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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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AKTIVITAS ANTIOKSIDAN EKSTRAK Andrographis paniculata (Burm.f.) Ness DENGAN DUA PERBEDAAN PENGUAPAN Rais, Ichwan Ridwan
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Andrographis paniculata (Burm.f.) Ness is one of the native tradisional medicine in Indonesia which contain active flavonoid. It has potential activity as antioxidant, antibacterial, and inflammation. Antioxidant sensitive to light and heat. Flavonoid antioxidant activity could be decline by heat and oxidation. We can find these caution while evaporate the liquid solvent with heating in conventional evaporation to get dry extract. One of the conventional evaporation instrument is Rotary Evaporator. Other evaporation system, lyophillization is alternative to evaporate solvent without heat. This system uses instrument called Freeze Dryer. Present study about antioxidant activity influenced by two different evaporation using IC50 determination in DPPH oxidation proved that evaporation difference could change antioxidant ability. The result shows freeze dryer evaporation result with 17.06% of extract yield and 585.730 Âµg/mL IC50 value better than rotary evaporator with 24.96% of extract yield and 792.196 Âµg/mL IC50 value in solvent evaporate ability and antioxidant activity.

UJI AKTIVITAS KOMBINASI EKSTRAK AIR LIDAH BUAYA ( Aloe vera L.) DAN AKAR MANIS (Glycyrrhiza glabra L.) SEBAGAI PENYUBUR RAMBUT Indriaty, Sulistiorini; Indrawati, Teti; Taurhesia, Shelly
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aloe vera (Aloe vera L.) contains amino acids, vitamins, folic acid, and liquorice (Glycyrrhiza glabra L) containing glisirizin, and flavonoids, which have properties as fertilizer hair. This study aims to obtain a combination of extracts with activity most optimal fertilizer hair, made 3 combination with a combination of 1 (the water extract of liquorice concentration of 2.5% and 7.5% aloe vera), a combination of 2 (the water extract of liquorice concentrations of 2, 5% and 2.5% aloe vera), and combinations of 3 (the water extract of liquorice concentration of 5% and 7.5% aloe vera). Testing the activity of hair growth is done by measuring the rate of hair growth, hair growth acceleration and weight of rabbit hair for 28 days. Rabbit hair growth results showed the combination 1 has an average length of the largest hair with hair growth rate value of 2.97 cm, accelerated hair growth amounted to 0.15 cm / day on day 7 and weighing 0.13 gram hair.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP AKTIVITAS ANALGESIK DAN ANTIINFLAMASI MELALUI EKSPRESI ENZIM SIKLOOKSIGENASE Sulistyawati, Rini; Pratiwi, Pramita Yulli
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kelor (Moringa oleifera L.) contains flavonoid as a major of bioactive constituent. Quercetin as a flvonoid group inhibits COX-2 in inflammatory process. This study aimed to determine the effect of etanol extract of the kelor leaves on the analgesics and antiiinflamatory in mice. Etanol extract of the kelor leaves were evaluated for analgesics activity through writhing assay test at doses of 12.5; 25 and 50 mg/kgBW using Â Swiss albino mice. On the other hand antiinflammatory assay was performed by carrageenan induced paw edema of the etanol extract of the kelor leaves at 35; 70 and 140 mg/kgBW. Aspirin and sodiumdiclofenac were employeed as a standard for analgesic and antiinflammatory studies respectively. The result of the analysis show that etanol extract of the kelor leaves at doses 25 and 50 mg/kgBW decrease the number of writhing so that it have an analgesic power of 76.41Â±2.73% and 80.41Â±5.20%. Etanol extract of the kelor leaves at dosage 140 mg/kgBW show 24.30Â±2.960% antiinflammatory power and 46.37Â±6.434% on decreased COX-2 expression.

STUDI KINETIKA ADSORPSI Al-MCM 41 TERHADAP METILEN BIRU Ahda, Mustofa; Sutarno, Sutarno; Kunarti, Eko Sri
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The synthesis and kinetics studies of Al-MCM 41 of the methylene blue adsorption have been done. The observations of the adsorption kinetics are very important parameter in the adsorption process. This is the higher of adsorption kinetics tend to faster adsorption process. The results of characterization of Al-MCM 41 have a wall thickness is 15.173 Ã, Pore Volume Pore is 0.584 cm3/g, Pore Diameter is 30.446 Ã, Surface Area is 995.513 m2/g. The results of the adsorption kinetics of Al-MCM 41 toÂ methylene blue adsorption follows pseudo second order with coefficient of determination (r2) value of 0.999 and the value of adsorption rate constant of Al-MCM 41 is 10-2 g.mg-1.min-1.

PENGARUH PEMBERIAN EKSTRAK ETANOL DAN KLOROFORM DAUN SIRSAK TERHADAP KOLESTEROL TOTAL DAN TRIGLISERIDA PADA TIKUS YANG DIINDUKSI ALOKSAN Firmansyah, Deni; Bachri, Moch Saiful; Nurkhasanah, Nurkhasanah
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Annona muricata plant is a medicinal plant using by research and drug for human healthy including diabetes mellitus. This research aimed to determine the effect of ethanol extract and chloroform extract of the sirsak leaf as antidiabetes mellitus. This research was conducted in 9 groups of male Wistar rats consisting of 5 rats per group, consisting of normal control, alloxan control, glibenclamide control dose of 10 mg/Kg BW, group of ethanol extract sirsak leaf dose of 50 mg/Kg BW; 100 mg/Kg BW; 200 mg/Kg BW, and group of chloroform extract sirsak leaf dose of 50 mg/kg BW; 100 mg/Kg BW; 250 mg/Kg BW. Tests carried out for 2 weeks. It also conducted assays of total flavonoids and histopathological tests of pancreatic Î² cells. Results of this research showed that the ethanol extract ofÂ sirsak leaves dose of 200 mg/Kg BW has activity in decreasing blood glucose levels better than any other group. Results of the ethanol extract and chloroform extract all doses except the ethanol extract treatment group dose of 200 mg/kg BW and 100 mg/kg BW after a 14-day look is still high triglyceride levels and decrease in total cholesterol (TC) were seen in all group Ethanol extract dose of 200 mg / kgBWÂ has a good potential to reduce levels of triglycerides and total cholesterol. The conclusion of this research is the ethanol extract of sirsak leaf have activity antidiabetic mellitusand decreased total cholesterol.Â

PENGARUH PEMBERIAN KOMBINASI FRAKSI ETIL ASETAT AKAR PASAK BUMI DAN DOXORUBICIN TERHADAP BERAT BADAN DAN JUMLAN NODUL TIKUS SPRAGUE DAWLEY BETINA YANG DIINDUKSI 7,12 DIMETILBENZ(Î±) ANTRASEN (DMBA) Nurani, Laela Hayu; Mursyidi, Achmad; Widyarini, Sitarina
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pasak Bumi roots contain quasinoid compounds that have carcinogenesis inhibitory, imunomudulator, antiulcer, and antimalaria effects. This study aims to determine the effect of a combination of ethyl acetate fraction of Pasak Bumi roots and doxorubicin on DMBA-induced white mice by weight and palpation observation. The mice were divided into 8 groups. Each group consisted of 7 female Sprague Dawley mice. Group 1 (normal) was only given food and drink, Group 2 was given fraction of ethyl acetate of Pasak Bumi roots (100 mg/kg body weight, Group 3 (positive control) was given doxorubicin (1.17 mg/kg body weight) 1 times a week for 5 weeks, Group 4 was given DMBA (20 mg/kg) two times a week for 5 weeks, Groups 5 was given DMBA (20 mg/kg) + doxorubicin (1.17 mg/kg), Group 6 was given DMBA (20 mg / kg) + ethyl acetate fractions of Pasak Bumi roots (100 mg / kg), Group 7 was given DMBA (20 mg / kg) + doxorubicin (1.17 mg / kg) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg) and Group 8 doxorubicin ( 1.17 mg / kg body weight) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg). Observations were made on the basis of body weight of mice and tumor incidence by palpation at week 6 of treatment. The result ofÂ this research shows that the administration of ethyl acetate fraction of Pasak Bumi roots and doxorubicin combination can increase body weight of the mice and decrease the number of tumors compared to single doxorubicin.

EFEKTIFITAS PEMBERIAN PROBIOTIK TERHADAP DURASI DIARE ANAK DI RUMAH SAKIT PKU MUHAMMADIYAH BANTUL YOGYAKARTA Mulyani, Sri; Perwitasari, Dyah Aryani; Umam, Nurcholid
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diarrhea is the second leading cause of childrenâs death worldwide, including in Indonesia.With regard to reducing the number of death, it is highly needed to provide a quick and accurate treatment. In clinical practice, prebiotics has been widely used as a treatment, particularly in the case of acute diarrhea in children. However, it is still not recommended by WHO. This study is aimed to determine the treatment pattern of diarrhea in childrenâs ward at PKU Muhammadiyah Bantul Hospital and determine whether probiotic supplementation on standard therapy results a decrease in the duration of diarrhea which is better than only the standard therapy in the management of acute diarrhea in children. This study used retrospective cohort design using data from medical records with diagnose acute diarrhea or acute gastroenteritis (ICD A09). The data was collected from January to December 2014, at childrenâ2 ward, PKU Muhammadiyah Bantul Hospital, Yogyakarta. Data was divided into three groups: (i) Group I those who were treated by using standard therapeutic with rehydration and zinc, (ii). Group II those who were treated by combination of rehydration, zinc and probiotics, (iii) Group III those who were treated with rehydration and probiotics. Data duration of diarrhea as an outcome of the effectiveness of probiotics analyzed statistically to determine differences in outcomes between groups. Among the three groups, Group I, Group II and group III gained an average duration of diarrhea 66.33 (SD 21.66) hours, 55.32 (SD 19.07) hours and 54.79 (SD 17.69) hours, respectively. The statistical test shows that there is significant different from diarrhea duration among the three groups (p = 0.014). The test results between probiotic groups (II and III) and the control group is significantly different with p-value 0.018 and 0.011, respectively. While the group II and group III do not differ significantly (p = 0.898). Treatment pattern therapy of diarrhea in PKU Muhammadiyah Bantul Hospital divided into three kinds of therapy. The first is rehydration therapy and zinc supplementation, the second is rehydration therapy and zinc supplementation and probiotics, the third is rehydration therapy and probiotics. Probiotic supplementation is proven effective in reducing the duration of diarrhea significantly compared to patients who were received standard therapy.

AKTIVITAS ANTIFUNGI EKSTRAK DAUN BELUNTAS, JAWER KOTOK, DAN SIRIH SERTA KOMBINASINYA TERHADAP Candida albicans Yuniarni, Umi; Lukmayani, Yani
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piper betle, Coleus scutellarioides and Pluchea indica have been used empirically to overcome vaginal discharge and scientifically proven to inhibit the growth of Candida albicans. The goal of this research was to search for a combined extract with effective antimicrobial activity against Candida albicans. Single extract,combination of two and three extracts evaluated antimicrobial activity against Candida albicans using agar diffusion method. Inhibitory effect of Piper betle showed the greatest activity against Candida albicans compared to other single extract. Combination of Piper betle and Pluchea indica (26.57Â±0.56 mm) gave greater inhibition than two otherÂ combination extracts (Piper betle and Coleus scutellarioides (25.17Â±0.96 mm); Coleus scutellarioides and Pluchea indica (22.73Â±0.95 mm).The combination of Piper betle, Pluchea indica and Coleus scutellarioides gave inhibition of 27.53Â±1.10 mm. extracts did not give a better diameter compared to the betle extract.

Effect of Sargassum polycystum extract on liver and kidney of diabetic rats Firdaus, Muhamad; Chamidah, Anies; Nurcholis, Annafi Riski; Yulaikah, Siti; Anggraeni, Pangestuty Yeni; Suryanata, Widya Adi; Alghafihqi, Denny; Hardiansyah, Rendi
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hyperglycemia has been known able to incuce the free radical formation. The reactivity of free radical can affect the dysfunction and structural adjustment on liver and kidney of the diabetic. Polyphenol is bioactive that able to ameliorate the reactivity of free radical. This substance is also contained in brown seaweed.One of brown seaweeds that found on the Indonesia waters is Sargassum polycystum. The objective of this study was to evaluate the S. polycystum extract (SPE) to reduce the damage of the function and structure of liver and kidney in diabetic rats. SPE was obtained by drying, milling, extraction by methanol, concentrating, degassing by nitrogen gas, and finally freeze-drying, respectively. The male of rat strain Wistar was induced to diabetic by streptozotocin. This study was divided into four groups, i.e., normal, diabetic, diabetic + gliclazide and diabetic + SPE, respectively. The treatments of this experiment were executed for 45 days. The polyphenol content, malondialdehyde level, SGPT and SGOT levels, and creatinine levels were measured by the spectrophotometer, the blood glucose level was quantified by glucometer, and the insulin content was determined by ELISA method. The altering of the tissue structure was analyzed by staining method of hematoxylin and eosin. The result showed that the treatment of SPE on diabetic rats able to reduce the blood glucose level, malondialdehyde level of liver, and kidney,Â SGPT and SGOT level of liver, creatinine level of blood, and increase of insulin level and improve the liver, and kidney tissue profiles, respectively. These results indicate that SPE can reduce the destruction of structure and function on liver and kidney of the diabetics.Â

Effect of nitrogen fertilizer to the flavonoid content of red amaranth (Amaranthus gangeticus L.) Pratiwi, Ambar
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACT Red amaranth (Amaranthus gangeticus L.) is a vegetable that has been frequently consumed. The red color in red spinach leaves due to the anthocyanin that is included in the flavonoid compounds. Flavonoid compounds are very usefull to the health, such as antioxidant, anticancer and antibacterial. Biosynthesis of flavonoids in the plant is influenced by environmental factors, one of which is a nutrient that is nitrogen. This study aimed to determine the effect of nitrogen fertilizer on the content of flavonoids in Red amaranth leaves. The results of this study are expected to provide information to the public about the optimal nitrogen fertilizer to increase the levels of flavonoids in Red amaranth leaves. In this research, red amaranth seed planting with the addition of nitrogen fertilizers of different concentrations (0%, 2%, 4%, 6%, 8% and 10%) from week 1 through week 5. The leaves are harvested to extract and analyze the content of flavonoids. The parameters measured were the growth of a Red amaranth plant height, number of leaves and leaf width; and levels of flavonoids with aluminum chloride method. The results showed that nitrogen fertilizer application significantly increases the growth and flavonoids in Red amaranth.Keywords: red amaranth, nitrogen fertilizer, flavonoid.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Daerah istimewa yogyakarta

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