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INDONESIA
MANDALA of Health
Published by Universitas Jenderal Soedirman
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Health Professions
Arjuna Subject : -
Articles 36 Documents
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PENGARUH PEMBERIAN MORFIN DOSIS LETHAL TERHADAP PERTUMBUHAN LARVA LALAT Chrysomya sp. PADA MEDIA BANGKAI TIKUS Rattus norvegicus GALUR WISTAR Fadhlurrahman, Ahmad Reza; Baskoro, Aswin D; Permatasari, Nur
MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Death is the end of life. To identify unproper death on corpses, we use Post Mortem Interval (PMI). Insect evidence on the corpses can be used to estimate the Post Mortem Interval, however many factors including drugs may affect the rate of fly larva growth. Two rats with average BW 200 grams were used in this experimental study in order to analyze the influence of morphine on growth rate of fly larvae. One rat were given 120 grams of morphine orally (LD50 = 461mg/KgBW), and the other were killed by cervical dislocation and used as control. The rats were then simultaneously killed and caged individually into Chrysomya sp. cages to let the flies deposit their eggs on the rat corpses. Five developing larvae were sampled twice daily to determine the body length, weight and the growth rate until they were emerging to be adult. Result of this study showed that the length and the weight were lower and the growth of Chrysomya sp. larvae in rat corpses containing morphine were faster than control. The significant result occured at third stadium (p < 0,005) This result suggested that morphine can precipitate the growth rate of fly larvae.
PENGARUH INJEKSI LEPTIN JANGKA PENDEK TERHADAP KADAR ADIPONEKTIN DALAM SERUM Rattus norvegicus STRAIN WISTAR YANG DIBERI DIET TINGGI LEMAK Prawibawa, Dian; Indra, M Rasjad; Prijadi, Bambang
MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Obesitas dan kelebihan berat badan akan menimbulkan masalah kesehatan yang serius seperti penyakit kronis yaitu DM tipe II, penyakit jantung hipertensi, stroke, hiperkolesterolemia, hipertrigliseridemia, arthritis, asma. Diketahui penyebab obesitas yang tersering adalah Diet tinggi Lemak. Diet tinggi lemak ini dapat menyebabkan resistensi leptin dan penurunan kadar adiponektin tubuh. Sejak penemuan leptin pada tahun 1994, para ilmuwan telah memiliki harapan besar bahwa memanipulasi jalur axis leptin dapat membawa kesuksesan pengobatan obesitas yang berakibat meningkatnya kadar adiponektin tapi hal tersebut masih menjadi kontrofesi. Penelitian eksperimental ini bertujuan untuk membuktikan bahwa injeksi leptin eksogen secara akut dapat mengatasi resistensi leptin sehingga terjadi peningkatan kadar adiponektin di dalam serum tikus yang di beri diet tinggi lemak. Pada penelitian ini dua puluh lima ekor tikus dibagi menjadi 5 kelompok, yaitu kelompok kontrol negative (tanpa diet tinggi lemak dan injeksi leptin), kelompok kontrol positif (dengan diet tinggi lemak dan tanpa injeksi leptin), kelompok dengan diet tinggi lemak dengan injeksi leptin 50 ng/ml, 100 ng/ml, dan 200 ng/ml injeksi leptin. Setiap kelompok terdiri dari 5 ekor tikus. Tikus diberi diet tinggi lemak selama dua bulan, kemudian tikus di suntik leptin eksogen selama 3 hari. Pada hari ke 3, serum tikus diambil dan diukur kadar adiponektinnya dengan ELISA. Hasil penelitian menunjukkan rata-rata kadar adiponektin untuk kelompok I,II, dan III adalah 503,2; 455,9; dan 485,4 secara berturutan; kelompok kontrol negative 451,9; dan kelompok kontrol positif adalah 477,9. Dari hasil statistik di dapatkan perbedaan kadar adiponektin secara nyata antara kelompok kontrol (-) dengan kelompok I (p = 0.002) dan antara kelompok I dan kelompok II ( p = 0,04). Sedangkan pada kelompok yang lain tidak di dapatkan perbedaan secara nyata ( p > 0,05 ). Berdasarkan hal tersebut, dapat disimpulkan bahwa injeksi leptin dengan dosis rendah secara akut menyebabkan peningkatan kadar adiponektin
HUBUNGAN KADAR ANTI-MULLERIAN HORMON (AMH) DENGAN SIKLUS HAID TIDAK TERATUR PADA MAHASISWI JURUSAN KEDOKTERAN FAKULTAS KEDOKTERAN DAN ILMU – ILMU KESEHATAN UNIVERSITAS JENDERAL SOEDIRMAN ., Mustofa; A, Setyawan; UA, Pekerti
MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Background : Anti-Mullerian Hormone (AMH), also known as Müllerian inhibiting substance, is a protein hormone to follicle development. Menstrual cycle that occurs outside the normal state or the interval pattern of menstruation that is less than 21 or more than 35 days with normal uterine bleeding time span of less than 3 or more than 7 days is irregular menstrual cycles. Objective : This study aimed to know the association AMH level and irregularly menstrual cycle at student of medical faculty and health sciences Jenderal Soedirman University. Method : This study was done at 26 subjects, use Analytic observational method with cross-sectional approach. Subjects was chosen by consecutive sampling technic and adapted to inclusion and exclusion criteria. Subjects asked to fasting 12 hours and then collect their blood until reach 10 cc. Data analysis used chi square then followed to coefficient contingency test with alt lambda test. Result : The level of AMH in irregular menstrual cycle group is 8.87 ng/ml. It shows a higher yield than regular menstruation group (4.28 ng/ml). The result of this study there is have association between AMH level and irregularly menstrual cycle at student of medical faculty and health sciences Jenderal Soedirman University. p 0,001 and 95 % CI = 1,828 – 83,767 that showed there was moderate association. Conclusion : There is strong association between AMH level and irregularly menstrual cycle at student of medical faculty and health sciences General Soedirman University, The study shows a very strong association that abnormal of serum AMH will have irregular menstrual cycles, whereas AMH levels are relatively normal will have regular menstrual cycles
PENGARUH AKTIVITAS FISIK TERHADAP STRES OKSIDATIF Candrawati, Susiana
MANDALA of Health Vol 6, No 1 (2013): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

At the moment, degenerative diseases have become the highest cause for morbidity and mortality in the world. One of the risk factors for degenerative disease to develop is low physical activity. Several theories revealed that there is a relationship between physical activity and oxidative stress, which is one of the basic pathogenesis of degenerative diseases. Physical activity have acute respon to increase the oxidative stress by several mechanism : hyperoxic injury in mitochondria, ischemia – reperfusion injury and inflammation. Besides that, reguler physical activity can cause chronic respon to decrease the oxidative stress by several mechanism : increasing proteasome activity & DNA repairing enzyme, decreasing DNA binding by redox-sensitive transcription factors (NF-κB, AP-1, MAPK, dan CREB) and increasing endogenous antioxydant (superoxide dismutase / SOD & glutathione peroxidase / GSH-px). Therefore, it is important to perform reguler physical activity for the prevention of degenerative disease in the future
FAKTOR-FAKTOR RISIKO PENULARAN HIV/AIDS PADA LAKI-LAKI DENGAN ORIENTASI SEKS HETEROSEKSUAL DAN HOMOSEKSUAL DI PURWOKERTO DL, Agung Saprasetya; Dwi Lestari, Diyah Woro
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Indonesia is a country with the highest HIV/AIDS cases acceleration in the world. Purwokerto hasa high number of HIV/AIDS cases, rank number two in Central Java Province. However, risk factor forHIV/AIDS transmission among high risk groups, especially among men who have sex with men, has notbeen identified. This research aimed to examine HIV/AIDS transmission risk factors among homosexualand heterosexual men in Purwokerto. This study is a cross sectional study. Study population is all menaged at least 17 years old living in Purwokerto and its surrounding area. Sampling method used wassnowballing sampling. Data were collected with a quessionere. The result shows that homosexual men hashigher risk to suffer from HIV/AIDS through sexual behavior, these are having sex with multiple partner.No differences in HIV/AIDS transmission risk factors by parenteral and sexually transmitted disease werefound between homosexual and heterosexual men. In conclusion, homosexual men have higher risk factorsfor the transmission of HIV/AIDS than that of heterosexual men, especially through sex partner more thanone and anal sex.
PROFIL SITOGENETIK KROMOSOM Y PADA LAKI-LAKI NORMAL Wasilah, Siti
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Normal prenatal developments of male and female genitalia are very complicated. Some crucial locion Y chromosome have a role in normal sexual development. Descriptive study about cytogenetics profile ofY chromosome presented in 30 normal male was done using G-banding and C-banding techniques todescribed the mean length and heterochromatin profile of y chromosome. Cytogenetics method using Gbandingshow 30 male with normal karyotype (46,XY) and there is no structure aberration of Y chromosome,the mean length of Y chromosome in normal male was 2,54 μm (SD 0.31). Heterochromatin profile of Ychromosome analyzed by C-banding technique show that all normal male has C-band positive.
VALIDITAS DIAGNOSTIK BIOPSI ASPIRASI JARUM HALUS PADA KARSINOMA PAYUDARA Novrial, Dody
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Breast cancer incidence is still in the second position after cervical cancer within womenmalignancy. Fine needle aspiration biopsy (FNAB) has been widely known and used in diagnosing breastlesions last few decades. FNAB diagnostic procedure is considered less invasive and relatively lessexpensive than surgery biopsy. This research was diagnostic study with cross sectional design. Researchdone by reading FNAB cytology and histopathology slides from 86 patients with breast tumor betweenJanuary 2004 until December 2007. WHO classification and Elston & Ellis method was used to diagnosebreast tumor variant and grading. While fnab cytology used the NHS Breast Screening Program(NHSBSP) guidelines. Diagnostic tests of FNAB showed sensitivity 91%, specificity 79%, and accuracy87%. The sensitivity and specificity values of FNAB on this research was still quite high, because in manyliterature explained that the sensitivity and specificity rates of FNAB ranged between 66% and 92%depending on the experience of diagnostic and hospital procedure
HUBUNGAN ANTARA MEROKOK DENGAN PENYAKIT PARKINSON DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Setyono, Joko; Noviani, Erni; Gunarto, Untung
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Cigarettes contain 2,3,6-trimethyl-4-napthoquinone which can inhibit the breakdown of dopamine;therefore, smoking can reduce the risk of Parkinson’s disease. On the other hand, smoking is the secondcause of death in the world. This study was aimed to investigate the relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease. This study was ananalytical observational research using case control approach that involved 34 patients of Parkinson’sdisease as a case group and 34 respondents that were non Parkinson as a control group. The former and thelater were age- and sex-matched control subjects selected by using purposive sampling technique. InParkinson group it was obtained that as much as 64.7% of the respondents were non smokers, 14.7% wereformer smokers, 8.8% were current less than daily smokers, and 8.8% were current daily smokers. In nonParkinson group, 41.2% of the respondents were non smokers, 23.5% were former smokers, 8.8% werecurrent less than daily smokers, and 26.5% were current daily smokers. The data were analyzed usingWilcoxon test and it was found that there was a significantly negative relationship between smoking status,smoking duration, smoking quantity, types of cigarettes and Parkinson’s disease (p<0,05). There was asignificantly negative relationship between smoking status, smoking duration, smoking quantity, types ofcigarettes and Parkinson’s disease.
IDENTIFIKASI VANCOMYCIN RESISTANT Staphylococcus aureus (VRSA) PADA MEMBRAN STETOSKOP DI RUMAH SAKIT MARGONO SOEKARJO PURWOKERTO Darmawan, Anton Budi; Anjarwati, Dwi Utami
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Vancomycin-resistant Staphylococcus aureus (VRSA) was first discovered in 2002 by a clinician inthe USA. Vancomycin resistance mediated by the van gene which will result in a change in the terminalS.aureus cell wall. Data on epidemiology of VRSA from RSUD Margono Soekarjo (RSMS), Purwokertogenerally were not available. The purpose of the study was identify VRSA on stethoscopes membrane inRSUD Margono Soekarjo (RSMS), Purwokerto. A Laboratory observational study with cross sectionaldesign was conducted to 69 stethoscopes membrane in RSUD Margono Soekarjo (RSMS), Purwokerto.Isolates were taken from stethoscopes membrane for Vancomycin discs testing to detect VRSA. The resultshowed that 10 of 64 isolates with S.aureus positive (15,6%) found on stethoscopes membrane were VRSA.In conclusion, VRSA was found on stethoscopes membrane in RSUD Margono Soekarjo (RSMS),Purwokerto.
TINJAUAN HISTOLOGIS PEMBULUH DARAH TIKUS PUTIH (Rattus norvegicus) DIABETES YANG DIBERI REBUSAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpha (Scheff.) Boerl.) Sulistyoningrum, Evy; Kautsari, Septina; Susatyo, Priyo
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Prevalence of Diabetes Mellitus among adult in Indonesia reached 4,1% in 1995 and projected to 6,5% in 2025. Complication of diabetes mellitus which come earlier and widely distributed yis atherosclerosis.Atherosklerosis can lead to other serious complications such as gangrene, stroke, cardiomiopathy, andcoronary artery diseases. This research was aimed to know the effect of Mahkota dewa (Phaleriamacrocarpha (Scheff.) Boerl.) boiled water to regeneration of aorta’s atherosclerosis post diabetic inductionwith alloxan. The research was conduct in four weeks to 25male albino rats (Rattus norvegicus) 3 monthaged, 120-180 grama weighed. The subjects was divided into five groups:positive control, negative control,A, B and C. A, B and C groups was treated Mahkota dewa boiled water with 4,5%, 9%, and 13,5%concentration respectively. The drug was administered orally. III, IV, and V groups are injected by alloxan toinduce diabetes. Atherosclerosis frequency was counted from histological section stained with Haematoxylineosin.Statistical analysis using Chi square analysis showed that Mahkota Dewa boiled water significantlyreduced atherosclerosis frequency in aorta. It can be concluded that Mahkota dewa (P.macrocarpha(Scheff.) Boerl.) regenerates atherosclerosis injury in diabetic blood vessel.

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