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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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The effect of intravenous neem's (Azadirachta indica A. Juss) seed oil on Plasmodium berghei in mice Budi Mulyaningsih Budi Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Malaria is one of the most important public health problems in the tropical countries such a Indonesia. Several actions have been taken to overcome this problem, however, its prevalence is still high. Vector resistance to insecticide and parasite resistance to drug were two of the major constraints in dealing with malaria. Therefore, alternative methods to control malaria which are effective and safe are needed.Objectives: To detect the effect of neem's (Azadirachta indica A. Juss) seed oil on Plasmodium berghei administered intravenously in mice.Methods: Seventy five Swiss mice were divided into 7 groups and each group was treated intravenously with 50 mg/KgBW, 100 mg/KgBW, 200 mg/KgBW, 400 mg/KgBW, 500 mg/KgBW neem's seed oil; 5 mg/KgBW chloroquine and 50 ml physiological salt respectively for a period of 4 days after infection. The blood samples were collected every day (D.,0 to D.3) from all experimental animals and the parasitemia were examined with Giemsa staining.Results: Effective dose (ED50) of neem's (Azadirachta indica A. Juss) seed oil on Plasmodium berghei in mice administered intravenously was 144.12 mg/Kg BW, and the inhibition effect of the dose of 800 mg/ KgBW was 78.61%.Conclusion: The neem's (Azadirachta indica A. Juss) seed oil on Plasmodium berghei administered intravenously in mice (800 mg/KgBW) has a potential inhibition effect on development of P. berghei.Keywords: Plasmodium berghei - Azadirachta indica A. Juss - effective dose - parasitemia - resistance
Cancer research: Epidemiological and clinical concepts Soeripto Soeripto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

There are differences in background between cancer and other diseases, among others the difference in sex incidence, behaviour, cellular changes, and clinical aspects. Therefore, research on cancer is suggested to be based on cancer epidemiology, basic research, and clinical research. This article discusses the basic principles of cancer research from the point of view of epidemiological and clinical concepts.It is concluded that research in cancer epidemiology must be based on the well-developed cancer registry. The epidemiological and clinical research of cancer must be brought into a comprehensive scheme. It will be useful if basic research is correlated with research in cancer epidemiology. Clinical research must be based on epidemiological and basic research.Key Words: cancer research - cancer registry - cancer epidemiology - oncology - clinical trials
Morfologi Brugia malayi nonperiodik penyebab filariasis di Kalimantan Timur FA Sudjadi FA Sudjadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 02 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Morphological observations were made on the adult filarial worms of nonperiodic form of B.malayi (32 worms), the new subspecies of the causative agent of filariasis in East Kalimantan (3,4). The filaria parasites were compared to the old subspecies of nocturnally subperiodic form of B.malayi (25 worms) from Kendari and the animal filaria of B.pahangi (20 worms) which were also sympatric in East Kalimantan. The adult filarial worms (originated from human/animal carrier) were available from dissection of artificially infected laboratory animal of Meriones unguiculatus. For the artificial infection, Aedes togoi Theobald mosquito were used as laboratory vector.The observations revealed a morphological gap, between B.malayi (nonperiodic form) and B.pahangi coexisting in East Kalimantan showed a reproductive isolation as a different species. Morphologically, the B.malayi from East Kalimantan should be put in the same species category with the nocturnally subperiodic form of B.malayi from Kendari. Showing more anthropo or zoophilic (cf 1,2) properties of parasite intraspecific variabilities in morphology, were also recorded from the filarial worms with an average of the nonperiodic form shorter than the nocturnally subperiodic form of B.malayi, but longer than the animal parasites of B.pahangi.Key words: B. malayi — morphological gap — reproductive isolation — morphological variabilities
Studies of Blood Pressure in Primary School Children in a Rural Area in Indonesia A. Samik Wahab A. Samik Wahab
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 04 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Telah diukur tekanan darah pada 506 anak sekolah yang berumur antara 6-14 tahun dan terdiri atas 227 anak laki-laki dan 279 anak wanita. Sampel ini diambil secara duster dan acak dari suatu populasi anak sekolah di pedesaan. Tekanan darah ini diukur pada anak sekolah clari 17 sekolah dasar kecamatan Sewon, Bantu!, Daerah lstimewa Yogyakarta. 17 sekolah ini merupakan sampel dari seluruh sekolah dasar yang ada di kecamatan Sewon.Alat yang dipakai untuk mengukur adalah sphygmomanometer bahan air raksa, dan pengukuran dilakukan oleh hanya sacs orang. Semua anak mula•mula diukur tekanan darahnya pada posisi duduk, kemudian pada posisi telentang.Hasilnya pada posisi duduk tekanan darah sistolik berbeda secara bermakna antara anak lakilaki dan wanita, kecuali pada anak umur 6 tahun. Demikian juga tekanan darah diastolik, kecuali pada anak umur 14 tahun.Tekanan darah pada posisi duduk dan tidur berbeda bermakna balk pada laki-laki maupun pada wanita.Key Words: blood pressure - rural primary school children - systolic pressure - diastolic pressure
PSIKOSA DEPRESI REAKTIF(Psychotic Depressive Reaction) Soebagyo Hadinoto Soebagyo Hadinoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 8, No 03 (1976)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Secara global dapat kita katakan, bahwa data yang diperoleh dari catatancatatan dalam status-status itu secara kwalitatif adalah konsisten dengan landasan teoretis, tetapi secara kwantitatif tidak dapat kita nilai, karena data perbandingan kurang atau tidak ada. Data khusus untuk P.D.R. tidak kita ketahui, dan ketemendapatkan gambaran perbandingan yang lebih lengkap, lebih valid serta reliable perlu diadakan studi klinis dan epidemiologis lebih lanjut tentang P.D.R. dan depresi pada umumnya.Dalam hubungan itu alangkah baiknya apabila kita dapat meningkatkan observasi kita ke arah pengukuran kwantitatif, agar mendapat data obyektif yang dapat dibandingkan secara nasional dan internasional. Untuk keperluan itu kiranya dapat dipertimbangkan penggunaan "rating scale" depresi Hamilton (1961) dan "measuring inventory" untuk depresi Beck et al. (1961) yang sudah distandardisasi dan dipakai secara internAionaI.Untuk survey dalam masarakat dapat kiranya dipertimbangkan penggunaan "standardized psychiatric interview for use in community surveys" oleh Goldberg et al. (1970).rangan-keterangan dalam status-status itu kurang terperinci, lagipula jumlah kasus terlalu sedikit untuk mendapatkan gambaran perbandingan kwantitatif yang "valid" dan "reliable". Oleh karena itu untuk
Hyperbilirubinemia in the newborn infants; unbound bilirubin approach Achmad Surjono Achmad Surjono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 01 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A guideline for management of hyperbilirubinemia in the newborns based solely on total/indirect serum bilirubin levels is considered outmoded. An approach to the identification of newborns at risk of bilirubin toxicity due to the increase of unbound bilirubin is proposed. Unbound bilirubin can easily enter the brain and bind to the nerve cells.A peroxidase oxidation method using unbound bilirubin - analyzer (UB-analyzer) offers a rapid, accurate and reproducible measurement of unbound bilirubin. Phototherapy, either continuous or intermittent can be applied to term and preterm infants on the monitoring of unbound bilirubin levels.Temporary cessation of breast-feeding is not advised in healthy term newborns with hyperbilirubinemia. On the contrary, more frequent feeding is advocated. Caution and substitution should be taken in giving any drugs having a potent displacer on bilirubin-albumin binding, especially In premature infants.Key words : newborn infants --hyperbilirubinemia -- unbound bilirubin -- phototherapy -- displacing drugs
Pengaturan Kehamilan Dan Keadaan Gizi Bayi Rossi Sanusi Rossi Sanusi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 01 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

This study examined the effect of parity, maternal age, and interval between pregnancies on body- weights of ill infants of a rural village in Central Java during the first 12 months of life. With a few exceptions, differences in these pregnancy factors were not accompanied by differences in body-weight growth.The pregnancy data were dichotomized at 2, 3, and 4 pregnancies for parity, at 35 years for maternal age, and at 17 months for pregnancy interval.Key Words: parity - birth intervals - age-specific birth rate - infant morbidity - infant nutrition
α-Lipoic acid can not prevent effet on cell viability, collagen synthesis inhibition, collagen degradation induction in ultraviolet A irradiated human fibroblast cell Putu Dyah Ayu Saraswati Soedirman Sastrodiprodjo Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 02 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Ultraviolet A (UVA) irradiation on human skin can generate free radical and stimulate matrix metalloproteinaseproduction resulting in collagen degradation and transforming growth factor beta (TGF-β) inhibition. It causes synthesiscollagen inhibition and induces cell death. α-Lipoic acid (ALA) is an universal antioxidant and a powerful scavengerof free radicals. In this study we investigated the effect of ALA on viability, collagen synthesis and degradation inUVA irradiated human fibroblasts. Normal human skin fibroblasts cell culture were irradiated with UVA for threetimes with each dose of 3000 mJ/cm2 UVA. α-Lipoic acid in various concentration was added to the culturefollowing UVA irradiation and incubated for 48 hours. The cell viability was determined by MTT-assay while collagensynthesis and degradation were determined by Sirius red binding assay. The difference of cell viability and collagensynthesis and degradation between fibroblasts cell after and without UVA irradiation were analyzed using paired-ttest with 95% confidence interval (p<0.05). The results showed that UVA irradiation decreased cell viability,inhibited collagen synthesis and induced collagen degradation in fibroblasts cell. However, ALA was not sufficient toincrease viability, to increase collagen synthesis and to inhibit collagen degradation in fibroblasts cell due to UVAirradiation. In conclusion, ALA can not prevent UVA irradiation effect on human skin fibroblasts cell.Key words: UVA – irradiation - human skin fibroblasts – antioxidants – α-lipoic acid
Utilization of Statins, an HMG-CoA reductase inhibitors, in Ambon District Hospital, Maluku: a retrospective study Simatupang, Abraham; Huningkor, Yusuf; Gasperz, Westi C; Nindatu, Maria; Noya, Farah; Sanaky, Marliyati; Hutagalung, Inggrid; Yolanda, Denny; Kailola, Natalie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.282 KB) | DOI: 10.19106/JMedSci005002201810

Abstract

Non-infectious diseases, including hypercholesterolemia, are now ranked top 10 inIndonesia. Statins are inhibitors of HMG-CoA reductase, an enzyme for biosynthesis ofcholesterol in the liver. Statins have been proven to reduce the risk of death due to CHDand mortality from various reasons. The objective of the study is to know the utilizationof statins in peripheral area of Indonesia. This retrospective study on utilization of statinsprescribed for hypercholesterolemia was taken from medical record year of 2014-2015of a District Hospital – Dr. Haulussy, Ambon, and Maluku. We collected demographicdata, pre- and treated concentrations of total cholesterol (TC), low-density lipoproteincholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG),types and dosages of statins or other lipid-lowering medications given. Student t-testusing was performed to check statistical differences for all cholesterol and TG differencesprior to therapy versus during treatment. Eighty three respondents consisted of 26 men(31.3%) and 57 women (68.7%) with mean age 60 ± 11 years old. The pre-treatment/post-treatment values (mg/dL) of TC: 245.22 ± 51.40/224.97 ± 98.79 (p=0.004);LDL-C: 166.07 ± 45.36/146.00 ± 41.07; HDL-C: 54.52 ± 37.95/43.00 ± 0.00; andTG: 177.36 ± 103.25/121.00 ± 52.87, respectively. Seventy-nine patients (95.2%)were treated with statins. The dosage given were 10 mg (n=19, 22.9%), 20 mg (n=63, 75.9%), and 40 mg (n=1, 1.2%). Twenty-eight patients (33.7%) had no posttreatmentdata of cholesterol, and 31 out of 55 patients (56%) were responders. Allcholesterol levels were decreased, but responder rate was only 56%. Therefore, dosageadjustment and prerequisite cholesterol level during and post-treatment measurementshould be made regularly.
Neonatal outcomes in In vitro fertilization (IVF) pregnancies Muhammad Buchori; Suryono Yudha Patria; Tunjung Wibowo; Ita Fauzia Hanoum
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.778 KB) | DOI: 10.19106/JMedSci005002201805

Abstract

small-for-gestational age (SGA), and low birth weight (LBW) rates are approximately twiceas high in IVF pregnancies than in natural pregnancies. The IVF procedures have becomemore routine in recent years in Indonesia, but there have been few assessments ofneonatal outcomes. The study aimed to evaluate the risk of preterm birth, SGA, and LBWin IVF infants. This was a retrospective cohort study performed in Dr. Sardjito GeneralHospital, Yogyakarta from January 2012 to December 2016. Pre-coded questionnaireswere used to collect data from medical records. The relative risk of preterm birth, SGA,and LBW among IVF infants were calculated and compared to naturally conceived infants.A total sampling method was used for the IVF infants and a simple random samplingmethod was used for naturally conceived infants, who were born on the same day as aninfant in the IVF group.A total of 108 infants were recruited, consisting of 54 IVF infants and 54 naturallyconceived infants. The IVF infants had increased risk of preterm birth (RR = 2.0; 95%CI0.52 - 7.58) and LBW (RR = 1.25; 95%CI 0.53 - 2.92). However, the IVF infants didnot have an increased risk of SGA (RR = 1.0; 95%CI 0.21 - 4.73). In conclusion, therisk of preterm birth and LBW in IVF infants are higher than in naturally conceived infants,but not statistically significant. However, there is no increased risk of SGA in IVF infants.

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