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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Sah Putra, Suyandra; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used Â was divided into groups (n=6) including normal groups, positive control, negatif control, and Â groups were treated byÂ khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freundâs Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.

UJI SITOTOKSISITAS DAN ANTIPROLIFERATIF FRAKSI ETIL ASETAT EKSTRAK ETANOL BIJI JINTEN HITAM (Nigella sativa, Lour) TERHADAP SEL MIELOMA Nurani, Laela Hayu
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cancer is the formation of new tissue which is abnormal and malignant. A groupof cells suddenly become disorganized and reduplicate themselves rigorously(hyperproliferation). Nigella sativa L. is one of the herbs which have an anticancereffect. This research aims to assess the cytotoxic and antiproliferative effect of Nigellasativa L. ethanol extract of Myeloma cells. Ethanolic extract was produced fromNigella sativa L. powder with maseration method. The cytotoxicity test was done byincubating Myeloma cells with the treatment concentration group of N. sativa L. ethylacetic fraction of ethanolic extract 2000; 1000; 500; 250; and 62,5 Âµg/ml, respectively.The test was done with an MTT method and then with a calculation of its deathpercentage. The LC50 is calculated using a probit analysis method. The test was thencontinued with the antiproliferative test to assess the doubling time at treatmentconcentration 125; 62,5 Âµg/ml and cellular control at hours 24, 48, and 72. The resultsshowed that Nigella sativa L. ethanolic extract had cytotoxic activity towards theMieloma cells with an LC50 value 177,01 Âµg/ml. The antiproliferative test showed thatthere was a growth inhibition, even cell death at the extract treatments. The doublingtime was 253 hours at 62,5 Âµg/ml concentration, 298,4 hours at 125 ug/ml, while thecell control had 54,52 hours.

SINTESIS 4âHIDROKSIâ3âKLOROBENZALDEHID DARI pâHIDROKSIBENZALDEHID DAN GAS Cl2 Warsi, Warsi
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcumin is a compound which potential to be developed. The curcumin analogues havebeen synthesized. The compound 3âchloroâ4âhydroxybenzaldehyde was used as starting material inthe synthesis of curcumin analogues with Cl substituent on the aromatic ring. The compound of3âchloroâ4âhydroxybenzaldehyde were synthesized by chlorination reaction betweenpâhydroxybenzaldehyde and Cl2 gas. The purity of 3âchloroâ4âhydroxybenzaldehyde wasdetermined base on the melting range, thin layer chromatography and LCâMS. The structureidentification of the compound was observed done by spectrometry techniques, including massspectra (ESIâMS), infrared spectra (cm-1, KBr), Nuclear Magnetic resonance proton spectra (Î´, ppm,DMSO-d6, 1HâNMR, 500 MHz) and UVâVis spectra. Chlorination reaction ofpâhydroxybenzaldehyde produced yellow crystal of 3âchloroâ4âhydroxybenzaldehyde, its meltingrange is 128.1 to 130.8ÂºC. The average yield obtained of this reseach is 51.37%.

EFEK LIKOPEN TERHADAP GAMBARAN MIKROSKOPIK LIMPA TIKUS BETINA SPRAGUE DAWLEY Yuliani, Sapto
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Carotenoid compound, include licopene and lutein, has ability to increaseimmune system. One of organs included in immune system is spleen. The objective of thestudy is to observe the effect of licopene to the histopathologic appearance of ratspleen. Twenty female Sprague Dawley rat, 1 month old, 100 grams of weight devideinto 4 groups. The first group got licopene dosage 3 ug/kg of body weight, the secondgroup got licopene dosage 6 ug/kg of body weight, the third group got corn oil (vehiclecontrol) and the fourth group got aquadest. The treatment were given during 17 days,orally. At the day 14, the first, second and third groups were injected by aloxansubcutaneuslly. Three days after injection of aloxan, all of rats were sacrified, spleenwere taken in order to histopathological examination. Histopathologic appearances ofspleen were analized descriptivelly. The result showed that licopene dosage 6 ug/kg ofbody weigh able to increase centrum germinativum formation of spleen white pulp morethan licopene dosage 3 ug/kg of body weight. Base on the result can be concluded thatlicopene administration can increase centrum germinativum formation of spleen whitepulp.

OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Sugihartini, Nining
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Octyl methoxycinnamate is an active ingredient in sunscreen that will bedegradated after exposure by sunlight. On the other hand, antioxidants have potentialcapability as photoprotector which in this study is used the ethanol fraction of leaf ofPlantago major, L to support activity of OMS. In addition, rice flour is added toobecause it has the ability to reflect sunlight. The aim of this study is to obtain theoptimum composition of them, based on the effectivity of OMS. This study used threeformulas based on the simplex lattice design method with a comparison of octylmethoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%:50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the valueof % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed toget the optimum composition which has the highest of response. The results showed that100% rice flour was the optimum addition to support activity of OMS as sunscreen withdecreasing of % erythema transmission and pigmentation was 200%, 75%,respectively.

PENGEMBANGAN PREPARASI NANOPARTIKEL THYMOQUINONE-KITOSAN DENGAN METODE KOSOLVEN MENGGUNAKAN ISOPROPIL ALKOHOL Binarjo, Annas; Yuwono, Tedjo; Priyanti, Renny
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Thymoquinone, an active compound isolated from black cumin seeds (Nigella sativa L.), has pharmacological activity as anticancer, antiinflammatory, and immunomodulator. This compound has a volatile nature, easily oxidized, and low melting point, leading to difficulties in tablet formulation. Moreover, its low solubility in water leading to low bioavailability. Therefore, it is necessary to develop nanoparticle drug delivery systems to solve these problems. Chitosan-thymoquinone nanoparticles can be formed using sodium tripolyphosphate as cross linker by cosolven method. Chitosan solution in acetate buffer pH 4 was added to thymoquinone solution in 50%, 75%, 100% isopropyl alcohol, than sodium tripoliphosphate solution in water was added slowly in a gently stirrer.Â The nanoparticle produced was characterized in its loading capacity (LC), particle morphology, particle size, and zeta potential, as well as the loading efficiency (LE) of nanoparticle. Factorial Design Optimization resulted that the best condistion is achieved by 75% isopropyl alcohol using thymoquinone level of 10 mg/mL and chitosan level of 10 mg/mL. In this condition, the nanoparticle has LC of 8.71%, LE of 76.29%, 609.8 nm in diameter and zeta potential of 137.9 mV. It can be concluded that isopropyl alcohol can help the formation of nanoparticles thymoquinone. The particle size and zeta potential is too big, therefore it is craved to modify the process by variation in thymoquinone, chitosan, and sodium tripoliphosphat concentration.

EFEK EKSTRAK ETANOL RIMPANG TEMUGIRING (Curcuma heyneana val) TERHADAP KADAR TRIGLISERIDA Widyaningsih, Wahyu
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The study of effect ethanolic extract Curcuma heyneana rhizoma as antihypertrigliseridaexamine of rats after given by dietary of high fat has been carried out.This experiment use 28 white male Wistar grooved rats with weight about 150-200gram body weight, at about 2 -3 months old. They were divided into seven grouprandomly and each group 4 rats. The first group was given by standart treatment ofdietary (BR II) and aquadest, the second group was given by dietary of high fatty andaquadest, the third group was given by CMC Na solution, the fourth was given bygemfibrosil in CMC Na suspension, the fifth group, the sixth group and the seventhwere orally given by of ethanolic extract with dose 10g/kgBW; 20 g/kgBW; and 40g/kgBW. Hyperlipidemia was treated with higth dietary fatty (5 gram fat cows and 10gram egg yolk) at the second period (two weeks). The treatment of ethanolic extractCurcuma heyneana rhizoma was given after hyperlipidemia. The trigliserida contentdetermined with GPO (Glycerol-3-Phosphate Oxidase) test. The trigliserida level inthe serum analyzed on the before treatment, during the treatment and after treatment.The result of the research showed that ethanolic extract Curcuma heyneana rhizoma 2weeks can decrease trigliserida level.

GAMBARAN JUMLAH SKS MATA KULIAH PERGURUAN TINGGI FARMASI INDONESIA YANG MENDUKUNG PENGGUNAAN OBAT YANG RASIONAL Ristiono, Hendy; Suryawati, Sri; Saleh Danu, Sulanto
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

According to World Â Health Organization (WHO), there are two major steps as a commitment to make changes in the implementation of pharmacy practice that are national drug policy and learning system changes in pharmacy education. The aim of the research was to obtain the cummulative credit overview in college of pharmacy in Indonesia that supporting Rational Drug Use based on promotion rational drug use (PRDU) and International network Â rational use of drug (INRUD). This study used a analytic descriptive design. The study was located in some colleges of pharmacy in Indonesia. Data was collected through observation of the recent curriculum used in the Indonesian college of pharmacy. Research were conducted by giving a questionnaire on the rational drug use topic in the curriculum and in-depth interviews with the dean or faculties appointed by the dean. The number of credits developed by 21 colleges of pharmacy as respondents have in between 140-158 credits. Median number of credits developed by C accreditation level are more than A and B accreditation level. Three ofÂ A accreditation level of colleges have number of credits in between 66-171 credits and a college with B accreditation level as much as 36.9 credits. Whereas in total of credits semester that support the RDU in Community and Clinical Pharmacy (CCP) interests has more than the non-CCP interests.

EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH Maysara, Risha; Yuliani, Sapto
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Liver is one of the most important organ for drug metabolism in the body. Thedamage to the liver can be marked by increased activity of the enzyme alanineaminotransferase (ALT) in the blood. Lycopene is an antioxidant that has the ability toeliminate free radicals and detoxifies electrophilic compounds that damage can beprevented. The purpose of this research is to know whether lycopene can inhibit theincrease alanine aminotransferase activity of SD (Sprague Dawley) rats induced byparasetamol. This experiment using 20 male rats Sprague Dawley. They were dividedinto 4 groups. Group I is a healthy control (baseline) was only given aquadest, group IIwere given paracetamol as pain control, group III and IV are treatment group wereeach given lycopene with a dosage 15 Âµg/kg BW and 30 Âµg/kg BW for 21 days. On 19thday group II, as well as all treatment groups induced paracetamol. The blood samplingwas performed on orbital sinus on 19th day (before induced by paracetamol) and on 21thday or two days after induced paracetamol to know the difference alanineaminotransferase activity. The data were analyzed using non-parametric statisticalmethods with Kruskal-Wallis test followed by Mann-Whitney test with 95% confidencelevel. The result has showed that the lycopene doses 15 Âµg/kgBW had alanineaminotransferase activity of 130.10 Â± 11.83 U/I and lycopene doses 30 Âµg/kgBW hadalanine aminotransferase activity of 106.46 Â± 2.36 U/I. If compared with paracetamolcontrol had alanine aminotransferase activity of 92.53 Â± 2.57 U/I, should take asummary that the lycopene doses 15 Ã¬g/kg BW and 30 Ã¬g/kg BW couldnât decreasealanine aminotransferase activity on SD (Sprague Dawley) male rats.

STABILITAS KONSENTRASI GLUKOSA DARAH SIMPAN JANGKA PENDEK DALAM TABUNG BERTEKNOLOGI PEMISAH JELl Furqon, Ayi; Nurmukhlis, Hilman; Kasiman, Sussylawati
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

SerumÂ glucoseÂ levelÂ isÂ screeningÂ forÂ diabeticÂ patients.Â PreanaliticalÂ factorsÂ suchÂ asÂ sample preparationÂ andÂ handlingÂ willÂ influenceÂ theÂ qualityÂ ofÂ finalÂ resultÂ ofÂ determination.Â GelÂ sparation technology used for faster sparation between plasmaÂ or serum andÂ blood cells. ThisÂ technology was applied in clinical laboratory technology in stead of public health laboratory. Requested test of glucose levelÂ determinationÂ isÂ higherÂ thenÂ otherÂ analytes. DirectÂ contactÂ ofÂ bloodÂ cellsÂ to serumÂ willÂ reduce availabilityÂ ofÂ glucoseÂ inÂ serumÂ due toÂ glycolysisÂ process asÂ wellÂ asÂ withoutÂ additionalÂ enzyme inhibitorsÂ such asÂ fluorideÂ andÂ withoutÂ separatingÂ cellsÂ fromÂ serumÂ immediately. Serum separating Tube (SST)contains gel and clot activators, it will work faster than plain tube does to become serum. MainÂ purposeÂ ofÂ research,howÂ stabilityÂ ofÂ glucoseÂ levelÂ betweenÂ SSTÂ tubeÂ andÂ plainÂ tube . Experimental stepsÂ Â are preparing freshÂ Â blood thatÂ Â isÂ collectedÂ Â from 16 volunteredÂ Â students, incorporating the glucose oxidase enzymatic assay and quality control. Test performed at immediately late 4 hours, and very late 12 haours. Statistical method for the time to time analysis, one way Anova isÂ used within significant level 0.05. From 16 serum (duplicates), glucose serum level was reduced earlyÂ at 4 -12 hours by 8,1Â mg/dlÂ (p-valueÂ =Â 0.013) andÂ 7,7Â mg/dlÂ (p-valueÂ 0.012).Â Percents increasesÂ of glucose level withinÂ plain tubeÂ 4 hours by 4,75% and within 12 hours by 13,12%. The increased serum glucoseÂ levelÂ in SSTÂ tube wereÂ atÂ earlyÂ 4 hours and 12 hoursby 4,33%Â and 12,29% respectively. Conclussion, glucose serum level is in steady at room temperature until 4 hours for both SST Tube as well as plain tube.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Daerah istimewa yogyakarta

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Home Page

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA