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INDONESIA
MANDALA of Health
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions
Arjuna Subject : -
Articles 36 Documents
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PENGARUH PEMBERIAN SIMETIDIN TERHADAP KADAR SGOT DAN SGPT TIKUS PUTIH (Rattus norvegicus) YANG DIBERI ANTI TUBERKULOSIS RIFAMPISIN DAN ISONIAZID Siswandari, Wahyu; Pribadi, Fajar Wahyu; Perdini, Eska
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberkulosis (TB) has long been known as an infection diseases, and has been reported to increased.The INH dan Rifampisin are two different drugs that are known tobe the most active drugs, therefore bothdrugs are being used as never ending drugs in curing the TB. Utilization of both INH and rifampisin in acombination to cure the TB patients, however could increase the possibility of hepar lession risk. Thisresearch was aimed to firstly, knowing whether cimetidine could prevent increase of SGOT and SGPT levelsof rats (Rattus norvegicus) given by both drugs INH and rifampisin, and secondly what was the minimumdose of cimetidine that able to prevent the increase of SGOT and SGPT levels. A Completely Random Design(CRD) was applied in this research, 24 male rats (Rattus norvegicus) of the wistar variety were divided into4 different groups. The first group, was only given the INH and rifampisin orally at the doses of 50 mg/Kgbody weight/day, the next groups groups II, III, and IV were also given those two drugs at the same dose, butthe cimetidine was also given at 112,5 , 225, and 450 mg/Kg body weight/day for the 28 days. Consequentlythe SGOT and SGPT levels were measured twice pre and post treatments. The data obtained were analysiedby the paired t test, a one way ANOVA, Post Hoc Tukey’s HSD, Kruskal-Wallis and Mann-Whitney test. Thisresearch result showed that the cimetidine that given following the INH and rifampisin could prevent theincrease of SGOT and SGPT levels. The highest dose of 450 mg/Kg body weight/day that given orally showedhighly significant different from other (p<0,00) in preventing the SGOT and SGPT of treated animals
HUBUNGAN ANTARA INDEKS MASSA TUBUH (IMT) DENGAN TES FUNGSI PARU Rujito, Lantip; Ristianingrum, Ika; Rahmawati, Indah
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Body mass index (BMI) is a tool of measuring the nutritional status of individu. One of the effects ofobesity is the mechanics disturbance led to abnormality on pulmonary function tests. This study was aimed todetermine the relationship between body mass index with pulmonary function tests (PFTs) on medical studentJenderal Soedirman University. Analityc observational study with cross sectional design was used in thisinvestigation. The sampling technique used proportional random sampling with 82 samples. Pulmonaryfunction tests was classified into vital capacity (VC), tidal volume (TV), inspiration reserve volume (IRV),expiratory reserve volume (ERV), inspiration capacity (IC), forced vital capacity (FVC) dan FEV1.Univariate analysis, which was using table of frequency to see chategorichal variables and central tendencymeasurement to see numerical variables, and bivariate analysis, which was using Pearson and Spearmancorrelation to see the relationship between BMI with PFTs; unpaired t tests and Mann Whitney to know thedifferences of PFTs results between men and women, were used in this research. From the results weconcluded that there are significant relationship between between BMI with VC (p = 0,015), IRV (p = 0,026),IC (p = 0,016), FVC (p = 0,004) and FEV1 (p = 0,021) with low power relationship and was no relationshipBMI with TV (p = 0,489) and ERV (p = 0,231). In the unpaired t test and Mann Whitney we found that thereare differences all PFTs in a group of men and women.
SURVEI CEPAT: STRATA PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) SERTA FUNGSI FISIOLOGIS KELUARGA DI DESA TAMBAKSARI KIDUL KECAMATAN KEMBARAN MEI – JUNI 2010 Wibowo, Yudhi
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

In order to improve the Healthy and Clean Life Behavior (PHBS), the Community Health Center(Puskesmas) I Kembaran, Kembaran Sub-District, Banyumas District has tried to apply the healthpromotion strategy. But the survey of PHBS on community have not done yet by Puskesmas I Kembaran,specifically for Tambaksari Kidul village. The purpose of this rapid survey study is to know the level ofPHBS and APGAR family in the households in Tambaksari Kidul, Kembaran Sub-District, BanyumasDistrict. The population of this study is all of the 3.960 people lived in Tambaksari Kidul, Kembaran Sub-District, Kembaran District. Through the simple random sampling on the second staged, 210 heads ofhouseholds of each cluster/village were selected to be the samples for this study. The data were analyzed bystatistics descriptive. This study showed that the level of PHBS in Tambaksari Kidul, Kembaran Subdistrictwere Pratama (0,50%), Madya (21,80%), Utama (73,70%), Paripurna (3,60%) respectively. Thetarget of PHBS by 2010 was achieved beyond 65%. The value of APGAR family were the healthy family(82,25%), enough healthy family (13,82%) and unhealthy family (0,92%) respectively. The policymakers are suggested to guarantee and to keep the availability and continuity of population-based surveyfor the availability data of PHBS and APGAR family. Puskesmas must be able to manage the potential ofcommunity and the available word business in its work area and to analyze the situation as the basic of thePHBS health strategy program planning and development. Puskesmas should improve the quality of intersectoralcooperation between the unit of government organization and that of community organization.
TINJAUAN MOLEKULAR DAN ASPEK KLINIS RESISTENSI INSULIN Sulistyoningrum, Evy
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Insulin resistance is defined by an unresponsive condition in the target organ that normallyresponded to insulin hormone. Insulin resistance play a major role in many serious health problem such asmetabolic syndrome, type II diabetes, polycistic ovarii syndrome, cancer and cardiovascular diseases. Themechanism of insulin resistance is still unclearly understood. Researchers postulated two mechanism ofinsulin resistance, based on inflammatory theory and obesity theory. These two causes of insulin resistancehave different mechanism of action. Clinical diagnosis of insulin resistance can be performed by clampmethod and minimal model of frequency sampled intravenous glucose tolerance test (FSIVGTT) but thesegold standard diagnosis are very invasive. Non-invasive methods for diagnosing insulin resistance can beperformed by using various formulas derived from base examination in glucose and insulin plasma level.One of the formulas which have high sensitivity and specificity is HOMA-IR index (Homeostasis ModelAssessment-Insulin Resistance). Different characteristic of population required different cut-off fordetermining insulin resistant condition.
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
POLIMORFISME GENA RESEPTOR MCP-1 (CCR2) SEBAGAI FAKTOR RISIKO NEFROPATI DIABETIKA PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD PROF DR MARGONO SOEKARJO DAN RSUP SARDJITO Setyono, Joko; Sadewa, A Hamim; Madiyan, Maliyah
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

The infiltration of the glomeruli and interstitium by immunocompetent cells are common finding ofkidney with diabetic nephropathy. On the other hand, there is an increasing synthesis of chemokines andother inflammatory mediators by glomerular and tubular cells in hyperglycemic conditions. Single nucleotidepolymorphisms (SNPs) G46295A of MCP-1 (CCR2 are thought playing a key role in the development ofdiabetic nephropathy in type 2 diabetes. Therefore, the aim of this research is to determine whether the riskof diabetic nephropathy is influenced by polymorphisms of CCR2. In addition, this research is also aimed todetermine whether the gender in the diabetic nephropathy patient is influenced by polymorphisms of CCR2 intype 2 diabetes in Indonesian population especially ethnic of Java. A case-control study was performed,including 60 type 2 diabetes patients, 31 subjects with diabetic nephropathy and 29 subjects with nondiabetic nephropathy in Margono Soekarjo Hospital and Sardjito hospital. Polymorphisms of CCR2 wereanalyzed by PCR-RFLP method. The results were analyzed by chi-square. Amount of male in the casesubjects (67,7%) more than amount of male in control subjects (44,8%). G46295A of MCP-1 (CCR2)receptor gene had higher risk of developing diabetic nephropathy in type 2 diabetes (X2 = 12.308, p =0.002). Male individual carry the GA genotype of CCR2 had significant risk of developing diabeticnephropathy (p = 0.004, OR 9.6). This study showed that G46295A MCP-1 (CCR2) receptor gene had higherrisk of developing diabetic nephropathy in type 2 diabetes in Indonesian population especially ethnics ofJava. Male with G46295A MCP-1 (CCR2) receptor gene were more than female and had higher risk ofdeveloping diabetic nephropathy in type 2 diabetes in Indonesian population, especially Java ethnic.

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