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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 192   193   194   195   196 
Cytotoxic effect on human cancer cell using SRB method (in vitro) rimpang temu mangga (Curcuma Mangga Val. & V. Zijp.) dan kunir putih (Curcuma Zedoaria I.) Mae Sri Hartati W, Mae Sri Hartati W
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 4 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Temu mangga (Curcuma mangga) and kunir putih (Curcuma zedoaria) rhizomes have been utilized by people to treat cancer lately although clinically their activity has not been tested. Objectives: This study is aimed to prove their activity as anticancer on 7 major human cancers cell lines (in vitro), and to evaluate whether these two rhizomes are potential for new anticancer drug. Methods: The two rhizomes were separately extracted with chloroform followed by methanol to give chloroform extracts of C. mangga (CmCh) and C. zedoaria (CzCh); and methanol extracts of C. mangga (CmMe) and C. zedoaria (CzMe) respectively. These extracts were tested their cytotoxic effect on 7 major human cancer cell lines using SRB method (in vitro). Doxorubicin and cisplatin were used as positive controls, and their cytotoxic effects were measured by comparing their ID50 with that of the positive controls.Results: Those four extracts (CmCh, CzCh, CmMe and CzMe) practically did not perform cytotoxic effect on those human cancer cell lines, because the extract's ID50 was far higher than the positive controls on those human, cancers cell linesConclusion: The C. mangga and C. zedoaria rhizomes did not active as anticancer and they were not pOtential as the source of a new anticancer drug.Key words: anticancer - Curcuma mangga - Curcuma zedoaria - cytotoxic - drug discovery
A cephalometric study (The compare study of Javanese in Yogyakarta and Naulunese in Seram is/and, Mid/e Maluku) Neni Trilusiana Rahmawati, Neni Trilusiana Rahmawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 4 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Regional variation in anthropometric measurements and anthroposcopic always found, even in one population or subrace. Therefore, it is interesting to study these composite physical traits in rural population of Indonesia with different environment.Objectives: To examine the characteristics of the cephalometry of Javanese population in Yogyakarta, and to compare with Naulunese population in Seram Island of Middle Maluku. Methods: 100 people of Java in Yogyakarta consists of 50 males and 50 females, aged 20 - 75 years, were studied and compared with Naulu people (62 males and 110 females). Stature, weight, maximum head breadth and length, minimal frontal breadth, bizygomatic breadth, face height, breadth and height of nasal were measured. Analysis of variance and t-test were used to study the difference of cephalometric between males and females of Javanese population, and to study the difference between Javanese and Naulunese populations.Results: The results showed that Javanese population has mesocephalic head, wide forehead, narrow face and mesorhine nasal type. There were significant differences between Javanese males and females in regard to their height, weight, bizygomatic breadth, face height, nasal breadth and nasal index. There were significant differences between Javanese and Naulunese populations in terms of their height, head breadth, minimal frontal breadth, face height, frontoparietalis and facial index. In addition, there were similarities of head shape, width forehead and nasal shape among both populations.Conclusions: The finding indicated that Javanese and Naulunese populations have mesocephalic head, wide forehead and mesorhine nasal type.Key words: cephalometric - Javanese - Naulunese - cephalic index - anthropometric
Lipid profiles and fibrinogen levels in coronary heart disease and dyslipidemic patients in Dr. Sardjito Hospital Yogyakarta Pramudji Hastuti Tasmini, Radityo PA, Ahmad Husain Asdi Tri Hartati, Abdul Salam M Sofro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Epidemiological studies indicated that fibrinogen and dyslipidemia were important risk factors for cardiovasculardisease (CVD). For several populations in theworld, increase in cholesterol level and decrease in high-density lipoproteincholesterol (HDL-C) were risk factors for coronary heart disease (CHD). The role of elevated fibrinogen in thrombosissuggests that it may be the causal pathway for certain risk factors of CHD. The aim of this study is to determine therole of lipid profile and fibrinogen level as risk factors of coronary heart disease. Blood samples were obtained fromCHD patients, dyslipidemic patients, and controls after they had fasted. Lipid profiles and fibrinogen level of CHDand dyslipidemic patients were determined and compared with controls. There were 92 subjects in this study,consisted of 35 CHD patients, 31 dyslipidemic patients, and 26 controls. There were significant difference intriglyceride level between CHD and dyslipidemic patients, also between dyslipidemic patients and controls (p<0.05).Significant difference in level of cholesterol also existed between CHD patients and dyslipidemic patients, alsobetween CHD patients and controls (p<0.05). In dyslipidemic patients, decreased in HDL-C level was risk factorfor CHD. Meanwhile for controls, high level of cholesterol and LDL-C also low level of HDL-C were risk factor forCHD, but fibrinogen level was not risk factor for CHD. In conclusion, lipid profile was risk factor for CHD whereasfibrinogen level was not risk factor for CHD.Keywords: lipid profile – fibrinogen - coronary heart disease - dyslipidemia
Ekspresi protein P53 pada hiperplasi prostat benigna, prostatic intraepithelial neoplasia dan adenokarsinoma prostat Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 02 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: The mutant type of p53 protein looses its ability to inhibit cell proliferation and the increase of this protein expression has been detected among several human cancers. The p53 mutant protein is stable and therefore can be detected by immunohistochemical technique. The over expression of p53 in the several prostatic lesions has widely been investigated but the result is still controversial. The relation between p53 expression with the histological grading of the prostatic lesions is still unclear.Objective: To study the correlation between p53 expression with the histological grading of the prostatic lesions.Methods: Sixty two paraffin blocks of specimens which were diagnosed as benign prostate hyperplasia, prostatic intraepithelial neoplasia, and adenocarcinoma of the prostates collected from several anatomic pathology laboratories in 'Yogyakarta were chosen. Specimens containing heavy inflamatory cells and necrotic tissues were excluded from this study. The chosen specimens were reexamined and histological malignant grading were also determined. The specimens were then stained with p53 MoAb-DO-7 (DAKO) immunohistochemically and the score of p53 positive cells, p53 intensity, the distribution of p53 positive cells, and total expression of p53 were determined among them. The correlation between malignant grading and those scores were analyzed by defining the correlation coefficient of Spearman.Results: There was a weak significant correlation 
Trait genetik biokimia yang berkaitan dengan malaria pada penduduk P. Alor. keuntungan lain terhadap virus hepatitis-B? Abdul Salam M. Sofro Abdul Salam M. Sofro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Meskipun secara geografis, budaya dan antropologi ragawi orang Alor berhubungan erat dengan penduduk Nusa Tenggara Timur lainnya yang berada dalam Master Indonesia timur, tetapi dengan analisis jarak genetik mereka berada sedikit di luar. Namun demikian secara umum populasi Indonesia khususnya populasi di Nusa Tenggara telah lama terpapar.faktor seleksi alam yang kurang lebih sama yaitu malaria. Di samping itu, kawasan ini dikenal memiliki prevalensi infeksi virus hepatitis B (HBV) cukup tinggi.Penelitian ini dimaksudkan untuk melihat trait genetika biokimia yang mencirikan pola klinal populasi di Indonesia Berta yang barangkali menawarkan keunggulan selektif terhadap malaria yang merupakan salah satu faktor seleksi alam utama di daerah Alor. Di samping itu juga akan dipelajari kemungkinan antaraksi trait genetik tersebut dengan hepatitis.Hasil pemeriksaan sistem golongan darah ABO menunjukkan tingginya frekuensi golongan darah 0 (49,18%), sedangkan A dan B masing-masing 24,59°.6 dan 23,77%. Hasil ini agak berbeda dengan distribusi di Yogyakarta dengan populasi yang lebih Mongolid dengan frekuensi golongan darah B agak tinggi (29,23%) sebagaimana kebanyakan populasi Asia Tenggara. Dari tiga trait yang terkail dengan malaria, lidak satupun HbE atau pengemban thalassemia-fi ditemukan dari 122 subjek yang diperiksa. Namun demikian, kekurangan glucose-6-phosphate dehydrogenase (G6PD) ditemukan pada 8 subjek (6,6%) dan ovalositosis pada 15 subjek (12.3%). Dari pemeriksaan HBsAg yang dapat dilakukan pada 109 subjek, didapatkan 13 subjek dengan HBsAg positif. Yang menarik,.dari 7 subjek dengan kekurangan G6PD hanya satu subjek menunjukkan HBsAg positif, sementara tidak satupun dari 8 subjek ovalositosis menunjukkan HbsAg positif. Meskipun secara statistik tidak bermakna, kemungkinan bahwa gena mutan khususnya untuk ovalositosis memiliki keunggulan selektif terhadap infeksi hepatitis perlu dipikirkan. Mungkin saja bahwa gena mutan diekspresikan di sel hati yang menyebabkan gangguan adsorbsi dan penetrasi virus ke dalam sel hati. Diperlukan penelitian lebih lanjut untuk dapat menjelaskan fenomena yang menarik ini.Key words : biochemical genetic trait - glucose-6-phosphatedehydrogenase deficiency - ovalositosis--p. thalassemia
The development of larvae of Brugia pahangi in several species ofinosquito in the laboratory Suyoko Suyoko
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 03 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Many species of mosquito were made to bite cat which contain microfilaria of Brugia pahangi in infective stage.Microfilaria will develop to infective stage (L3) in non-cibarial armature mosquitoes and will not in mosquitoes which have cibarial armature. This period depends on the species of mosquitoes. In Armigeres subalbatus we found first, second and third stage larvae on the fourth, sixth and seventh day.Key Words: Brugia pahangi cibarial armature mosquitoes - Armigeres - Mansonia - Anopheles
A comparative study of antiarrhytmic of propranolol ("inderal") and lidocaine on the heart Abdulcholiq Chuseri Abdulcholiq Chuseri
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 5, No 01 (1973)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

keywords: propanolol, arrithmias, lidocaine
The effect of active compound isolated from the leaves of kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] on cell cycle and angiogenesis of WiDr cell line Indwiani Astuti, Hajid Rahmadianto Mardihusodo Mae Sri Hartati Wahyuningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 03 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Colorectal cancer is the tenth most common form of malignant tumor of hospital inpatients inIndonesia. Advance approaches in anticancer development is discovery molecular-targeted drugs.Molecular targets for anticancer drug have been identified including genes associated with cellcycle control and angiogenesis. Previously, an active and selective compound against WiDr fromTithonia diversifolia (Hemsley) A. has been isolated. The aim of this study was to evaluate theeffect of the isolated active compound fromT. diversifolia on the WiDr cell cycle and angiogenesis.Isolation of the active compound was performed by preparative thin layer chromatography (TLC)method. WiDr cell cycle was analyzed by flowcytometry using propidium iodide (PI).Antiangiogenesis effect was evaluated by immunocytochemistry method using anti-human VEGFmonoclonal antibody. The results showed that the effect of the isolated active compound onthe WiDr cell cycle depended on the concentration and the incubation time periods. Atconcentration of 4 μg/mL, it inhibited the WiDr cell cycle SubG1 phase after 36 and 48 hoursincubation and G1 phase after 72 hours incubation. While at concentration of 8 μg/mL, it clearlyinhibited the WiDr cell cycle G1 phase after 36, 48 and 72 hours incubation. Furthermore, theisolated active compound at concentration of 4 μg/mL significantly inhibited the VEGF expressionuntil 47.38% compared to control. In conclusion, the isolated active compound fromT. diversifoliainhibited cell cycle and angiogenesis of WiDr cell.
Prognostic factors for heart valve surgery outcomes in Dr Sardjito General Hospital Yogyakarta, Indonesia Wahyu Priyatno; . Supomo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 2 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.821 KB) | DOI: 10.19106/JMedSci005102201908

Abstract

Heart valve disease is a serious health probem due its significant effect on mortality.Surgical intervention plays an importan roleinthe management of moderate to the severe valvular heart disease. The evaluation of the patientoutcomes has been widely accepted as one of the important steps to improve the quality of patient care.Recognition of post operative complications might significantly affect the patient quality of life.Therefore, the identification of prognostic factors and morbidity of heart surgery patients can provide valuable insights on improving the quality of patient care.This study aimedto investigat the prognostic factors for heart valve surgery outcomes in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. This study was conducted using data ofpatient’s medical records who underwent heart valve surgeryincluded morbidities and their prognostic factors.The data were analyzed using Chi-square test and logistic regression with significance level of 0.05. During 2010 to 2014, 82 patients underwent heart valve surgeries at the hospital. The kidney disorders and heart failure were significantly associated with the patient morbidity (p<0.05),while the gender, pulmonary disease, angina, and impaired ventricular function were not (p>0.05). Multivariate analysis showed that the heart failure is the most significant factor of morbidity. The risk of New York Heart Association (NYHA) class 3 patients were 7.18 times compared with NYHA class 2 patients. In conclusion, the heart failure is the most significant factor for the morbidityof heart valve surgery followed by the kidney disorders at the Dr. Sardjito General Hospital.
Patient prognosis after relief of obstruction R Danarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

ABSTRACTObstructive uropathy may lead to irreversible kidney damage. The insertion of ureteral stent is one of procedure to relief obstruction and prevent further kidney damaged, septicemia as well as urosepsis. A study to evaluate the predictive factor of urinary diversion in improving kidney function is needed. This study aimed to assess prognosis factors post-relief of obstruction in patients with uropathic obstruction focusing on kidney function recovery. This was a retrospective cohort study conducted at An-Nur Private Hospital in Yogyakarta Special Region, Indonesia using the medical record of patients with obstructive uropathy whom underwent DJ Stent insertion from a period of 2011 to 2015. The data of clinical assessment, laboratory and radiologic examination data were collected and analyzed using Chi square or student t test. A total 59 patients with obstructive uropathy aged around 50.9 years whom underwent DJ Stent were involved in this study. The results showed that release of obstruction with the installation of ureteral stents was significantly able to improve kidney function. The duration of obstruction, etiology, and hemoglobin (Hb) levels were associated with creatinine levels, whereas gender, urinary tract infection (UTI) and comorbid were not. In conclusion, prognosis factors of postrelief obstuction are duration of obstruction, etiology of obstruction and Hb levels before the release of obstruction

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