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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Tablet kunyah ekstrak etanol herba pegagan (Centella asiatica (L.), Urban) menurunkan kadar kreatinin tikus putih jantan (Rattus norvegicus L.) galur wistar yang diberi diet lemak tinggi Akrom, Dr., dr., M.Kes, Akrom; Prasetyawan, Nur
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

A chewable tablet dosage ethanol extract of herb gotu kola (TKEEHP) has developed. Research to determine the impact of TKEEHP on kidney function has been conducted. Gotu kola herb is one of the medicinal plants that allegedly serves as antioxidative nefroprotektor. The purpose of this study is to assess the effect of TKEEHP on the changes in serum levels of creatinine and urea of male Wistar rats that had been given a high-fat diet. The experimental research was conducted on 21 Wistar rats aged 2-3 months (150-200 g body weight). Rats were divided into seven groups. Group I (normal) was given normal diet. Group II, III, IV, V, VI, and VII were given a high fat diet for 5 weeks. In the week 5 and 6 group III (positive control) was given SimvastatinÂ®, group IV was given placebo tablets, and the group V, VI and VII were given 100, 200 and 300 mg / KgBW TKEEHP, respectively. At the end of week 6 rats have blood drawn through orbital sinus and then tested serum levels of creatinine and urea.Data examination of urea and creatinine serum levels were analyzed with ANOVA) and LSD with confience interval of 95%. The results showed TKEEHP reduce the levels of creatinine in male Wistar rats given a high fat diet, but did not affect serum urea levels. TKEEHP with the dose of 100 mg / KgBW, 200 mg / KgBW, and 300 mg / KgBW show potency to lower creatinine levels and decrease serum creatinine levels at the highest dose of 300 mg / KgBW.

The gastroprotective effects of canna edulis ker. tuber starch on peptic ulcer and the histopathological profile of rat stomach Najini, Robby; Bachri, Moch Saiful; Yuliani, Sapto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ganyong rhizome (Canna edulis Ker.) empirically use for treating gastritis (peptic ulcers). Ganyong rhizome contains carbohydrates and flavonoid that can reduce inflammation in the gastric tissues and againsts free radicals that are contributing to the pathogenesis of peptic ulcers. This research aims to know the gastroprotective effect of ganyong rhizome on white female rats, Wistar strain, which were given alcohol (ethanol 96%) by dose 1 ml/200gBB and measuring the total flavonoids content in ganyong rhizome. This research is Post Test Only Control Group Design, using 30 rats, weight 150-200 g, age 6-8 weeks, health condition. It is divided into six groups. Group I (normal) were fed and watered only, Group II (control) were given a CMC-Na 0,5%, Group III-V were given a suspension of ganyong rhizome starch (SGRS) with each doses 250, 500, and 1000 mg/kgBB, then Group VI were given a sucralfate dose 360 mg/kgBB. Rats were given oral treatment for 14 days. An hour after the treatment on 14th day, the whole groups unless the group I were given ethanol 96% 1 ml/200gBB orally. Twenty four hours later the rats were sacrificed, dissected and taken its gastric for further analyzed the number of ulcers as well as the description of histopathology of the gastric. The results showed that ganyong rhizome starch can decrease the index ulcer and increase the protection ratio value to the control group with results of doses SGRS 250, 500, 1000 mg/kgBB sequentially i.e., 12,5; 50; and 75%. The description of histopathology also showed significant improvement of gastric tissue at a dose of 1000 mg/kgBB. In addition, on TLC-Densitometri test also obtained the total flavonoid compound in ganyong rhizome is 112,49 Â± 7,97 ppm. Conclusions of this research are that the ganyong rhizome positive contains flavonoid and it has gastroprotective effect by decreasing the number of index ulcer, increasing the protection ratio value, and improving the histopathology of gastric tissue which had given alcohol.

Application method of Fourier Transform Infrared (FTIR) combined with chemometrics for analysis of rat meat (Rattus Diardi) in meatballs beef Guntarti, Any; Prativi, Seshilia Rarasati
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Food product forgery begins to become a new problem in Indonesia, the main problem is there is a concern that food product is mixed with forbidden meat, one of may is rat meat in meatball.Â This study is expected to become one basic in order to meet meatball authenticity guarantee.Study about the utilization of infrared spectrophotometry Fourier Transform (FTIR) which was combined with chemometric was carried out to identified rat meat in meatball quantitative and qualitatively. Concentration variation of beef and rat meat in producing meatball is 0%, 25%, 35%, 65%, 75% and 100% rat meat in meatball dough and 5 samples of market meatball. Beef and rat fat which were contained in meatball was extracted by Soxhlet in temperature â¤ 70oC for 7 hours with n-hexane solvent.Qualitative and quantitative analysis was carried out in wave range 750-1600 cm-1 by using partial least square (PLS) multivariate analysis technique and principal component analysis (PCA). The result of calibration with y = 0,9720x + 1,580, coefficient of determination (R2) = 0,9941, and root mean square error of calibration (RMSEC) value was 1.63%. Validation model with, mean root mean square error of cross validation (RMSECV) value was 1.79%, and root mean square error of prediction (RMSEP) value was 2.60%. Using Principal Component Analysis (PCA), grouping of cow fat and mouse fat in the meatballs successfully.Â

The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol Parfati, Nani; Rani, Karina Citra
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of Î²-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q30 minutes= 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.

Gambaran pelaksanaan swamedikasi dan pendapat konsumen apotek mengenai konseling obat tanpa resep di wilayah Bantul candradewi, susan fitria; Kristina, Susi Ari
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

PenggunaanÂ obat tanpa resep dalam upaya swamedikasi telah dilakukan secara luas oleh masyarakat untuk mengobati berbagai kondisi penyakit ringan. Obat-obat yang sering digunakan dalam swamedikasi pada umumnya termasuk ke dalam golongan obat tanpa resep. Perilaku masyarakat daam swamedikasi dipengaruhi beberapa hal salah satunya kemudahan mengakses berbagai informasi mengenai obat, dan juga merupakan salah satu pertimbangan konsumen dalam pemilihan obat. . Perkembangan konsep âPelayanan Kefarmasianâ berarti Apoteker secara langsung bertanggung jawab pada pasien dalam peningkatkan mutu pelayanan sehingga Apoteker memiliki kewajiban dalam pemberian informasi yang benar terkait penggunaan obat-obat tanpa resep. Penelitian ini bertujuan untuk mengetahui pendapat konsumen apotek mengenaikonseling obat tandap resep dan gambaran pelaksanaan swamedikasi di wilayah bantul. Rancangan penelitian deskriptif dengan metode penelitian survei secara langsung menggunakan kuesioner dan lembar observasi. Penentuan sampel apotek dan pasien dilakukan menggunakan teknik purposive sampling. Hasil dari penelitian ini menunjukkan bahwa tiga golongan obat yang paling banyak dibeli dalam pelaksanaan swamedikasi adalah analgesik antipiretik (28,8%), vitamin/suplemen (19,3%), dan obat batuk pilek (15,1%). Sebagian besar konsumen telah mengetahui aturan pemakaian obat (71%0, dan Apoteker merupakan faktor pertimbangan dalam pemilihan obat (34%). Sebanyak 95,7% konsumen mengaku membaca label obat pada saat pertama kali pembelian (95,7%). Pendapat konsumen mengenai konseling yaitu bahwa sebagian besar memerlukan adanya konseling obat tanpa resep (89%), sebanyak 24,8% pernah mendapatkan konseling obat tanpa resep dengan durasi konseling 1-5 menit. Kesimpulan dari penelitian ini adalah Gambaran pelaksanaan swamedikasi obat tanpa resep di Wilayah Bantul menunjukkan bahwa golongan obat tanpa resep yang paling banyak dibeli adalah analgesik antipiretik. Pelaksanaan swamedikasi obat tanpa resep di wilayah Bantul sudah dilakukan dengan baik, ditunjukkan dengan sebagian besar konsumen pernah mendapatkan konseling dengan durasi 1-5 menit. Konsumen juga merasa perlu mendapatkan konseling obat tanpa resep oleh Apoteker.

Validation of UV-Vis spectrophotometry methode for analysis of apigenin in celery extract (Apium graveolens L.) Yulianto, Asep Nurrahman; Rusdiana, Taofik; Muchtaridi, Muchtaridi; Subarnas, Anas
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Apigenin is one of the flavonoid compounds contained in celery (Apium graveolens L.) and has been used for the treatment of various diseases. This study aims were to ensure the validity and accuracy of analytical method for apigenin assay in celery extract using UV-Vis spectrophotometry. The flavonoids test of celery extract give a positive result which produces a yellow color that can be drawn by amyl alcohol. The result of TLC test using a mobile phase of chloroform and methanol (9.5 : 0.5) produced Rf value of 0.75. Validation of analytical methods were sensitivity, linearity, limit of detection as well as limit of quantification, accuracy, and precision. Validation of analytical methods showed that sensitivity results as represented by molar extinction (Îµ) was 77004.35 M-1cm-1. Linearity from calibration curve at concentration of 2, 4, 6, 8, and 10 mgL-1 resulted an equation of y = 0.074x â 0.0011 with coefficient correlation (r) of 0.9996. The limit of detection and limit of quantification were 2.99 mgL-1 and 9.92 mgL-1 respectively with recovery percentage of 97.59% and the coefficient variation values were 1.53%; 2.43% and 1.68%. The average contents of apigenin in the celery extract were of 3.74 Â± 0.09%.Â

Kandungan flavanoid total dan aktivitas antimikroba serbuk biji kakao (Theobroma cacao) asal kabupaten enrekang Sulawesi Selatan Emelda, Andi; Rusli, Rusli; Nurlina, Nurlina; Santi, Irma
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cocoa and its derivatives are rich in flavonoids. Flavonoid content of cocoa beans is affected by the treatment process. The aim of this study are to determine total flavonoids and antimicrobial activity of cocoa powder. This study used unfermented cocoa beans in the form of powder. Testing of the total flavonoids was conducted using an aluminum chloride colorimetric assay. The minimum inhibitory concentration (MIC), Minimum Bactericidal Concentration (MBC), and antimicrobial activity of cocoa bean powder were tested by using ten bacteria: Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli, Salmonella thypi, Shigella dysentriae, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans, Vibrio cholerae, and Propioni bacterium agne. The result of measurement of the total flavonoid of unfermented cocoa powder is 22.62 mg EC/g. The screening of antimicrobial with concentration of 0.1% of cocoa powder gives inhibition in Streptococcus mutans, dysentriae Shigella, Escherichia coli, Vibrio cholerae bacterium and Propioni bacterium agne, while at a concentration of 0.5% gives inhibition at all test bacteria. In the antimicrobial activity test using a concentration of 0.5%, 1%, 2% and 4%, the highest resistance zone is shown at a concentration of 4 %. The results show that the diameter zone of inhibition for the bacteria Shigella dysentriae is 11.33 mm. The 10 mm of diameter zone of inhibition are indicated by streptococcus mutans, Escherichia coli, Propioni bacterium agne, Staphylococcus aureus and Bacillus subtilis while 11 mm zone of inhibition demonstrated by Salmonella thypi and Staphylococcus epidermidis. The number of the diameter zone of inhibition, 12 mm, was shown in Pseudomonas aeruginosa. In conclusion, the powder of unfermented cocoa beans provides flavonoids 22,62 mg EK/g and have the antimicrobial activity.

Optimasi formula gel ekstrak kubis ungu (Brassica Oleracea L. Var. Capitata F. Rubra) menggunakan simplex lattice design dan pengujian aktivitas antioksidan secara in vitro Senja, Rima Yulia; Nugroho, Akhmad Kharis; Setyowati, Erna Prawita
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTA study of optimization of red cabbage (Brassica oleracea.L. var. capitata f. rubra) gel extract formula has been performed by using Simplex Lattice Design (SLD) method and antioxidant activity of the formula gel was also evaluated by using in vitro method.The red cabbage was extracted by soxhletation by using ethanol 96% followed by optimization of red cabbage extract in antioxidant gel preparation used SLD method by Design-ExpertÂ® software version 7 (DX7) and determination of its IC50 used UV-Spectrophotometry. The stability of optimum gel formula is seen through comparison of physycal properties at the beginning and after four weeks storage used ANOVA, with a 95% significant level. Optimum gel formula of red cabbage extract obtained in the proportion of Metolose 3,883%, propilen glikol 13.5%, Tween 80 1.117%. The evaluation results of optimum gel formula of red cabbage extract is the surface area of gel dispersive of 38.99 Â± 3.27cm2; viscosity gel dPa.s of 295.56 Â± 1.93 and viscosity change 3.89 Â± 0.96%. From the results of statistical analysis of one t-test sample was concluded that there was no difference between the prediction price of software with the observation result (p> 0.05). The IC50 test result of the optimum formula of red cabbage extract gel was 257.25 Â± 0.35 Âµg / mL. The testing result of the physical stability of the optimum formula of red cabbage extract gel suffered a pH decrease after 4 weeks of storage (p <0.05).

Factors relate to the hypercreatininemia event of patients at the risk of metabolic syndrome in Jetis I public health center Akrom, Akrom; Darmawan, Endang; Maulida, Nuril
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatientÂ at risk of Â MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted Â from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical Â data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia. Â About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.

The gel formulation of the aqueous phase of snakehead fish (Channa striata) extract with various combinations of HPMC K4M and Carbopol 934 Taurina, Wintari; Andrie, Mohamad; Anjeli, Lea
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gel is a clear and semi-solid material, translucent and contains active material. The liquid phase of Ekstrak Ikan Gabus contains reactive Albumin benefits to advance the wound-healing process. HPMC and carbopol is the gelling agent uses to form gel material. This research aims to acknowledge the effect of basic combination variety (gelling agent) towards physical and chemical stability of gel material during liquid phase of Ekstrak Ikan Gabus in length of period 28 days.Â Variety of HPMC: Carbopol used, 25:75%, 50:50%, and 75:25%. Physical and chemical test conducted they are, organoleptic test, dispersion test, bonding strength test and pH test. The result is analyzed through one-way ANOVA and continued by LSD test with validity 95%. The whole formula is resulted a stable physical and chemical during 28 days. The higher the consentration of HPMC the the better its physic and chemistry stability. The best and optimum formula was shown by F3 (75:25%), with a stable organoleptic result during 28 days, homogen, the result of the dispere power weight 50 g (Â±14,517 cm2) weight 100 g (Â±16,169 cm2) weight 150 g (Â±16,957 cm2 ) and the average weight is (Â±15,881 cm2), the sticky power (Â±2301,78 second) and pH (Â±6,42) in which can be considered safe for skin.

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Muhammad Syahrir

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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OAI Link

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA