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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 14 Documents

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Search results for , issue " Vol 4, No 2 (2014): Pharmaciana" : 14 Documents clear

EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4 Adikusuma, Wirawan; Bachri, Moch. Saiful
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study was designed to evaluate the hepatoprotective effect of the powder Eurycomalongifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twentyfive male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept asnormal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV weretreated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectivelyand CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BWp.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination ofSGPT-SGOT. The study showed the activity level of SGPT from the rats was treated byEurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groupsare 150.0Â±5.099 U/L; 113.6Â±5.508 U/L; 60.5Â±2.887 U/L; and 129.0Â±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4Â±11.165;263.0Â±1.803; 194.5Â±7.448; and 451.5Â±16.759 U/L respectively. The Eurycoma longifoliaJack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)than control group. The results concluded that Eurycoma longifolia Jack. powder hashepatoprotective effect.

SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT Noor Pratiwi, Artie; Mahfudh, Nurkhasanah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized bynucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantrolinemonohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determinedbased on the melting range data and TLC. Identification of the structure of the compoundssynthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is acolorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with anoptimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount ofyield product, there is an optimal yield in the mole ratio of 1:1.

EVALUASI KEPUASAN KONSUMEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK KOTA YOGYAKARTA Baroroh, Faridah
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Customer satisfaction with pharmaceutical care in pharmacy can be measured bycomparing the expectations of consumers on the quality of pharmacy services desired by thefact that it received. This study was aimed to identify the dimensions of the expected quality ofpharmaceutical care, is considered important, and which has a good performance with a modelof quality pharmaceutical care to costumer at pharmacy in Yogyakarta. This study wasobservational descriptive method and the results are presented with quadrant diagram. Theresults showed that the costumer at pharmacy in Yogyakarta satisfied with pharmaceutical carein Tangible and Empathy dimension. The Tangible and Empathy dimensions are in quadrant IIof the diagram. Howefer, the Assurance, Responsiveness and Reliability dimension, costumersless satisfied because the assume of patients if the pharmacy performance is still lower than theexpectations of consumers. That showed the Assurance, Responsiveness and Reliabilitydimensions are in quadrant III of the diagram.

UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO Nurani, Laela Hayu; Utami, Dwi; Widyaningsih, Wahyu; Narwanti, Iin; Nurwening, Eti; Jumina, Jumina
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme. Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)- 1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide and chloroquine by successively are 0,571Â±0,071; 25,498Â±1,876 mg/mL. The result showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide hadnât the heme polymerization inhibitory activity.

PENETAPAN KADAR Ã-KAROTEN PADA BEBERAPA JENIS CABE (Genus Capsicum) DENGAN METODE SPEKTROFOTOMETRI TAMPAK Octaviani, Tri; Guntarti, Any; Susanti, Hari
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Beta carotene is provitamin essential role for vitamin A formation. Most of vitamin Asources are Ã-carotene. In the body, Ã-carotene will be converted into vitamin A. Chilies areconsidered as one of the essential food. Chillies are known as very good sources of Ã-carotene.Therefore, it is important to conduct a research in order to observe the content of Ã-carotene inthe chillies using visible spectrophotometry. Fresh chillies were extracted with a mixture ofhexane:acetone:ethanol (2:1:1) v/v using a maceration method. After the extraction process wascomplete, aquabidest was added. The extraction result was non-polar phase. It was separatedand evaporated. The residue was further subjected to qualitative and quantitative analysis102 PharmaÒ«iana, Vol. 4, No. 2, 2014: 101-109obtained. Qualitative analysis by using Carr-Price method. Determination of Ã-carotene wasconducted using visible spectrophotometry method at 452,4 nm. The qualitative test resultsshowed that the Capsicum annuum L. Var. abreviatum Fingerhuth, Capsicum annuum L. Var.Longum sendt) and Capsicum frutescens L. contain Ã-carotene. From the research, it wasobtained that the average levels of Ã-carotene on the Capsicum annuum L. Var. abreviatumFingerhuth was (10,54Â±0,07) mg/100g, Capsicum annuum L. Var. Longum sendt was(5,57Â±0,13) mg/100g and Capsicum frutescens L. was about (0,36Â±0,01) mg/100g. Statisticalanalysis using LSD test of Ã-carotene levels in the Capsicum annuum L. Var. abreviatumFingerhuth, Capsicum annuum L. Var. Longum sendt) and Capsicum frutescens L. weresignificantly different at P of 0.05.

PENGARUH PEMBERIAN INFORMASI OBAT TERHADAP TINGKAT KEPATUHAN PENGGUNAAN ANTIBIOTIKA PADA PASIEN ISPA DI PUSKESMAS KOTAGEDE I YOGYAKARTA Muljabar, Stefy Muliyani; Supadmi, Woro
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ARI is an acute respiratory infection requiring antibiotics. The use of antibiotics shouldbe routinely to prevent resistance. The design of this research was experimental by treatment ofthe cases. How to collect the data used prospective method. The subjects of research who fulfilthe inclusion criteria were 44 patients with acute respiratory infection were divided into twogroups: 22 patients who were given information as the treatment group and 22 patients whowere not given information as the control group. Data was collected through interview to knowthe rest of the drug and questionnaires filling compliance with Modification Morisky AdherenceScale (MMAS). The pattern for antibiotic used in patients of acute respiratory infection atcommunity health centre Kotagede I Yogyakarta were Amoxicillin (65.9%), Cotrimoksazol (25%), Erithromycin (6.8%), and Ciprofloxacin (2.3%). The level of patients compliance byquestionnaire MMAS was 59.09% high compliance, and 40.91 % low compliance. The level ofpatients compliance by the rest of drug was 86.36% and patients uncompliance was 11.36%.The results of questionnaire MMAS with the Chi-Square test p=0.220 (p>0.05), this shows thatgiving drug informations had no influence to level compliance for antibiotic used in patiens ofacute respiratory infection at Community Health Centre Kotagede I Yogyakarta.

PEMANFAATAN PERASAN BUAH KEPEL (Stelechocarpus burahol (Blume) Hook & Thomson) SEBAGAI ANTISEPTIK LUKA Pribadi, Prasojo; Latifah, Elmiawati; Rohmayanti, Rohmayanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Fruit of kepel known contain of saponin and flavonoid, fruit of kepel is a plant that hasantibacterial and antiinflamation activity. This research purposed for made juice of fruit kepeland test of open wound healing process activity. Juice of fruit kepel is made with variety ofconcentration, which 20%, 40%, 60%, and 80%. Negative control used aquadest and positivecontrol used BetadineÂ® (Povidon Iodine). This type of research is experimental research,procedure start from the preparation of test materials, first identifying plants, then make fruitjuice of kepel and divide into several concentration, followed by grouping into six group of testanimals. All quantitative data were statistically analyzed using Anaylsis of Variance (Anova)and continued with Tukey Test, The lowest activity on the negative control and increase on thegroup of juice with concentration 20%, 40%, 80%, and 60%, higher activity on the positivecontrol. With wound healing broad parameters result that the group fruit juice of kepelconcentration 60% and 80% showed the statistically analyzed was more significant (p<0.05) 178 PharmaÒ«iana, Vol. 4, No. 2, 2014: 177-183than the negative control. So it can be taken conclusion that fruit juice of kepel concentration60% and 80% having wound healing activity.

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

High Performance Liquid Chromatography (HPLC) was one of analytical methodscommonly used to determine the concentration of epigallocatechin gallate (EGCG) on green teaextract. The method must be validated in order to fit to its purpose. The aim of this research was toprove that the used method has selectifity, liniearity, precise, accurate and know limit of detection(LOD) and limit of quantification (LOQ) is acceptable. The selectivity of analytical method wasdetermined by calculating the resolution value between two peak. Data from 10 Î¼g/mL and100 Î¼g/mL with 5 replicates would give precition and accuration. Precition was known from CV value and accuration was known from recovery value in each concentration. Liniearity was knownfrom regression linear between concentration and wide area of peak. From regresion linear couldcalculate LOD and LOQ. Research show that method of analyse have selectificity withRs= 2.27>1.5; liniearity with r= 0.99; precision with CV 8.74% at concentration 200 Âµg/mL and3.74% at concentration 500 Âµg/mL; accuration with recovery 99.76% at concentration 200 Âµg/mLand 100.52% at concentration 500 Âµg/mL and the value of LOD is 33.28 Î¼g/mL and LOQ is110.93 Î¼g/mL.

PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA Witasari, Hardi Astuti; Pinzon, Rizaldy Taslim; Kristin, Erna
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The secondary prevention of ischemic stroke can be implemented by giving aspirin.However, some cases of aspirin resistance have been found. The purpose of this study was toexamine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic strokepatients at Bethesda Hospital Yogyakarta. This study was using a nested case-control studydesign. The Cases group was subjects who resistance to aspirin therapy. The control group wassubjects who response to aspirin therapy. The factors that affect the incidence of aspirinresistance were analyzed by bivariate analysis chi square test. The proportion of diabetesmellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at BethesdaHospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirinresistance than the patients without diabetes mellitus.

PENGEMBANGAN POTENSI EKSTRAK DAUN PANDAN (Pandanus amaryllifolius Roxb) SEBAGAI AGEN ANTIBAKTERI Mardiyaningsih, Ana; Aini, Resmi
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pandanus amayllifolius Roxb which commonly used as a flavoring and food coloring waspotentially have antibacterial activity. It should be an effort to develop a safe naturalpreservatives to reduce cases of food poisoning (foodborne disease) which mainly caused bybacterial pathogens. This study aims to determine the antibacterial potency of the water extract,ethanol, ethyl acetate, and a mixture of ethanol-ethyl acetate (1:1 v/v) extract againstStaphylococcus aureus and Escherichia coli based on the value of MIC (Minimum InhibitoryConcentration) and MBC (Minimum Batericidal Activity). The antibacterial activity wasevaluated by the Kirby-Bauer diffusion method by making the extract concentration of 25 and50 %, as well as the loading dose tested was 2.5 mg and 5 mg/disc. MIC and MBC wasevaluated by solid dilution method. The results showed that the ethanol extract and water extractdonât have antibacterial activity against Staphylococcus aureus and Escherichia coli, whereasthe ethyl acetate extract and a mixture of ethanol-ethyl acetate (1:1 v/v) have an antibacterialactivity. Ethyl acetate extract showed the highest inhibitory potency. The MIC and MBC was 186 PharmaÒ«iana, Vol. 4, No. 2, 2014: 185-192obtained at a level of 1.1% w/v and 6.7% w/v against Staphylococcus aureus, and 0.5% w/v and4.5% w/v against Escherichia coli.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Home Page

OAI Link

Editorial Team

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA