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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Uji sifat fisik repelan minyak atsiri kombinasi rimpang temulawak dan rimpang jahe basis cold cream fatima, fatma; Widyaningsih, Wahyu; Ikhsanudin, Azis
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Rimpang jahe (Zingiber officinale Roxb. Rhizome) dan rimpang temulawak (Curcuma xanthorrhiza roxb. Rhizome) memiliki kandungan minyak atsiri yang dapat berfungsi sebagai repelan. Guna mengatasi mahalnya rimpang jahe dan sifat iritatif minyak atsiri rimpang jahe, maka dikombinasikan dengan minyak atsiri rimpang temulawak. Basis cold cream memiliki fase minyak yang lebih banyak yang dapat meningkatkan kemampuan pengikatan minyak atsiri. Adanya basis tersebut diharapkan dapat meningkatkan efek repelan. Oleh karenanya, terkait efek repelan perlu dilakukan uji sifat fisik minyak atsiri untuk memastikan kemurnian dan mutunya, kemudian sebelum dilakukan uji efek repelan, perlu dilakukan uji sifat fisik sediaan repelan untuk memperoleh formula terbaik, yaitu formula yang dapat dioleskan dengan mudah dan nyaman jika digunakan.Â Â Â Â Â Â Â Â Â Â Â Minyak atsiri rimpang temulawak dan rimpang jahe diisolasi dengan metode destilasi uap dan air dan diuji sifat fisiknya, yang terdiri dari uji organolepstis, indeks bias dan berat jenis. Repelan dibuat dalam berbagai konsentrasi 2% v/b, 5% v/b, 10% v/b, 15% v/b, 20% v/b, dan 25% v/b, kemudian dilakukan uji daya sebar, daya lekat, dan viskositasÂ Â Â Â Â Â Â Â Â Â Â Berdasar hasil uji sifat fisik, minyak atsiri rimpang temulawak dan minyak atisri rimpang jahe telah terbukti kemurniannya. Semakin besar konsentrasi miyak atsiri kombinasi rimpang temulawak dan rimpang jahe pada sediaan repelan dengan basis cold cream, semakin kecil viskositasnya, sehingga daya lekat semakin kecil namun daya sebar semakin besar. Berdasar hasil tersebut, konsentrasi 25% Â b/v s(konsentrasi terbesar) adalah sediaan repelan yang paling baik karena paling lunak sehingga mudah diambil, dioleskan karena konsistensinya tidak keras dan paling mudah untuk dibersihkan dengan air

Studi pharmacovigilance obat di puskesmas X Yogyakarta muthaharah, mustika; Perwitasari, Dyah Aryani; Kertia, Nyoman
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTÂ The increasingÂ use of herbal medicine in community also increase adverse event and toxicity report. Adverse events and toxicity can be detected with pharmacovigilance system. Adverse Drug Reaction (ADR) of herbal medicines are rarely studied in Indonesia. With the increasing use of herbal medicines in Indonesia, pharmacovigilance studies are necessary to detect the incidence of ADR. The purpose of this study is to describe the incidence of ADR on the use of herbal medicines. This research is a descriptive study using retrospective data. Research was conducted for 3 months by taking 10-month retrospective data backward using medical record. Interviews were conducted to identify the occurrence of ADR and assessment of quality of life using Naranjo algorithm.The result showed that three (13.63%) of 22 patients experiencing the ADR with probability of probable categories (1) and possible (2). The symptom of ADR that showed was the increased frequency of defecation, decreased in stool consistence and diuresis.The results of this study concluded that there are ADR event in patients who have been prescribed herbal medicine in Public Health Center X Yogyakarta.Â Keywords: ADR, herbal medicine, pharmacovigilance.

Pakan banyu (Croton argyratus Blume) stembark ethanol extract effectiveness to total spermatogenic cells of white male rats (Rattus norvegicus) cahaya, Noor; Sholihin, M. Aditya; Nurlely, Nurlely
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Stembark of Pakan Banyu (Croton argyratus Blume) empirically used as traditional contraception. The stembark contained active substances as steroids, saponins and alkaloids tannins alleged antifertillity for men. The purpose of this study was to demonstrate the potential of Pakan Banyu stembark ethanol extract to the total number of spermatogonium cells, primary spermatocytes, spermatids and spermatozoa in male rats. This study was an experimental research design posttest only control group design using 20 male rats into 4 groups of 5 mice. The control rats were used in treatment group, the rats were given the pakan banyu stembark extract at a dose of 100, 200 and 500 mg / kg with 0.5% CMC Na suspending agent. The treatment was given orally for 15 days at the 16th days surgery was done to the testicles organs, then microanatomy preparations were made using paraffin method and using HE colour. Analysis of data using One-way ANOVA and Kruskal Wallis with 95% confidence level. The results showed that there is no effect of Pakan Banyu stembark ethanol extract against spermatogonium cells, primary spermatocytes, spermatids and spermatozoa.Â

Proporsi peresepan probiotik pada gastroenteritis akut pasien pediatri di bangsal rawat inap RS X pada Februari 2015 Virginia, Dita Maria
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pediatric patients are one of the target groups of the National Health System in Indonesia that requires special attention in therapy because their anatomy physiology was immature. A lot of probiotics indicated for acute gastroenteritis (AGE) for pediatric patients. Probiotic prescribing includes the types of probiotic, dosage and duration for AGE has not been discussed clearly. The aim of our study was to determine the proportion of probiotic that have prescribed for acute gastroenteritis topediatric agedin hospitalized. This study was analytical observational with cross sectional design. Data was obtained retrospectively with non-purposive sampling.Samplesize was based on cross-sectional design calculation and obtained a number of 200 medical records from Hospital X, IndonesiaonFebruary 2015. This study used secondary data from medical records. Data collected was patient identity, patientaged, probiotic prescribing includes the types of probiotic, dosage and duration. Data have been analyzed in descriptive and Mann-Whitney to observe the difference between types of probiotic, dosage and duration probiotic used topediatric aged. This study showed this hospital only used 5 probiotic brands. Group aged <2 years is more used of 3 types of probiotic species while at the age of> 2 years is prefer to use 6 types. The mean dose of probiotic is greater in the group aged >2 years. Probiotic duration in the group <2 years is for 4 days while in those aged >2 years in duration 5 days. The number of cases that do not fit with the recommended dose packs is more commonly found at age <2 years. There is a different proportion between type of probiotic (p=0.000), dose of probiotic (p=0.040), and probiotic duration (p=0.008) with pediatric aged. There was a statistically significant difference between types of probiotic, dosage and duration probiotic used to pediatric aged.

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability Lestari, Pramulani Mulya; Yati, Kori; Savira, Nanda
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.

The relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 diabetes mellitus at Ulin Regional Public Hospital, Banjarmasin Mulyani, Risya; Hartanto, Dedi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diabetes melitus dapat menimbulkan masalah yang signifikan terhadap kualitas hidup melalui peningkatan risiko terjadinya berbagai komplikasi. Ketidakpuasan terhadap terapi juga ikut berkontribusi terhadap rendahnya efektifitas terapi. Kepuasan terapi memiliki peranan penting dalam pengelolaan DM yaitu untuk mengoptimalkan efektifitas terapi dan diyakini akan memberikan pengaruh terhadap pengambilan keputusan untuk pasien yang berhubungan dengan kesehatannya. Penilaian rutin kepuasan terapi pada pasien DM berguna bagi profesional kesehatan untuk mengidentifikasi masalah potensial yang dialami pasien dengan pengobatan DM yang sedang dijalaninya. Penelitian ini bertujuan untuk mengetahui hubungan kepuasan terapi berbasis insulin dengan efektifitas terapi pada pasien DM tipe 2 di RSUD Ulin Banjarmasin.PenelitianÂ ini merupakan jenis penelitian non eksperimental dengan rancangan penelitian cross sectional. pengambilan data dilakukan secara prospektif dengan melakukan purposive sampling pasien DM tipe 2 di Instalasi Farmasi RSUD Ulin Banjarmasin. Data kepuasan terapi diperoleh dengan kuesioner PSIT dan efektifitas terapi diperoleh melalui pemeriksaaan nilai HbA1c. Kuesioner diisi oleh subyek penelitian sebanyak 56 responden kemudian dianalisis menggunakan analisis bivariat yaitu uji chi-square.Hasil penelitian menunjukkan bahwa tingkat kepuasan cara terapi responden ada pada tingkat kepuasan sedang yaitu 33 orang (58,9%). Selain itu responden dengan efektifitas terapi baik (<6,5%) hanya 3,6% sedangkan yang lain 96,4% dianggap efektifitas terapinya belum terkontrol dengan baik. Terdapat hubungan yang positif dan signifikan antara kepuasan terapi dengan nilai HbA1c (r=0828 ; p<0,05). Ada hubungan yang positif dan signifikan antara kepuasan terapi berbasis insulin dengan efektifitas terapi pada pasien DM tipe 2 di Instalasi Farmasi RSUD Ulin Banjarmasin

Analisis faktor-faktor yang mempengaruhi pilihan karir mahasiswa farmasi di Universitas Andalas Pratiwi, Erniza; Putra, Deddi Prima; Syahrul, Laura
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Scope of pharmacy practices as well as the role of pharmacist have been improving recently. Pharmacists have responsibility for doing the pharmacy practices, including pharmacist it self and also the technicians. According to PP 51 of the year 2009 it was known that pharmaceutical practices have vary of choice of carreer-field. This present study was a descriptive study which was conducted by survey method using stratified random sampling. The respondents of this study were 1st, 2nd, 3rd and 4th grade students from Faculty of Pharmacy, Andalas University. The result showed that, in term of the profile of respondent, it was known that most of the students chose to work at industry of pharmacy of 48.2%, followed by hospital ofÂ 35.3%, University/Research Institute of 4.7%, pharmacy of 3.5%, pharmacy retail of 2.4% and others career-field (such as BPOM, civil servant at ministry of health and enterpreneur) up to 5.9%. Based on descriptive analysis, it was described that field of work was the most important criteria of affecting factors for pharmacy student in choosing their future career. The others important criterias those also afforded as the affecting factors were geographis, payment/income, flexibility of work-schedule, possibility of career-development and benefit, successively. As for result of independent sample t-test in term of gender, both of men and women chose same three main affecting factors in choosing career-field (including field of work, geographis as well as payment/income). The different result showed for 4th, 5th and 6th factors.

Effectiveness of web based educational on improving knowledge of acne vulgaris self medication among senior high school students Lolita, Lolita; Meita Putri, Ni Putu Isabela
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The presence of technology canÂ provide realÂ alternativesÂ to build knowledge in delivering health education materials. The aim of this study was to investigate if web-based education methods may rising a studentâs knowledge about self medication of acne. This research using an experimental pretest-posttest control group design while the sampling technique using convenience nonprobability sampling. Inclusion criteria for participants were senior high school students aged 13-19 years, active social media users, and willing to fill out the research questionnaire. Participants were allocated to the exclusion criteria as students who perform routine skin care in the acne treatment. Control group consisted of 62 respondents who were given face to face education and treatment group consisted of 62 respondents who were given website-based education. Data analysis were performed with a student t-test to assess the effect of educational intervention on studentâs knowledge. The independent t-test showed there was a significant increase of knowledge between the control and the treatment groupsÂ Â (p = 0,000) with 95% confidence level. This study demonstrate that web-based educational intervention had a significant increase on the studentâs knowledge about acne vulgaris self medication.

Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) Rahmawati, Indah Fortuna; Pribadi, Prasojo; Hidayat, Imron Wahyu
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The purpose of this research are to find out whether the formulation of effervescent granules from binahong leaves extract has met the standards for effervescent granules and determine the best formulation of effervescent granules. This research is descriptive experimental with data collection from evaluation of effervescent granules. To be able to make effervescent granules, extraction of binahong leaves must be made first. The extracts resulted from a maseration method with 70% ethanol. The effervescent granules formulation were made by 3 design based on their concentration F1 7.4%; F2 14.8%; and F3 22.2%. Effervescent granules of binahong leaves extract are prepared by using wet granulation method. Several physical tests were carried out on the results of effervescent granules of binahong leaves, including organoleptic test, moisture content test, pour volume test, volume of shringkage test, flow capacity test, dispersion test, and pH. The test results showed that all the effervescent granules of binahong leaves (Anredera cordifolia (Tenore) Steen.) have met the standard requirements as good granules. The third formula became the best formulation, With the best value in moisture content test, volume of shringkage test, flow capacity test, and pH.

Clearance profile of radioactive gold nanoparticle (198Au) conjugates-poliamidoamin generation 4-nimotuzumab ; potential radio-pharmaceutical theranostic agent Halid, Nurhatidjah Awaliyah; Mutalib, Abdul; Pujiyanto, Anung; Gunawan, Adang Hardi
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter Î² (961 keV) capable for killing cancer cells and (412 keV) Î³ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA