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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 150 Documents

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Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Chitosan dan Enhancer Tween-80 Jennifer Rachel Willyanto; Iwan Sahrial Hamid; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Onion is a traditional medicine that has a lot of pharmacological potential. Flavanoid compounds found in onions have an antipyretic effect that acts as an inhibitor of cyclooxygenase (COX) enzymes that play a role in the formation of prostaglandins. In this study red onion is formulated into a patch because of its practical use and can avoid the first metabolic pathway. This study aims to analyze the effect of onion ethanol extract patch (Allium ascalonicum L.) on the decrease of body temperature and the number of monocytes in white rats induced by DPT vaccine. This study used 4 treatment groups: positive controls administered paracetamol syrup, negative controls given placebo patch, treatment group 1 treated with red onion ethanol extract without enhancers and treatment group 2 treated with an red onion ethanol extract with enhancers. Rats adapted for 7 days before temperature being measured and the blood being collected from the rat tail in order to calculate the number of monocytes. The animal temperature was measured after injected with vaccine DPT at 15, 30, 45, 60, 75, 90, 105, 120, 150, 180 minutes meanwhile number of monocyte were calculated every 15 minutes for 120 minutes. The results showed that there was no significant difference in monocyte count of treatment group with positive control but there were significant differences in temperature. The use of onion ethanol extract patch may decrease the temperature and number of monocytes in white mice induced by DPT vaccine.

Uji Aktivitas Antimikroba Ekstrak Etanol Daun Cayratia trifolia terhadap Staphylococcus aureus dan Candida albicans Sari, Rizki Sari Endah; Soegianto, Lisa; Hermanu, Liliek S,
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Cayratia trifolia is a wild plant that is easily found in the lowlands, tropical and subtropical regions. Cayratia trifolia is known to be efficacious as an antibacterial, antifungal, antiprotozoa, hypoglycemia, anticancer and diuretic. This study aims to determine whether the ethanol extract of Cayratia trifolia leaves has antimicrobial activity against Candida albicans and Staphylococcus aureus using well diffusion method; to determine the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) using microdilution method; and to determine the secondary metabolite groups which have antimicrobial activity against Staphylococcus aureus and Candida albicans. In this study bioautography method was carried out to determine the secondary metabolite group that can inhibit microbial growth. Ethanol extract of Cayratia trifolia (Galing-galing) leaves has no antimicrobial activity against Candida albicans. The MIC value of the ethanol extract of Cayratia trifolia (Galing-galing) leaves against Staphylococcus aureus is at a concentration of 125 ppm, while the MBCvalue is at a concentration of 250 ppm. The group of compounds that have antibacterial activity against Staphylococcus aureus is polyphenol, meanwhile flavonoid suspected has activity against Candida albicans.

Formulasi Sediaan Eyeshadow Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Dwiwulandari, Fransisca Yunita; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Coloring substance are needed in eyeshadow. It is used to give colors, shadows, and glittery effect on eyes. The trend in beauty world nowadays is using a natural dye because of safety issues. Antocyanine, which is contained in â€œjuwetâ€ fruit (Syzygium cumini), is one of the potential natural dyes. The aim of this research is to know the effect of Syzygium cumini in different concentration (20%, 25% dan 30%) on the physical quality and ffectiveness of the eyeshadow. The extract of Syzygium cumini fruit was formulated into compact powder eyeshadow. This type of preparation is the dominant dosage form used because it has good adhesiveness to the skin. The extract was obtained by extracting the juice and evaporated it using thermostatic water bath in the temperature of 40-60Â°C. The result showed that the increase in extract concentration significantly affected the physical quality test results (organoleptic, pH, particle size, friability and hardness), but did not affect the color dispersion and effectiveness. Based on the evaluation, formula II (extract of Syzyium cumini 25 %) was chosen as the best formula.

Pola Penggunaan Antihipertensi pada Pasien Diabetes Mellitus Tipe 2 di Poli Penyakit Dalam RS Bhayangkara Surabaya Pramadani, Yana; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia. This disease can be caused due to abnormalities in insulin secretion, insulin action or both. Management of diabetes mellitus in general is to improve the quality of life of people with diabetes, namely to eliminate complaints of diabetes mellitus, improve quality of life, and reduce the risk of acute complications; to achieve this goal their blood pressure must be controlled using antihypertensive therapy. The purpose of this study was to examine the pattern of antihypertensive drug use related to the type, dose, and frequency of administration in reducing blood pressure in patients with type 2 diabetes mellitus in the internal medicine clinic of Bhayangkara Hospital Surabaya. The method of this study was observational because researchers did not provide treatment directly to patients. Data were collected retrospectively between August 1 and September 15, 2015. The results showed 80 patients (48%) used single therapy and 86 patients (52%) used combination therapy. The antihypertensive drug that is often used as a single therapy is valsartan (1x80 mg) given orally in 16 patients (20%) and as a combination is valsartan (1x80 mg) + amlodipine (1x10 mg).

Observasi Klinik Ramuan Jamu untuk Menurunkan Berat Badan Pamadyo(, Sunu; Novianto, Fajar; Mujahid, Rohmat
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

The prevalence of overweight (obesity) has increased significantly in the world. During this decade, obesity will become a health problem. Even today, obesity is referred to as the New World Syndrome, where it is continuity increasing the number of events almost all over the world. Based on Riskesdas in 2010, the prevalence of adult obesity in Indonesia had reached 21.7%, significantly increasing if it was compared to the previous Riskesdas in 2007 which were 10.3%. Obesity in the younger people was associated with the increased of the incident risk of coronary heart disease, hypertension, hypercholesterolemia, diabetes mellitus and metabolic disorders. Obesity has a strong correlation with morbidity and mortality, and received serious attention on the causes, prevention and treatment efforts. Until now, there has been no specific drugs used for weight loss. People saw fitoterapi as a weight loss (besides diet)drug, because it has been considered relatively safe and without significant side effects. Jamu consisting of Jati Belanda, Kemuning, Kelembak and tempuyung was used in Saintifikasi Jamu Clinic. The results in this jamu showed that capsule weight loss has gave lower Body Mass Index (BMI) for 2 months but it has not lowered the BMI category of overweight to normal. The jamu could significantly reduce the weight of research subyek after administration for 28 days, with an average decline of 3.9 Kg and a highly significantly decrease after 56 days administration, with an average decrease of 6.7 Kg, compared to the initial weight. Medicinal herb could reduce the waist 41.1 cm, after 56 days administration. The herbs could not reduce the upper arm circumference, after 56 days administration.

Optimasi Formula Tablet Ekstrak Kering Daun Jati Belanda Menggunakan Kombinasi Starch 1500 sebagai Pengikat dan Crospovidone sebagai Penghancur Gunawan, Indra; Darsono, Farida Lanawati; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Bastard cedar leaves (Guazuma ulmifolia L.) can lower cholesterol level on blood. Tannins and musilago are the components in bastar cedar leaves that play a role in lowering cholesterol. The purpose of this study was to determine the effect of starch 1500, crospovidone and its interaction on the physical quality of tablets. Tablets were made using wet granulation method. Optimization of tablet formulation consists of two factors. The first factor is the Starch 1500 which is used as a binder with the level (+1) that is 3% and the level (-1) that is 1.5%, and the second factor is the crospovidone used as disintegrant with the level (+1) that is 5% (-1) that is 2%. The response used is tablet hardness, fragility, and time of disintegration. The results of this study indicate that starch 1500 can increase the hardness, but can prolong the disintegration time of the tablet and can decrease the tablet fragility, while crospovidone can decrease the hardness, increase the fragility, and accelerated tablet disintegration time. The interaction of these two factors has a significant effect on tablet hardness, fragility and time of disintegration. The optimum formula was obtained with the combination of Starch 1500 2.22% and crospovidone 3.54% with estimated result of physical hardness test quality of 5.2Kgf; Fragility 0.643%; and disintegration time 11.54 minutes.

Studi Penggunaan Omeprazole pada Pasien Sirosis Hati dengan Hemetamesis Melena Rawat Inap di RSUD Kabupaten Sidoarjo Wiranata, I Made; Hasmono, Didik; Surdijati, Siti
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Liver cirrhosis is a process of liver cell damage which later becomes fibrosis tissue. Then, the occurrence of liver structural distortion and increased vascularization to the liver resulting in varicose veins or dilation of blood vessels in the gastrointestinal and esophageal areas. Patients with esophageal varices, there is a risk of bleeding from esophageal rupture, the undergone hematemesis (vomiting of blood) and melena (blackish defecate). The therapies used to reduce gastrointestinal bleeding are gastric ulcers drugs such as H2Ras and PPI. The study aimed to determine the pattern of omeprazole use in liver cirrhosis patients with hematemesis melena. The method used was an observational retrospective study in medic record data patients. Sampling was done by consecutive sampling, the period of Juli 1, 2015 until Descember 31, 2015. The results obtained from the study were single use of omeprazole with a dose of 2x40mg/i.v used the most by 22 patients (73.3%). The use of omeprazole with a dose of 2x40mg/i.v combined with other gastric ulcer drugs was 7 patients (23.3%), omeprazole with ranitidin 6 patients, omeprazole with antacid for 1 patient. The use of omeprazole with a dose of 2x40mg was replaced with ranitidin 2x25mg/ml was 1 patient (3.3%). The use of omeprazole given in liver cirrhosis patients with hematemesis melena at the Inpatient Installation of Regional Hospital of Sidoarjo, related dose, route, frequency, interval, and duration of giving was in appropriate with the guidelines contained in the National Formulary.

Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya Pambudi, Rien Esti; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.

Ekstrak Daun Sirsak (Annona muricata) Sebagai Penghambat Perkembangan Tumor Payudara Hussaana, Atina; Djamâ€™an, Qathrunnada; Goenarwo, Edijanti; ., Chodidjah
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Kanker payudara merupakan penyebab kematian kedua setelah kanker leher rahim pada wanita. Pengobatan kanker sampai sekarang masih belum berhasil dengan baik. Daun sirsak merupakan obat tradisional yang secara empirik dipakai masyarakat Indonesia sebagai obat antiinflamasi dan antikanker. Kandungan aktif acetogenin pada daun sirsak diketahui dapat menginduksi apoptosis dengan meningkatkan aktivitas caspase-3 dan menghambat proliferasi pada kultur sel kanker. Dengan tujuan untuk mengetahui potensi antikanker ekstrak daun sirsak, penelitian ini dilakukan dengan rancangan post test randomized control group design, menggunakan 24 ekor mencit C3H yang telah diinokulasi bubur tumor jenis adenokasrsinoma mamma dan telah tumbuh tumor. Mencit kemudian dikelompokkan secara random menjadi kelompok 1 (kontrol), 2 dan 3, berturut-turut mendapatkan aquades, ekstrak daun sirsak dosis 10 mg/kg dan 20 mg/kg. Perlakuan diberikan peroral selama 30 hari. Selama perlakuan, volume tumor diamati tiap 3 hari untuk mengetahui penghambatan per-kembangan tumor payudara. Pada hari ke-31, jaringan tumor diambil dan dibuat preparat histopatologi untuk pengecatan imunohistokimia terhadap ekspresi protein Ki-67 dan pengecatan Tunnel, berturut-turut untuk mengetahui tingkat proliferasi serta jumlah sel kanker yang mengalami apoptosis. Data di uji dengan uji One Way Anova. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak mampu memperlambat pertumbuhan tumor payudara tetapi tidak mengurangi besar tumor akhir. Disamping itu, ekstrak daun sirsak mampu meng-hambat proliferasi sel melalui hambatan ekspresi Ki-67 dan mampu meningkatkan apoptosis. Kata kunci : daun sirsak, Annona muricata, tumor payudara, Ki-67, apoptosis.

Uji Efektivitas Ekstrak Daun Binahong (Anredera cordifolia (TEN) Steenis) terhadap Jumlah Fibroblas dan Ketebalan Kolagen pada Luka Infeksi Tikus Wistar Ratu, Maria T H; Syahrial, Iwan; Hermanu, Liliek
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Binahong (Anredera cordifolia) is a medicinal plant that can be used to accelerate the healing process of wound infections. The purpose of this study was to determine the effect of the ethanol extract of binahong leaves (Anredera cordifolia) on the healing process of incision wounds infected by Staphylococcus aureus. The ethanol extract of binahong leaves is made in the form of ointments to facilitate the application and release of the drug into the skin layer. The study used 24 male Wistar rats which were divided into 4 treatment groups namely the group without treatment, the group with fusidic acid ointment, the group with 20% extract of binahong leaf ethanol extract and the group with 40% extract of binahong leaf ethanol. Infected mice were treated and then observed the number of fibroblasts and collagen thickness on day 3 and day 7. Data was analyzed using One Way Anova followed by Duncan Test. The results showed that the ethanol extract of binahong leaves 40% could increase the number of fibroblasts on the 3rd day (43.33 Â± 8.08) and the 7th day (61.67 Â± 7.02), the ethanol extract of the binahong leaf 20% on 3rd day (31.67 Â± 5.50) and 7th day (57.00 Â± 7.55). The ethanol extract of binahong leaves 40% increased the thickness of collagen on the 3rd day (10.37 Â± 2.69) and the 7th day (16.55 Â± 0.32), the ethanol extract of the binahong leaf 20% on the 3rd day ( 8.87 Â± 0.71) and 7th day (12.09 Â± 1.26). Based on the results of the study, it can be concluded that the ethanol extract of binahong leaves 40% can accelerate the healing process of wound infections by increasing the number of fibroblasts and collagen thickness better than the administration of ethanol extracts of binahong leaves 20%.

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