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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
 75   76   77   78   79 
Reduction of aspirin bioavailability by cimetidine R.H.Yudono, R.H.Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 16, No 04 (1984)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The effect of cimetidine on the oral bioavailability of aspirin has been investigated in seven healthy adult volunteers. The estimation of bioavailability was performed by calculating the amount of the total salicylate recovered in the 72 hour urinary sample following an oral aspirin dose of 500 mg, first during control and second after pretreatment with oral cimetidine (RlUlcedin) 400 mg single dose given one hour prior to the administration of aspirin.The bioavailability of aspirin after cimetidine (36.5% ± SEM 4,2%) was significantly (paired. t-test, P
Cloning and expression of cDNA encoding 28 kDa soluble protein (GRA2) tachyzoite of Toxoplasma gondii local isolate Jarot Subandono, Jarot Subandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 36, No 2 (2004)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Toxoplasma gondii is an intracellular parasite that causes toxoplasmosis and found in tropical countries. Toxoplasmosis is dangerous if suffered by pregnant woman or immunodeficiency patients. T. gondii has 28 kDa soluble protein from dense granule (GRA2) and among GRA proteins, GRA2 is probably the most immunogenic. Disruption of the GRA2 locus in T. gondii has resulted in decreasing of the parasite virulence in mice. Invasion of tachyzoite T. gondii into macrophages was also significantly inhibited by anti GRA2 antibody, therefore the availability of GRA2 protein is essential for development of protective vaccine.Objective: The aim of this research was to produce 28 kDa soluble protein (GRA2) by cloning and expression of cDNA encoding soluble protein tachyzoite of T. gondii local isolate.Methods: Total ribonucleic acid (RNA) and messenger RNA was isolated from tachyzoite of local T. gondii grown up in Balb/c mice. Messenger RNA was isolated from total RNA using polyATtract mRNA Isolation Systems and synthesis of cDNA using Universal RiboClone cDNA Synthesis Systems. Recombinants of pUC18 were transformed into E. co/i XL1-Blue by heat shock technique. Expression of recombinant protein was analysed by immunoblotting using polyclonal antibodies against soluble protein of T. gondii. Results: Two recombinant clones were isolated which expressed 28 kDa recombinant protein.Conclusion: Two recombinant clones were isolated. The immunoblotting result indicates that the recombinant expressed 28 kDa recombinant protein which hybridized with the antibody polyclonal against soluble protein of T. gondii and the proteins are possibly GRA2 proteins.Key words : Toxoplasma gondii - tachyzoite - cDNA - 28 kDa soluble protein.
Proses Menjadi Tua (Proses Menua) Dilihat Dari Sudut Pahologi dan Immunologi R. Moh Saleh, R. Moh Saleh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 7, No 03 (1975)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Proses menjadi tua (proses menua) merupakan kejadian-kejadian faali (proses physiologis) yang dimulai sejak lahir dan diakhiri pada kematian, merupakan proses keausan (slijtage-proces).2. Orang-orang tua dianjurkan untuk menyadari keadaan tubuhnya, baik jasynaniah maupun rohaniah, sehingga mereka dapat menyesuaikan dini dan selanjutnya dapat hidup tenang, tenteram dan bahagia.
Laparoscopic Assessment of Pelvic Inflammatory Diseases Among IUD Users Ibnu Pranoto, Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 03 (1992)
Publisher : Universitas Gadjah Mada

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Abstract

Penyakit Radang Panggul (PRP) adalah salah satu komplikasi terpenting yang terjadi pada pemakaian IUD. Telah diteliti 390 talon akseptor sterilisasi ligasi tuba secara laparoskopi, dengan perincian 194 kasus (49,7%) akseptor IUD dan 196 (50,3%) bukan akseptor IUD; dilakukan eksplorasi rongga panggul untuk melihat adanya PRP sebelum dilakukan sterilisasi ligasi tuba. Didapat angka risiko relatif 95% PRD pada aksep for IUD sebany-ak 2,52 dibandingdengan non-IUD. Makin lama pemakaian IUD, makin besar risiko terjadinya PRP clan kenaikan yang tajam PRP se telah pemakaian 2 tahun. hisersi IUD oleh bidan atau dokter umum mempunyai risiko hampir sama untuk terjadinya PRP. Bila insersi dilakukan dengan tempat dan peralatan medis yang kurang baik, maka risiko kejadian PRP lebih besar.Disimpulkan bahwa laparoskopi eksplorasi memberikan keuntungan yang lebih dalam mendiagnosis PRP, terutama yang secara klinis ridak dapat ditentukan.Key Words: pelvic inflammatory disease - laparoscopic sterilization - IUD - family planning program - gynaecology
Cytogenetic examination Risanto Siswosudarmo, Risanto Siswosudarmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 02 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Cytogenetic examination on six normal persons, four men and two women, was carried out using a technique proposed by Dutrillaux with slight modification. Five drops of blood were taken from a peripheral vessel and was incubated on a PHA (phytohemarglutinine)-containing medium at 37°C for about 72 hours. Cell division was blocked by adding colchicine solution, an antimitotic agent, into this medium. A mixture of distilled water, magnesium chloride, hyaluronidase, and goat serum was used as hypotonic shock solution. Two out of these six examinations showed good results. The possibility of using this technique to examine some clinical syndromes, such as Down, Turner, and Klinefelter syndromes, as well as 13 and 18 trisomies, has also been discussed.Key Words: cytogenetics - chromosome - blood culture - colchicine - hypotonic shock solution
Sensitivitas rapid test untuk mendeteksi hepatitis surface antigen (HBsAg) pada penderita hepatitis-B Suwarso, Suwarso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A new rapid-test, sandwich immunochromatography assay technique has been recently introduced for the routine, rapid, qualitative detection of the presence hepatitis-B surface antigen (HBsAgl. To evaluate the sensitivity of rapid test, we studied 39 sera positive and one sera negative for HBsAg with conventional ELISA method. The study found that the minimal detectable level of HBsAg with rapid test was 4.03 ng/ml (range 3,25-4,03 ng/ml), it was 8 times less sensitive than conventional ELISA method (4,03 vs 0,47 ng/m1)• Many factors such as "eddy diffusion" and structure of HBsAg, humidity, direct contact with sunlight and sera of borderline-low level of HBsAg with conventional ELISA had a potency for lower sensitivity of rapid test; conversely, technical factors such as adhesion, migration and viscosity of the samples do not.Key words : rapid test - dry chemistry hepatitis surface antigen (HBsAg) - sensitivity - ELISA.
Pentotal anaesthetic induction time laps at the Central Operation Installation of Dr. Sardjito Central General Hospital Ismail Sujud, Ismail Sujud
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 03 (1987)
Publisher : Universitas Gadjah Mada

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Abstract

This investigation was done randomly at the Central Operation Installation of Dr. Sardjito Central General Hospital during the months of September, October, November and December 1986. Ninety-one patients were included who needed general anaesthesia with the degree risk of anaesthesia ASA I, ASA II and ASA III. The results showed that the mean induction time laps were as follows: I. adult patients with premedication drugs need (29.5 ± 5.385) seconds, 2.adult patients without premedication drugs need (50.4 ± 6.202) seconds, 3.geriatric patients with premedication drugs need (36.8 ± 4.408) seconds, 4. geriatric patients without premedication drugs need (61.0 ± 7.116) seconds. Key Words: anaesthetic induction time laps — premedication drugs — general anae
Relationship between toe-heel length and body weight of newborn babies Heru Pradjatmo, Heru Pradjatmo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 04 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Relationships between toe-heel length and body weight among newborn babies have been investigated. Five hundred and eighty eight infants were divided into two groups. The first group (training set) consisting of 293 cases was used to obtain the correlation between toe-heel length and body weight quantitatively defining mathematical functions (linear regression). Correlation coefficient was obtained by least squares method. The second group (test set) consisting of 295 cases was used to test whether the mathematical function could be generalized.Mathematical function describing the relationship between toe-heel length and body weight was Y= 77.854X - 2695.6 with correlation coefficient.r = 0.7887.Results of the test with the second group for estimating the body weight showed statistically no significant difference with the actual body weight (P > 0.05).Key words: toe-heel length - body weight - newborn babies - breech presentation - perinatal mortality
Beberapa effek samping serta penentuan toxisitas pestisida di dalam lingkungan Harminani S, Harminani S
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 10, No 04 (1978)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Keyword : effek samping penentuan toxisitas, pestisida
Analysis of haplotype associated with mutation in a-thalassemia Sunarto, Sunarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 03 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

B-thalassemia is mainly caused by point mutation of B-gene. There are more than 130 mutations, while only a little more than 20 haplotypes in B-gene. Many types of mutation are assosiated with one haplotype. On the other hand, one type of mutation may be associated with more than one chromosome haplotypes. The association of mutation and haplotype raises many questions. An analysis of haplotype has proved to be very useful to discover many aspects of thalassemia. The occurrence of certain mutation in a population might be predicted from the common haplotype of the population. Haplotype has been used to answer the question whether a certain mutation has multiple or single origin; for example the multiple origin of BE-gene in Cambodian population and the single origin of codon 39(CAG -+TAG) are associated with nine different haplotypes in Sardinia. It is suggested that haplotype probably influences the manifestation of thalassemia resulting in thalassemia intermedia.Key words : thalassemia - haplotype - point mutation - recombination - phenotype

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