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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23388404     EISSN : 26572311     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.
Arjuna Subject : -
Articles 150 Documents
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Prediksi Farmakokinetik, Toksisitas, dan Aktivitas Enzim Protease HIV-1 Inhibitor dari Daun J. gendarussa Widodo, Agustinus
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.098 KB) | DOI: 10.33508/jfst.v6i1.2005

Abstract

Justicia gendarussa Burm.f. (Acanthaceae) has been known to have anti-HIV activity. This study was conducted to determine the interaction of flavonoids (gendarusin A, B, C, D, and E) on the J. gendarussa leaves against HIV-1 protease receptor. It is expected that this research will provide scientific information on the development of J. gendarussa leaves as an anti-HIV drug. This study used in silico testing methods with FAF-Drugs4 to predict the ADMET (absorption, distribution, metabolism, and excretion–toxicity), and Molegro Virtual Docker (MVD) to predict the activity of five gendarusin compounds to the receptor of HIV-1 protease (PDB ID: 4HLA). The activity prediction was reflected by hydrogen bond and steric bond visible in MVD program with amino acid residue of the receptor of HIV-1 protease. Gendarusin compounds had good oral bioavailability and were not toxic, and from molecular docking test, it was found that gendarusin of J. gendarussa leaves could inhibit the activity of HIV protease enzyme. Gendarusin of J. gendarussa has potential as an anti-HIV.
Analisis Vitamin B6 (Piridoksin) pada Sediaan Tablet Multivitamin Neurotropik Menggunakan Spektrofotometri UV-Vis Maritha, Vevi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.966 KB) | DOI: 10.33508/jfst.v6i1.2010

Abstract

Vitamin B6 analysis in neurotrophic multivitamin tablet preparations requires a simple, fast and cheap method. UV-Vis spectrophotometer is having these criteria. Vitamin B6 analysis using UV Vis spectrophotometry is very quick so that the substance degradation can be inhibited and the results obtained will be accurate. Selection of single maximum wavelength for vitamin B6 will be able to separate with other components of vitamins B1 and B6 although all three are soluble in water. The optimal condition of vitamin B6 analysis in neurotropic multivitamin samples was using UV-Vis spectrophotometry at 325 nm wavelength. The solvent used is water. The calibration result curve in series of 60 ppm, 70 ppm, 80 ppm, 90 ppm, 100 ppm, 110 ppm, 120 ppm and 130 ppm have r value of 0, 9965. Determination of vitamin B6 levels using three brands of neurotrophic multivitamin samples performed. The measured theoretical level was 100 ppm, whereas the recovery of neurotropic multivitamin A samples were 98.24 ppm, 95 ppm and 95.78 ppm respectively with SD 1.69. The theoretical content of vitamin B6 in the neurotrophic multivitamin sample of B brand was 100 ppm, whereas the recovery was 99 ppm, 102 ppm and 98 ppm with SD 1.15. Determination of vitamin B6 concentration in the neurotropic multivitamin brand C the measured theoretical level was 100 ppm, while the recovery was 102 ppm, 101 ppm and 99 ppm with SD value of 1.53. The recovery of vitamin B6 level determination has been in accordance with AOAC requirements, ie for 100% ppm% analytical calculation 90-107%. The primary SD values of the three neurotrophic multivitamin samples of less than 2 indicate that vitamin B6 levels are acceptable. The results of this study indicate that vitamin B6 in a neurotrophic multivitamin sample can be analyzed using UV-VIS spectrophotometry at a wavelength of 325 nm using a water solvent.
Pengaruh Gugus Metil pada Posisi Para dari Turunan 2-(P-Klorofenil)-Kuinazolin-4(3h)-On terhadap Aktivitas Analgesik pada Mencit Soeliono, Ivonne; Budiati, Tutuk; Tamayanti, Wahyu Dewi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2006

Abstract

This study has evaluated analgesic activity of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one and 3-(4-methylbenzylideneamino)-2-(p-chlorophenyl)-quinazoline-4(3H)-one. The purposes of this study were to measure analgesic activity, to compare their analgesic potency against mefenamic acid, and to determine the effect of methyl substituent addition on para position of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one toward analgesic activity in mice. Analgesic activity evaluation was performed in mice using writhing test method with acetic acid as pain inducer. The significance difference of writhing frequencies between each group was tested using one-way ANOVA followed by Tukey HSD test as a post-hoc test. The statistic comparison results showed that the synthesized drug and the reference compound had an analgesic activity, in which the synthesized drug had the same analgesic potency with mefenamic acid on the same dosage, and the addition of methyl substituent on para position of 3-benzylideneamino-2-(p-chlorophenyl)-quinazoline-4(3H)-one did not lead to the increase of analgesic activity in mice.
Formulasi Sediaan Krim Pelembab Ekstrak Air Buah Semangka (Citrullus lanatus) Ekayanti, Ni Luh Putu Serly; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.576 KB) | DOI: 10.33508/jfst.v6i1.2011

Abstract

Watermelon is a tropical fruit which rich of carbohydrates such as sucrose, glucose and fructose that can moisturized the skin. Carotenoids such as lycopene in watermelons can acts as an antioxidant which protected skin from free radicals. Moisturizer are preparations used to improve dry skin. These preparations may decrease the Trans Epidermal Water Loss (TEWL) by forming a thin layer of fat on the surface of the skin as a barrier and restore skin softness. Watermelon extracts in this study are formulated into moisturizing cream. This study aims to determine the effect of the increasing concentration of the watermelon extract against its physical quality, effectiveness, safety, acceptability and cream stability. The watermelon extract obtained using is fresh fruit juice thickened with waterbath thermostat temperature ≤ 800C. Watermelon extract concentration used was 10% (Formula 1), 20% (Formula 2) and 30% (Formula 30. Evaluation of the cream includes the physical quality test; effectiveness test which; safety test; acceptability test and stability test. The results of this study showed the increasing concentrations of watermelon extract affect the results of the evaluation of moisturizing cream were organoleptic, pH, viscosity, dispersive power, adhesion, water washing power, effectiveness, and aseptability. Preparations which have the best quality are formula 3 containing extract 30%.
Profil Penggunaan Insulin Pada Pasien Diabetes Melitus Tipe 2 Dengan Ulkus/ Gangren Di Rumah Sakit Umum Daerah (RSUD) Kabupaten Sidoarjo Hariyati, Fera; Hasmono, Didik; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.227 KB) | DOI: 10.33508/jfst.v5i1.2053

Abstract

Diabetis mellitus is still a health problem in the world. It is a condition of hyperglycemia which is at risk of causing macrovascular and microvaskular complications. The prevalence of diabetes mellitus continues to increase throughout the world, including in Indonesia. One of diabetes complications is diabetic ulcer or gangrene. Diabetic ulcer or gangrene is common complication of diabetes mellitus wich can be caused by uncontrolled blood glucose levels. The aim of this study was to find the profile of insulin use in patiens with type 2 diabetes mellitus with ulcer or gangren in RSUD Kabupaten Sidoarjo. It was an observational-descriptive study. Data were collected retrospective using purposive sampling method in the period of January 2017 to December 2017 at RSUD Kabupaten Sidoarjo. The results of observational study on 19 patients showed the insulin therapy used in this study, where 42% of patients used single insulin therapy and 58% of patiens used combination insulin therapy. In this study the commonly used single insulin was rapid acting insulin (Novorapid®) 42%, whereas the combination insulin used was rapid acting insulin with long acting insulin (Novorapid®-Lantus®) 58%. Based on glycemic target, patients with blood glucose levels reached the glycemic target were 10% of patients, the ones that not reached the glycemic target were 80% of patients and the ones that reached hypoglicemia were 10% of patients. In this study, the severity category of diabetes mellitus patients with ulcers/ gangrene was gangrene 58%, ulcers 26%, cellulitis 11% and sepsis 5%.
Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.402 KB) | DOI: 10.33508/jfst.v5i1.2049

Abstract

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.
Pola Penggunaan Omeprazole pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Ariana, Dona; Trijono, Erwin Astha; Surdijati, Sri; Nathalia, Aditya
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.365 KB) | DOI: 10.33508/jfst.v5i1.2054

Abstract

Human Immunodeficiency Virus (HIV) is a virus that spreads through body fluids and attacks the immune system, especially CD4 + lymphocyte-T cells (CD4). AIDS is a retroviral disease characterized by severe immune suppression that causes opportunistic diseases, secondary neoplasms, and neurological disorders. Patients suffering from chronic diseases, such as HIV & AIDS patients may experience severe shocks or trauma. This condition can trigger the release of excessive stomach acid to experience erosion or acute gastric ulcers with bleeding. This injury is classified as a gastric ulcer. Treatment of ulcers is needed, because a continuous ulcer can cause bleeding. Gastrointestinal bleeding can manifest in the direction of melena and hematemesis. The therapy that can be used is omeprazole which is a class of proton pump inhibitors. Omeprazole can prevent mucosal damage from gastric acid and can inhibit excess acid production from gastric parietal cells. This study aims to present omeprazole therapy data which includes dosage, route of drug administration, duration of use and qualitative analysis of interactions related to medical record data at UPIPI Hospital Dr. Soetomo Surabaya. The research method used was observational retrospective on the medical record of patients with HIV & AIDS. Sampling was carried out from January 1 to December 31, 2015. The results showed that omeprazole was the most widely used gastric ulcer drug in HIV & AIDS patients, as many as 56 patients (91.80%). The most frequent doses, frequencies, and routes were omeprazole 40 mg 2x1 IV in 55 patients (90.16%). Omeprazole therapy was given to patients with HIV & AIDS at UPIPI Hospital Dr. Surabaya Soetomo, regarding the dosage, frequency, route, and duration of administration are in accordance with existing guidelines.
Uji Potensi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Terhadap Peningkatan Ketebalan Jaringan Granulasi dan Waktu Penyembuhan Luka Bakar Tikus Betriksia, Dea; Hamid, Iwan Syahrial; Hermanu, Liliek Suyatmiatun
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.697 KB) | DOI: 10.33508/jfst.v5i1.2050

Abstract

Burns are skin damage caused by high-temperature which contact to the skin. Second-degree burns are the most common accident at home. The process of wound healing can be accelerated using traditional medicines, one of which is Binahong (Anredera cordifolia (Ten.) Steenis). Binahong contains saponins, flavonoids, alkaloids, tannins, and steroids which have been shown to accelerate the wound healing process in previous experiments. The purpose of this study was to analyze the potential of binahong leaf extract to increase granulation tissue thickness and reduce healing time of burns. This study uses an experimental method. Wistar rats were used in this study, which were divided into 4 groups, namely K (-), K (+), and treatment groups namely the concentration of binahong leaf extract 20% (P1) and 40% (P2). Burns are made using an iron plate that has been heated to 95° C and pasted for 30 seconds on the lower back of the mouse to cause second-degree burns. The binahong leaf extract used in this study was made in the form of an ointment and given twice a day for 7 days. Increased granulation tissue thickness and wound healing time were observed on day 3 and day 7. The results showed an increase in granulation tissue thickness and shorter healing time in the experimental group given binahong leaf extract with a concentration of 40% (P2) compared to the experimental group that was given binahong leaf extract with a concentration of 20% (P1).
Standarisasi Simplisia Kering Daun Kelor (Moringa oleifera) Dari Tiga Daerah Berbeda Bata, Maria H C; Wijaya, Sumi; Setiawan, Henry K
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.352 KB) | DOI: 10.33508/jfst.v5i1.2055

Abstract

Miracle tree (Moringa oleifera) is known for its many benefits, and has been used in traditional medicine. This study aims to determine macroscopic and microscopic characteristics of Miracle tree leaves and to determine specific and non specific parameter os standardization of Miracle tree dried powder. Miracle tree dried powder was obtained from three different locations (Batu, Bogor and Pacet). Determination of specific parameter of Miracle tree dried powder include macroscopic, microscopic, determination of soluble extract, chromatogram pattern determination by TLC, determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of quantitative secondary metabolite compounds. Non specific parameters including determination of total ash content, ash content water soluble, acid soluble ash content, drying shrinkage and pH. Determinations of quantitative secondary metabolite compounds were done using colorimetric method. Based on the results, Miracle tree dried powder contain alkaloid, flavonoids, polyphenols, saponins, tannins, steroids and triterpenoids. Ethyl acetate: n-hexan (7: 3 v / v) can be used as eluent on thin layer chromatography. Miracle tree dried powder gave wave number of 3277 – 3281, 2917 – 2918, 2849 – 2850, 1603 – 1607, 1408, 1235 – 1236, 1048 – 1051, 889, 534 – 536 and 452 - 455. Miracle tree dried powder gave standardization value of dried shrink rate 5.5% w/ w and total alkaloid content> 1.0% w/w.
Studi Penggunaan Asam Traneksamat pada Penderita Tuberkulosis dengan Hemoptisis di Instalasi Rawat Jalan Rumah Sakit Umum Haji Surabaya Yuni, Santi Eka; Hasmono, Didik; Kasih, Elisabeth; Ayumuyas, Nur Palestin
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.766 KB) | DOI: 10.33508/jfst.v5i1.2051

Abstract

Tuberculosis is one of the world's health problems, especially in developing countries with coughing in the form of blood (hemoptysis) as a sign of this disease. Tranexamic acid can be used as one of the treatments for hemoptysis. Tranexamic acid is a synthesis derivative of aminolenic acid which provides antifibrinolytic effects through reversible blocking of lysine binding sites on plasminogen molecules and inhibits plasmin. This study aims to analyze the pattern of use of tranexamic acid in tuberculosis patients with hemoptysis including dosage, frequency and duration of use in the Outpatient Installation of Surabaya Haji General Hospital. The study was conducted observationally with a retrospective method on medical records of patients diagnosed with tuberculosis with hemoptysis and received treatment for tranexamic acid, then analyzed descriptively. Sampling was done by purposive sampling, from January 1, 2016 to December 31, 2017. From the results of the study, the use of tranexamic acid single dose (3x500mg) as many as 2 patients (67%), 500 mg intravenously as many as 1 patient (33%) and combination with Vitamin K as many as 3 patients. The highest duration of use was 3 days in 11 patients (56%). The use of tranexamic acid in hemoptysis patients related to dose, frequency and duration of use is in accordance with the existing literature.

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