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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 981 Documents
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Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Septiani, Linda; aflika happy, terza; Graharti, Risti; Andrifianie, Femmy; Setyaningrum, Endah
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Tinjauan Literatur Sistematis: Protokol Kriptografi untuk Menjamin Keamanan dan Privasi Data Genomik Wijaya, Angga; Idris, Mohamad; Septiani, Linda; Pestalozi, George
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1840

Abstract

precision medicine. However, the static and hereditary nature of genomic data poses significant privacy risks for individuals and their families. This article aims to conduct a systematic literature review of various modern cryptographic protocols designed to protect genomic data. The research method utilizes a Systematic Literature Review (SLR) approach, analyzing relevant literature from 2018 to 2026. The findings indicate that protocols such as Homomorphic Encryption (HE) and Secure Multi-party Computation (SMPC) offer robust protection but face challenges regarding computational efficiency and bandwidth. Differential Privacy (DP) provides an efficient alternative but carries risks of reduced data accuracy. In conclusion, securing genomic data requires hybrid models that integrate algorithmic efficiency with long-term resilience, particularly against quantum computing threats. Aligning these technologies with Indonesia's Personal Data Protection Law (UU PDP) is crucial for building a secure and credible national health data ecosystem.
Diagnostik Holistik Dan Penatalaksanaan Komprehensif Ibu Hamil Pada Pasien Ny. N 30 Tahun Dengan Kehamilan Risiko Tinggi Kek Dan Anemia Di Puskesmas Bangetayu Semarang Rohman, Fatuh; Ratnawatia, Ratnawati; Maulan, Aris
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1716

Abstract

High-risk pregnancy due to chronic energy deficiency (CED) and anemia remains a significant concern in primary healthcare because of its association with adverse maternal and neonatal outcomes. This case report describes a 30-year-old pregnant woman at 28 weeks of gestation diagnosed with CED (mid-upper arm circumference 22.5 cm) and iron deficiency anemia (hemoglobin 10.1 g/dL) at Bangetayu Community Health Center, Semarang. A holistic diagnostic approach was applied, integrating medical assessment with family function evaluation (Family APGAR and SCREEM), nutritional behavior analysis, and environmental factors. Management included iron and folic acid supplementation, provision of fortified supplementary food, intensive nutrition counseling, and structured family and community involvement. The distinguishing aspect of this case lies in the integration of clinical management with systematic family and environmental assessment to address multifactorial risk determinants. The expected clinical outcomes were improvement in maternal nutritional status, optimized weight gain during pregnancy, prevention of low birth weight and stunting, and reduced risk of perinatal complications. This case highlights that comprehensive, family-centered, and community-oriented interventions are essential in strengthening early detection and management of high-risk pregnancies in primary care settings.  
Persebaran Indeks Massa Tubuh Mahasiswi Tahun Ke-4 Pendidikan Dokter Universitas Lampung Rio Sanjaya; Setiorini, Anggi; Rahmadhani, Eka Putri; Rudiyanto, Waluyo
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1781

Abstract

Students in early adulthood are vulnerable to lifestyle changes associated with academic demands and the university environment, which may ultimately affect their nutritional status. One commonly used indicator for assessing nutritional status is Body Mass Index (BMI). Changes in dietary patterns, irregular physical activity, and suboptimal sleep quality may increase the risk of nutritional imbalance among students. This study aimed to determine the distribution of Body Mass Index among female medical students of the 2022 cohort at the Faculty of Medicine, University of Lampung. This study employed an observational design with a cross-sectional approach and involved 175 female students as research participants. Data were collected through anthropometric measurements, including body weight on a digital scale and height on a microtoise. BMI values were calculated as body weight divided by height squared and then classified according to standard anthropometric criteria. The results showed that the majority of respondents had normal nutritional status based on BMI, with 123 students (70.3%). Meanwhile, 23 students (13.1%) were classified as underweight, 11 students (6.3%) as overweight, and 18 students (10.3%) as obese. These findings are consistent with previous studies reporting a predominance of normal BMI among student populations. However, the presence of nearly one-third of respondents with abnormal BMI indicates the influence of lifestyle-related factors, such as dietary habits, physical activity levels, sleep quality, and daily behaviors. Therefore, promotive and preventive efforts through nutritional education and the adoption of healthy lifestyle practices are necessary to maintain optimal nutritional status among students.
Efektivitas Amoxicillin dan Piperacillin Terhadap Klebsiella pneumoniae pada Kasus Infeksi Saluran Pernapasan Akut di RSUD Dr. H. Abdul Moeloek Periode 2019 – 2023 Azalia, Nadhira; Soleha, Tri Umiana; Larasati, Ratri Mauluti; Utama, Winda Trijayanthi
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1846

Abstract

Acute respiratory tract infection (ARI) is one of the leading causes of morbidity that often requires antibiotic therapy, with Klebsiella pneumoniae being one of the most commonly found bacterial pathogens and known to have a high level of antibiotic resistance. Irrational use of antibiotics can accelerate the development of resistance, so the effectiveness of antibiotics needs to be evaluated periodically. Amoxicillin and piperacillin are commonly used antibiotics in the management of ARTI. This study aimed to evaluate the effectiveness of amoxicillin and piperacillin against Klebsiella pneumoniae in cases of ARTI at Dr. H. Abdul Moeloek General Hospital from 2019 to 2023. This study is an observational analytical study with a cross-sectional design using secondary data in the form of culture results and antibiotic sensitivity tests from patient medical records. The sampling technique used total sampling with a total of 106 Klebsiella pneumoniae isolates. Data analysis was performed using the Chi-Square test. The results showed that the resistance rate of Klebsiella pneumoniae to amoxicillin was 92.5% with a sensitivity of 7.5%. In contrast, piperacillin showed a higher sensitivity of 58.5% although resistance was still found at 41.5%. Statistical tests showed a significant relationship between the type of antibiotic and the level of bacterial sensitivity (p-value < 0.001). The conclusion of this study indicates that piperacillin is more effective than amoxicillin in the management of ARI caused by Klebsiella pneumoniae and can be considered in the selection of empirical antibiotic therapy.
Eksisi luas karsinoma sel basal pada aksila Khusna, Asmaul; Devi, Dinna; Putri, Heffi Anindya
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1857

Abstract

Basal cell carcinoma (BCC) is a malignant neoplasm arising from the basal layer of the epidermis and is the most common type of skin cancer, yet it is rarely found in the axillary region due to minimal ultraviolet exposure. Wide local excision is the main therapeutic option to achieve tumor-free margins and prevent recurrence. We report a case of a 46-year-old man presenting with a tumor in the left axilla that had gradually enlarged over one year and developed ulceration within the last three months. The initial lesion appeared as a small pruritic nodule that progressively enlarged and ruptured due to scratching. Physical examination revealed a 5 × 2 × 2 cm tumor with a necrotic base, regular margins, elevated edges, and firm consistency. A clinical diagnosis of BCC was established and confirmed by histopathological examination as nodular type. The patient underwent wide local excision with adequate margins. One-month postoperative evaluation showed good wound healing without signs of recurrence. Repeated trauma and chronic inflammation are considered potential risk factors for BCC in sun-protected areas such as the axilla. BCC rarely metastasizes and has a favorable prognosis when diagnosed and treated early. Adequate wide local excision plays a crucial role in reducing recurrence, with a recurrence rate of approximately 1% when completely excised.
A CONGESTIVE HEART FAILURE PADA PASIEN HYPERTENSIVE HEART DISEASE LAPORAN KASUS Djamil, Putri Amelia; Ernawati, Tutik
Medula Vol 16 No 4 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i4.1867

Abstract

Chronic heart failure is a major cause of morbidity among older adults and is frequently associated with uncontrolled hypertension. This case report aims to describe the management of chronic heart failure in a patient with hypertensive heart disease using a comprehensive family medicine approach. Data were obtained through detailed history taking, physical examination, medical record review, and home visits to assess family dynamics, health behaviors, and environmental factors influencing the patient’s condition. A 65 year old woman presented with progressive dyspnea that worsened during physical activity and when lying down. Her blood pressure was 142 over 95 mmHg, and chest radiography showed cardiomegaly. The patient was diagnosed with chronic heart failure with a history of long standing uncontrolled hypertension. Interventions included pharmacological and non pharmacological strategies consisting of optimization of antihypertensive therapy, low sodium diet education, fluid intake adjustment based on clinical status, structured physical activity recommendations, and active family involvement in monitoring treatment adherence and lifestyle modification. After three weeks of follow up, clinical improvement was observed with blood pressure reduced to 123 over 76 mmHg and a decrease in dyspnea severity measured by the visual analog scale from three to one. The knowledge score of the patient and family increased from 60 percent to 100 percent, accompanied by better medication adherence and routine follow up. A family based comprehensive approach contributed to symptom improvement, enhanced treatment adherence, and better blood pressure control in a patient with chronic heart failure and hypertension.
Sebuah Laporan Kasus Subdural Hematom: Subdural Hematom: Sebuah Laporan Kasus Anggela, Anggela; Afrida, Frecilia; Fitriyani, Fitriyani
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1906

Abstract

Subdural hematoma (SDH) is a neurological disorder characterized by the accumulation of blood beneath the dura mater. Its incidence ranges from 1.7 to 20.6 cases per 100,000 population annually, with a higher prevalence observed in the elderly. Known risk factors associated with SDH include traumatic brain injury such as traffic accidents, advanced age, alcohol consumption, anticoagulant use, and various medical conditions such as epilepsy, hemophilia, hydrocephalus, cerebral aneurysm, and malignancies. A 19-year-old female patient, Ms. ZA, presented to the Emergency Department of Abdul Moeloek Regional General Hospital (RSUDAM) with complaints of persistent headaches radiating to the posterior neck region, which significantly interfered with daily activities. The patient had a history of a traffic accident two weeks prior to admission. According to her family, she lost consciousness for approximately two hours and experienced hematemesis following the incident. There were no reported symptoms of limb weakness, epistaxis, otorrhagia, or seizures. On physical and neurological examination, no abnormalities were identified. However, a cranial CT scan revealed a subacute subdural hematoma in the left frontoparietal region with a thickness of 0.47 cm. The patient was managed conservatively with both pharmacological and planned surgical interventions. Medical therapy included intravenous Mannitol titration dose, Paracetamol 3x750 mg, Ranitidine 2x1 ampoule, along with oral supplementation of vitamin B12 and folic acid, each administered twice daily. Surgical management involved a planned burr hole drainage procedure by the attending neurosurgeon.
Prolaps Rekti Komplit pada Pasien dengan Kecurigaan Benign Prostatic Hyperplasia: Laporan Kasus Fatinah Zhohiroh, Jannah; Fathurrahman, Yusmaidi
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1909

Abstract

Rectal prolapse is a condition characterized by the protrusion of the full thickness of the rectal wall through the anus due to weakness of the pelvic floor supporting structures, which is chronic and progressive in nature. Repeated increases in intra-abdominal pressure, such as in chronic constipation and lower urinary tract disorders, play a role in its pathogenesis. We report a case of a 55-year-old male presenting with a protruding anal mass that could not be manually reduced for 8 hours prior to admission, with a history of progressively worsening prolapse over approximately ±10 years. Complaint accompanied by chronic constipation, with hard, infrequent bowel movements and habitual excessive straining during defecation and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH). Physical examination revealed a cylindrical prolapsed mass with a central orifice, characteristic of complete rectal prolapse. No signs of acute complications or significant systemic abnormalities were found on supporting investigations. The patient underwent surgical management with suture rectopexy as the definitive treatment combined with the Thiersch procedure. This combined approach was selected due to the long-standing, large prolapse and the suspected sphincter weakness, aiming to provide anatomical stabilization along with additional mechanical support to reduce the risk of recurrence. Postoperatively, the patient showed clinical improvement without complications. This case highlights the importance of identifying factors that increase intra-abdominal pressure and considering combined surgical approaches in managing complete rectal prolapse to achieve optimal clinical outcomes.
Analisis Faktor Prediksi Peningkatan Kontrol Glikemik Pada Pasien Diabetes Melitus Tipe 2 Di RSUD Abdul Moeloek Provinsi Lampung Periode Januari-Desember 2022 Ananda, Yovani Tria; Kurniati, Intanri; Carolia, Novita; Sangging, Putu Ristyaning Ayu
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1910

Abstract

The 2018 Basic Health Research report indicated that prevalence of Diabetes Mellitus (DM) in Indonesia increased to 8,3%. This rise was accompanied by an increase in obesity prevalence, a major risk factor for DM, from 14,8% in 20113 to 21,8% in 2018. These findings suggest that the number of individuals with DM in Indonesia is substantial and continues to grow annually. Data from Bandar Lampung City in 2021 showed that out of 6,467,624 individuals aged ≥15 years, approximately 198,046 (3%) were diagnosed with DM. This study aimed to analyze the association between predictive factors and glycemic control among patients with type 2 diabetes mellitus at Abdul Moeloek Hospital, Lampung Province, during January-December 2022. This research employed an observational study with a cross-sectional design. Secondary data were obtained from medical records of both inpatient and outpatient type 2 diabetes mellitus patients. Data analysis was performed using the Chi-Square test, with the Mann-Whitney test as an alternative. The result demonstrated significant associations between age at diagnosis (p=0,006), duration of Diabetes (p=0,012), body mass index (p=0,016), and comorbidities (p=0,020) with glycemic control. In conclusion, age at diagnosis, duration of disease, body mass index, and comorbid conditions were significantly associated with glycemic control among patients with type 2 diabetes mellitus receiving oral antidiabetic drugs and insulin therapy at Abdul Moeloek Hospital, Lampung Province, during January-December 2022.

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