weeks. Bloodsamples were taken in week 2, 4, 6, 8, 10, and 12 after treatment. Serum (ferric) iron level was measured with Vitros Fe Slides method. Result: Minimum,maximum, and average steady-state ironlevels (Css min, Css max, Css average) of treatment 1 were 104.1 ::I:14.03 ug/dL, 96.44::1:13.22 ug/dL, and 112.38::1:14.03 ug/dL (mean ::I:SEM),respectively; while minimum, maximum, and average steady-state iron levels (Css min, Css max, Css average) of treatment 2 were 125.77::1:9.31 ug/dL, 118.03::1:9.21 ug/dL, and 125.77::1:9.31 ug/dL (mean::l:SEM),respectively. No statistical significant difference was found within treatment in minimumsteady-state level between week 2, 4, 6, 8, 10, 12 after treatment. There was also no significant difference in minimumsteady-state level between treatment groups in week 2, 4, 6, 8, 10, and 12. Conclusion: There were no differences in serum iron level after ingestion of repeated dose of ironshortly after and 2 hours after meal for 12 weeks intrimester 2 pregnant women with iron deficiency anemia.
The Classical and Early methods of myringoplasty and tympanoplasty-I. Soewito Soewito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 01 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

There is still a controversial vision about the appropriate time to carry out myringotomy or tympanoplasty-1 on chronic otitis media. Some experts agree that the most appropriate time is two or three months after dry tympanic cavity (Classical method). Other experts state that it is not necessary to wait too long, even though there is still mucoid discharge, surgery can be directly caned out (Early method).The myringoplasty and tyrnpanoplasty-I was carried out on 72 cases of active chronic otitis media, of which 43 cases using Classical method and the rest of 29 cases using Early method. The criteria of successful myringoplasty and tympanoplasty-1 surgery was a positive graft take and followed by improvement of hearing.The successful result of myringoplasty and tympanoplasty-I with Classical method was 93.02 % and with Early method was 89.65%. The statistical analysis showed that there is no significant difference in the succesful of the myringoplasty and tymphanoplasty-I surgery, between the Classical and Early method.Key Words: myringoplasty tympanoplasty-I chronic suppurative otitis media classical method early method.
Aspek Dasar Penggunaan CT Scan dalam Kedokteran Suroyo Suroyo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 18, No 01 (1986)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

CT scan is a reconstruction of tomographic slices of objects by a computer. The first application in the clinic was done in 1967 by the efforts of Godfrey Mounsfield in the Central Research Laboratory of EMI Ltd. in England. Its superiority compared with conventional tomography lies in the high power of resolution and its ability to distinguish soft tissues with 0.5% of the emission difference of X-ray, while with the conventional tomography the emission difference must be more than 5%. CT scan is very useful in both diagnostics and radiation therapy. Key Words: CT scan — conventional tomography — resolution power — radiation therapy —X-ray
Beberapa effek samping serta penentuan toxisitas pestisida di dalam lingkungan Harminani S Harminani S
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 04 (1978)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : effek samping penentuan toxisitas, pestisida
Correlation between clinical findings and patient’s survival rate in congenital duodenal obstruction Chandra Adipurwadi; Akhmad Makhmudi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.043 KB) | DOI: 10.19106/JMedSci004804201602

Abstract

Congenital duodenal obstruction (CDO) is one of the most common anomalies in newborns (0-30 days), and accounting for nearly half of all cases of neonatal intestinal obstruction. Although survival in infants with congenital intestinal obstruction has improved, duodenal obstruction continues to present unique challenges. A retrospective correlational study was used in this study, 49 patients with CDO were analyzed within the years of 2004 to 2009. A chi-square test was used to investigate the correlation between clinical findings (age, weight, gestational age, surgical techniques, comorbidity, and early enteral feeding) and patient’s survival rate. None of clinical findings showed a significant correlation with patient’s survival rate, except comorbidity (sepsis) and early enteral feeding showed a significant correlation with patient’s survival rate (p<0.05). In conclusion, this study revealed that comorbidity (sepsis) and early internal feeding correlated with patients’ survival rate.
The Experience of Breast Reconstructive Microsurgery Bayu Brahma; Samuel J Haryono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 4 (2016): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Autologous techniques in oncoplastic breast surgery may result in graft donor site morbidity. Microsurgery has become a new surgical modality for breast reconstruction; it is a less invasive procedure. In recent experience, we have applied microsurgical technique in oncoplastic breast procedures to minimize morbidity.We reviewed the charts of breast cancer/tumor patients with microsurgical reconstruction.From February 2013 to July 2016, we performed 36 perforator flaps for breast reconstruction. The mean age of the patients was 44.4±6.7 years old, with the median tumor size of 3.7 (1.5-20) cm. No special type of carcinoma (NST) was accounted in 25 (69.4%) cases. Oncoplastic breast conserving surgery (OPS) was the procedure of choice in 17 (47.2%) cases and mastectomy was followed by free flap in 19 (52.8%) patients. In OPS, we used various perforator flaps to cover the defect. Thoracodorsal artery perforator flap (TDAP) was the most common technique used in 8 (22.2%) cases, then lateral intercostal artery (LICAP) flap in 6 (16.7%) cases, anterior intercostal artery (AICAP) flap in 1 (2.8%) cases, and superficial epigastric artery (SEAP) flap in 2 (5.6%) cases. Deep inferior artery perforator (DIEP) free flap was the reconstruction option after mastectomy. During follow-up with the mean time of 12.7±11.4 months, there were 1 local recurrence, 2 regional and systemic metastases, and 1 death due to cerebrovascular disease. There were no flap loss after pedicle perforator reconstruction but total flap necrosis occurred in 5 patients with DIEP free flap. In one patient, we successfully salvaged the flap that had venous congestion. There was no seroma at donor site and no limitation in abdominal wall function after DIEP reconstruction.In our experience, microsurgical reconstruction in breast surgery has been a safe procedure and has less donor site morbidity. Flap failure rate may be improved by refining microsurgical technique
Comparing P-Selectin (CD62P) expression in patients receiving non-leukodepleted vs leukodepleted thrombocyte concentrates Teguh Triyono; Budi Mulyono; . Sutaryo; Abdul Salam Sofro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 3 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.863 KB) | DOI: 10.19106/JMedSci004903201704

Abstract

Thrombocyte concentrate (TC) transfusion is an important supportive therapy in patients with thrombocytopenia. The risks in platelet transfusions may be related to the content of TC including the contaminant leukocytes. The aim of this study was to assess the risk of increased level of P-Selectin (CD62P) expression of non-leukodepleted TC transfusions.This was a quasi-experimental study. Subjects were children patients aged 1-18 years who received a non-leukodepleted or a leukodepleted TC transfusions. Comparison of the proportion of  increased expression of CD62P in both groups expressed as relative risk. The subjects consisted of 51 patients who received non-leukodepleted and 52 patients who received leukodepleted TC transfusions. The risk of increased expression of CD62P in patients receiving non-leukodepleted TC transfusions were 2.38 (95%CI:1.60-3.53) times higher than those who received leukodepleted TC. Non-leukodepleted have significant higher risks of increased CD62P expression than leukodepleted  TC transfusions.

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